| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Islam Gamaleddin, Alexander Zvonok, Alexandros Makriyannis, Steven R Goldberg, Bernard Le Fol. Effects of a selective cannabinoid CB2 agonist and antagonist on intravenous nicotine self administration and reinstatement of nicotine seeking. PloS one. vol 7. issue 1. 2012-06-04. PMID:22291896. |
two types of cannabinoid receptors (cb1 and cb2) have been identified. |
2012-06-04 |
2023-08-12 |
human |
| Alexandra Wojtalla, Frank Herweck, Michaela Granzow, Sabine Klein, Jonel Trebicka, Sebastian Huss, Raissa Lerner, Beat Lutz, Frank Alexander Schildberg, Percy Alexander Knolle, Tilman Sauerbruch, Manfred Vincenz Singer, Andreas Zimmer, Sören Volker Siegmun. The endocannabinoid N-arachidonoyl dopamine (NADA) selectively induces oxidative stress-mediated cell death in hepatic stellate cells but not in hepatocytes. American journal of physiology. Gastrointestinal and liver physiology. vol 302. issue 8. 2012-05-29. PMID:22301114. |
although the cannabinoid receptors cb1, cb2, or transient receptor potential cation channel subfamily v, member 1 were expressed in hscs, their pharmacological or genetic blockade failed to inhibit nada-mediated death, indicating a cannabinoid-receptor-independent mechanism. |
2012-05-29 |
2023-08-12 |
human |
| María S García-Gutiérrez, Borja García-Bueno, Silvia Zoppi, Juan C Leza, Jorge Manzanare. Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABA(A) receptors. British journal of pharmacology. vol 165. issue 4. 2012-05-17. PMID:21838753. |
chronic blockade of cannabinoid cb2 receptors induces anxiolytic-like actions associated with alterations in gaba(a) receptors. |
2012-05-17 |
2023-08-12 |
Not clear |
| Sharon Anavi-Goffer, Gemma Baillie, Andrew J Irving, Jürg Gertsch, Iain R Greig, Roger G Pertwee, Ruth A Ros. Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids. The Journal of biological chemistry. vol 287. issue 1. 2012-05-08. PMID:22027819. |
in this study, we investigated the gpr55 pharmacology of various cannabinoids, including analogues of the cb1 receptor antagonist rimonabant®, cb2 receptor agonists, and cannabis sativa constituents. |
2012-05-08 |
2023-08-12 |
Not clear |
| Suneeta Tumati, Tally M Largent-Milnes, Attila Keresztes, Jiyang Ren, William R Roeske, Todd W Vanderah, Eva V Varg. Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist. Journal of neuroimmunology. vol 244. issue 1-2. 2012-05-08. PMID:22285397. |
since activation of glial cb2 cannabinoid receptors attenuates spinal glial activation in neuropathies, we hypothesized that cb2 agonists may also attenuate sustained morphine-mediated spinal glial activation and pain sensitization. |
2012-05-08 |
2023-08-12 |
rat |
| Vedrana Reichenbach, Josefa Ros, Guillermo Fernández-Varo, Gregori Casals, Pedro Melgar-Lesmes, Teresa Campos, Alexandros Makriyannis, Manuel Morales-Ruiz, Wladimiro Jiméne. Prevention of fibrosis progression in CCl4-treated rats: role of the hepatic endocannabinoid and apelin systems. The Journal of pharmacology and experimental therapeutics. vol 340. issue 3. 2012-05-04. PMID:22160265. |
endocannabinoids behave as antifibrogenic agents by interacting with cannabinoid cb2 receptors, whereas the apelin (ap) system acts as a proangiogenic and profibrogenic mediator in the liver. |
2012-05-04 |
2023-08-12 |
rat |
| Péter Jankovics, András Váradi, László Tölgyesi, Szilvia Lohner, Júlia Németh-Palotás, József Ball. Detection and identification of the new potential synthetic cannabinoids 1-pentyl-3-(2-iodobenzoyl)indole and 1-pentyl-3-(1-adamantoyl)indole in seized bulk powders in Hungary. Forensic science international. vol 214. issue 1-3. 2012-04-27. PMID:21813254. |
3-naphthoyl- and 3-phenylacetylindoles represent a group of substances of cannabimimetic activity with affinities - strongly influenced by their functional groups - to cannabinoid receptors cb1 and cb2. |
2012-04-27 |
2023-08-12 |
Not clear |
| Valentina Pomatto, Francesco Palermo, Gilberto Mosconi, Erika Cottone, Paolo Cocci, Massimo Nabissi, Luca Borgio, Alberta M Polzonetti-Magni, Maria Fosca Franzon. Xenoestrogens elicit a modulation of endocannabinoid system and estrogen receptors in 4NP treated goldfish, Carassius auratus. General and comparative endocrinology. vol 174. issue 1. 2012-04-25. PMID:21855545. |
our results confirm in goldfish the effect of 4np on erα and erβ1 receptors and point out a different sensitivity of cb1 and cb2 for this compound, suggesting distinct roles of these cannabinoid receptors in some adaptive processes to contrast stress induced by xenoestrogen exposure. |
2012-04-25 |
2023-08-12 |
zebrafish |
| Alexander Ternianov, José M Pérez-Ortiz, María E Solesio, María S García-Gutiérrez, Antonio Ortega-Álvaro, Francisco Navarrete, Carlos Leiva, María F Galindo, Jorge Manzanare. Overexpression of CB2 cannabinoid receptors results in neuroprotection against behavioral and neurochemical alterations induced by intracaudate administration of 6-hydroxydopamine. Neurobiology of aging. vol 33. issue 2. 2012-04-19. PMID:20980074. |
overexpression of cb2 cannabinoid receptors results in neuroprotection against behavioral and neurochemical alterations induced by intracaudate administration of 6-hydroxydopamine. |
2012-04-19 |
2023-08-12 |
mouse |
| Alexander Ternianov, José M Pérez-Ortiz, María E Solesio, María S García-Gutiérrez, Antonio Ortega-Álvaro, Francisco Navarrete, Carlos Leiva, María F Galindo, Jorge Manzanare. Overexpression of CB2 cannabinoid receptors results in neuroprotection against behavioral and neurochemical alterations induced by intracaudate administration of 6-hydroxydopamine. Neurobiology of aging. vol 33. issue 2. 2012-04-19. PMID:20980074. |
the role of cb2 cannabinoid receptors in the behavioral and neurochemical changes induced by intracaudate administration of 6-hydroxydopamine (6-ohda) was evaluated. |
2012-04-19 |
2023-08-12 |
mouse |
| Alexander Ternianov, José M Pérez-Ortiz, María E Solesio, María S García-Gutiérrez, Antonio Ortega-Álvaro, Francisco Navarrete, Carlos Leiva, María F Galindo, Jorge Manzanare. Overexpression of CB2 cannabinoid receptors results in neuroprotection against behavioral and neurochemical alterations induced by intracaudate administration of 6-hydroxydopamine. Neurobiology of aging. vol 33. issue 2. 2012-04-19. PMID:20980074. |
the results revealed that overexpression of cb2 cannabinoid receptors decreased the extent of motor impairment and dopaminergic neuronal loss, reduced the recruitment of astrocytes and microglia to the lesion, and decreased the level of various oxidative parameters. |
2012-04-19 |
2023-08-12 |
mouse |
| Ferdinando A Giannone, Maurizio Baldassarre, Marco Domenicali, Giacomo Zaccherini, Franco Trevisani, Mauro Bernardi, Paolo Caracen. Reversal of liver fibrosis by the antagonism of endocannabinoid CB1 receptor in a rat model of CCl(4)-induced advanced cirrhosis. Laboratory investigation; a journal of technical methods and pathology. vol 92. issue 3. 2012-04-19. PMID:22184091. |
we also assessed the hepatic expression of cb1 and cb2 receptors and that of the enzymes implicated in the endocannabinoid metabolism. |
2012-04-19 |
2023-08-12 |
rat |
| Ravil R Petrov, Maria E Ferrini, Zeina Jaffar, Charles M Thompson, Kevan Roberts, Philippe Dia. Design and evaluation of a novel fluorescent CB2 ligand as probe for receptor visualization in immune cells. Bioorganic & medicinal chemistry letters. vol 21. issue 19. 2012-04-16. PMID:21855337. |
cannabinoid cb2 receptor has emerged as a very promising target over the last decades. |
2012-04-16 |
2023-08-12 |
Not clear |
| Chia-En A Chang, Rizi Ai, Michael Gutierrez, Michael J Marsell. Homology modeling of cannabinoid receptors: discovery of cannabinoid analogues for therapeutic use. Methods in molecular biology (Clifton, N.J.). vol 819. 2012-04-13. PMID:22183560. |
these compounds primarily target the cannabinoid receptors 1 (cb1) and cannabinoid receptors 2 (cb2). |
2012-04-13 |
2023-08-12 |
Not clear |
| A M Wasik, S Almestrand, X Wang, K Hultenby, Å-L Dackland, P Andersson, E Kimby, B Christensson, B Sande. WIN55,212-2 induces cytoplasmic vacuolation in apoptosis-resistant MCL cells. Cell death & disease. vol 2. 2012-04-10. PMID:22048168. |
cannabinoid receptors 1 (cb1) and/or 2 (cb2) are overexpressed in many types of human malignancies including mantle cell lymphoma (mcl). |
2012-04-10 |
2023-08-12 |
human |
| María Gracia Gervasi, Claudia Osycka-Salut, Julieta Caballero, Mónica Vazquez-Levin, Elba Pereyra, Silvia Billi, Ana Franchi, Silvina Perez-Martine. Anandamide capacitates bull spermatozoa through CB1 and TRPV1 activation. PloS one. vol 6. issue 2. 2012-04-02. PMID:21347292. |
anandamide (aea), a major endocannabinoid, binds to cannabinoid and vanilloid receptors (cb1, cb2 and trpv1) and affects many reproductive functions. |
2012-04-02 |
2023-08-12 |
cattle |
| I R Dinu, Simona Georgiana Popa, Maria Moţa, E Moţa, Camelia Stănciulescu, M Ioana, M Cruc. The association of the rs1049353 polymorphism of the CNR1 gene with hypoadiponectinemia. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 52. issue 3. 2012-03-29. PMID:21892520. |
it is comprised of the cannabinoid receptors (cb1 and cb2), the endogenous lipid ligands of these receptors and the enzymes that mediate the endogenous ligands' biosynthesis and degradation. |
2012-03-29 |
2023-08-12 |
human |
| Eric Murillo-Rodriguez, Alwin Poot-Ake, Oscar Arias-Carrion, Elda Pacheco-Pantoja, Alfredo de la Fuente-Ortegon, Gloria Arankowsky-Sandova. The emerging role of the endocannabinoid system in the sleep-wake cycle modulation. Central nervous system agents in medicinal chemistry. vol 11. issue 3. 2012-03-29. PMID:21919868. |
narachidonoylethanolamide (anandamide; ana) and 2-arachidonoylglycerol (2-ag) are endogenous cannabinoids (endocannabinoids) ligands for the cannabinoid family of g-protein-coupled receptors named cb1 and cb2. |
2012-03-29 |
2023-08-12 |
Not clear |
| Richard F Cox, Vincent Ras. Characterization of cannabinoid receptors. Current protocols in pharmacology. vol Chapter 1. 2012-03-27. PMID:22294073. |
this unit describes the use of cannabinoid radioligands in competitive binding assays for determining affinity parameters (ic(50), k(i)) of unlabeled compounds at cloned cb1 and cb2 receptors expressed in cells. |
2012-03-27 |
2023-08-12 |
Not clear |
| J Michael Bostwic. Blurred boundaries: the therapeutics and politics of medical marijuana. Mayo Clinic proceedings. vol 87. issue 2. 2012-03-26. PMID:22305029. |
pubmed searches were conducted using the following keywords: medical marijuana, medical cannabis, endocannabinoid system, cb1 receptors, cb2 receptors, thc, cannabidiol, nabilone, dronabinol, nabiximols, rimonabant, marijuana legislation, marijuana abuse, marijuana dependence, and marijuana and schizophrenia. |
2012-03-26 |
2023-08-12 |
human |