| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mario van der Stelt, Jos Cals, Silvia Broeders-Josten, Jean Cottney, Antoon A van der Doelen, Marcel Hermkens, Vera de Kimpe, Angela King, Jan Klomp, Julia Oosterom, Ilse Pols-de Rooij, Jeroen de Roos, Martin van Tilborg, Susan Boyce, James Bake. Discovery and optimization of 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives as a novel class of selective cannabinoid CB2 receptor agonists. Journal of medicinal chemistry. vol 54. issue 20. 2012-01-03. PMID:21923175. |
1 is a potent and selective cannabinoid cb2 receptor agonist (hcb2 pec(50) = 8.6). |
2012-01-03 |
2023-08-12 |
rat |
| Mario van der Stelt, Jos Cals, Silvia Broeders-Josten, Jean Cottney, Antoon A van der Doelen, Marcel Hermkens, Vera de Kimpe, Angela King, Jan Klomp, Julia Oosterom, Ilse Pols-de Rooij, Jeroen de Roos, Martin van Tilborg, Susan Boyce, James Bake. Discovery and optimization of 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives as a novel class of selective cannabinoid CB2 receptor agonists. Journal of medicinal chemistry. vol 54. issue 20. 2012-01-03. PMID:21923175. |
systematic modification of physicochemical properties, such as lipophilicity and basicity, was used to optimize the pharmacokinetic profile and herg affinity of this novel class of cannabinoid cb2 receptor agonists. |
2012-01-03 |
2023-08-12 |
rat |
| Mario van der Stelt, Jos Cals, Silvia Broeders-Josten, Jean Cottney, Antoon A van der Doelen, Marcel Hermkens, Vera de Kimpe, Angela King, Jan Klomp, Julia Oosterom, Ilse Pols-de Rooij, Jeroen de Roos, Martin van Tilborg, Susan Boyce, James Bake. Discovery and optimization of 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives as a novel class of selective cannabinoid CB2 receptor agonists. Journal of medicinal chemistry. vol 54. issue 20. 2012-01-03. PMID:21923175. |
this led to the identification of 44 as a potent, selective, and orally bioavailable cannabinoid cb2 receptor agonist (hcb2 pec(50) = 8.0; herg pk(i) < 4; f(po) = 100%), which was active in a rat spinal nerve ligation model of neuropathic pain. |
2012-01-03 |
2023-08-12 |
rat |
| Hua Zhang, David A Hilton, C Oliver Hanemann, John Zajice. Cannabinoid receptor and N-acyl phosphatidylethanolamine phospholipase D--evidence for altered expression in multiple sclerosis. Brain pathology (Zurich, Switzerland). vol 21. issue 5. 2011-12-23. PMID:21251115. |
we examined expression of the major cannabinoid receptors [(cbrs) cannabinoid receptor 1 (cb1) and cannabinoid receptor 2 (cb2)] and a key enzyme involved in synthesis of the endocannabinoid anandamide [n-acyl phosphatidylethanolamine phospholipase d (nape-pld)] in autopsy brain samples from patients with ms. cb1 was expressed in neurons, injured axons, oligodendrocytes, macrophages/microglia, some astrocytes, endothelial cells, smooth muscle cells and pericytes. |
2011-12-23 |
2023-08-12 |
human |
| Ana Belén López Rodríguez, Beatriz Mateos Vicente, Silvana Y Romero-Zerbo, Noé Rodriguez-Rodriguez, María José Bellini, Fernando Rodriguez de Fonseca, Francisco Javier Bermudez-Silva, Iñigo Azcoitia, Luis M Garcia-Segura, María-Paz Vivero. Estradiol decreases cortical reactive astrogliosis after brain injury by a mechanism involving cannabinoid receptors. Cerebral cortex (New York, N.Y. : 1991). vol 21. issue 9. 2011-12-09. PMID:21258044. |
to test this hypothesis, the effects of estradiol, the cannabinoid cb1 antagonist/inverse agonist am251, and the cannabinoid cb2 antagonist/inverse agonist am630 were assessed in the cerebral cortex of male rats after a stab wound brain injury. |
2011-12-09 |
2023-08-12 |
rat |
| Ana Belén López Rodríguez, Beatriz Mateos Vicente, Silvana Y Romero-Zerbo, Noé Rodriguez-Rodriguez, María José Bellini, Fernando Rodriguez de Fonseca, Francisco Javier Bermudez-Silva, Iñigo Azcoitia, Luis M Garcia-Segura, María-Paz Vivero. Estradiol decreases cortical reactive astrogliosis after brain injury by a mechanism involving cannabinoid receptors. Cerebral cortex (New York, N.Y. : 1991). vol 21. issue 9. 2011-12-09. PMID:21258044. |
the effect of estradiol may be in part mediated by alterations in endocannabinoid signaling because the hormone increased in the injured cerebral cortex the messenger rna levels of cb2 receptors and of some of the enzymes involved in the synthesis and metabolism of endocannabinoids. |
2011-12-09 |
2023-08-12 |
rat |
| C Li, J E Bowe, G C Huang, S A Amiel, P M Jones, S J Persau. Cannabinoid receptor agonists and antagonists stimulate insulin secretion from isolated human islets of Langerhans. Diabetes, obesity & metabolism. vol 13. issue 10. 2011-12-07. PMID:21564460. |
the role of cannabinoid receptors in human islets of langerhans has not been investigated in any detail, so the current study examined cb1 and cb2 receptor expression by human islets and the effects of pharmacological cannabinoid receptor agonists and antagonists on insulin secretion. |
2011-12-07 |
2023-08-12 |
human |
| Takashi Tanikawa, Kohta Kurohane, Yasuyuki Ima. Regulatory effect of cannabinoid receptor agonist on chemokine-induced lymphocyte chemotaxis. Biological & pharmaceutical bulletin. vol 34. issue 7. 2011-12-05. PMID:21720018. |
cannabinoids elicit biological responses through two types of specific receptors, cb1 and cb2. |
2011-12-05 |
2023-08-12 |
Not clear |
| Takashi Tanikawa, Kohta Kurohane, Yasuyuki Ima. Regulatory effect of cannabinoid receptor agonist on chemokine-induced lymphocyte chemotaxis. Biological & pharmaceutical bulletin. vol 34. issue 7. 2011-12-05. PMID:21720018. |
immune cells including naïve b-lymphocytes are known to selectively express peripheral cannabinoid receptors, cb2. |
2011-12-05 |
2023-08-12 |
Not clear |
| Alexandre Louvet, Fatima Teixeira-Clerc, Marie-Noële Chobert, Vanessa Deveaux, Catherine Pavoine, Andreas Zimmer, Françoise Pecker, Ariane Mallat, Sophie Lotersztaj. Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice. Hepatology (Baltimore, Md.). vol 54. issue 4. 2011-11-29. PMID:21735467. |
cannabinoid cb2 receptors protect against alcoholic liver disease by regulating kupffer cell polarization in mice. |
2011-11-29 |
2023-08-12 |
mouse |
| Alexandre Louvet, Fatima Teixeira-Clerc, Marie-Noële Chobert, Vanessa Deveaux, Catherine Pavoine, Andreas Zimmer, Françoise Pecker, Ariane Mallat, Sophie Lotersztaj. Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice. Hepatology (Baltimore, Md.). vol 54. issue 4. 2011-11-29. PMID:21735467. |
because cannabinoid cb2 receptors (cb2) display potent anti-inflammatory properties, we investigated their role in the pathogenesis of alcoholic liver disease, focusing on the impact of cb2 on kupffer cell polarization and the consequences on liver steatosis. |
2011-11-29 |
2023-08-12 |
mouse |
| Micaela S Sordelli, Jimena S Beltrame, Juliana Burdet, Elsa Zotta, Romina Pardo, Maximiliano Cella, Ana M Franchi, Maria Laura Ribeir. The effect of anandamide on uterine nitric oxide synthase activity depends on the presence of the blastocyst. PloS one. vol 6. issue 4. 2011-11-28. PMID:21559512. |
anandamide (aea), an endocannabinoid, binds to cannabinoid receptors type 1 (cb1) and type 2 (cb2), and high concentrations are toxic for implantation and embryo development. |
2011-11-28 |
2023-08-12 |
rat |
| Steven G Kinsey, Anu Mahadevan, Bingjun Zhao, Hang Sun, Pattipati S Naidu, Raj K Razdan, Dana E Selley, M Imad Damaj, Aron H Lichtma. The CB2 cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects. Neuropharmacology. vol 60. issue 2-3. 2011-11-22. PMID:20849866. |
the cb2 cannabinoid receptor-selective agonist o-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects. |
2011-11-22 |
2023-08-12 |
Not clear |
| Giuseppina Chianese, Ernesto Fattorusso, Orazio Taglialatela-Scafati, Giorgio Bavestrello, Barbara Calcinai, Henny A Dien, Alessia Ligresti, Vincenzo Di Marz. Desulfohaplosamate, a new phosphate-containing steroid from Dasychalina sp., is a selective cannabinoid CB2 receptor ligand. Steroids. vol 76. issue 10-11. 2011-11-15. PMID:21530566. |
desulfohaplosamate, a new phosphate-containing steroid from dasychalina sp., is a selective cannabinoid cb2 receptor ligand. |
2011-11-15 |
2023-08-12 |
Not clear |
| John C Ashto. Knockout controls and the specificity of cannabinoid CB2 receptor antibodies. British journal of pharmacology. vol 163. issue 6. 2011-11-15. PMID:21707587. |
knockout controls and the specificity of cannabinoid cb2 receptor antibodies. |
2011-11-15 |
2023-08-12 |
Not clear |
| Mariagrazia Rita Scuderi, Giuseppina Cantarella, Mimmo Scollo, Laurence Lempereur, Marco Palumbo, Gloria Saccani-Jotti, Renato Bernardin. The antimitogenic effect of the cannabinoid receptor agonist WIN55212-2 on human melanoma cells is mediated by the membrane lipid raft. Cancer letters. vol 310. issue 2. 2011-11-15. PMID:21807457. |
here are reported the antiproliferative effects of the cannabinoid agonist win upon human melanoma cells expressing mrna and protein for both cb1 and cb2 receptors. |
2011-11-15 |
2023-08-12 |
human |
| Y Okahisa, M Kodama, M Takaki, T Inada, N Uchimura, M Yamada, N Iwata, M Iyo, I Sora, N Ozaki, H Ujik. Association Study of Two Cannabinoid Receptor Genes, CNR1 and CNR2, with Methamphetamine Dependence. Current neuropharmacology. vol 9. issue 1. 2011-11-10. PMID:21886587. |
to examine the possible association of the cnr1 and cnr2 genes, which encode cannabinoid receptors cb1 and cb2, with methamphetamine dependence, we investigated three single nucleotide polymorphisms (snps) (rs806379, rs1535255, rs2023239) in intron 2 of the cnr1 gene and a nonsynonymous snp, q63r, in the cnr2 gene. |
2011-11-10 |
2023-08-12 |
Not clear |
| E S Onaiv. Commentary: Functional Neuronal CB2 Cannabinoid Receptors in the CNS. Current neuropharmacology. vol 9. issue 1. 2011-11-10. PMID:21886591. |
commentary: functional neuronal cb2 cannabinoid receptors in the cns. |
2011-11-10 |
2023-08-12 |
human |
| Sarah A Maher, Eric D Dubuis, Maria G Belvis. G-protein coupled receptors regulating cough. Current opinion in pharmacology. vol 11. issue 3. 2011-11-08. PMID:21727026. |
activation of the β2-adrenoceptor and cannabinoid cb2 receptors can inhibit sensory nerves and prevent cough. |
2011-11-08 |
2023-08-12 |
Not clear |
| M A Cosenza-Nashat, A Bauman, M-L Zhao, S Morgello, H-S Suh, S C Le. Cannabinoid receptor expression in HIV encephalitis and HIV-associated neuropathologic comorbidities. Neuropathology and applied neurobiology. vol 37. issue 5. 2011-11-07. PMID:21450051. |
the expression of cannabinoid receptors (cb1 and cb2) has been reported in neurodegenerative diseases and in simian immunodeficiency virus encephalitis, yet the receptor expression in the central nervous system of hiv+ individuals is not known. |
2011-11-07 |
2023-08-12 |
Not clear |