| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lucian Del Fabbro, Carlos Borges Filho, Leandro Cattelan Souza, Lucielli Savegnago, Diego Alves, Paulo Henrique Schneider, Helena Domingues de Salles, Cristiano R Jess. Effects of Se-phenyl thiazolidine-4-carboselenoate on mechanical and thermal hyperalgesia in brachial plexus avulsion in mice: mediation by cannabinoid CB1 and CB2 receptors. Brain research. vol 1475. 2013-06-14. PMID:22902772. |
effects of se-phenyl thiazolidine-4-carboselenoate on mechanical and thermal hyperalgesia in brachial plexus avulsion in mice: mediation by cannabinoid cb1 and cb2 receptors. |
2013-06-14 |
2023-08-12 |
mouse |
| John C Ashto. The atypical cannabinoid O-1602: targets, actions, and the central nervous system. Central nervous system agents in medicinal chemistry. vol 12. issue 3. 2013-06-13. PMID:22831390. |
o-1602 is a cannabidiol analogue that does not bind with high affinity to either the cannabinoid cb1 receptor or cb2 receptor. |
2013-06-13 |
2023-08-12 |
Not clear |
| Raphael Mechoulam, Linda A Parke. The endocannabinoid system and the brain. Annual review of psychology. vol 64. 2013-06-10. PMID:22804774. |
the psychoactive constituent in cannabis, Δ(9)-tetrahydrocannabinol (thc), was isolated in the mid-1960s, but the cannabinoid receptors, cb1 and cb2, and the major endogenous cannabinoids (anandamide and 2-arachidonoyl glycerol) were identified only 20 to 25 years later. |
2013-06-10 |
2023-08-12 |
Not clear |
| Rahman Md Mostafeezur, Hossain Md Zakir, Hanako Takatsuji, Yoshiaki Yamada, Kensuke Yamamura, Junichi Kitagaw. Cannabinoids facilitate the swallowing reflex elicited by the superior laryngeal nerve stimulation in rats. PloS one. vol 7. issue 11. 2013-05-22. PMID:23209814. |
cannabinoids have been reported to be involved in affecting various biological functions through binding with cannabinoid receptors type 1 (cb1) and 2 (cb2). |
2013-05-22 |
2023-08-12 |
rat |
| Andrea Rotter, Kristina Bayerlein, Max Hansbauer, Judith Weiland, Wolfgang Sperling, Johannes Kornhuber, Teresa Bierman. CB1 and CB2 receptor expression and promoter methylation in patients with cannabis dependence. European addiction research. vol 19. issue 1. 2013-05-17. PMID:22948261. |
cb1 and cb2 receptors are influenced via exogenous and endogenous cannabinoids. |
2013-05-17 |
2023-08-12 |
human |
| Serena Pasquini, Maria De Rosa, Alessia Ligresti, Claudia Mugnaini, Antonella Brizzi, Nicola P Caradonna, Maria Grazia Cascio, Daniele Bolognini, Roger G Pertwee, Vincenzo Di Marzo, Federico Corell. Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors. European journal of medicinal chemistry. vol 58. 2013-05-16. PMID:23085772. |
within our studies on structure-activity relationships of 4-quinolone-3-carboxamides as cannabinoid ligands, a new series of compounds characterized by a fluoro or phenylthio group at 7-position and different substituents at n1 and carboxamide nitrogen were synthesized and evaluated for their binding ability to cannabinoid type 1 (cb1) and type 2 (cb2) receptors. |
2013-05-16 |
2023-08-12 |
Not clear |
| Serena Pasquini, Maria De Rosa, Alessia Ligresti, Claudia Mugnaini, Antonella Brizzi, Nicola P Caradonna, Maria Grazia Cascio, Daniele Bolognini, Roger G Pertwee, Vincenzo Di Marzo, Federico Corell. Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors. European journal of medicinal chemistry. vol 58. 2013-05-16. PMID:23085772. |
most of the compounds showed affinity for one or both cannabinoid receptors at nanomolar concentration, with k(i)(cb1) and k(i)(cb2) values ranging from 2.45 to >10,000 nm and from 0.09 to 957 nm, respectively. |
2013-05-16 |
2023-08-12 |
Not clear |
| Fang He, Akhilesh Kumar, Zhao-Hui Son. Heat shock protein 90 is an essential molecular chaperone for CB2 cannabinoid receptor-mediated signaling in trabecular meshwork cells. Molecular vision. vol 18. 2013-05-14. PMID:23233786. |
heat shock protein 90 is an essential molecular chaperone for cb2 cannabinoid receptor-mediated signaling in trabecular meshwork cells. |
2013-05-14 |
2023-08-12 |
Not clear |
| W Schmidt, F Schäfer, V Striggow, K Fröhlich, F Striggo. Cannabinoid receptor subtypes 1 and 2 mediate long-lasting neuroprotection and improve motor behavior deficits after transient focal cerebral ischemia. Neuroscience. vol 227. 2013-05-09. PMID:23069763. |
we have investigated the localization of cannabinoid cb1 and cb2 receptors in adult rat brains before and after focal cerebral ischemia due to endothelin-induced transient occlusion of the middle cerebral artery (emcao). |
2013-05-09 |
2023-08-12 |
rat |
| Antonella Contartese, Massimo Valoti, Federico Corelli, Serena Pasquini, Claudia Mugnaini, Federica Pessina, Carlo Aldinucci, Giampietro Sgaragli, Maria Frosin. A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury. Pharmacological research. vol 66. issue 6. 2013-05-07. PMID:23036353. |
cannabinoid cb2 receptor activation has been shown to have many pharmacological but not psychotropic effects. |
2013-05-07 |
2023-08-12 |
rat |
| Angel Arevalo-Martin, Daniel Garcia-Ovejero, Yolanda Sierra-Palomares, Beatriz Paniagua-Torija, Ines Gonzalez-Gil, Silvia Ortega-Gutierrez, Eduardo Molina-Holgad. Early endogenous activation of CB1 and CB2 receptors after spinal cord injury is a protective response involved in spontaneous recovery. PloS one. vol 7. issue 11. 2013-05-07. PMID:23152849. |
since 2-ag and aea act through cb1 and cb2 cannabinoid receptors, we administered at 20 minutes after lesion a single injection of their respective antagonists am281 and am630 alone or in combination to block the effects of this early endocannabinoid accumulation. |
2013-05-07 |
2023-08-12 |
rat |
| A M Sanchez, P Vigano, A Mugione, P Panina-Bordignon, M Candian. The molecular connections between the cannabinoid system and endometriosis. Molecular human reproduction. vol 18. issue 12. 2013-05-06. PMID:22923487. |
the endocannabinoid system consists of an array of endogenously produced bioactive lipids that activate cannabinoid 1 (cb1) and 2 (cb2) receptors. |
2013-05-06 |
2023-08-12 |
Not clear |
| A M Sanchez, P Vigano, A Mugione, P Panina-Bordignon, M Candian. The molecular connections between the cannabinoid system and endometriosis. Molecular human reproduction. vol 18. issue 12. 2013-05-06. PMID:22923487. |
the components of the endocannabinoid system, cb1 and cb2 receptors and the enzymes n-acylphosphatidylethanolamine-phospholipase d and fatty acid amide hydrolase are differentially regulated throughout the menstrual cycle in the endometrium and are expressed in deep endometriotic nodules and in sensory and sympathetic neurons innervating the lesions. |
2013-05-06 |
2023-08-12 |
Not clear |
| Guillermo B Silva, Douglas K Atchison, Luis I Juncos, Néstor H Garcí. Anandamide inhibits transport-related oxygen consumption in the loop of Henle by activating CB1 receptors. American journal of physiology. Renal physiology. vol 304. issue 4. 2013-04-29. PMID:23220721. |
to test the role of the cannabinoid receptors, we used specific agonists and antagonists of cb1 and cb2 receptors. |
2013-04-29 |
2023-08-12 |
Not clear |
| Roberta Ottria, Silvana Casati, Pierangela Ciuffred. Optimized synthesis and characterization of N-acylethanolamines and O-acylethanolamines, important family of lipid-signalling molecules. Chemistry and physics of lipids. vol 165. issue 7. 2013-04-19. PMID:22850591. |
the endocannabinoid anandamide (n-arachidonoylethanolamine, aea), a physiologically occurring bioactive compound on cb1 and cb2 receptors, has multiple physiological functions. |
2013-04-19 |
2023-08-12 |
Not clear |
| Pretal P Muldoon, Aron H Lichtman, Loren H Parsons, M Imad Dama. The role of fatty acid amide hydrolase inhibition in nicotine reward and dependence. Life sciences. vol 92. issue 8-9. 2013-04-17. PMID:22705310. |
the endogenous cannabinoid anandamide (aea) exerts the majority of its effects at cb1 and cb2 receptors and is degraded by fatty acid amide hydrolase (faah). |
2013-04-17 |
2023-08-12 |
mouse |
| Rukiyah Van Dross, Eman Soliman, Shalini Jha, Travious Johnson, Somnath Mukhopadhya. Receptor-dependent and receptor-independent endocannabinoid signaling: a therapeutic target for regulation of cancer growth. Life sciences. vol 92. issue 8-9. 2013-04-17. PMID:23069587. |
the endocannabinoid system comprises the g-protein coupled cb1 cannabinoid receptor (cb1r) and cb2 cannabinoid receptor (cb2r), their endogenous ligands (endocannabinoids), and the enzymes responsible for their synthesis and catabolism. |
2013-04-17 |
2023-08-12 |
Not clear |
| Catherine A Newton, Thomas W Klei. Cannabinoid 2 (CB2) receptor involvement in the down-regulation but not up-regulation of serum IgE levels in immunized mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 7. issue 3. 2013-04-10. PMID:22552780. |
cannabinoid 2 (cb2) receptor involvement in the down-regulation but not up-regulation of serum ige levels in immunized mice. |
2013-04-10 |
2023-08-12 |
mouse |
| Catherine A Newton, Thomas W Klei. Cannabinoid 2 (CB2) receptor involvement in the down-regulation but not up-regulation of serum IgE levels in immunized mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 7. issue 3. 2013-04-10. PMID:22552780. |
these results suggest that in this ige induction model in mice, non-selective cannabinoids such as thc increase ige through receptors other than cb1 and cb2 but that cb2 receptors do play a suppressive role in the control of serum ige levels. |
2013-04-10 |
2023-08-12 |
mouse |
| Marek Tkaczyk, Ewa Florek, Wojciech Piekoszewsk. [Marihuana and cannobinoids as medicaments]. Przeglad lekarski. vol 69. issue 10. 2013-04-10. PMID:23421098. |
biological activity of cannabinoids is caused by binding to two cannabinoid receptors cb1 and cb2. |
2013-04-10 |
2023-08-12 |
Not clear |