| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cássia C Coelhoso, Douglas S Engelke, Renato Filev, Dartiu X Silveira, Luiz E Mello, Jair G Santos-Junio. Temporal and behavioral variability in cannabinoid receptor expression in outbred mice submitted to ethanol-induced locomotor sensitization paradigm. Alcoholism, clinical and experimental research. vol 37. issue 9. 2014-04-22. PMID:23647533. |
this study investigated possible differential expression of cannabinoid receptors cb1 (cb1r) and cb2 (cb2r) in an outbred mice strain displaying behavioral variability to ethanol (etoh)-induced locomotor sensitization. |
2014-04-22 |
2023-08-12 |
mouse |
| Stephen D Skaper, Laura Facci, Pietro Giust. Glia and mast cells as targets for palmitoylethanolamide, an anti-inflammatory and neuroprotective lipid mediator. Molecular neurobiology. vol 48. issue 2. 2014-04-21. PMID:23813098. |
these actions may be mediated by pea acting through "receptor pleiotropism," i.e., both direct and indirect interactions of pea with different receptor targets, e.g., cannabinoid cb2 and peroxisome proliferator-activated receptor-alpha. |
2014-04-21 |
2023-08-12 |
mouse |
| Mahmoud A Elsohly, Waseem Gul, Amira S Wanas, Mohamed M Radwa. Synthetic cannabinoids: analysis and metabolites. Life sciences. vol 97. issue 1. 2014-04-15. PMID:24412391. |
cannabimimetics (commonly referred to as synthetic cannabinoids), a group of compounds encompassing a wide range of chemical structures, have been developed by scientists with the hope of achieving selectivity toward one or the other of the cannabinoid receptors cb1 and cb2. |
2014-04-15 |
2023-08-12 |
Not clear |
| Erika Cottone, Valentina Pomatto, Fulvio Cerri, Ezio Campantico, Ken Mackie, Massimiliano Delpero, Alda Guastalla, Claudio Dati, Patrizia Bovolin, Maria Fosca Franzon. Cannabinoid receptors are widely expressed in goldfish: molecular cloning of a CB2-like receptor and evaluation of CB1 and CB2 mRNA expression profiles in different organs. Fish physiology and biochemistry. vol 39. issue 5. 2014-04-07. PMID:23504102. |
cannabinoid receptors are widely expressed in goldfish: molecular cloning of a cb2-like receptor and evaluation of cb1 and cb2 mrna expression profiles in different organs. |
2014-04-07 |
2023-08-12 |
zebrafish |
| Erika Cottone, Valentina Pomatto, Fulvio Cerri, Ezio Campantico, Ken Mackie, Massimiliano Delpero, Alda Guastalla, Claudio Dati, Patrizia Bovolin, Maria Fosca Franzon. Cannabinoid receptors are widely expressed in goldfish: molecular cloning of a CB2-like receptor and evaluation of CB1 and CB2 mRNA expression profiles in different organs. Fish physiology and biochemistry. vol 39. issue 5. 2014-04-07. PMID:23504102. |
cannabinoids, the bioactive constituents of cannabis sativa, and endocannabinoids, among which the most important are anandamide and 2-arachidonoylglycerol, control various biological processes by binding to specific g protein-coupled receptors, namely cb1 and cb2 cannabinoid receptors. |
2014-04-07 |
2023-08-12 |
zebrafish |
| H Ikeda, M Ikegami, M Kai, M Ohsawa, J Kame. Activation of spinal cannabinoid CB2 receptors inhibits neuropathic pain in streptozotocin-induced diabetic mice. Neuroscience. vol 250. 2014-04-04. PMID:23892011. |
activation of spinal cannabinoid cb2 receptors inhibits neuropathic pain in streptozotocin-induced diabetic mice. |
2014-04-04 |
2023-08-12 |
mouse |
| H Ikeda, M Ikegami, M Kai, M Ohsawa, J Kame. Activation of spinal cannabinoid CB2 receptors inhibits neuropathic pain in streptozotocin-induced diabetic mice. Neuroscience. vol 250. 2014-04-04. PMID:23892011. |
the selective cannabinoid cb2 receptor agonist l-759,656 (19 and 38 μg, i.t.) |
2014-04-04 |
2023-08-12 |
mouse |
| H Ikeda, M Ikegami, M Kai, M Ohsawa, J Kame. Activation of spinal cannabinoid CB2 receptors inhibits neuropathic pain in streptozotocin-induced diabetic mice. Neuroscience. vol 250. 2014-04-04. PMID:23892011. |
the protein levels of cannabinoid cb1 receptors, cb2 receptors and diacylglycerol lipase α (dgl-α), the enzyme that synthesizes endocannabinoid 2-arachidonoylglycerol, in the spinal cord were examined using western blotting. |
2014-04-04 |
2023-08-12 |
mouse |
| H Ikeda, M Ikegami, M Kai, M Ohsawa, J Kame. Activation of spinal cannabinoid CB2 receptors inhibits neuropathic pain in streptozotocin-induced diabetic mice. Neuroscience. vol 250. 2014-04-04. PMID:23892011. |
the protein levels of both cannabinoid cb1 and cb2 receptors were increased in stz-induced diabetic mice, whereas the protein level of dgl-α was significantly decreased. |
2014-04-04 |
2023-08-12 |
mouse |
| H Ikeda, M Ikegami, M Kai, M Ohsawa, J Kame. Activation of spinal cannabinoid CB2 receptors inhibits neuropathic pain in streptozotocin-induced diabetic mice. Neuroscience. vol 250. 2014-04-04. PMID:23892011. |
these results indicate that spinal cannabinoid systems are changed in diabetic mice and suggest that cannabinoid cb2 receptor agonists might have an ability to recover diabetic neuropathic pain. |
2014-04-04 |
2023-08-12 |
mouse |
| Maurizio Baldassarre, Ferdinando A Giannone, Lucia Napoli, Alessandra Tovoli, Carmen S Ricci, Manuel Tufoni, Paolo Caracen. The endocannabinoid system in advanced liver cirrhosis: pathophysiological implication and future perspectives. Liver international : official journal of the International Association for the Study of the Liver. vol 33. issue 9. 2014-03-31. PMID:23890208. |
endogenous cannabinoids (ec) are ubiquitous lipid signalling molecules providing different central and peripheral effects that are mediated mostly by the specific receptors cb1 and cb2. |
2014-03-31 |
2023-08-12 |
Not clear |
| Aymen I Idri. The promise and dilemma of cannabinoid therapy: lessons from animal studies of bone disease. BoneKEy reports. vol 1. 2014-03-24. PMID:24363927. |
although no distinct abnormalities in bone development were observed in healthy adult mice deficient in cannabinoid type 2 receptors (cb2), pharmacological blockage of this receptor was effective in suppressing bone loss associated with increased bone turnover, particularly in mouse models of osteoporosis, arthritis and osteolytic bone disease. |
2014-03-24 |
2023-08-12 |
mouse |
| M Álvaro-Bartolomé, J A García-Sevill. Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents. Neuroscience. vol 247. 2014-03-18. PMID:23727505. |
this study evaluated the status of cannabinoid (cb) cb1 and cb2 receptors, the endocytic cycle of cb1 receptors, g protein-coupled receptor regulatory kinases (grk), and associated signaling (mammalian target of rapamicin (mtor) and 70kda ribosomal protein s6 kinase (p70s6k)) in brain cortices of drug abusers and cocaine- and cannabinoid-treated rodents. |
2014-03-18 |
2023-08-12 |
mouse |
| Aurélien Tourteau, Virginie Andrzejak, Mathilde Body-Malapel, Lucas Lemaire, Amélie Lemoine, Roxane Mansouri, Madjid Djouina, Nicolas Renault, Jamal El Bakali, Pierre Desreumaux, Giulio G Muccioli, Didier M Lambert, Philippe Chavatte, Benoît Rigo, Natascha Leleu-Chavain, Régis Mille. 3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis. Bioorganic & medicinal chemistry. vol 21. issue 17. 2014-03-18. PMID:23849204. |
recent investigations showed that anandamide, the main endogenous ligand of cb1 and cb2 cannabinoid receptors, possesses analgesic, antidepressant and anti-inflammatory effects. |
2014-03-18 |
2023-08-12 |
mouse |
| Sangdon Han, Jayant Thatte, Daniel J Buzard, Robert M Jone. Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists. Journal of medicinal chemistry. vol 56. issue 21. 2014-03-18. PMID:23865723. |
cb2 was identified among cdnas based on its similarity in amino acid sequence to the cb1 receptor and helped provide an explanation for the established effects of cannabinoids on the immune system. |
2014-03-18 |
2023-08-12 |
Not clear |
| Sangdon Han, Jayant Thatte, Daniel J Buzard, Robert M Jone. Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists. Journal of medicinal chemistry. vol 56. issue 21. 2014-03-18. PMID:23865723. |
several "mixed" cannabinoid agonists are currently in clinical use primarily for controlling pain, and it is believed that selective cb2 agonism may afford a superior analgesic agent devoid of the centrally mediated cb1 effects. |
2014-03-18 |
2023-08-12 |
Not clear |
| S Valdeolivas, M R Pazos, T Bisogno, F Piscitelli, F A Iannotti, M Allarà, O Sagredo, V Di Marzo, J Fernández-Rui. The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG. Cell death & disease. vol 4. 2014-03-12. PMID:24136226. |
the cannabinoid cb2 receptor, which is activated by the endocannabinoid 2-arachidonoyl-glycerol (2-ag), protects striatal neurons from apoptotic death caused by the local administration of malonate, a rat model of huntington's disease (hd). |
2014-03-12 |
2023-08-12 |
rat |
| Khalid A Alswa. The role of endocannabinoids system in fatty liver disease and therapeutic potentials. Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association. vol 19. issue 4. 2014-03-11. PMID:23828743. |
this system refers to the cannabinoid receptors type 1 (cb1) and type 2 (cb2), with both their endogenous ligands and machinery dedicated to ec synthesis and degradation. |
2014-03-11 |
2023-08-12 |
Not clear |
| Weimin Kong, Hongbo Li, Ronald F Tuma, Doina Gane. Selective CB2 receptor activation ameliorates EAE by reducing Th17 differentiation and immune cell accumulation in the CNS. Cellular immunology. vol 287. issue 1. 2014-03-10. PMID:24342422. |
cb2, the cannabinoid receptor expressed primarily on hematopoietic cells and activated microglia, mediates the immunoregulatory functions of cannabinoids. |
2014-03-10 |
2023-08-12 |
Not clear |
| I Dando, M Donadelli, C Costanzo, E Dalla Pozza, A D'Alessandro, L Zolla, M Palmier. Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells. Cell death & disease. vol 4. 2014-02-25. PMID:23764845. |
we used cannabinoids specific for the cb1 (acpa) and cb2 (gw) receptors and metabolomic analyses to unravel the potential pathways mediating cannabinoid-dependent inhibition of pancreatic cancer cell growth. |
2014-02-25 |
2023-08-12 |
Not clear |