| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Prakash Nagarkatti, Rupal Pandey, Sadiye Amcaoglu Rieder, Venkatesh L Hegde, Mitzi Nagarkatt. Cannabinoids as novel anti-inflammatory drugs. Future medicinal chemistry. vol 1. issue 7. 2011-07-11. PMID:20191092. |
the fact that both cb1 and cb2 receptors have been found on immune cells suggests that cannabinoids play an important role in the regulation of the immune system. |
2011-07-11 |
2023-08-12 |
mouse |
| Jarogniew J Luszczki, Marta Misiuta-Krzesinska, Magdalena Florek, Piotr Tutka, Stanislaw J Czuczwa. Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice. Pharmacology, biochemistry, and behavior. vol 98. issue 2. 2011-07-08. PMID:21238473. |
the aim of this study was to determine the effect of win 55,212-2 mesylate (win--a non-selective cannabinoid cb1 and cb2 receptor agonist) on the protective action of four classical antiepileptic drugs (carbamazepine, phenytoin, phenobarbital, and valproate) in the mouse maximal electroshock seizure (mes) model. |
2011-07-08 |
2023-08-12 |
mouse |
| G Appendino, G Chianese, O Taglialatela-Scafat. Cannabinoids: occurrence and medicinal chemistry. Current medicinal chemistry. vol 18. issue 7. 2011-07-04. PMID:21254969. |
many of the potential therapeutic uses of cannabinoids are related to the interaction with (at least) two cannabinoid g-protein coupled receptors (cb1 and cb2). |
2011-07-04 |
2023-08-12 |
Not clear |
| Nicole M Tsutahara, Yoshie S Weems, J Alejandro Arreguin-Arevalo, Torrance M Nett, Magen E LaPorte, Janelle Uchida, Janelle Pang, Tonya McBride, Ronald D Randel, Charles W Weem. Effects of endocannabinoid 1 and 2 (CB1; CB2) receptor agonists on luteal weight, circulating progesterone, luteal mRNA for luteinizing hormone (LH) receptors, and luteal unoccupied and occupied receptors for LH in vivo in ewes. Prostaglandins & other lipid mediators. vol 94. issue 1-2. 2011-06-28. PMID:21109016. |
effects of endocannabinoid 1 and 2 (cb1; cb2) receptor agonists on luteal weight, circulating progesterone, luteal mrna for luteinizing hormone (lh) receptors, and luteal unoccupied and occupied receptors for lh in vivo in ewes. |
2011-06-28 |
2023-08-12 |
cattle |
| Nicole M Tsutahara, Yoshie S Weems, J Alejandro Arreguin-Arevalo, Torrance M Nett, Magen E LaPorte, Janelle Uchida, Janelle Pang, Tonya McBride, Ronald D Randel, Charles W Weem. Effects of endocannabinoid 1 and 2 (CB1; CB2) receptor agonists on luteal weight, circulating progesterone, luteal mRNA for luteinizing hormone (LH) receptors, and luteal unoccupied and occupied receptors for LH in vivo in ewes. Prostaglandins & other lipid mediators. vol 94. issue 1-2. 2011-06-28. PMID:21109016. |
cannabinoid (cb) type 1 (cb1) or type 2 (cb2) receptor agonists and an inhibitor of the enzyme fatty acid amide hydrolase, which catabolizes endocannabinoids, decreased luteal progesterone, prostaglandin e (pge), and prostaglandin f(2α) (pgf(2α)) secretion by the bovine corpus luteum in vitro by 30 percent. |
2011-06-28 |
2023-08-12 |
cattle |
| Raquel Taléns-Visconti, Irene Sanchez-Vera, Jelena Kostic, Maria Amparo Perez-Arago, Slaven Erceg, Miodrag Stojkovic, Consuelo Guerr. Neural differentiation from human embryonic stem cells as a tool to study early brain development and the neuroteratogenic effects of ethanol. Stem cells and development. vol 20. issue 2. 2011-06-24. PMID:20491543. |
we further demonstrate, for the first time, that human nps express the endocannabinoid receptors (cb1 and cb2) and the enzymes involved in endocannabinoids synthesis (nape-pld) and degradation (faah). |
2011-06-24 |
2023-08-12 |
human |
| Ester M López, Patricia Tagliaferro, Emmanuel S Onaivi, Juan J López-Cost. Distribution of CB2 cannabinoid receptor in adult rat retina. Synapse (New York, N.Y.). vol 65. issue 5. 2011-06-23. PMID:20803619. |
cannabinoid effects are mediated through two receptors, cb1 and cb2. |
2011-06-23 |
2023-08-12 |
rat |
| R Moaddel, A Rosenberg, K Spelman, J Frazier, C Frazier, S Nocerino, A Brizzi, C Mugnaini, I W Waine. Development and characterization of immobilized cannabinoid receptor (CB1/CB2) open tubular column for on-line screening. Analytical biochemistry. vol 412. issue 1. 2011-06-20. PMID:21215722. |
cannabinoid receptors, cb1 and cb2, are therapeutic targets in the treatment of anxiety, obesity, movement disorders, glaucoma, and pain. |
2011-06-20 |
2023-08-12 |
Not clear |
| Simone Brogi, Federico Corelli, Vincenzo Di Marzo, Alessia Ligresti, Claudia Mugnaini, Serena Pasquini, Andrea Taf. Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2. European journal of medicinal chemistry. vol 46. issue 2. 2011-06-08. PMID:21183257. |
this paper describes a three-dimensional quantitative structure-selectivity relationships (3d-qssr) study for selectivity of a series of ligands for cannabinoid cb1 and cb2 receptors. |
2011-06-08 |
2023-08-12 |
Not clear |
| Simone Brogi, Federico Corelli, Vincenzo Di Marzo, Alessia Ligresti, Claudia Mugnaini, Serena Pasquini, Andrea Taf. Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2. European journal of medicinal chemistry. vol 46. issue 2. 2011-06-08. PMID:21183257. |
the identification of a new selective cb2 receptor ligand lends support for the practicability of quantitative ligand-based selectivity models for cannabinoid receptors. |
2011-06-08 |
2023-08-12 |
Not clear |
| De-chun Geng, Yao-zeng Xu, Hui-lin Yang, Guang-ming Zhu, Xian-bin Wang, Xue-song Zh. Cannabinoid receptor-2 selective antagonist negatively regulates receptor activator of nuclear factor kappa B ligand mediated osteoclastogenesis. Chinese medical journal. vol 124. issue 4. 2011-06-08. PMID:21362286. |
the cannabinoid receptor-2 (cb2) is important for bone remodeling. |
2011-06-08 |
2023-08-12 |
Not clear |
| Barbara Rossi, Elena Zenaro, Stefano Angiari, Linda Ottoboni, Simona Bach, Laura Piccio, Enrica C Pietronigro, Elio Scarpini, Mariella Fusco, Alberta Leon, Gabriela Constanti. Inverse agonism of cannabinoid CB1 receptor blocks the adhesion of encephalitogenic T cells in inflamed brain venules by a protein kinase A-dependent mechanism. Journal of neuroimmunology. vol 233. issue 1-2. 2011-06-07. PMID:21216016. |
cannabinoid receptors cb1 and cb2 are expressed on t lymphocytes and mediate the immunomodulatory effects of cannabinoids on t cell functions. |
2011-06-07 |
2023-08-12 |
Not clear |
| Javier Ramos, Víctor L Cruz, Javier Martínez-Salazar, Nuria E Campillo, Juan A Páe. Dissimilar interaction of CB1/CB2 with lipid bilayers as revealed by molecular dynamics simulation. Physical chemistry chemical physics : PCCP. vol 13. issue 9. 2011-06-03. PMID:21173968. |
cannabinoid receptors cb1 and cb2 are a striking class of transmembrane proteins involved in a high number of important biological processes. |
2011-06-03 |
2023-08-12 |
Not clear |
| Chen Li, Peter M Jones, Shanta J Persau. Role of the endocannabinoid system in food intake, energy homeostasis and regulation of the endocrine pancreas. Pharmacology & therapeutics. vol 129. issue 3. 2011-05-19. PMID:21055418. |
the endocannabinoid system (ecs) is a signalling cascade consisting of cb1 and cb2 receptors, and enzymes for the synthesis and degradation of endogenous ligands for these receptors. |
2011-05-19 |
2023-08-12 |
Not clear |
| Chen Li, Peter M Jones, Shanta J Persau. Role of the endocannabinoid system in food intake, energy homeostasis and regulation of the endocrine pancreas. Pharmacology & therapeutics. vol 129. issue 3. 2011-05-19. PMID:21055418. |
more recently, it has become apparent that both cb1 and cb2 receptors are more widely expressed than originally thought, and the capacity of endocannabinoids to regulate energy balance also occurs through their interactions with cannabinoid receptors on a variety of peripheral tissues. |
2011-05-19 |
2023-08-12 |
Not clear |
| Tapio Nevalainen, Andrew J Irvin. GPR55, a lysophosphatidylinositol receptor with cannabinoid sensitivity? Current topics in medicinal chemistry. vol 10. issue 8. 2011-05-02. PMID:20370712. |
although gpr55 has only a low sequence identity with the cb1 or cb2 cannabinoid receptors, it clearly interacts with certain cannabinoid ligands. |
2011-05-02 |
2023-08-12 |
Not clear |
| Charles A Lun. Updating the chemistry and biology of cannabinoid CB2 receptor-specific inverse agonists. Current topics in medicinal chemistry. vol 10. issue 8. 2011-05-02. PMID:20370714. |
updating the chemistry and biology of cannabinoid cb2 receptor-specific inverse agonists. |
2011-05-02 |
2023-08-12 |
Not clear |
| Anju Preet, Zahida Qamri, Mohd W Nasser, Anil Prasad, Konstantin Shilo, Xianghong Zou, Jerome E Groopman, Ramesh K Ganj. Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 1. 2011-04-28. PMID:21097714. |
cannabinoid receptors, cb1 and cb2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis. |
2011-04-28 |
2023-08-12 |
Not clear |
| Anju Preet, Zahida Qamri, Mohd W Nasser, Anil Prasad, Konstantin Shilo, Xianghong Zou, Jerome E Groopman, Ramesh K Ganj. Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 1. 2011-04-28. PMID:21097714. |
hence, we investigated the role of cannabinoid receptors, cb1 and cb2, as novel therapeutic targets against nsclc. |
2011-04-28 |
2023-08-12 |
Not clear |
| Kayte A Jenkin, Andrew J McAinch, Esther Grinfeld, Deanne H Hryci. Role for cannabinoid receptors in human proximal tubular hypertrophy. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 26. issue 6. 2011-04-21. PMID:21220919. |
endogenous endocannabinoids bind to cannabinoid receptors; namely cb1, cb2, trpv1 and gpr55, to activate intracellular pathways that control many cellular functions. |
2011-04-21 |
2023-08-12 |
human |