| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chen Li, Alonso Vilches-Flores, Min Zhao, Stephanie A Amiel, Peter M Jones, Shanta J Persau. Expression and function of monoacylglycerol lipase in mouse β-cells and human islets of Langerhans. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 30. issue 2. 2012-11-20. PMID:22739267. |
elements of the endocannabinoid system (ecs) are expressed by islet endocrine cells and activation of cb1 and cb2 cannabinoid receptors regulates insulin secretion from mouse and human β-cells. |
2012-11-20 |
2023-08-12 |
mouse |
| Gema Vera, Visitación López-Miranda, Esperanza Herradón, María Isabel Martín, Raquel Abal. Characterization of cannabinoid-induced relief of neuropathic pain in rat models of type 1 and type 2 diabetes. Pharmacology, biochemistry, and behavior. vol 102. issue 2. 2012-11-19. PMID:22609797. |
selective cb1 and cb2 cannabinoid antagonists were used to characterize win antineuropathic effects. |
2012-11-19 |
2023-08-12 |
rat |
| Przemysław Adamczyk, Joanna Miszkiel, Andrew C McCreary, Małgorzata Filip, Mariusz Papp, Edmund Przegalińsk. The effects of cannabinoid CB1, CB2 and vanilloid TRPV1 receptor antagonists on cocaine addictive behavior in rats. Brain research. vol 1444. 2012-11-13. PMID:22325096. |
the effects of cannabinoid cb1, cb2 and vanilloid trpv1 receptor antagonists on cocaine addictive behavior in rats. |
2012-11-13 |
2023-08-12 |
rat |
| Przemysław Adamczyk, Joanna Miszkiel, Andrew C McCreary, Małgorzata Filip, Mariusz Papp, Edmund Przegalińsk. The effects of cannabinoid CB1, CB2 and vanilloid TRPV1 receptor antagonists on cocaine addictive behavior in rats. Brain research. vol 1444. 2012-11-13. PMID:22325096. |
to further explore the importance of other endocannabinoid-related receptors in an animal model of cocaine addiction, the present paper examines cannabinoid cb2 receptor antagonist n-((1s)-endo-1,3,3-trimethylbicyclo(2.2.1)heptan-2-yl)-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyrazole-3-carboxamide (sr144528) and the transient receptor potential vanilloid type-1 (trpv1) receptor antagonist n-(3-methoxyphenyl)-4-chlorocinnamide (sb366791) on intravenous (i.v.) |
2012-11-13 |
2023-08-12 |
rat |
| S Y Romero-Zerbo, M S Garcia-Gutierrez, J Suárez, P Rivera, I Ruz-Maldonado, M Vida, F Rodriguez de Fonseca, J Manzanares, F Javier Bermúdez-Silv. Overexpression of cannabinoid CB2 receptor in the brain induces hyperglycaemia and a lean phenotype in adult mice. Journal of neuroendocrinology. vol 24. issue 8. 2012-11-05. PMID:22487302. |
overexpression of cannabinoid cb2 receptor in the brain induces hyperglycaemia and a lean phenotype in adult mice. |
2012-11-05 |
2023-08-12 |
mouse |
| S Y Romero-Zerbo, M S Garcia-Gutierrez, J Suárez, P Rivera, I Ruz-Maldonado, M Vida, F Rodriguez de Fonseca, J Manzanares, F Javier Bermúdez-Silv. Overexpression of cannabinoid CB2 receptor in the brain induces hyperglycaemia and a lean phenotype in adult mice. Journal of neuroendocrinology. vol 24. issue 8. 2012-11-05. PMID:22487302. |
however, functional cannabinoid cb2 receptors have also been described in the brain, with no studies addressing their putative role in body weight control and glucose homeostasis. |
2012-11-05 |
2023-08-12 |
mouse |
| S Y Romero-Zerbo, M S Garcia-Gutierrez, J Suárez, P Rivera, I Ruz-Maldonado, M Vida, F Rodriguez de Fonseca, J Manzanares, F Javier Bermúdez-Silv. Overexpression of cannabinoid CB2 receptor in the brain induces hyperglycaemia and a lean phenotype in adult mice. Journal of neuroendocrinology. vol 24. issue 8. 2012-11-05. PMID:22487302. |
however, cannabinoid cb1 and cb2 receptor expression in the endocrine pancreas and glucagon plasma levels were decreased. |
2012-11-05 |
2023-08-12 |
mouse |
| S Y Romero-Zerbo, M S Garcia-Gutierrez, J Suárez, P Rivera, I Ruz-Maldonado, M Vida, F Rodriguez de Fonseca, J Manzanares, F Javier Bermúdez-Silv. Overexpression of cannabinoid CB2 receptor in the brain induces hyperglycaemia and a lean phenotype in adult mice. Journal of neuroendocrinology. vol 24. issue 8. 2012-11-05. PMID:22487302. |
taken together, these results suggest a role for central cannabinoid cb2 receptors in body weight control and glucose homeostasis. |
2012-11-05 |
2023-08-12 |
mouse |
| Xinyi Liu, Indira Jutooru, Ping Lei, KyoungHyun Kim, Syng-Ook Lee, Lisa K Brents, Paul L Prather, Stephen Saf. Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer. Molecular cancer therapeutics. vol 11. issue 7. 2012-10-31. PMID:22553354. |
betulinic acid-dependent repression of sp1, sp3, sp4, and sp-regulated genes was due, in part, to induction of the sp repressor zbtb10 and downregulation of microrna-27a (mir-27a), which constitutively inhibits zbtb10 expression, and we show for the first time that the effects of betulinic acid on the mir-27a:zbtb10-sp transcription factor axis were cannabinoid 1 (cb1) and cb2 receptor-dependent, thus identifying a new cellular target for this anticancer agent. |
2012-10-31 |
2023-08-12 |
Not clear |
| Alpha K Gebeh, Jonathon M Willets, Emma L Marczylo, Anthony H Taylor, Justin C Konj. Ectopic pregnancy is associated with high anandamide levels and aberrant expression of FAAH and CB1 in fallopian tubes. The Journal of clinical endocrinology and metabolism. vol 97. issue 8. 2012-10-24. PMID:22701012. |
anandamide activates cannabinoid receptors (cb1 and cb2) and, together with its degrading [e.g. |
2012-10-24 |
2023-08-12 |
mouse |
| Sandeep Singla, Rajesh Sachdeva, Jawahar L Meht. Cannabinoids and atherosclerotic coronary heart disease. Clinical cardiology. vol 35. issue 6. 2012-10-11. PMID:22278660. |
the pharmacologic effects of marijuana, based on stimulation of cannabinoid receptors cb1 and cb2, which are widely distributed in the cardiovascular system, have been well described. |
2012-10-11 |
2023-08-12 |
human |
| Hsin-Ying Wu, Kathleen Goble, Miriam Mecha, Chia-Chi Wang, Chung-Hsiung Huang, Carmen Guaza, Tong-Rong Ja. Cannabidiol-induced apoptosis in murine microglial cells through lipid raft. Glia. vol 60. issue 7. 2012-09-20. PMID:22535572. |
mechanistic studies revealed that antioxidants, including n-acetyl-l-cysteine and glutathione, the g protein-coupled receptor 55 agonist abnormal-cbd and specific antagonists for vanilloid, and cb1 and cb2 cannabinoid receptors did not counteract the apoptosis induced by cbd. |
2012-09-20 |
2023-08-12 |
Not clear |
| Tang-feng Su, Ling-hong Zhang, Miao Peng, Cai-hua Wu, Wen Pan, Bo Tian, Jing Shi, Hui-lin Pan, Man L. Cannabinoid CB2 receptors contribute to upregulation of β-endorphin in inflamed skin tissues by electroacupuncture. Molecular pain. vol 7. 2012-09-19. PMID:22177137. |
cannabinoid cb2 receptors contribute to upregulation of β-endorphin in inflamed skin tissues by electroacupuncture. |
2012-09-19 |
2023-08-12 |
Not clear |
| Tang-feng Su, Ling-hong Zhang, Miao Peng, Cai-hua Wu, Wen Pan, Bo Tian, Jing Shi, Hui-lin Pan, Man L. Cannabinoid CB2 receptors contribute to upregulation of β-endorphin in inflamed skin tissues by electroacupuncture. Molecular pain. vol 7. 2012-09-19. PMID:22177137. |
endogenous cannabinoids and peripheral cannabinoid cb2 receptors (cb2rs) are also involved in the antinociceptive effect of ea on inflammatory pain. |
2012-09-19 |
2023-08-12 |
Not clear |
| Nashaat Turkman, Aleksander Shavrin, Vincenzo Paolillo, Hsin Hsien Yeh, Leo Flores, Suren Soghomonian, Brian Rabinovich, Andrei Volgin, Juri Gelovani, Mian Alauddi. Synthesis and preliminary evaluation of [18F]-labeled 2-oxoquinoline derivatives for PET imaging of cannabinoid CB2 receptor. Nuclear medicine and biology. vol 39. issue 4. 2012-09-17. PMID:22226022. |
synthesis and preliminary evaluation of [18f]-labeled 2-oxoquinoline derivatives for pet imaging of cannabinoid cb2 receptor. |
2012-09-17 |
2023-08-12 |
Not clear |
| Yosefa Avraham, Johnny Amer, Sarit Doron, Lina Abu-Tair, Mahmud Mahamid, Areej Khatib, Elliot M Berry, Rifaat Safad. The direct profibrotic and indirect immune antifibrotic balance of blocking the cannabinoid 2 receptor. American journal of physiology. Gastrointestinal and liver physiology. vol 302. issue 12. 2012-09-13. PMID:22517772. |
cannabinoid 2 (cb2) receptors expressed on immune cells are considered to be antifibrogenic. |
2012-09-13 |
2023-08-12 |
mouse |
| Doris Riethe. Selective cannabinoid receptor 2 modulators: a patent review 2009--present. Expert opinion on therapeutic patents. vol 22. issue 5. 2012-09-06. PMID:22537079. |
questions around the involvement of cb1 activation in these effects remain, but efforts have been directed toward the discovery of highly selective cb2 modulators lacking the psychotropic effects of cannabinoids, which are mediated by the cb1 receptor. |
2012-09-06 |
2023-08-12 |
Not clear |
| Francesca Rossi, Giulia Bellini, Carlo Tolone, Livio Luongo, Silvia Mancusi, Alfonso Papparella, Craig Sturgeon, Alessio Fasano, Bruno Nobili, Laura Perrone, Sabatino Maione, Emanuele Miraglia del Giudic. The cannabinoid receptor type 2 Q63R variant increases the risk of celiac disease: implication for a novel molecular biomarker and future therapeutic intervention. Pharmacological research. vol 66. issue 1. 2012-08-27. PMID:22465144. |
cells of the immune system express the cannabinoid receptor type 2 (cb2), a plasma-membrane receptor activated by both endogenous and exogenous cannabinoids. |
2012-08-27 |
2023-08-12 |
Not clear |
| Lucía Callén, Estefanía Moreno, Pedro Barroso-Chinea, David Moreno-Delgado, Antoni Cortés, Josefa Mallol, Vicent Casadó, José Luis Lanciego, Rafael Franco, Carmen Lluis, Enric I Canela, Peter J McCormic. Cannabinoid receptors CB1 and CB2 form functional heteromers in brain. The Journal of biological chemistry. vol 287. issue 25. 2012-08-24. PMID:22532560. |
cannabinoid receptors cb1 and cb2 form functional heteromers in brain. |
2012-08-24 |
2023-08-12 |
rat |
| Emmanuel S Onaivi, Hiroki Ishiguro, Shanzhi Gu, Qing-Rong Li. CNS effects of CB2 cannabinoid receptors: beyond neuro-immuno-cannabinoid activity. Journal of psychopharmacology (Oxford, England). vol 26. issue 1. 2012-08-21. PMID:21447538. |
cns effects of cb2 cannabinoid receptors: beyond neuro-immuno-cannabinoid activity. |
2012-08-21 |
2023-08-12 |
mouse |