| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chen Li, Peter M Jones, Shanta J Persau. Cannabinoid receptors are coupled to stimulation of insulin secretion from mouse MIN6 beta-cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 26. issue 2. 2010-12-08. PMID:20798502. |
min6 beta-cells express the cannabinoid synthesising enzyme diacylglycerol lipase and cb1 and cb2 receptors, which are coupled to inhibition of beta-cell cyclic amp generation and stimulation of intracellular calcium levels. |
2010-12-08 |
2023-08-12 |
mouse |
| Chen Li, Peter M Jones, Shanta J Persau. Cannabinoid receptors are coupled to stimulation of insulin secretion from mouse MIN6 beta-cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 26. issue 2. 2010-12-08. PMID:20798502. |
synthesis of endocannabinoids by beta-cells may provide an additional mechanism for stimulation of insulin secretion through activation of beta-cell cb1 and/or cb2 cannabinoid receptors. |
2010-12-08 |
2023-08-12 |
mouse |
| C E Pinto, E Moura, M P Serrão, M J Martins, M A Vieira-Coelh. Effect of (-)-Delta(9)-tetrahydrocannabinoid on the hepatic redox state of mice. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 43. issue 4. 2010-12-06. PMID:20445947. |
the levels of mrna of the cannabinoid receptors cb1 and cb2 were also monitored. |
2010-12-06 |
2023-08-12 |
mouse |
| Amélie Servettaz, Niloufar Kavian, Carole Nicco, Vanessa Deveaux, Christiane Chéreau, Andrew Wang, Andreas Zimmer, Sophie Lotersztajn, Bernard Weill, Frédéric Batteu. Targeting the cannabinoid pathway limits the development of fibrosis and autoimmunity in a mouse model of systemic sclerosis. The American journal of pathology. vol 177. issue 1. 2010-12-06. PMID:20508030. |
balb/c mice injected subcutaneously every day for 6 weeks with pbs or hypochlorite were treated intraperitoneally with either win-55,212, an agonist of the cannabinoid receptors 1 (cb1) and receptors 2 (cb2), with jwh-133, a selective agonist of cb2, or with pbs. |
2010-12-06 |
2023-08-12 |
mouse |
| R Talevi, V Barbato, S De Iorio, V Mollo, T Capriglione, L Ricchiari, A Samo, R Gualtier. Is there a role for endocannabinoids in sperm-oviduct interaction? Reproduction (Cambridge, England). vol 140. issue 2. 2010-12-03. PMID:20511399. |
data showed that 1) the endocannabinoid receptors 1 and 2 (cb1 and cb2) are present in bovine spermatozoa both in the initial ejaculate and in spermatozoa bound to the oviduct in vitro; 2) cb1 receptor is still detectable in spermatozoa released from the oviduct through penicillamine but not in those released through heparin; 3) arachidonylethanolamide (aea) does not affect sperm viability, whereas it depresses sperm progressive motility and kinetic values; 4) sperm-oviduct binding and release in vitro are not influenced by aea; 5) aea depresses sperm-zona pellucida (zp) binding; 6) binding of heparin-capacitated spermatozoa to the zp is not affected by aea; 7) n-acylphosphatidylethanolamine-selective phospholipase d, the main enzyme involved in anandamide synthesis, is expressed in oviductal epithelial cells. |
2010-12-03 |
2023-08-12 |
cattle |
| Sieglinde Marquart, Pawel Zerr, Alfiya Akhmetshina, Katrin Palumbo, Nicole Reich, Michal Tomcik, Angelika Horn, Clara Dees, Matthias Engel, Jochen Zwerina, Oliver Distler, Georg Schett, Jörg H W Distle. Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis. Arthritis and rheumatism. vol 62. issue 11. 2010-11-30. PMID:20617520. |
cannabinoids are derivates of the marijuana component Δ(9) -tetrahydrocannabinol that exert their effects on mesenchymal cells and immune cells via cb1 and cb2 receptors. |
2010-11-30 |
2023-08-12 |
Not clear |
| Andrew G Horti, Yongjun Gao, Hayden T Ravert, Paige Finley, Heather Valentine, Dean F Wong, Christopher J Endres, Alena V Savonenko, Robert F Dannal. Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2). Bioorganic & medicinal chemistry. vol 18. issue 14. 2010-11-23. PMID:20554448. |
synthesis and biodistribution of [11c]a-836339, a new potential radioligand for pet imaging of cannabinoid type 2 receptors (cb2). |
2010-11-23 |
2023-08-12 |
mouse |
| Sadiye Amcaoglu Rieder, Ashok Chauhan, Ugra Singh, Mitzi Nagarkatti, Prakash Nagarkatt. Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. Immunobiology. vol 215. issue 8. 2010-10-28. PMID:19457575. |
with the recent discovery of the cannabinoid receptors (cb1 and cb2) and the endocannabinoid system, research in this field has expanded exponentially. |
2010-10-28 |
2023-08-12 |
Not clear |
| Sadiye Amcaoglu Rieder, Ashok Chauhan, Ugra Singh, Mitzi Nagarkatti, Prakash Nagarkatt. Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. Immunobiology. vol 215. issue 8. 2010-10-28. PMID:19457575. |
studies from our laboratory have focused on mechanisms of apoptosis induction by natural and synthetic cannabinoids through activation of cb2 receptors. |
2010-10-28 |
2023-08-12 |
Not clear |
| Sadiye Amcaoglu Rieder, Ashok Chauhan, Ugra Singh, Mitzi Nagarkatti, Prakash Nagarkatt. Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. Immunobiology. vol 215. issue 8. 2010-10-28. PMID:19457575. |
in this review, we will focus on apoptotic mechanisms of immunosuppression mediated by cannabinoids on different immune cell populations and discuss how activation of cb2 provides a novel therapeutic modality against inflammatory and autoimmune diseases as well as malignancies of the immune system, without exerting the untoward psychotropic effects. |
2010-10-28 |
2023-08-12 |
Not clear |
| Lucie Jean-Gilles, Bruno Gran, Cris S Constantinesc. Interaction between cytokines, cannabinoids and the nervous system. Immunobiology. vol 215. issue 8. 2010-10-28. PMID:20153076. |
the endocannabinoid system (es) is comprised of the cb1 and cb2 cannabinoid receptors, endogenous ligands, and proteins involved in endocannabinoid synthesis and inactivation. |
2010-10-28 |
2023-08-12 |
Not clear |
| b' Lucie Martyk\\xc3\\xa1nov\\xc3\\xa. [Endocannabinoid system I--the role in regulation of physiology functions]. Casopis lekaru ceskych. vol 149. issue 8. 2010-10-28. PMID:20925267.' |
the system consists of cannabinoid receptors cb1 and cb2, endocannabinoids and their biosynthetic and degrading enzymes. |
2010-10-28 |
2023-08-12 |
Not clear |
| Ming-xiu Hao, Li-sheng Jiang, Ning-yuan Fang, Jun Pu, Liu-hua Hu, Ling-Hong Shen, Wei Song, Ben H. The cannabinoid WIN55,212-2 protects against oxidized LDL-induced inflammatory response in murine macrophages. Journal of lipid research. vol 51. issue 8. 2010-10-20. PMID:20305287. |
these results demonstrate the involvement of the endocannabinoid system in regulating the oxldl-induced inflammatory response in macrophages, and indicate that the cb2 receptor may offer a novel pharmaceutical target for treating atherosclerosis. |
2010-10-20 |
2023-08-12 |
mouse |
| P Bagavandoss, S Grimsha. Temporal and spatial distribution of the cannabinoid receptors (CB1, CB2) and fatty acid amide hydroxylase in the rat ovary. Anatomical record (Hoboken, N.J. : 2007). vol 293. issue 8. 2010-10-13. PMID:20665820. |
temporal and spatial distribution of the cannabinoid receptors (cb1, cb2) and fatty acid amide hydroxylase in the rat ovary. |
2010-10-13 |
2023-08-12 |
rat |
| Torunn Fiskerstrand, Dorra H'mida-Ben Brahim, Stefan Johansson, Abderrahim M'zahem, Bjørn Ivar Haukanes, Nathalie Drouot, Julian Zimmermann, Andrew J Cole, Christian Vedeler, Cecilie Bredrup, Mirna Assoum, Meriem Tazir, Thomas Klockgether, Abdelmadjid Hamri, Vidar M Steen, Helge Boman, Laurence A Bindoff, Michel Koenig, Per M Knappsko. Mutations in ABHD12 cause the neurodegenerative disease PHARC: An inborn error of endocannabinoid metabolism. American journal of human genetics. vol 87. issue 3. 2010-10-07. PMID:20797687. |
the abhd12 enzyme was recently shown to hydrolyze 2-arachidonoyl glycerol (2-ag), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors cb1 and cb2. |
2010-10-07 |
2023-08-12 |
Not clear |
| Gorka Larrinaga, Adolfo Varona, Itxaro Pérez, Begoña Sanz, Aitziber Ugalde, M Luz Cándenas, Francisco M Pinto, Javier Gil, José I Lópe. Expression of cannabinoid receptors in human kidney. Histology and histopathology. vol 25. issue 9. 2010-10-05. PMID:20607655. |
the presence of cb1 and cb2 cannabinoid receptors and their physiological role in the kidney has been described in animal models but not in humans. |
2010-10-05 |
2023-08-12 |
human |
| M A Engel, C A Kellermann, G Burnat, E G Hahn, T Rau, P C Konture. Mice lacking cannabinoid CB1-, CB2-receptors or both receptors show increased susceptibility to trinitrobenzene sulfonic acid (TNBS)-induced colitis. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 61. issue 1. 2010-10-01. PMID:20228420. |
lacking of both cannabinoid receptors did not result in potentiation of colitis severity compared to lacking of each cb1 or cb2, respectively. |
2010-10-01 |
2023-08-12 |
mouse |
| Qiao Yang, Hong Yan Liu, Yao Wen Zhang, Wen Jie Wu, Wang Xian Tan. Anandamide induces cell death through lipid rafts in hepatic stellate cells. Journal of gastroenterology and hepatology. vol 25. issue 5. 2010-09-27. PMID:20059638. |
anandamide (aea), the most extensively studied endocannabinoid, and its putative cannabinoid receptors, cb1 and cb2, exert a variety of physiological and pharmacological effects in chronic liver diseases, such as hyperdynamic circulation. |
2010-09-27 |
2023-08-12 |
rat |
| Jos H M Lange, Martina A W van der Neut, Henri C Wals, Gijs D Kuil, Alice J M Borst, Arie Mulder, Arnold P den Hartog, Hicham Zilaout, Wouter Goutier, Herman H van Stuivenberg, Bernard J van Vlie. Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB2 receptor antagonists with high binding efficiencies. Bioorganic & medicinal chemistry letters. vol 20. issue 3. 2010-09-20. PMID:20031412. |
synthesis and sar of novel imidazoles as potent and selective cannabinoid cb2 receptor antagonists with high binding efficiencies. |
2010-09-20 |
2023-08-12 |
Not clear |
| Anthony H Taylor, Muna S Abbas, Marwan A Habiba, Justin C Konj. Histomorphometric evaluation of cannabinoid receptor and anandamide modulating enzyme expression in the human endometrium through the menstrual cycle. Histochemistry and cell biology. vol 133. issue 5. 2010-09-20. PMID:20369362. |
plasma anandamide (aea) levels fluctuate throughout the menstrual cycle and in early pregnancy in a pattern suggesting its involvement in implantation and early pregnancy maintenance through mechanisms that might involve its binding to cannabinoid receptors cb1 and cb2. |
2010-09-20 |
2023-08-12 |
human |