| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Belinda J Cridge, Rhonda J Rosengre. Critical appraisal of the potential use of cannabinoids in cancer management. Cancer management and research. vol 5. 2013-09-20. PMID:24039449. |
cannabinoids are largely defined by an ability to activate the cannabinoid receptors - cb1 or cb2. |
2013-09-20 |
2023-08-12 |
Not clear |
| Yan Li, Yan Sun, Zhaocun Zhang, Xiaodi Feng, Hui Meng, Shun Li, Yaofeng Zhu, Shouzhen Chen, Yang Wang, Jun Wang, Deqing Zhang, Xuewen Jiang, Ning Li, Benkang Sh. Cannabinoid receptors 1 and 2 are associated with bladder dysfunction in an experimental diabetic rat model. BJU international. vol 112. issue 2. 2013-09-06. PMID:23795792. |
to investigate diabetes-associated changes in urinary bladder expression of cannabinoid receptors 1 and 2 (cb1 and cb2) and the functional role of cb agonists and antagonists in mediating phasic contractions of isolated bladder strips using a streptozotocin-induced diabetic rat model. |
2013-09-06 |
2023-08-12 |
rat |
| Heba Mahmoud Gouda, Nermin R Mohamed Kame. Cannabinoid CB2 receptor gene (CNR2) polymorphism is associated with chronic childhood immune thrombocytopenia in Egypt. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. vol 24. issue 3. 2013-08-30. PMID:23406660. |
cannabinoid cb2 receptor gene (cnr2) polymorphism is associated with chronic childhood immune thrombocytopenia in egypt. |
2013-08-30 |
2023-08-12 |
Not clear |
| Heba Mahmoud Gouda, Nermin R Mohamed Kame. Cannabinoid CB2 receptor gene (CNR2) polymorphism is associated with chronic childhood immune thrombocytopenia in Egypt. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. vol 24. issue 3. 2013-08-30. PMID:23406660. |
the cb2 receptor is thought to be the principal cannabinoid receptor that mediates immune modulation by endocannabinoid. |
2013-08-30 |
2023-08-12 |
Not clear |
| Heba Mahmoud Gouda, Nermin R Mohamed Kame. Cannabinoid CB2 receptor gene (CNR2) polymorphism is associated with chronic childhood immune thrombocytopenia in Egypt. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. vol 24. issue 3. 2013-08-30. PMID:23406660. |
in this study, we investigated the association between cannabinoid cb2 receptor gene (cnr2) q63r polymorphism and the susceptibility to childhood itp in egyptian population. |
2013-08-30 |
2023-08-12 |
Not clear |
| Ioanna Vasileiou, Georgia Fotopoulou, Marina Matzourani, Efstratios Patsouris, Stamatios Theochari. Evidence for the involvement of cannabinoid receptors' polymorphisms in the pathophysiology of human diseases. Expert opinion on therapeutic targets. vol 17. issue 4. 2013-08-28. PMID:23293857. |
es is comprised of cannabinoid receptors (cb1 and cb2), their endogenous ligands (endocannabinoids) and proteins responsible for their metabolism. |
2013-08-28 |
2023-08-12 |
human |
| Pritesh Kumar, Zhao-Hui Son. Identification of raloxifene as a novel CB2 inverse agonist. Biochemical and biophysical research communications. vol 435. issue 1. 2013-08-27. PMID:23611779. |
raloxifene antagonism is most likely competitive in nature, as these rightward shifts were parallel and were not associated with any changes in the efficacy of cannabinoid agonists on cb2. |
2013-08-27 |
2023-08-12 |
Not clear |
| Vincenzo Micale, Vincenzo Di Marzo, Alexandra Sulcova, Carsten T Wotjak, Filippo Drag. Endocannabinoid system and mood disorders: priming a target for new therapies. Pharmacology & therapeutics. vol 138. issue 1. 2013-08-26. PMID:23261685. |
the endocannabinoid system (ecs), comprising two g protein-coupled receptors (the cannabinoid receptors 1 and 2 [cb1 and cb2] for marijuana's psychoactive principle ∆(9)-tetrahydrocannabinol [∆(9)-thc]), their endogenous small lipid ligands (namely anandamide [aea] and 2-arachidonoylglycerol [2-ag], also known as endocannabinoids), and the proteins for endocannabinoid biosynthesis and degradation, has been suggested as a pro-homeostatic and pleiotropic signaling system activated in a time- and tissue-specific way during physiopathological conditions. |
2013-08-26 |
2023-08-12 |
Not clear |
| Vincenzo Micale, Vincenzo Di Marzo, Alexandra Sulcova, Carsten T Wotjak, Filippo Drag. Endocannabinoid system and mood disorders: priming a target for new therapies. Pharmacology & therapeutics. vol 138. issue 1. 2013-08-26. PMID:23261685. |
it has been proposed that synthetic molecules that inhibit endocannabinoid degradation can exploit the selectivity of endocannabinoid action, thus activating cannabinoid receptors only in those tissues where there is perturbed endocannabinoid turnover due to the disorder, and avoiding the potential side effects of direct cb1 and cb2 activation. |
2013-08-26 |
2023-08-12 |
Not clear |
| In-Young Choi, Chung Ju, Angela M A Anthony Jalin, Da In Lee, Paul L Prather, Won-Ki Ki. Activation of cannabinoid CB2 receptor-mediated AMPK/CREB pathway reduces cerebral ischemic injury. The American journal of pathology. vol 182. issue 3. 2013-08-08. PMID:23414569. |
activation of cannabinoid cb2 receptor-mediated ampk/creb pathway reduces cerebral ischemic injury. |
2013-08-08 |
2023-08-12 |
rat |
| Jade M Franklin, Gonzalo A Carrasc. G-protein receptor kinase 5 regulates the cannabinoid receptor 2-induced up-regulation of serotonin 2A receptors. The Journal of biological chemistry. vol 288. issue 22. 2013-08-06. PMID:23592773. |
interestingly, we found that cannabinoid agonist-induced up-regulation of grk5 involves cb2 receptors, β-arrestin 2, and erk1/2 signaling because treatment with cb2 shrna lentiviral particles, β-arrestin 2 shrna lentiviral particles, or erk1/2 inhibitor prevented the cannabinoid agonist-induced up-regulation of grk5. |
2013-08-06 |
2023-08-12 |
rat |
| Jade M Franklin, Gonzalo A Carrasc. G-protein receptor kinase 5 regulates the cannabinoid receptor 2-induced up-regulation of serotonin 2A receptors. The Journal of biological chemistry. vol 288. issue 22. 2013-08-06. PMID:23592773. |
repeated cannabinoid exposure was also associated with enhanced phosphorylation of cb2 receptors and increased interaction between β-arrestin 2 and erk1/2. |
2013-08-06 |
2023-08-12 |
rat |
| Jacqueline L Blankman, Benjamin F Cravat. Chemical probes of endocannabinoid metabolism. Pharmacological reviews. vol 65. issue 2. 2013-08-01. PMID:23512546. |
the principal ligands of the endocannabinoid system are the lipid transmitters n-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol (2-ag), which activate the two major cannabinoid receptors, cb1 and cb2. |
2013-08-01 |
2023-08-12 |
Not clear |
| Zun-Yi Wang, Peiqing Wang, Dale E Bjorlin. Activation of cannabinoid receptor 2 inhibits experimental cystitis. American journal of physiology. Regulatory, integrative and comparative physiology. vol 304. issue 10. 2013-07-22. PMID:23515618. |
cannabinoids have been shown to exert analgesic and anti-inflammatory effects, and the effects of cannabinoids are mediated primarily by cannabinoid receptors 1 and 2 (cb1and cb2). |
2013-07-22 |
2023-08-12 |
human |
| Elisa Bisicchia, Valerio Chiurchiù, Maria Teresa Viscomi, Laura Latini, Filomena Fezza, Luca Battistini, Mauro Maccarrone, Marco Molinar. Activation of type-2 cannabinoid receptor inhibits neuroprotective and antiinflammatory actions of glucocorticoid receptor α: when one is better than two. Cellular and molecular life sciences : CMLS. vol 70. issue 12. 2013-07-19. PMID:23296125. |
endocannabinoids (ecbs) and glucocorticoids (gcs) are two distinct classes of signaling lipids that exert both neuroprotective and immunosuppressive effects; however, the possibility of an actual interaction of their receptors [i.e., type-2 cannabinoid (cb2) and glucocorticoid receptor α (grα), respectively] remains unexplored. |
2013-07-19 |
2023-08-12 |
human |
| Claudius Füllhase, Andrea Russo, Fabio Castiglione, Fabio Benigni, Lysanne Campeau, Francesco Montorsi, Christian Gratzke, Arianna Bettiga, Christian Stief, Karl-Erik Andersson, Petter Hedlun. Spinal cord FAAH in normal micturition control and bladder overactivity in awake rats. The Journal of urology. vol 189. issue 6. 2013-07-17. PMID:23219540. |
we also determined the expression of faah, and the cannabinoid receptors cb1 and cb2 in the sacral spinal cord. |
2013-07-17 |
2023-08-12 |
rat |
| M Waldman, E Hochhauser, M Fishbein, D Aravot, A Shainberg, Y Sarn. An ultra-low dose of tetrahydrocannabinol provides cardioprotection. Biochemical pharmacology. vol 85. issue 11. 2013-07-16. PMID:23537701. |
tetrahydrocannabinol (thc), the major psychoactive component of marijuana, is a cannabinoid agonist that exerts its effects by activating at least two specific receptors (cb1 and cb2) that belong to the seven transmembrane g-protein coupled receptor (gpcr) family. |
2013-07-16 |
2023-08-12 |
mouse |
| Panagiotis Zogopoulos, Ioanna Vasileiou, Efstratios Patsouris, Stamatios Theochari. The neuroprotective role of endocannabinoids against chemical-induced injury and other adverse effects. Journal of applied toxicology : JAT. vol 33. issue 4. 2013-07-09. PMID:23296873. |
the endocannabinoid system is comprised of cannabinoid receptors (cb1 and cb2), their endogenous ligands (endocannabinoids) and proteins responsible for their metabolism. |
2013-07-09 |
2023-08-12 |
Not clear |
| Arnau Busquets-Garcia, Maria Gomis-González, Thomas Guegan, Carmen Agustín-Pavón, Antoni Pastor, Susana Mato, Alberto Pérez-Samartín, Carlos Matute, Rafael de la Torre, Mara Dierssen, Rafael Maldonado, Andrés Ozait. Targeting the endocannabinoid system in the treatment of fragile X syndrome. Nature medicine. vol 19. issue 5. 2013-07-03. PMID:23542787. |
the cannabinoid receptors cb1 (cb1r) and cb2 (cb2r) are activated by phospholipid-derived endocannabinoids, and cb1r-driven long-term regulation of synaptic strength, as a consequence of mglur5 activation, is altered in several brain areas of fmr1 knockout mice. |
2013-07-03 |
2023-08-12 |
mouse |
| Nazila Pourkhalili, Mohammad Hossein Ghahremani, Narges Farsandaj, Shohreh Tavajohi, Maryam Majdzadeh, Maliheh Parsa, Nasir Jafar Lavasani, Seyed Nasser Osta. Evaluation of anti-invasion effect of cannabinoids on human hepatocarcinoma cells. Toxicology mechanisms and methods. vol 23. issue 2. 2013-07-02. PMID:22978792. |
as most of cannabinoids have shown anticancer effect against different cell lines in a number of reports, a biological investigation of two cannabinoids, cb65 (cb2 receptor agonist) and acea (cb1 receptor agonist) was carried out in this study. |
2013-07-02 |
2023-08-12 |
human |