| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chen Li, Peter M Jones, Shanta J Persau. Role of the endocannabinoid system in food intake, energy homeostasis and regulation of the endocrine pancreas. Pharmacology & therapeutics. vol 129. issue 3. 2011-05-19. PMID:21055418. |
the endocannabinoid system (ecs) is a signalling cascade consisting of cb1 and cb2 receptors, and enzymes for the synthesis and degradation of endogenous ligands for these receptors. |
2011-05-19 |
2023-08-12 |
Not clear |
| Chen Li, Peter M Jones, Shanta J Persau. Role of the endocannabinoid system in food intake, energy homeostasis and regulation of the endocrine pancreas. Pharmacology & therapeutics. vol 129. issue 3. 2011-05-19. PMID:21055418. |
more recently, it has become apparent that both cb1 and cb2 receptors are more widely expressed than originally thought, and the capacity of endocannabinoids to regulate energy balance also occurs through their interactions with cannabinoid receptors on a variety of peripheral tissues. |
2011-05-19 |
2023-08-12 |
Not clear |
| Tapio Nevalainen, Andrew J Irvin. GPR55, a lysophosphatidylinositol receptor with cannabinoid sensitivity? Current topics in medicinal chemistry. vol 10. issue 8. 2011-05-02. PMID:20370712. |
although gpr55 has only a low sequence identity with the cb1 or cb2 cannabinoid receptors, it clearly interacts with certain cannabinoid ligands. |
2011-05-02 |
2023-08-12 |
Not clear |
| Charles A Lun. Updating the chemistry and biology of cannabinoid CB2 receptor-specific inverse agonists. Current topics in medicinal chemistry. vol 10. issue 8. 2011-05-02. PMID:20370714. |
updating the chemistry and biology of cannabinoid cb2 receptor-specific inverse agonists. |
2011-05-02 |
2023-08-12 |
Not clear |
| Anju Preet, Zahida Qamri, Mohd W Nasser, Anil Prasad, Konstantin Shilo, Xianghong Zou, Jerome E Groopman, Ramesh K Ganj. Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 1. 2011-04-28. PMID:21097714. |
cannabinoid receptors, cb1 and cb2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis. |
2011-04-28 |
2023-08-12 |
Not clear |
| Anju Preet, Zahida Qamri, Mohd W Nasser, Anil Prasad, Konstantin Shilo, Xianghong Zou, Jerome E Groopman, Ramesh K Ganj. Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 1. 2011-04-28. PMID:21097714. |
hence, we investigated the role of cannabinoid receptors, cb1 and cb2, as novel therapeutic targets against nsclc. |
2011-04-28 |
2023-08-12 |
Not clear |
| Kayte A Jenkin, Andrew J McAinch, Esther Grinfeld, Deanne H Hryci. Role for cannabinoid receptors in human proximal tubular hypertrophy. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 26. issue 6. 2011-04-21. PMID:21220919. |
endogenous endocannabinoids bind to cannabinoid receptors; namely cb1, cb2, trpv1 and gpr55, to activate intracellular pathways that control many cellular functions. |
2011-04-21 |
2023-08-12 |
human |
| Ling Tong, B B Shankar, Lei Chen, Razia Rizvi, Joseph Kelly, Eric Gilbert, Chunli Huang, De-Yi Yang, Joseph A Kozlowski, N-Y Shih, W Gonsiorek, R William Hipkin, Asra Malikzay, Charles A Lunn, Daniel J Lundel. Expansion of SAR studies on triaryl bis sulfone cannabinoid CB2 receptor ligands. Bioorganic & medicinal chemistry letters. vol 20. issue 22. 2011-03-29. PMID:20850969. |
expansion of sar studies on triaryl bis sulfone cannabinoid cb2 receptor ligands. |
2011-03-29 |
2023-08-12 |
rat |
| Alexandra Kibbl. American Chemical Society - 240th national meeting - chemistry for preventing and combating disease: part 2. IDrugs : the investigational drugs journal. vol 13. issue 10. 2011-03-29. PMID:20878583. |
this conference report highlights selected presentations on (s)-adenosylhomocysteine (ahcy) inhibitors for the treatment of alzheimer's disease, 2,4-diphenyl-1h-imidazole analogs as cannabinoid cb2 agonists for the treatment of pain, checkpoint kinase 1 (chk1) and aurora kinase b as therapeutic targets for cancer treatment, pyridylmethylthio derivatives as vegfr2 inhibitors, and janus kinase 2 (jak2) for the treatment of myeloproliferative disorders. |
2011-03-29 |
2023-08-12 |
Not clear |
| Jing Zhang, Lin Chen, Tangfeng Su, Fuyuan Cao, Xianfang Meng, Lei Pei, Jing Shi, Hui-Lin Pan, Man L. Electroacupuncture increases CB2 receptor expression on keratinocytes and infiltrating inflammatory cells in inflamed skin tissues of rats. The journal of pain. vol 11. issue 12. 2011-03-21. PMID:20627823. |
endogenous cannabinoids and peripheral cannabinoid cb2 receptors (cb2rs) are involved in the antinociceptive effect of electroacupuncture (ea) on inflammatory pain. |
2011-03-21 |
2023-08-12 |
rat |
| Noha A Osman, Amr H Mahmoud, Marco Allarà, Raimund Niess, Khaled A Abouzid, Vincenzo Di Marzo, Ashraf H Abad. Synthesis, binding studies and molecular modeling of novel cannabinoid receptor ligands. Bioorganic & medicinal chemistry. vol 18. issue 24. 2011-03-08. PMID:21074998. |
the novel compounds had been evaluated for their binding affinity to cb1/cb2 cannabinoid receptors, binding studies showed that some of the newly developed compounds have measurable affinity and selectivity for the cb2 receptor. |
2011-03-08 |
2023-08-12 |
Not clear |
| Bruce A Watkins, Heather Hutchins, Yong Li, Mark F Seifer. The endocannabinoid signaling system: a marriage of PUFA and musculoskeletal health. The Journal of nutritional biochemistry. vol 21. issue 12. 2011-02-28. PMID:20934863. |
this signaling system consists of the g-protein coupled cannabinoid receptors, cb1 and cb2, expressed in central and peripheral tissues and cells, which are variably activated by the production and on demand release of endogenous and synthetic agonists and antagonists. |
2011-02-28 |
2023-08-12 |
Not clear |
| N Schuelert, C Zhang, A J Mogg, L M Broad, D L Hepburn, E S Nisenbaum, M P Johnson, J J McDougal. Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain. Osteoarthritis and cartilage. vol 18. issue 11. 2011-02-24. PMID:20863899. |
paradoxical effects of the cannabinoid cb2 receptor agonist gw405833 on rat osteoarthritic knee joint pain. |
2011-02-24 |
2023-08-12 |
rat |
| Andrea De Gottardi, Laurent Spahr, Florence Ravier-Dall'Antonia, Antoine Hadengu. Cannabinoid receptor 1 and 2 agonists increase lipid accumulation in hepatocytes. Liver international : official journal of the International Association for the Study of the Liver. vol 30. issue 10. 2011-02-11. PMID:20602678. |
cannabinoid receptors cb1 and cb2 are expressed in the liver, but their regulation in fatty hepatocytes is poorly documented. |
2011-02-11 |
2023-08-12 |
Not clear |
| Sharleen Yuan, Brian D Burrel. Endocannabinoid-dependent LTD in a nociceptive synapse requires activation of a presynaptic TRPV-like receptor. Journal of neurophysiology. vol 104. issue 5. 2011-02-11. PMID:20884761. |
recent studies have found that some forms of endocannabinoid-dependent synaptic plasticity in the hippocampus are mediated through activation of transient potential receptor vanilloid (trpv) receptors instead of cannabinoid receptors cb1 or cb2. |
2011-02-11 |
2023-08-12 |
Not clear |
| Ana Crespillo, Juan Suárez, Francisco J Bermúdez-Silva, Patricia Rivera, Margarita Vida, Monica Alonso, Ana Palomino, Miguel A Lucena, Antonia Serrano, Margarita Pérez-Martín, Manuel Macias, Pedro Fernández-Llébrez, Fernando Rodríguez de Fonsec. Expression of the cannabinoid system in muscle: effects of a high-fat diet and CB1 receptor blockade. The Biochemical journal. vol 433. issue 1. 2011-02-10. PMID:20955176. |
cb2 (cannabinoid type 2) receptor and pparα (peroxisome-proliferator-activated receptor α) gene expression was decreased in hfd-fed rats, whereas magl (monoglyceride lipase) gene expression was up-regulated. |
2011-02-10 |
2023-08-12 |
rat |
| Lankun Wu, Eric W Rowe, Ksenija Jeftinija, Srdija Jeftinija, Ludmila Rizshsky, Basil J Nikolau, Jodi McKay, Marian Kohut, Eve Syrkin Wurtel. Echinacea-induced cytosolic Ca2+ elevation in HEK293. BMC complementary and alternative medicine. vol 10. 2011-01-20. PMID:21092239. |
one likely mode of action is that alkamides from echinacea bind to cannabinoid type 2 (cb2) receptors and induce a transient increase in intracellular ca2+. |
2011-01-20 |
2023-08-12 |
Not clear |
| Elena Cichero, Sara Cesarini, Luisa Mosti, Paola Foss. CoMFA and CoMSIA analyses on 1,2,3,4-tetrahydropyrrolo[3,4-b]indole and benzimidazole derivatives as selective CB2 receptor agonists. Journal of molecular modeling. vol 16. issue 9. 2011-01-03. PMID:20174844. |
novel classes of cannabinoid 2 receptor (cb2) agonists based on 1,2,3,4-tetrahydropyrrolo[3,4-b]indole and benzimidazole scaffolds have shown high binding affinity toward cb2 receptor and good selectivity over cannabinoid 1 receptor (cb1). |
2011-01-03 |
2023-08-12 |
Not clear |
| Pranab K Chanda, Ying Gao, Lilly Mark, Joan Btesh, Brian W Strassle, Peimin Lu, Michael J Piesla, Mei-Yi Zhang, Brendan Bingham, Albert Uveges, Dianne Kowal, David Garbe, Evguenia V Kouranova, Robert H Ring, Brian Bates, Menelas N Pangalos, Jeffrey D Kennedy, Garth T Whiteside, Tarek A Sama. Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system. Molecular pharmacology. vol 78. issue 6. 2010-12-17. PMID:20855465. |
endocannabinoids are lipid molecules that serve as natural ligands for the cannabinoid receptors cb1 and cb2. |
2010-12-17 |
2023-08-12 |
mouse |
| Chen Li, Peter M Jones, Shanta J Persau. Cannabinoid receptors are coupled to stimulation of insulin secretion from mouse MIN6 beta-cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 26. issue 2. 2010-12-08. PMID:20798502. |
endocannabinoid lipids are known to exert orexigenic effects via central cannabinoid cb1 and cb2 receptors, which have also been identified in islet endocrine cells. |
2010-12-08 |
2023-08-12 |
mouse |