| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Weis, A Beiras-Fernandez, D Hauer, C Hornuss, R Sodian, S Kreth, J Briegel, G Schellin. Effect of anaesthesia and cardiopulmonary bypass on blood endocannabinoid concentrations during cardiac surgery. British journal of anaesthesia. vol 105. issue 2. 2010-08-02. PMID:20525978. |
the endocannabinoid system (ecs) is an endogenous signalling system which includes the endocannabinoids anandamide (aea) and 2-arachidonoylglycerol (2-ag) and specific g-protein-coupled endocannabinoid receptors (cb1 and cb2). |
2010-08-02 |
2023-08-12 |
human |
| Maider López De Jesús, Cristina Hostalot, Jesús M Garibi, Joan Sallés, J Javier Meana, Luis F Callad. Opposite changes in cannabinoid CB1 and CB2 receptor expression in human gliomas. Neurochemistry international. vol 56. issue 6-7. 2010-07-29. PMID:20307616. |
opposite changes in cannabinoid cb1 and cb2 receptor expression in human gliomas. |
2010-07-29 |
2023-08-12 |
human |
| Patricia H Reggi. Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown. Current medicinal chemistry. vol 17. issue 14. 2010-07-28. PMID:20166921. |
the cannabinoid cb1 and cb2 receptors are class a g protein-coupled receptors (gpcrs). |
2010-07-28 |
2023-08-12 |
Not clear |
| Hiroki Ishiguro, Yasue Horiuchi, Maya Ishikawa, Minori Koga, Keiko Imai, Yoshimi Suzuki, Miyuki Morikawa, Toshiya Inada, Yuichiro Watanabe, Makoto Takahashi, Toshiyuki Someya, Hiroshi Ujike, Nakao Iwata, Norio Ozaki, Emmanuel S Onaivi, Hiroshi Kunugi, Tsukasa Sasaki, Masanari Itokawa, Makoto Arai, Kazuhiro Niizato, Shyuji Iritani, Izumi Naka, Jun Ohashi, Akiyoshi Kakita, Hitoshi Takahashi, Hiroyuki Nawa, Tadao Arinam. Brain cannabinoid CB2 receptor in schizophrenia. Biological psychiatry. vol 67. issue 10. 2010-07-22. PMID:19931854. |
brain cannabinoid cb2 receptor in schizophrenia. |
2010-07-22 |
2023-08-12 |
Not clear |
| Hiroki Ishiguro, Yasue Horiuchi, Maya Ishikawa, Minori Koga, Keiko Imai, Yoshimi Suzuki, Miyuki Morikawa, Toshiya Inada, Yuichiro Watanabe, Makoto Takahashi, Toshiyuki Someya, Hiroshi Ujike, Nakao Iwata, Norio Ozaki, Emmanuel S Onaivi, Hiroshi Kunugi, Tsukasa Sasaki, Masanari Itokawa, Makoto Arai, Kazuhiro Niizato, Shyuji Iritani, Izumi Naka, Jun Ohashi, Akiyoshi Kakita, Hitoshi Takahashi, Hiroyuki Nawa, Tadao Arinam. Brain cannabinoid CB2 receptor in schizophrenia. Biological psychiatry. vol 67. issue 10. 2010-07-22. PMID:19931854. |
two endocannabinoid receptors, cb1 and cb2, are found in the brain and elsewhere in the body. |
2010-07-22 |
2023-08-12 |
Not clear |
| Mingzhang Gao, Min Wang, Kathy D Miller, Gary D Hutchins, Qi-Huang Zhen. Synthesis and in vitro biological evaluation of carbon-11-labeled quinoline derivatives as new candidate PET radioligands for cannabinoid CB2 receptor imaging. Bioorganic & medicinal chemistry. vol 18. issue 6. 2010-07-06. PMID:20189815. |
synthesis and in vitro biological evaluation of carbon-11-labeled quinoline derivatives as new candidate pet radioligands for cannabinoid cb2 receptor imaging. |
2010-07-06 |
2023-08-12 |
Not clear |
| Mingzhang Gao, Min Wang, Kathy D Miller, Gary D Hutchins, Qi-Huang Zhen. Synthesis and in vitro biological evaluation of carbon-11-labeled quinoline derivatives as new candidate PET radioligands for cannabinoid CB2 receptor imaging. Bioorganic & medicinal chemistry. vol 18. issue 6. 2010-07-06. PMID:20189815. |
cannabinoids have been recently proposed as a new family of potential antitumor agents, and cannabinoid receptor 2 (cb2) is believed to be over-expressed in tumor cells. |
2010-07-06 |
2023-08-12 |
Not clear |
| Yan Zhao, Zuyi Yuan, Yan Liu, Jiahong Xue, Yuling Tian, Weimin Liu, Weiping Zhang, Yan Shen, Wei Xu, Xiao Liang, Tao Che. Activation of cannabinoid CB2 receptor ameliorates atherosclerosis associated with suppression of adhesion molecules. Journal of cardiovascular pharmacology. vol 55. issue 3. 2010-07-02. PMID:20075743. |
activation of cannabinoid cb2 receptor ameliorates atherosclerosis associated with suppression of adhesion molecules. |
2010-07-02 |
2023-08-12 |
mouse |
| Angel Arevalo-Martin, Daniel Garcia-Ovejero, Eduardo Molina-Holgad. The endocannabinoid 2-arachidonoylglycerol reduces lesion expansion and white matter damage after spinal cord injury. Neurobiology of disease. vol 38. issue 2. 2010-07-01. PMID:20156559. |
here we report that a single dose of the neuroprotective endocannabinoid 2-arachidonoyl glycerol (2-ag) administered early after sci reduces lesion expansion, which was prevented by simultaneous blockade of both cb1 and cb2 receptors but not by blockade of either receptor alone. |
2010-07-01 |
2023-08-12 |
Not clear |
| Jader Nones, Tania C L S Spohr, Daniel R Furtado, Rafaela C Sartore, Bruna S Paulsen, Marilia Z P Guimarães, Stevens K Rehe. Cannabinoids modulate cell survival in embryoid bodies. Cell biology international. vol 34. issue 4. 2010-06-24. PMID:19947926. |
herein, we investigated how two cannabinoid receptors, cb1 and cb2, may affect the outcome of escs aggregated as ebs. |
2010-06-24 |
2023-08-12 |
Not clear |
| Jader Nones, Tania C L S Spohr, Daniel R Furtado, Rafaela C Sartore, Bruna S Paulsen, Marilia Z P Guimarães, Stevens K Rehe. Cannabinoids modulate cell survival in embryoid bodies. Cell biology international. vol 34. issue 4. 2010-06-24. PMID:19947926. |
these data indicate that both cannabinoid receptors, cb1 and cb2, are involved in reducing cell death in ebs mediated by exogenous cannabinoids. |
2010-06-24 |
2023-08-12 |
Not clear |
| Dow P Hurst, Alan Grossfield, Diane L Lynch, Scott Feller, Tod D Romo, Klaus Gawrisch, Michael C Pitman, Patricia H Reggi. A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor. The Journal of biological chemistry. vol 285. issue 23. 2010-06-24. PMID:20220143. |
recent isothiocyanate covalent labeling studies have suggested that a classical cannabinoid, (-)-7'-isothiocyanato-11-hydroxy-1',1'dimethylheptyl-hexahydrocannabinol (am841), enters the cannabinoid cb2 receptor via the lipid bilayer (pei, y., mercier, r. w., anday, j. k., thakur, g. a., zvonok, a. m., hurst, d., reggio, p. h., janero, d. r., and makriyannis, a. |
2010-06-24 |
2023-08-12 |
Not clear |
| Dow P Hurst, Alan Grossfield, Diane L Lynch, Scott Feller, Tod D Romo, Klaus Gawrisch, Michael C Pitman, Patricia H Reggi. A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor. The Journal of biological chemistry. vol 285. issue 23. 2010-06-24. PMID:20220143. |
here, we test the hypothesis that the endogenous cannabinoid sn-2-arachidonoylglycerol (2-ag) attains access to the cb2 receptor via the lipid bilayer. |
2010-06-24 |
2023-08-12 |
Not clear |
| Maria Grazia Cascio, Daniele Bolognini, Roger G Pertwee, Enza Palazzo, Federico Corelli, Serena Pasquini, Vincenzo Di Marzo, Sabatino Maion. In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB(2) receptor inverse agonists. Pharmacological research. vol 61. issue 4. 2010-06-17. PMID:19961936. |
we have previously developed quinolone-3-carboxamides with the aim of obtaining new ligands for both cannabinoid receptors, cb1 and cb2. |
2010-06-17 |
2023-08-12 |
mouse |
| Maria Grazia Cascio, Daniele Bolognini, Roger G Pertwee, Enza Palazzo, Federico Corelli, Serena Pasquini, Vincenzo Di Marzo, Sabatino Maion. In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB(2) receptor inverse agonists. Pharmacological research. vol 61. issue 4. 2010-06-17. PMID:19961936. |
these results identify in 2 and 3 two novel, potent and selective cb2 antagonists/inverse agonists and confirm previous reports in the literature that, in addition to agonists at cannabinoid cb2 receptors, also inverse agonists/antagonists at these receptors show promise as anti-inflammatory agents. |
2010-06-17 |
2023-08-12 |
mouse |
| John C Ashton, Michelle Glas. The cannabinoid CB2 receptor as a target for inflammation-dependent neurodegeneration. Current neuropharmacology. vol 5. issue 2. 2010-06-10. PMID:18615177. |
the cannabinoid cb2 receptor as a target for inflammation-dependent neurodegeneration. |
2010-06-10 |
2023-08-12 |
human |
| John C Ashton, Michelle Glas. The cannabinoid CB2 receptor as a target for inflammation-dependent neurodegeneration. Current neuropharmacology. vol 5. issue 2. 2010-06-10. PMID:18615177. |
we have found that cannabinoid cb2 receptors are up-regulated during the activation of microglia following brain injury. |
2010-06-10 |
2023-08-12 |
human |
| Zahida Qamri, Anju Preet, Mohd W Nasser, Caroline E Bass, Gustavo Leone, Sanford H Barsky, Ramesh K Ganj. Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer. Molecular cancer therapeutics. vol 8. issue 11. 2010-05-27. PMID:19887554. |
we have shown that the cannabinoid receptors cb1 and cb2 are overexpressed in primary human breast tumors compared with normal breast tissue. |
2010-05-27 |
2023-08-12 |
mouse |
| Masayuki Fujinaga, Katsushi Kumata, Kazuhiko Yanamoto, Kazunori Kawamura, Tomoteru Yamasaki, Joji Yui, Akiko Hatori, Masanao Ogawa, Yuichiro Yoshida, Nobuki Nengaki, Jun Maeda, Ming-Rong Zhan. Radiosynthesis of novel carbon-11-labeled triaryl ligands for cannabinoid-type 2 receptor. Bioorganic & medicinal chemistry letters. vol 20. issue 5. 2010-05-27. PMID:20137936. |
two novel triaryl ligands 2 and 5 with potent in vitro binding affinities for the cannabinoid subtype-2 (cb2) receptor were labeled with a positron-emitting radioactive nuclide (11)c. radioligands [(11)c]2, [(11)c]5, and their analogs [(11)c]3 and [(11)c]4 were synthesized by o-[(11)c]methylation of their corresponding phenol precursors with [(11)c]ch(3)i. |
2010-05-27 |
2023-08-12 |
mouse |
| Joshua E Heller, Darric E Baty, Ming Zhang, Hongbo Li, Martin Adler, Doina Ganea, John Gaughan, Christopher M Loftus, Jack I Jallo, Ronald F Tum. The combination of selective inhibition of the cannabinoid CB1 receptor and activation of the cannabinoid CB2 receptor yields improved attenuation of motor and autonomic deficits in a mouse model of spinal cord injury. Clinical neurosurgery. vol 56. 2010-05-18. PMID:20214038. |
the combination of selective inhibition of the cannabinoid cb1 receptor and activation of the cannabinoid cb2 receptor yields improved attenuation of motor and autonomic deficits in a mouse model of spinal cord injury. |
2010-05-18 |
2023-08-12 |
mouse |