| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Noriko Shinjyo, Fabiana Piscitelli, Roberta Verde, Vincenzo Di Marz. Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system. Journal of neuroscience research. vol 91. issue 7. 2014-01-03. PMID:23633391. |
neural stem cells express cannabinoid cb1 and cb2 receptors and the enzymes for the biosynthesis and metabolism of endocannabinoids (ecbs). |
2014-01-03 |
2023-08-12 |
Not clear |
| Congxia Zheng, Linjie Chen, Xiaopan Chen, Xiaobai He, Jingwen Yang, Ying Shi, Naiming Zho. The second intracellular loop of the human cannabinoid CB2 receptor governs G protein coupling in coordination with the carboxyl terminal domain. PloS one. vol 8. issue 5. 2013-12-17. PMID:23667597. |
the second intracellular loop of the human cannabinoid cb2 receptor governs g protein coupling in coordination with the carboxyl terminal domain. |
2013-12-17 |
2023-08-12 |
human |
| Congxia Zheng, Linjie Chen, Xiaopan Chen, Xiaobai He, Jingwen Yang, Ying Shi, Naiming Zho. The second intracellular loop of the human cannabinoid CB2 receptor governs G protein coupling in coordination with the carboxyl terminal domain. PloS one. vol 8. issue 5. 2013-12-17. PMID:23667597. |
the major effects of cannabinoids and endocannabinoids are mediated via two g protein-coupled receptors, cb1 and cb2, elucidation of the mechanism and structural determinants of the cb2 receptor coupling with g proteins will have a significant impact on drug discovery. |
2013-12-17 |
2023-08-12 |
human |
| Qian Li, Feng Wang, Yan-Min Zhang, Jing-Jing Zhou, Yi Zhan. Activation of cannabinoid type 2 receptor by JWH133 protects heart against ischemia/reperfusion-induced apoptosis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 31. issue 4-5. 2013-12-17. PMID:23711495. |
cannabinoid type 2 (cb2) receptor agonists can protect myocardium against ischemia/reperfusion (i/r) injury although the underlying mechanism remains unclear. |
2013-12-17 |
2023-08-12 |
Not clear |
| Krzysztof Bilmin, Beata Kopczyńska, Paweł Grie. Influence of serum and albumin on the in vitro anandamide cytotoxicity toward C6 glioma cells assessed by the MTT cell viability assay: implications for the methodology of the MTT tests. Folia neuropathologica. vol 51. issue 1. 2013-12-11. PMID:23553136. |
anandamide (aea), an endogenous ligand of cannabinoid cb1 and cb2 receptors, which also binds transient receptor potential vanilloid type 1 receptor (trpv1), has been shown to display substantial selective cytotoxicity toward some cancer cell lines in vitro, although the relevant data are not consistent. |
2013-12-11 |
2023-08-12 |
rat |
| María Ibáñez, Lubertus Bijlsma, Alexander L N van Nuijs, Juan V Sancho, Gonzalo Haro, Adrian Covaci, Félix Hernánde. Quadrupole-time-of-flight mass spectrometry screening for synthetic cannabinoids in herbal blends. Journal of mass spectrometry : JMS. vol 48. issue 6. 2013-11-18. PMID:23722959. |
the presence in the herbal blends of these synthetic cannabinoids might explain the psychotic and catatonic symptoms observed in the patient, as jwh compounds could act as potent agonists of cb1 and cb2 receptors located in the limbic system and basal ganglia of the human brain. |
2013-11-18 |
2023-08-12 |
human |
| Rodrigo Teodoro, Rareş-Petru Moldovan, Corinna Lueg, Robert Günther, Cornelius K Donat, Friedrich-Alexander Ludwig, Steffen Fischer, Winnie Deuther-Conrad, Bernhard Wünsch, Peter Brus. Radiofluorination and biological evaluation of N-aryl-oxadiazolyl-propionamides as potential radioligands for PET imaging of cannabinoid CB2 receptors. Organic and medicinal chemistry letters. vol 3. issue 1. 2013-11-15. PMID:24063584. |
radiofluorination and biological evaluation of n-aryl-oxadiazolyl-propionamides as potential radioligands for pet imaging of cannabinoid cb2 receptors. |
2013-11-15 |
2023-08-12 |
Not clear |
| Natalia Battista, Antonio Di Sabatino, Monia Di Tommaso, Paolo Biancheri, Cinzia Rapino, Paolo Giuffrida, Cinzia Papadia, Chiara Montana, Alessandra Pasini, Alessandro Vanoli, Francesco Lanzarotto, Vincenzo Villanacci, Gino R Corazza, Mauro Maccarron. Altered expression of type-1 and type-2 cannabinoid receptors in celiac disease. PloS one. vol 8. issue 4. 2013-11-11. PMID:23620805. |
anandamide (aea) is the prominent member of the endocannabinoid family and its biological action is mediated through the binding to both type-1 (cb1) and type-2 (cb2) cannabinoid receptors (cbr). |
2013-11-11 |
2023-08-12 |
human |
| Evangelia Kotsikorou, Frank Navas, Michael J Roche, Anne F Gilliam, Brian F Thomas, Herbert H Seltzman, Pritesh Kumar, Zhao-Hui Song, Dow P Hurst, Diane L Lynch, Patricia H Reggi. The importance of hydrogen bonding and aromatic stacking to the affinity and efficacy of cannabinoid receptor CB2 antagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide (SR144528). Journal of medicinal chemistry. vol 56. issue 17. 2013-11-11. PMID:23855811. |
despite the therapeutic promise of the subnanomolar affinity cannabinoid cb2 antagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-n-[(1s,2s,4r)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1h-pyrazole-3-carboxamide (sr144528, 1), little is known about its binding site interactions and no primary interaction site for 1 at cb2 has been identified. |
2013-11-11 |
2023-08-12 |
Not clear |
| Evangelia Kotsikorou, Frank Navas, Michael J Roche, Anne F Gilliam, Brian F Thomas, Herbert H Seltzman, Pritesh Kumar, Zhao-Hui Song, Dow P Hurst, Diane L Lynch, Patricia H Reggi. The importance of hydrogen bonding and aromatic stacking to the affinity and efficacy of cannabinoid receptor CB2 antagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide (SR144528). Journal of medicinal chemistry. vol 56. issue 17. 2013-11-11. PMID:23855811. |
we report here the results of glide docking studies in our cannabinoid cb2 inactive state model that were then tested via compound synthesis, binding, and functional assays. |
2013-11-11 |
2023-08-12 |
Not clear |
| Manoela Viar Fogaça, Ismael Galve-Roperh, Francisco Silveira Guimarães, Alline Cristina Campo. Cannabinoids, Neurogenesis and Antidepressant Drugs: Is there a Link? Current neuropharmacology. vol 11. issue 3. 2013-11-01. PMID:24179463. |
genetic or pharmacological manipulations of cannabinoid receptors (cb1 and cb2) or enzymes responsible for endocannabinoid-metabolism have also been shown to control proliferation and neurogenesis in the hippocampus. |
2013-11-01 |
2023-08-12 |
Not clear |
| Richard L Anderson, Michael D Randall, Susan L F Cha. The complex effects of cannabinoids on insulin secretion from rat isolated islets of Langerhans. European journal of pharmacology. vol 706. issue 1-3. 2013-10-28. PMID:23499687. |
the antagonists o-2050 (cb1) and am630 (cb2) failed to reveal the involvement of cannabinoid receptors in the inhibitory activity of anandamide on insulin release. |
2013-10-28 |
2023-08-12 |
rat |
| Linjing Mu, Daniel Bieri, Roger Slavik, Konstantin Drandarov, Adrienne Müller, Stjepko Cermak, Markus Weber, Roger Schibli, Stefanie D Krämer, Simon M Ametame. Radiolabeling and in vitro /in vivo evaluation of N-(1-adamantyl)-8-methoxy-4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxamide as a PET probe for imaging cannabinoid type 2 receptor. Journal of neurochemistry. vol 126. issue 5. 2013-10-28. PMID:23795580. |
the cannabinoid type 2 (cb2) receptor plays an important role in neuroinflammatory and neurodegenerative diseases such as multiple sclerosis, amyotrophic lateral sclerosis, and alzheimer’s disease and is therefore a very promising target for therapeutic approaches as well as for imaging. |
2013-10-28 |
2023-08-12 |
mouse |
| András Dékány, Rita Benko, Veronika Szombati, Lorand Barth. The contractile effect of anandamide in the guinea-pig small intestine is mediated by prostanoids but not TRPV1 receptors or capsaicin-sensitive nerves. Basic & clinical pharmacology & toxicology. vol 112. issue 5. 2013-10-24. PMID:23216932. |
neither capsaicin pre-treatment nor the trpv1 receptor antagonist bctc, the ganglionic blocking drug hexamethonium or cannabinoid (cb1 or cb2 ) receptor antagonists, influenced the effect of anandamide. |
2013-10-24 |
2023-08-12 |
Not clear |
| Gema Vera, Pablo Antonio Cabezos, María Isabel Martín, Raquel Abal. Characterization of cannabinoid-induced relief of neuropathic pain in a rat model of cisplatin-induced neuropathy. Pharmacology, biochemistry, and behavior. vol 105. 2013-10-23. PMID:23454533. |
selective cb1 and cb2 cannabinoid antagonists (am251 and sr144528, respectively) were used to characterize cannabinoid effects. |
2013-10-23 |
2023-08-12 |
rat |
| Gema Vera, Pablo Antonio Cabezos, María Isabel Martín, Raquel Abal. Characterization of cannabinoid-induced relief of neuropathic pain in a rat model of cisplatin-induced neuropathy. Pharmacology, biochemistry, and behavior. vol 105. 2013-10-23. PMID:23454533. |
this effect was mediated by both cb1 and cb2 cannabinoid receptors when the cannabinoid was systemically applied. |
2013-10-23 |
2023-08-12 |
rat |
| Svetlana Slavic, Dilyara Lauer, Manuela Sommerfeld, Ulrich Rudolf Kemnitz, Aleksandra Grzesiak, Manuela Trappiel, Christa Thöne-Reineke, Johannes Baulmann, Ludovit Paulis, Kai Kappert, Ulrich Kintscher, Thomas Unger, Elena Kaschin. Cannabinoid receptor 1 inhibition improves cardiac function and remodelling after myocardial infarction and in experimental metabolic syndrome. Journal of molecular medicine (Berlin, Germany). vol 91. issue 7. 2013-10-22. PMID:23636507. |
the cannabinoid receptors, cb1 and cb2, are expressed in the heart, but their role under pathological conditions remains controversial. |
2013-10-22 |
2023-08-12 |
rat |
| Fanny Astruc-Diaz, Steven W McDaniel, Jijun J Xu, Stéphane Parola, David L Brown, Mohamed Naguib, Philippe Dia. In vivo efficacy of enabling formulations based on hydroxypropyl-β-cyclodextrins, micellar preparation, and liposomes for the lipophilic cannabinoid CB2 agonist, MDA7. Journal of pharmaceutical sciences. vol 102. issue 2. 2013-10-17. PMID:23192786. |
in vivo efficacy of enabling formulations based on hydroxypropyl-β-cyclodextrins, micellar preparation, and liposomes for the lipophilic cannabinoid cb2 agonist, mda7. |
2013-10-17 |
2023-08-12 |
rat |
| Gorka Larrinaga, Begoña Sanz, Lorena Blanco, Itxaro Perez, María L Candenas, Francisco M Pinto, Amaia Irazusta, Javier Gil, José I Lópe. Cannabinoid CB1 receptor is expressed in chromophobe renal cell carcinoma and renal oncocytoma. Clinical biochemistry. vol 46. issue 7-8. 2013-09-30. PMID:23318578. |
to analyze the mrna and protein expression of cannabinoid receptors cb1 and cb2 in chromophobe renal cell carcinoma (chrcc) and renal oncocytoma (ro). |
2013-09-30 |
2023-08-12 |
Not clear |
| Nikhil Reddy Madadi, Narsimha Reddy Penthala, Lisa K Brents, Benjamin M Ford, Paul L Prather, Peter A Crook. Evaluation of (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)-quinuclidin-3-one analogues as novel, high affinity ligands for CB1 and CB2 cannabinoid receptors. Bioorganic & medicinal chemistry letters. vol 23. issue 7. 2013-09-30. PMID:23466226. |
evaluation of (z)-2-((1-benzyl-1h-indol-3-yl)methylene)-quinuclidin-3-one analogues as novel, high affinity ligands for cb1 and cb2 cannabinoid receptors. |
2013-09-30 |
2023-08-12 |
human |