| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jean-Ha Baek, Yiwen Zheng, Cynthia L Darlington, Paul F Smit. Cannabinoid CB2 receptor expression in the rat brainstem cochlear and vestibular nuclei. Acta oto-laryngologica. vol 128. issue 9. 2009-01-27. PMID:19086305. |
cannabinoid cb2 receptor expression in the rat brainstem cochlear and vestibular nuclei. |
2009-01-27 |
2023-08-12 |
rat |
| Ekaterina A Placzek, Yasuo Okamoto, Natsuo Ueda, Eric L Barke. Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown. Neuropharmacology. vol 55. issue 7. 2009-01-26. PMID:18760289. |
anandamide (aea) and 2-arachidonyl glycerol (2-ag), endogenous ligands for the cb1 and cb2 cannabinoid receptors, are referred to as endocannabinoids because they mimic the actions of delta9-tetrahydrocannabinol (delta9-thc), a plant-derived cannabinoid. |
2009-01-26 |
2023-08-12 |
Not clear |
| Alison E B Springs, Peer W F Karmaus, Robert B Crawford, Barbara L F Kaplan, Norbert E Kaminsk. Effects of targeted deletion of cannabinoid receptors CB1 and CB2 on immune competence and sensitivity to immune modulation by Delta9-tetrahydrocannabinol. Journal of leukocyte biology. vol 84. issue 6. 2009-01-22. PMID:18791168. |
effects of targeted deletion of cannabinoid receptors cb1 and cb2 on immune competence and sensitivity to immune modulation by delta9-tetrahydrocannabinol. |
2009-01-22 |
2023-08-12 |
mouse |
| Alison E B Springs, Peer W F Karmaus, Robert B Crawford, Barbara L F Kaplan, Norbert E Kaminsk. Effects of targeted deletion of cannabinoid receptors CB1 and CB2 on immune competence and sensitivity to immune modulation by Delta9-tetrahydrocannabinol. Journal of leukocyte biology. vol 84. issue 6. 2009-01-22. PMID:18791168. |
the role of cannabinoid receptors, cb1 and cb2, in immune competence and modulation by delta9-tetrahydrocannabinol (delta9-thc) was investigated in cb1(-/-)/cb2(-/-) mice. |
2009-01-22 |
2023-08-12 |
mouse |
| Christian Sinning, Bernhard Watzer, Ovidiu Coste, Rolf M Nüsing, Ingo Ott, Alessia Ligresti, Vincenzo Di Marzo, Peter Immin. New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide. Journal of medicinal chemistry. vol 51. issue 24. 2009-01-22. PMID:19053765. |
am404 inhibits endocannabinoid cellular uptake, binds weakly to cb1 and cb2 cannabinoid receptors, and is formed by fatty acid amide hydrolase (faah) in vivo. |
2009-01-22 |
2023-08-12 |
mouse |
| Christian Sinning, Bernhard Watzer, Ovidiu Coste, Rolf M Nüsing, Ingo Ott, Alessia Ligresti, Vincenzo Di Marzo, Peter Immin. New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide. Journal of medicinal chemistry. vol 51. issue 24. 2009-01-22. PMID:19053765. |
we prepared three derivatives of this new (endo)cannabinoid using bioisosteric replacement (1), homology (2), and derivatization (3) of the 4-aminophenol moiety in am404 and tested them against cb1, cb2, and faah. |
2009-01-22 |
2023-08-12 |
mouse |
| Jonathan Z Long, Weiwei Li, Lamont Booker, James J Burston, Steven G Kinsey, Joel E Schlosburg, Franciso J Pavón, Antonia M Serrano, Dana E Selley, Loren H Parsons, Aron H Lichtman, Benjamin F Cravat. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nature chemical biology. vol 5. issue 1. 2009-01-15. PMID:19029917. |
2-arachidonoylglycerol (2-ag) and anandamide are endocannabinoids that activate the cannabinoid receptors cb1 and cb2. |
2009-01-15 |
2023-08-12 |
mouse |
| Natalie E Freeman-Anderson, Theresa G Pickle, Courtney D Netherland, Alicia Bales, Nancy E Buckley, Douglas P Thewk. Cannabinoid (CB2) receptor deficiency reduces the susceptibility of macrophages to oxidized LDL/oxysterol-induced apoptosis. Journal of lipid research. vol 49. issue 11. 2009-01-14. PMID:18614816. |
cannabinoid (cb2) receptor deficiency reduces the susceptibility of macrophages to oxidized ldl/oxysterol-induced apoptosis. |
2009-01-14 |
2023-08-12 |
Not clear |
| Fernando Correa, Fabian Docagne, Leyre Mestre, Diego Clemente, Miriam Hernangómez, Frida Loría, Carmen Guaz. A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells. Biochemical pharmacology. vol 77. issue 1. 2008-12-29. PMID:18848818. |
together, our results provide the first demonstration of a role of aea in inhibiting il-12p70/il-23 axis in human and murine microglial cells via the cb2 receptor and suggest that the pharmacological manipulation of the endocannabinoid system is a potential tool for treating brain inflammatory and autoimmune diseases, like ms. |
2008-12-29 |
2023-08-12 |
human |
| Marco Koch, Iris Habazettl, Faramarz Dehghani, Horst-Werner Kor. The rat pineal gland comprises an endocannabinoid system. Journal of pineal research. vol 45. issue 4. 2008-12-24. PMID:18554250. |
immunohistochemical and immunoblot analyses revealed the presence of cb1 and cb2 receptor proteins, of n-acyl phosphatidyl ethanolamine hydrolyzing phospholipase d (nape-pld), an enzyme catalyzing endocannabinoid biosynthesis and of fatty acid amide hydrolase (faah), an endocannabinoid catabolizing enzyme, in pinealocytes, and in pineal sympathetic nerve fibers identified by double immunofluorescence with an antibody against tyrosine hydroxylase. |
2008-12-24 |
2023-08-12 |
rat |
| E S Onaivi, O Carpio, H Ishiguro, N Schanz, G R Uhl, R Benn. Behavioral effects of CB2 cannabinoid receptor activation and its influence on food and alcohol consumption. Annals of the New York Academy of Sciences. vol 1139. 2008-12-09. PMID:18991890. |
although past research revealed that the cb1 cannabinoid receptor is a potent regulator of food intake, the functional presence of neuronal cb2 cannabinoid receptors in the brain has been controversial. |
2008-12-09 |
2023-08-12 |
mouse |
| E S Onaivi, O Carpio, H Ishiguro, N Schanz, G R Uhl, R Benn. Behavioral effects of CB2 cannabinoid receptor activation and its influence on food and alcohol consumption. Annals of the New York Academy of Sciences. vol 1139. 2008-12-09. PMID:18991890. |
this is because cb2 cannabinoid receptors were thought to be absent from the brain and expressed primarily in immune cells and in the periphery. |
2008-12-09 |
2023-08-12 |
mouse |
| Emmanuel S Onaivi, Hiroki Ishiguro, Jian-Ping Gong, Sejal Patel, Paul A Meozzi, Lester Myers, Alex Perchuk, Zoila Mora, Patricia A Tagliaferro, Eileen Gardner, Alicia Brusco, B Emmanuel Akinshola, Qing-Rong Liu, Sanika S Chirwa, Bruce Hope, Javier Lujilde, Toshiya Inada, Shinya Iwasaki, David Macharia, Lindsey Teasenfitz, Tadao Arinami, George R Uh. Functional expression of brain neuronal CB2 cannabinoid receptors are involved in the effects of drugs of abuse and in depression. Annals of the New York Academy of Sciences. vol 1139. 2008-12-09. PMID:18991891. |
functional expression of brain neuronal cb2 cannabinoid receptors are involved in the effects of drugs of abuse and in depression. |
2008-12-09 |
2023-08-12 |
mouse |
| Emmanuel S Onaivi, Hiroki Ishiguro, Jian-Ping Gong, Sejal Patel, Paul A Meozzi, Lester Myers, Alex Perchuk, Zoila Mora, Patricia A Tagliaferro, Eileen Gardner, Alicia Brusco, B Emmanuel Akinshola, Qing-Rong Liu, Sanika S Chirwa, Bruce Hope, Javier Lujilde, Toshiya Inada, Shinya Iwasaki, David Macharia, Lindsey Teasenfitz, Tadao Arinami, George R Uh. Functional expression of brain neuronal CB2 cannabinoid receptors are involved in the effects of drugs of abuse and in depression. Annals of the New York Academy of Sciences. vol 1139. 2008-12-09. PMID:18991891. |
many laboratories were not able to detect the presence of cb2 cannabinoid receptors (cb2-rs) in healthy brains, but cb2-r expression has been demonstrated in rat microglial cells and other brain-associated cells during inflammation. |
2008-12-09 |
2023-08-12 |
mouse |
| A Brusco, P A Tagliaferro, T Saez, E S Onaiv. Ultrastructural localization of neuronal brain CB2 cannabinoid receptors. Annals of the New York Academy of Sciences. vol 1139. 2008-12-09. PMID:18991892. |
ultrastructural localization of neuronal brain cb2 cannabinoid receptors. |
2008-12-09 |
2023-08-12 |
Not clear |
| A Brusco, P A Tagliaferro, T Saez, E S Onaiv. Ultrastructural localization of neuronal brain CB2 cannabinoid receptors. Annals of the New York Academy of Sciences. vol 1139. 2008-12-09. PMID:18991892. |
the functional expression of neuronal cb2 cannabinoid receptors (cb2-rs) in the brain has been controversial. |
2008-12-09 |
2023-08-12 |
Not clear |
| Michelle Roche, John P Kelly, Maeve O'Driscoll, David P Fin. Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats. Immunology. vol 125. issue 2. 2008-12-04. PMID:18393970. |
furthermore, the selective cannabinoid cb1 and cb2 receptor antagonists, am251 and am630 respectively, and the transient receptor potential vanilloid receptor-1 (trpv1) antagonist, sb366791, reduced lps-induced tnf-alpha plasma levels both alone and in combination with am404. |
2008-12-04 |
2023-08-12 |
rat |
| Michelle Roche, John P Kelly, Maeve O'Driscoll, David P Fin. Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats. Immunology. vol 125. issue 2. 2008-12-04. PMID:18393970. |
in conclusion, inhibition of endocannabinoid degradation or transport in vivo potentiates lps-induced increases in circulating tnf-alpha levels, an effect which may be mediated by ppargamma and is also reduced by pharmacological blockade of cb1, cb2 and trpv1. |
2008-12-04 |
2023-08-12 |
rat |
| Ya Fatou Njie, Fang He, Zhuanhong Qiao, Zhao-Hui Son. Aqueous humor outflow effects of 2-arachidonylglycerol. Experimental eye research. vol 87. issue 2. 2008-12-04. PMID:18597752. |
in conclusion, the results from this study demonstrate that administration of 2-ag increases aqueous humor outflow facility and this effect of 2-ag is mediated through both the cb1 and cb2 cannabinoid receptors. |
2008-12-04 |
2023-08-12 |
Not clear |
| b' Ivana Sv\\xc3\\xadzensk\\xc3\\xa1, Petr Dubov\\xc3\\xbd, Alexandra Sulcov\\xc3\\xa. Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures--a short review. Pharmacology, biochemistry, and behavior. vol 90. issue 4. 2008-11-25. PMID:18584858.' |
cannabinoid receptors 1 and 2 (cb1 and cb2), their distribution, ligands and functional involvement in nervous system structures--a short review. |
2008-11-25 |
2023-08-12 |
Not clear |