| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| María Gracia Gervasi, Maximiliano Rapanelli, María Laura Ribeiro, Mariana Farina, Silvia Billi, Ana María Franchi, Silvina Perez Martine. The endocannabinoid system in bull sperm and bovine oviductal epithelium: role of anandamide in sperm-oviduct interaction. Reproduction (Cambridge, England). vol 137. issue 3. 2009-06-15. PMID:19042982. |
we observed that bull sperm and bovine oviductal epithelial cells express cannabinoid receptors, cb1 and cb2, and fatty acid amide hydrolase, the enzyme that controls intracellular anandamide levels. |
2009-06-15 |
2023-08-12 |
cattle |
| Sanjai Saxen. Fungal biotransformation of cannabinoids: potential for new effective drugs. Current opinion in drug discovery & development. vol 12. issue 2. 2009-06-04. PMID:19333876. |
the discovery of the cannabinoid receptors cb1 and cb2 led to the development of agonists and antagonists of these receptors for the treatment of a variety of diseases. |
2009-06-04 |
2023-08-12 |
Not clear |
| Alicia Brusco, Patricia Tagliaferro, Trinidad Saez, Emmanuel S Onaiv. Postsynaptic localization of CB2 cannabinoid receptors in the rat hippocampus. Synapse (New York, N.Y.). vol 62. issue 12. 2009-05-26. PMID:18798269. |
postsynaptic localization of cb2 cannabinoid receptors in the rat hippocampus. |
2009-05-26 |
2023-08-12 |
rat |
| Alicia Brusco, Patricia Tagliaferro, Trinidad Saez, Emmanuel S Onaiv. Postsynaptic localization of CB2 cannabinoid receptors in the rat hippocampus. Synapse (New York, N.Y.). vol 62. issue 12. 2009-05-26. PMID:18798269. |
the expression of cb2 cannabinoid receptors (cb2-rs) in the brain and their neuronal function has now attracted research interest, since we and others have demonstrated the presence of cb2-rs in neuronal and glial cells in the brain. |
2009-05-26 |
2023-08-12 |
rat |
| Paolo Caraceni, Marco Domenicali, Ferdinando Giannone, Mauro Bernard. The role of the endocannabinoid system in liver diseases. Best practice & research. Clinical endocrinology & metabolism. vol 23. issue 1. 2009-05-26. PMID:19285261. |
endogenous cannabinoids (ecs) are ubiquitous lipid signaling molecules provided by a number of central and peripheral effects, which are mediated mainly by the specific receptors cb1 and cb2. |
2009-05-26 |
2023-08-12 |
Not clear |
| Debra McGuinness, Asra Malikzay, Richard Visconti, Karen Lin, Marvin Bayne, Frederick Monsma, Charles A Lun. Characterizing cannabinoid CB2 receptor ligands using DiscoveRx PathHunter beta-arrestin assay. Journal of biomolecular screening. vol 14. issue 1. 2009-05-22. PMID:19171920. |
characterizing cannabinoid cb2 receptor ligands using discoverx pathhunter beta-arrestin assay. |
2009-05-22 |
2023-08-12 |
human |
| David R Janero, Alexandros Makriyanni. Cannabinoid receptor antagonists: pharmacological opportunities, clinical experience, and translational prognosis. Expert opinion on emerging drugs. vol 14. issue 1. 2009-05-22. PMID:19249987. |
the endogenous cannabinoid (cb) (endocannabinoid) signaling system is involved in a variety of (patho)physiological processes, primarily by virtue of natural, arachidonic acid-derived lipids (endocannabinoids) that activate g protein-coupled cb1 and cb2 receptors. |
2009-05-22 |
2023-08-12 |
human |
| Matthias Karst, Sonja Wipperman. Cannabinoids against pain. Efficacy and strategies to reduce psychoactivity: a clinical perspective. Expert opinion on investigational drugs. vol 18. issue 2. 2009-05-18. PMID:19236260. |
also cannabinoids, which primarily stimulate peripheral cannabinoid-1 (cb1) receptors or selectively cannabinoid-2 (cb2) receptors, can further separate analgesic activity from cannabimimetic activity. |
2009-05-18 |
2023-08-12 |
Not clear |
| Takayuki Sugiur. Physiological roles of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. BioFactors (Oxford, England). vol 35. issue 1. 2009-05-18. PMID:19319851. |
2-arachidonoylglycerol is an arachidonic acid-containing monoacylglycerol isolated from the rat brain and canine gut as an endogenous ligand for the cannabinoid receptors (cb1 and cb2). |
2009-05-18 |
2023-08-12 |
rat |
| Darric E Baty, Ming Zhang, Hongbo Li, Carolyn J Erb, Martin W Adler, Doina Ganea, Christopher M Loftus, Jack I Jallo, Ronald F Tum. Cannabinoid CB2 receptor activation attenuates motor and autonomic function deficits in a mouse model of spinal cord injury. Clinical neurosurgery. vol 55. 2009-04-30. PMID:19248685. |
cannabinoid cb2 receptor activation attenuates motor and autonomic function deficits in a mouse model of spinal cord injury. |
2009-04-30 |
2023-08-12 |
mouse |
| Hong Qian, Zuolin Jin, Shi Li, Na Huo, Chun Han, Hanfei San. Activation of CB2 cannabinoid receptors: a novel therapeutic strategy to accelerate osseointegration of dental implants. Medical hypotheses. vol 72. issue 3. 2009-04-28. PMID:19027245. |
activation of cb2 cannabinoid receptors: a novel therapeutic strategy to accelerate osseointegration of dental implants. |
2009-04-28 |
2023-08-12 |
Not clear |
| Hong Qian, Zuolin Jin, Shi Li, Na Huo, Chun Han, Hanfei San. Activation of CB2 cannabinoid receptors: a novel therapeutic strategy to accelerate osseointegration of dental implants. Medical hypotheses. vol 72. issue 3. 2009-04-28. PMID:19027245. |
recently, endocannabinoids and their receptors, cb2 cannabinoid receptors, have been discovered in the skeleton. |
2009-04-28 |
2023-08-12 |
Not clear |
| Hong Qian, Zuolin Jin, Shi Li, Na Huo, Chun Han, Hanfei San. Activation of CB2 cannabinoid receptors: a novel therapeutic strategy to accelerate osseointegration of dental implants. Medical hypotheses. vol 72. issue 3. 2009-04-28. PMID:19027245. |
osteoblasts, the bone-forming cells, and osteoclasts, the bone-resorbing cells, synthesize the endocannabinoids anandamide and 2-arachidonoylglycerol (2-ag) and express cb2 cannabinoid receptors. |
2009-04-28 |
2023-08-12 |
Not clear |
| Hanna Pettersson, Anne Bülow, Fredrik Ek, Jacob Jensen, Lars K Ottesen, Alma Fejzic, Jian-Nong Ma, Andria L Del Tredici, Erika A Currier, Luis R Gardell, Ali Tabatabaei, Darren Craig, Krista McFarland, Thomas R Ott, Fabrice Piu, Ethan S Burstein, Roger Olsso. Synthesis and evaluation of dibenzothiazepines: a novel class of selective cannabinoid-1 receptor inverse agonists. Journal of medicinal chemistry. vol 52. issue 7. 2009-04-28. PMID:19338356. |
the compounds were evaluated in a mammalian cell-based functional assay and in radioligand binding assays expressing recombinant human cannabinoid receptors (cb1 and cb2). |
2009-04-28 |
2023-08-12 |
human |
| F Akbas, C Gasteyger, A Sjödin, A Astrup, T M Larse. A critical review of the cannabinoid receptor as a drug target for obesity management. Obesity reviews : an official journal of the International Association for the Study of Obesity. vol 10. issue 1. 2009-04-23. PMID:18721231. |
cannabinoids act on two different receptors: cb1 receptors which are sited in the brain and many peripheral tissues, and cb2 receptors which are primarily found in immune system cells. |
2009-04-23 |
2023-08-12 |
Not clear |
| Jason R Clapper, Regina A Mangieri, Daniele Piomell. The endocannabinoid system as a target for the treatment of cannabis dependence. Neuropharmacology. vol 56 Suppl 1. 2009-04-15. PMID:18691603. |
this signaling system is engaged by the active component of cannabis, delta9-tetrahydrocannabinol (delta9-thc), which exerts its pharmacological effects by activation of g protein-coupled type-1 (cb1) and type-2 (cb2) cannabinoid receptors. |
2009-04-15 |
2023-08-12 |
Not clear |
| Fabiola Voznika Merriam, Zun-yi Wang, Simone Domit Guerios, Dale E Bjorlin. Cannabinoid receptor 2 is increased in acutely and chronically inflamed bladder of rats. Neuroscience letters. vol 445. issue 1. 2009-04-14. PMID:18778751. |
cannabinoid receptors 1 and 2 (cb1 and cb2) are g-protein coupled receptors that are expressed throughout the body. |
2009-04-14 |
2023-08-12 |
rat |
| Javier Garzón, Elena de la Torre-Madrid, María Rodríguez-Muñoz, Ana Vicente-Sánchez, Pilar Sánchez-Blázque. Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine. Molecular pain. vol 5. 2009-04-13. PMID:19284549. |
these effects are mediated by cannabinoids binding to peripheral, spinal and supraspinal cb1 and cb2 receptors, making it difficult to determine the relevance of each receptor type to these phenomena. |
2009-04-13 |
2023-08-12 |
Not clear |
| Anna Parfieniuk, Robert Flisia. Role of cannabinoids in chronic liver diseases. World journal of gastroenterology. vol 14. issue 40. 2009-04-02. PMID:18985799. |
cannabinoids are a group of compounds acting primarily via cb1 and cb2 receptors. |
2009-04-02 |
2023-08-12 |
Not clear |
| Guy A Cabral, LaToya Griffin-Thoma. Emerging role of the cannabinoid receptor CB2 in immune regulation: therapeutic prospects for neuroinflammation. Expert reviews in molecular medicine. vol 11. 2009-03-27. PMID:19152719. |
studies aimed at elucidating signal transduction events resulting from cb2 interaction with its native ligands, and of the role of exogenous cannabinoids in modulating this process, are providing novel insights into the role of cb2 in maintaining a homeostatic immune balance within the host. |
2009-03-27 |
2023-08-12 |
Not clear |