| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrea Chicca, Stefan Raduner, Federica Pellati, Thomas Strompen, Karl-Heinz Altmann, Roland Schoop, Jürg Gertsc. Synergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts. International immunopharmacology. vol 9. issue 7-8. 2009-11-13. PMID:19303464. |
we show that n-alkylamides act in concert and exert pleiotropic effects modulating the endocannabinoid system by simultaneously targeting the cb2 receptor, endocannabinoid transport and degradation. |
2009-11-13 |
2023-08-12 |
human |
| b' Bal\\xc3\\xa1zs Cs\\xc3\\xb3ka, Zolt\\xc3\\xa1n H N\\xc3\\xa9meth, Partha Mukhopadhyay, Zolt\\xc3\\xa1n Spolarics, Mohanraj Rajesh, Stephanie Federici, Edwin A Deitch, S\\xc3\\xa1ndor B\\xc3\\xa1tkai, P\\xc3\\xa1l Pacher, Gy\\xc3\\xb6rgy Hask\\xc3\\xb. CB2 cannabinoid receptors contribute to bacterial invasion and mortality in polymicrobial sepsis. PloS one. vol 4. issue 7. 2009-11-10. PMID:19641602.' |
cb2 cannabinoid receptors contribute to bacterial invasion and mortality in polymicrobial sepsis. |
2009-11-10 |
2023-08-12 |
Not clear |
| Rosa María Tolón, Estefanía Núñez, María Ruth Pazos, Cristina Benito, Ana Isabel Castillo, José Antonio Martínez-Orgado, Julián Romer. The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages. Brain research. vol 1283. 2009-10-23. PMID:19505450. |
the activation of cannabinoid cb2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages. |
2009-10-23 |
2023-08-12 |
human |
| Alexander A Zoerner, Frank M Gutzki, Maria T Suchy, Bibiana Beckmann, Stefan Engeli, Jens Jordan, Dimitrios Tsika. Targeted stable-isotope dilution GC-MS/MS analysis of the endocannabinoid anandamide and other fatty acid ethanol amides in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 877. issue 26. 2009-09-28. PMID:19414283. |
anandamide (arachidonoyl ethanol amide, aea) is an endocannabinoid, acting on cb1 and cb2 receptors. |
2009-09-28 |
2023-08-12 |
human |
| N Olea-Herrero, D Vara, S Malagarie-Cazenave, I Díaz-Laviad. Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)-Methanandamide and JWH-015: involvement of CB2. British journal of cancer. vol 101. issue 6. 2009-09-23. PMID:19690545. |
inhibition of human tumour prostate pc-3 cell growth by cannabinoids r(+)-methanandamide and jwh-015: involvement of cb2. |
2009-09-23 |
2023-08-12 |
human |
| Leonie Wyffels, Giulio G Muccioli, Sylvie De Bruyne, Lieselotte Moerman, Johan Sambre, Didier M Lambert, Filip De Vo. Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain. Journal of medicinal chemistry. vol 52. issue 15. 2009-09-21. PMID:19719235. |
compounds 17 and 18 did not display significant binding to cb1 and cb2 cannabinoid receptors and stand out as potential candidate metabolic trapping tracers. |
2009-09-21 |
2023-08-12 |
mouse |
| Onintza Sagredo, Sara González, Ilia Aroyo, María Ruth Pazos, Cristina Benito, Isabel Lastres-Becker, Juan P Romero, Rosa M Tolón, Raphael Mechoulam, Emmanuel Brouillet, Julián Romero, Javier Fernández-Rui. Cannabinoid CB2 receptor agonists protect the striatum against malonate toxicity: relevance for Huntington's disease. Glia. vol 57. issue 11. 2009-09-14. PMID:19115380. |
cannabinoid cb2 receptor agonists protect the striatum against malonate toxicity: relevance for huntington's disease. |
2009-09-14 |
2023-08-12 |
mouse |
| Lin Chen, Jing Zhang, Fan Li, Yue Qiu, Lu Wang, Ying-hua Li, Jing Shi, Hui-Lin Pan, Man L. Endogenous anandamide and cannabinoid receptor-2 contribute to electroacupuncture analgesia in rats. The journal of pain. vol 10. issue 7. 2009-09-14. PMID:19409856. |
in this report, we determined the effect of electroacupuncture (ea) on the level of anandamide in the skin tissue and the role of cannabinoid cb1 and cb2 receptors in the analgesic effect of ea in an animal model of inflammatory pain. |
2009-09-14 |
2023-08-12 |
rat |
| Yan Wei, Xu Wang, Ling Wan. Presence and regulation of cannabinoid receptors in human retinal pigment epithelial cells. Molecular vision. vol 15. 2009-09-14. PMID:19547718. |
here we analyzed the expression of and changes in cannabinoid receptors (cb1 and cb2) and one enzyme responsible for endocannabinoid hydrolysis, fatty acid amide hydrolase (faah), in rpe cell oxidative damage process, a cellular model of armd. |
2009-09-14 |
2023-08-12 |
human |
| Gianfranco Alpini, Sharon Demorro. Changes in the endocannabinoid system may give insight into new and effective treatments for cancer. Vitamins and hormones. vol 81. 2009-09-10. PMID:19647123. |
the endocannabinoid system comprises specific cannabinoid receptors such as cb1 and cb2, the endogenous ligands (anandamide and 2-arachidonyl glycerol among others) and the proteins responsible for their synthesis and degradation. |
2009-09-10 |
2023-08-12 |
Not clear |
| Rupal Pandey, Venkatesh L Hegde, Narendra P Singh, Lorne Hofseth, Uday Singh, Swapan Ray, Mitzi Nagarkatti, Prakash S Nagarkatt. Use of cannabinoids as a novel therapeutic modality against autoimmune hepatitis. Vitamins and hormones. vol 81. 2009-09-10. PMID:19647124. |
the induction of cb1 and cb2 cannabinoid receptors during liver injury and the potential involvement of endocannabinoids in the regulation of this process have sparked significant interest in further evaluating the role of cannabinoid systems during hepatic disease. |
2009-09-10 |
2023-08-12 |
Not clear |
| Bastien Reux, Tapio Nevalainen, Katri H Raitio, Ari M P Koskine. Synthesis of quinolinyl and isoquinolinyl phenyl ketones as novel agonists for the cannabinoid CB2 receptor. Bioorganic & medicinal chemistry. vol 17. issue 13. 2009-09-09. PMID:19477133. |
synthesis of quinolinyl and isoquinolinyl phenyl ketones as novel agonists for the cannabinoid cb2 receptor. |
2009-09-09 |
2023-08-12 |
Not clear |
| Ruben Nogueiras, Adenis Diaz-Arteaga, Sarah H Lockie, Douglas A Velásquez, Johannes Tschop, Miguel López, Charles C Cadwell, Carlos Diéguez, Matthias H Tschö. The endocannabinoid system: role in glucose and energy metabolism. Pharmacological research. vol 60. issue 2. 2009-09-02. PMID:19559361. |
the ecs acts through two cannabinoid receptors: types 1 and 2 (cb1 and cb2). |
2009-09-02 |
2023-08-12 |
Not clear |
| Simona Pisanti, Maurizio Bifulc. Endocannabinoid system modulation in cancer biology and therapy. Pharmacological research. vol 60. issue 2. 2009-09-02. PMID:19559362. |
the discovery of the endocannabinoid system and the recognition of its potential impact in a plethora of pathological conditions, led to the development of therapeutic agents related to either the stimulation or antagonism of cb1 and cb2 cannabinoid receptors, the majority of which are actually tested in preclinical studies for the pharmacotherapy of several diseases. |
2009-09-02 |
2023-08-12 |
Not clear |
| Himanshu Bhattacharjee, Steven N Gurley, Bob M Moor. Design and synthesis of novel tri-aryl CB2 selective cannabinoid ligands. Bioorganic & medicinal chemistry letters. vol 19. issue 6. 2009-08-20. PMID:19230659. |
design and synthesis of novel tri-aryl cb2 selective cannabinoid ligands. |
2009-08-20 |
2023-08-12 |
Not clear |
| Ahmed M Galal, Desmond Slade, Waseem Gul, Abir T El-Alfy, Daneel Ferreira, Mahmoud A Elsohl. Naturally occurring and related synthetic cannabinoids and their potential therapeutic applications. Recent patents on CNS drug discovery. vol 4. issue 2. 2009-08-18. PMID:19519560. |
most of these effects have been attributed to the ability of these compounds to interact with the cannabinoid cb1 and cb2 receptors. |
2009-08-18 |
2023-08-12 |
Not clear |
| Nicole Defer, Jinghong Wan, Richard Souktani, Brigitte Escoubet, Magali Perier, Philippe Caramelle, Sylvie Manin, Vanessa Deveaux, Marie-Claude Bourin, Andreas Zimmer, Sophie Lotersztajn, Françoise Pecker, Catherine Pavoin. The cannabinoid receptor type 2 promotes cardiac myocyte and fibroblast survival and protects against ischemia/reperfusion-induced cardiomyopathy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 23. issue 7. 2009-08-13. PMID:19246487. |
ex vivo studies have demonstrated the cardioprotective anti-inflammatory effect of the cannabinoid type 2 (cb2) receptor agonists within hours after ir. |
2009-08-13 |
2023-08-12 |
Not clear |
| Praveen Anand, Garth Whiteside, Christopher J Fowler, Andrea G Hohman. Targeting CB2 receptors and the endocannabinoid system for the treatment of pain. Brain research reviews. vol 60. issue 1. 2009-08-04. PMID:19150370. |
targeting cb2 receptors and the endocannabinoid system for the treatment of pain. |
2009-08-04 |
2023-08-12 |
human |
| Patrick M Beardsley, Brian F Thomas, Lance R McMaho. Cannabinoid CB1 receptor antagonists as potential pharmacotherapies for drug abuse disorders. International review of psychiatry (Abingdon, England). vol 21. issue 2. 2009-08-04. PMID:19367507. |
since the discovery of the cannabinoid cb1 receptor (cb1r) in 1988, and subsequently of the cb2 receptor (cb2r) in 1993, there has been an exponential growth of research investigating the functions of the endocannabinoid system. |
2009-08-04 |
2023-08-12 |
Not clear |
| David R Janero, Subramanian K Vadivel, Alexandros Makriyanni. Pharmacotherapeutic modulation of the endocannabinoid signalling system in psychiatric disorders: drug-discovery strategies. International review of psychiatry (Abingdon, England). vol 21. issue 2. 2009-08-04. PMID:19367506. |
two cannabinoid (cb) receptors (cb1 and cb2) currently represent prime endocannabinoid-system therapeutic targets for ligands that either mimic endocannabinoid signalling processes and/or potentiate endocannabinoid-system activity (agonists) or attenuate pathologically heightened endocannabinoid-system transmission (antagonists). |
2009-08-04 |
2023-08-12 |
Not clear |