| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sadiye Amcaoglu Rieder, Ashok Chauhan, Ugra Singh, Mitzi Nagarkatti, Prakash Nagarkatt. Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. Immunobiology. vol 215. issue 8. 2010-10-28. PMID:19457575. |
with the recent discovery of the cannabinoid receptors (cb1 and cb2) and the endocannabinoid system, research in this field has expanded exponentially. |
2010-10-28 |
2023-08-12 |
Not clear |
| Sadiye Amcaoglu Rieder, Ashok Chauhan, Ugra Singh, Mitzi Nagarkatti, Prakash Nagarkatt. Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. Immunobiology. vol 215. issue 8. 2010-10-28. PMID:19457575. |
studies from our laboratory have focused on mechanisms of apoptosis induction by natural and synthetic cannabinoids through activation of cb2 receptors. |
2010-10-28 |
2023-08-12 |
Not clear |
| Sadiye Amcaoglu Rieder, Ashok Chauhan, Ugra Singh, Mitzi Nagarkatti, Prakash Nagarkatt. Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. Immunobiology. vol 215. issue 8. 2010-10-28. PMID:19457575. |
in this review, we will focus on apoptotic mechanisms of immunosuppression mediated by cannabinoids on different immune cell populations and discuss how activation of cb2 provides a novel therapeutic modality against inflammatory and autoimmune diseases as well as malignancies of the immune system, without exerting the untoward psychotropic effects. |
2010-10-28 |
2023-08-12 |
Not clear |
| Lucie Jean-Gilles, Bruno Gran, Cris S Constantinesc. Interaction between cytokines, cannabinoids and the nervous system. Immunobiology. vol 215. issue 8. 2010-10-28. PMID:20153076. |
the endocannabinoid system (es) is comprised of the cb1 and cb2 cannabinoid receptors, endogenous ligands, and proteins involved in endocannabinoid synthesis and inactivation. |
2010-10-28 |
2023-08-12 |
Not clear |
| b' Lucie Martyk\\xc3\\xa1nov\\xc3\\xa. [Endocannabinoid system I--the role in regulation of physiology functions]. Casopis lekaru ceskych. vol 149. issue 8. 2010-10-28. PMID:20925267.' |
the system consists of cannabinoid receptors cb1 and cb2, endocannabinoids and their biosynthetic and degrading enzymes. |
2010-10-28 |
2023-08-12 |
Not clear |
| Ming-xiu Hao, Li-sheng Jiang, Ning-yuan Fang, Jun Pu, Liu-hua Hu, Ling-Hong Shen, Wei Song, Ben H. The cannabinoid WIN55,212-2 protects against oxidized LDL-induced inflammatory response in murine macrophages. Journal of lipid research. vol 51. issue 8. 2010-10-20. PMID:20305287. |
these results demonstrate the involvement of the endocannabinoid system in regulating the oxldl-induced inflammatory response in macrophages, and indicate that the cb2 receptor may offer a novel pharmaceutical target for treating atherosclerosis. |
2010-10-20 |
2023-08-12 |
mouse |
| P Bagavandoss, S Grimsha. Temporal and spatial distribution of the cannabinoid receptors (CB1, CB2) and fatty acid amide hydroxylase in the rat ovary. Anatomical record (Hoboken, N.J. : 2007). vol 293. issue 8. 2010-10-13. PMID:20665820. |
temporal and spatial distribution of the cannabinoid receptors (cb1, cb2) and fatty acid amide hydroxylase in the rat ovary. |
2010-10-13 |
2023-08-12 |
rat |
| Torunn Fiskerstrand, Dorra H'mida-Ben Brahim, Stefan Johansson, Abderrahim M'zahem, Bjørn Ivar Haukanes, Nathalie Drouot, Julian Zimmermann, Andrew J Cole, Christian Vedeler, Cecilie Bredrup, Mirna Assoum, Meriem Tazir, Thomas Klockgether, Abdelmadjid Hamri, Vidar M Steen, Helge Boman, Laurence A Bindoff, Michel Koenig, Per M Knappsko. Mutations in ABHD12 cause the neurodegenerative disease PHARC: An inborn error of endocannabinoid metabolism. American journal of human genetics. vol 87. issue 3. 2010-10-07. PMID:20797687. |
the abhd12 enzyme was recently shown to hydrolyze 2-arachidonoyl glycerol (2-ag), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors cb1 and cb2. |
2010-10-07 |
2023-08-12 |
Not clear |
| Gorka Larrinaga, Adolfo Varona, Itxaro Pérez, Begoña Sanz, Aitziber Ugalde, M Luz Cándenas, Francisco M Pinto, Javier Gil, José I Lópe. Expression of cannabinoid receptors in human kidney. Histology and histopathology. vol 25. issue 9. 2010-10-05. PMID:20607655. |
the presence of cb1 and cb2 cannabinoid receptors and their physiological role in the kidney has been described in animal models but not in humans. |
2010-10-05 |
2023-08-12 |
human |
| M A Engel, C A Kellermann, G Burnat, E G Hahn, T Rau, P C Konture. Mice lacking cannabinoid CB1-, CB2-receptors or both receptors show increased susceptibility to trinitrobenzene sulfonic acid (TNBS)-induced colitis. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 61. issue 1. 2010-10-01. PMID:20228420. |
lacking of both cannabinoid receptors did not result in potentiation of colitis severity compared to lacking of each cb1 or cb2, respectively. |
2010-10-01 |
2023-08-12 |
mouse |
| Qiao Yang, Hong Yan Liu, Yao Wen Zhang, Wen Jie Wu, Wang Xian Tan. Anandamide induces cell death through lipid rafts in hepatic stellate cells. Journal of gastroenterology and hepatology. vol 25. issue 5. 2010-09-27. PMID:20059638. |
anandamide (aea), the most extensively studied endocannabinoid, and its putative cannabinoid receptors, cb1 and cb2, exert a variety of physiological and pharmacological effects in chronic liver diseases, such as hyperdynamic circulation. |
2010-09-27 |
2023-08-12 |
rat |
| Jos H M Lange, Martina A W van der Neut, Henri C Wals, Gijs D Kuil, Alice J M Borst, Arie Mulder, Arnold P den Hartog, Hicham Zilaout, Wouter Goutier, Herman H van Stuivenberg, Bernard J van Vlie. Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB2 receptor antagonists with high binding efficiencies. Bioorganic & medicinal chemistry letters. vol 20. issue 3. 2010-09-20. PMID:20031412. |
synthesis and sar of novel imidazoles as potent and selective cannabinoid cb2 receptor antagonists with high binding efficiencies. |
2010-09-20 |
2023-08-12 |
Not clear |
| Anthony H Taylor, Muna S Abbas, Marwan A Habiba, Justin C Konj. Histomorphometric evaluation of cannabinoid receptor and anandamide modulating enzyme expression in the human endometrium through the menstrual cycle. Histochemistry and cell biology. vol 133. issue 5. 2010-09-20. PMID:20369362. |
plasma anandamide (aea) levels fluctuate throughout the menstrual cycle and in early pregnancy in a pattern suggesting its involvement in implantation and early pregnancy maintenance through mechanisms that might involve its binding to cannabinoid receptors cb1 and cb2. |
2010-09-20 |
2023-08-12 |
human |
| R Abalo, P A Cabezos, G Vera, R Fernández-Pujol, M I Martí. The cannabinoid antagonist SR144528 enhances the acute effect of WIN 55,212-2 on gastrointestinal motility in the rat. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 22. issue 6. 2010-09-16. PMID:20132133. |
the aim of this work was to radiographically analyze the acute effect of the mixed cannabinoid agonist win 55,212-2 (win) on gi motor function in the rat, focusing on the involvement of cb1 and cb2 receptors. |
2010-09-16 |
2023-08-12 |
rat |
| A Mallat, S Lotersztaj. Endocannabinoids and their role in fatty liver disease. Digestive diseases (Basel, Switzerland). vol 28. issue 1. 2010-09-10. PMID:20460921. |
the endocannabinoid system comprises receptors, cb1 and cb2, their endogenous lipidic ligands and machinery dedicated to endocannabinoid synthesis and degradation. |
2010-09-10 |
2023-08-12 |
Not clear |
| Nephi Stell. Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas. Glia. vol 58. issue 9. 2010-08-26. PMID:20468046. |
cb1 and cb2 receptors are activated by a plethora of cannabinoid compounds, be they endogenously-produced, plant-derived or synthetic. |
2010-08-26 |
2023-08-12 |
Not clear |
| Alban Pereira, Tom A Pfeifer, Thomas A Grigliatti, Raymond J Anderse. Functional cell-based screening and saturation transfer double-difference NMR have identified haplosamate A as a cannabinoid receptor agonist. ACS chemical biology. vol 4. issue 2. 2010-08-25. PMID:19175306. |
a marine natural product extract library has been screened with a functional cell-based g-protein coupled receptor assay to find compounds capable of binding the human cannabinoid receptors cb1 and cb2. |
2010-08-25 |
2023-08-12 |
human |
| William R Marrs, Jacqueline L Blankman, Eric A Horne, Aurore Thomazeau, Yi Hsing Lin, Jonathan Coy, Agnes L Bodor, Giulio G Muccioli, Sherry Shu-Jung Hu, Grace Woodruff, Susan Fung, Mathieu Lafourcade, Jessica P Alexander, Jonathan Z Long, Weiwei Li, Cong Xu, Thomas Möller, Ken Mackie, Olivier J Manzoni, Benjamin F Cravatt, Nephi Stell. The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. Nature neuroscience. vol 13. issue 8. 2010-08-20. PMID:20657592. |
the endocannabinoid 2-arachidonoylglycerol (2-ag) regulates neurotransmission and neuroinflammation by activating cb1 cannabinoid receptors on neurons and cb2 cannabinoid receptors on microglia. |
2010-08-20 |
2023-08-12 |
mouse |
| Yosefa Avraham, Neta Davidi, Moran Porat, David Chernoguz, Iddo Magen, Lia Vorobeiv, Elliot M Berry, Ronen R Leke. Leptin reduces infarct size in association with enhanced expression of CB2, TRPV1, SIRT-1 and leptin receptor. Current neurovascular research. vol 7. issue 2. 2010-08-10. PMID:20374198. |
infarct volume was determined and the expression of key genes involved in neuroprotection and survival including the cannabinoid receptors cb1, cb2 and trpv1, sirt-1, leptin receptor and bcl-2 was quantified in the cortex. |
2010-08-10 |
2023-08-12 |
mouse |
| Barbara L F Kaplan, Jody E Lawver, Peer W F Karmaus, Thitirat Ngaotepprutaram, Neil P Birmingham, Jack R Harkema, Norbert E Kaminsk. The effects of targeted deletion of cannabinoid receptors CB1 and CB2 on intranasal sensitization and challenge with adjuvant-free ovalbumin. Toxicologic pathology. vol 38. issue 3. 2010-08-03. PMID:20190202. |
the effects of targeted deletion of cannabinoid receptors cb1 and cb2 on intranasal sensitization and challenge with adjuvant-free ovalbumin. |
2010-08-03 |
2023-08-12 |
mouse |