| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guillermo B Silva, Douglas K Atchison, Luis I Juncos, Néstor H Garcí. Anandamide inhibits transport-related oxygen consumption in the loop of Henle by activating CB1 receptors. American journal of physiology. Renal physiology. vol 304. issue 4. 2013-04-29. PMID:23220721. |
to test the role of the cannabinoid receptors, we used specific agonists and antagonists of cb1 and cb2 receptors. |
2013-04-29 |
2023-08-12 |
Not clear |
| Roberta Ottria, Silvana Casati, Pierangela Ciuffred. Optimized synthesis and characterization of N-acylethanolamines and O-acylethanolamines, important family of lipid-signalling molecules. Chemistry and physics of lipids. vol 165. issue 7. 2013-04-19. PMID:22850591. |
the endocannabinoid anandamide (n-arachidonoylethanolamine, aea), a physiologically occurring bioactive compound on cb1 and cb2 receptors, has multiple physiological functions. |
2013-04-19 |
2023-08-12 |
Not clear |
| Pretal P Muldoon, Aron H Lichtman, Loren H Parsons, M Imad Dama. The role of fatty acid amide hydrolase inhibition in nicotine reward and dependence. Life sciences. vol 92. issue 8-9. 2013-04-17. PMID:22705310. |
the endogenous cannabinoid anandamide (aea) exerts the majority of its effects at cb1 and cb2 receptors and is degraded by fatty acid amide hydrolase (faah). |
2013-04-17 |
2023-08-12 |
mouse |
| Rukiyah Van Dross, Eman Soliman, Shalini Jha, Travious Johnson, Somnath Mukhopadhya. Receptor-dependent and receptor-independent endocannabinoid signaling: a therapeutic target for regulation of cancer growth. Life sciences. vol 92. issue 8-9. 2013-04-17. PMID:23069587. |
the endocannabinoid system comprises the g-protein coupled cb1 cannabinoid receptor (cb1r) and cb2 cannabinoid receptor (cb2r), their endogenous ligands (endocannabinoids), and the enzymes responsible for their synthesis and catabolism. |
2013-04-17 |
2023-08-12 |
Not clear |
| Catherine A Newton, Thomas W Klei. Cannabinoid 2 (CB2) receptor involvement in the down-regulation but not up-regulation of serum IgE levels in immunized mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 7. issue 3. 2013-04-10. PMID:22552780. |
cannabinoid 2 (cb2) receptor involvement in the down-regulation but not up-regulation of serum ige levels in immunized mice. |
2013-04-10 |
2023-08-12 |
mouse |
| Catherine A Newton, Thomas W Klei. Cannabinoid 2 (CB2) receptor involvement in the down-regulation but not up-regulation of serum IgE levels in immunized mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 7. issue 3. 2013-04-10. PMID:22552780. |
these results suggest that in this ige induction model in mice, non-selective cannabinoids such as thc increase ige through receptors other than cb1 and cb2 but that cb2 receptors do play a suppressive role in the control of serum ige levels. |
2013-04-10 |
2023-08-12 |
mouse |
| Marek Tkaczyk, Ewa Florek, Wojciech Piekoszewsk. [Marihuana and cannobinoids as medicaments]. Przeglad lekarski. vol 69. issue 10. 2013-04-10. PMID:23421098. |
biological activity of cannabinoids is caused by binding to two cannabinoid receptors cb1 and cb2. |
2013-04-10 |
2023-08-12 |
Not clear |
| Vincenzo Di Marzo, Luciano De Petrocelli. Why do cannabinoid receptors have more than one endogenous ligand? Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 367. issue 1607. 2013-04-08. PMID:23108541. |
the endocannabinoid system was revealed following the understanding of the mechanism of action of marijuana's major psychotropic principle, Δ(9)-tetrahydrocannabinol, and includes two g-protein-coupled receptors (gpcrs; the cannabinoid cb1 and cb2 receptors), their endogenous ligands (the endocannabinoids, the best studied of which are anandamide and 2-arachidonoylglycerol (2-ag)), and the proteins that regulate the levels and activity of these receptors and ligands. |
2013-04-08 |
2023-08-12 |
human |
| Claudia Grimaldi, Anna Capass. Role of lipid rafts/caveolae in the anticancer effect of endocannabinoids. Mini reviews in medicinal chemistry. vol 12. issue 11. 2013-04-01. PMID:22625418. |
the endocannabinoid system comprises the cannabinoid receptors type 1 (cb1) and type 2 (cb2), their endogenous ligands (endocannabinoids) and the whole apparatus appointed of their synthesis and degradation. |
2013-04-01 |
2023-08-12 |
Not clear |
| C Mugnaini, S Pasquini, F Corell. The bioisosteric concept applied to cannabinoid ligands. Current medicinal chemistry. vol 19. issue 28. 2013-03-28. PMID:22830341. |
two different cannabinoid receptors have been cloned from mammalian tissues, the cb1 receptor, mostly expressed in brain, and the cb2 receptor, mostly expressed in the immune system, both regulating a variety of physiological functions. |
2013-03-28 |
2023-08-12 |
Not clear |
| Dan Wang, Bing-Xu Ren, Cheng-Long Liu, Jie Zhu, Juan Zhang, Wei Zhang, Feng-Mei Mei, Xiao-Ping Gu, Zheng-Liang M. [Role of cannabinoid 2 receptor in the development of bone cancer pain]. Zhonghua yi xue za zhi. vol 92. issue 7. 2013-01-31. PMID:22490961. |
to explore the effects of cannabinoid 2 receptor (cb2) in the development of bone cancer pain in mice. |
2013-01-31 |
2023-08-12 |
mouse |
| Jade M Franklin, Gonzalo A Carrasc. Cannabinoid-induced enhanced interaction and protein levels of serotonin 5-HT(2A) and dopamine D₂ receptors in rat prefrontal cortex. Journal of psychopharmacology (Oxford, England). vol 26. issue 10. 2013-01-30. PMID:22791651. |
to date, two cannabinoids receptors have been found in brain, cb1 and cb2 receptors. |
2013-01-30 |
2023-08-12 |
rat |
| Bharati Prasad, Miodrag G Radulovacki, David W Carle. Proof of concept trial of dronabinol in obstructive sleep apnea. Frontiers in psychiatry. vol 4. 2013-01-25. PMID:23346060. |
on this basis, we examined the safety, tolerability, and efficacy of dronabinol (Δ(9)thc), an exogenous cannabinoid type 1 and type 2 (cb1 and cb2) receptor agonist in patients with obstructive sleep apnea (osa). |
2013-01-25 |
2023-08-12 |
Not clear |
| S E M Lewis, R Paro, L Borriello, L Simon, L Robinson, Z Dincer, G Riedel, N Battista, M Maccarron. Long-term use of HU210 adversely affects spermatogenesis in rats by modulating the endocannabinoid system. International journal of andrology. vol 35. issue 5. 2013-01-22. PMID:22435752. |
hu210, a selective agonist for cb1 and cb2 cannabinoid receptors impairs spermatogenesis and sperm motility and deregulates the endocannabinoid system. |
2013-01-22 |
2023-08-12 |
rat |
| Katrin Palumbo-Zerr, Angelika Horn, Alfiya Distler, Pawel Zerr, Clara Dees, Christian Beyer, Enrico Selvi, Benjamin F Cravatt, Oliver Distler, Georg Schett, Jörg H W Distle. Inactivation of fatty acid amide hydrolase exacerbates experimental fibrosis by enhanced endocannabinoid-mediated activation of CB1. Annals of the rheumatic diseases. vol 71. issue 12. 2013-01-14. PMID:22915616. |
selective targeting of the cannabinoid receptors cb1 and cb2 by synthetic compounds has revealed opposing roles of both receptors in fibrosis. |
2013-01-14 |
2023-08-12 |
Not clear |
| Cristoforo Silvestri, Vincenzo Di Marz. Second generation CB1 receptor blockers and other inhibitors of peripheral endocannabinoid overactivity and the rationale of their use against metabolic disorders. Expert opinion on investigational drugs. vol 21. issue 9. 2013-01-04. PMID:22780328. |
the endocannabinoid system (ecs) is composed of neutral lipids which signal through the g-protein coupled cannabinoid receptors cb1 and cb2. |
2013-01-04 |
2023-08-12 |
Not clear |
| Jarogniew J Luszczki, Magdalena Florek-Łuszczk. Synergistic interaction of pregabalin with the synthetic cannabinoid WIN 55,212-2 mesylate in the hot-plate test in mice: an isobolographic analysis. Pharmacological reports : PR. vol 64. issue 3. 2013-01-04. PMID:22814025. |
the aim of the study was to determine the type of interaction between pregabalin (a 3(rd)-generation antiepileptic drug) and win 55,212-2 mesylate (win - a highly potent non-selective cannabinoid cb1 and cb2 receptor agonist) administered in combination at a fixed ratio of 1:1, in the acute thermal pain model (hot-plate test) in mice. |
2013-01-04 |
2023-08-12 |
mouse |
| Jonathon C Arnold, Phoebe Hone, Michelle L Holland, John D Alle. CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells. Pharmacological reports : PR. vol 64. issue 3. 2013-01-04. PMID:22814029. |
cb2 and trpv1 receptors mediate cannabinoid actions on mdr1 expression in multidrug resistant cells. |
2013-01-04 |
2023-08-12 |
Not clear |
| Gracious R Ross, Aron Lichtman, William L Dewey, Hamid I Akbaral. Evidence for the putative cannabinoid receptor (GPR55)-mediated inhibitory effects on intestinal contractility in mice. Pharmacology. vol 90. issue 1-2. 2012-12-27. PMID:22759743. |
cannabinoids inhibit intestinal motility via presynaptic cannabinoid receptor type i (cb1) in enteric neurons while cannabinoid receptor type ii (cb2) receptors are located mainly in immune cells. |
2012-12-27 |
2023-08-12 |
mouse |
| Heather L Hutchins-Wiese, Yong Li, Kevin Hannon, Bruce A Watkin. Hind limb suspension and long-chain omega-3 PUFA increase mRNA endocannabinoid system levels in skeletal muscle. The Journal of nutritional biochemistry. vol 23. issue 8. 2012-12-07. PMID:22051448. |
arachidonic acid (aa) is the substrate for anandamide (aea) and 2-arachidonylgycerol (2-ag), which act as agonists for cannabinoid receptors cb1 and cb2 found in muscle. |
2012-12-07 |
2023-08-12 |
mouse |