| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ken-ichi Tomiyama, Masahiko Funad. Cytotoxicity of synthetic cannabinoids on primary neuronal cells of the forebrain: the involvement of cannabinoid CB1 receptors and apoptotic cell death. Toxicology and applied pharmacology. vol 274. issue 1. 2014-02-24. PMID:24211273. |
our results indicate that the cytotoxicity of synthetic cannabinoids towards primary neuronal cells is mediated by the cb1 receptor, but not by the cb2 receptor, and further suggest that caspase cascades may play an important role in the apoptosis induced by these synthetic cannabinoids. |
2014-02-24 |
2023-08-12 |
mouse |
| Evangelia Bakali, Ruth A Elliott, Anthony H Taylor, Jon Willets, Justin C Konje, Douglas G Tincell. Distribution and function of the endocannabinoid system in the rat and human bladder. International urogynecology journal. vol 24. issue 5. 2014-02-10. PMID:23081739. |
our aim was to compare expression and distribution of cannabinoid receptors cb1 and cb2, transient receptor potential vanilloid receptor 1 (trpv1), and modulating enzymes in human and rat bladder. |
2014-02-10 |
2023-08-12 |
human |
| Evangelia Bakali, Ruth A Elliott, Anthony H Taylor, Jon Willets, Justin C Konje, Douglas G Tincell. Distribution and function of the endocannabinoid system in the rat and human bladder. International urogynecology journal. vol 24. issue 5. 2014-02-10. PMID:23081739. |
we also evaluated effects of cannabinoid agonists (acea, agonist of cb1; gp1a, agonist of cb2) on contractile responses of rat bladder strips. |
2014-02-10 |
2023-08-12 |
human |
| John C M Brus. Spice, pot, and stroke. Neurology. vol 81. issue 24. 2014-02-10. PMID:24212392. |
the endocannabinoid system includes 2 types of g-protein coupled receptors: cb1 (mostly in the brain) and cb2 (in peripheral lymphoid tissue). |
2014-02-10 |
2023-08-12 |
Not clear |
| Rachel Ribeiro, Jie Wen, Shihe Li, Yumin Zhan. Involvement of ERK1/2, cPLA2 and NF-κB in microglia suppression by cannabinoid receptor agonists and antagonists. Prostaglandins & other lipid mediators. vol 100-101. 2014-01-24. PMID:23219970. |
however, the underlying molecular mechanisms and whether the action of cannabinoids is coupled to the activation of cannabinoid type 1 (cb1) and type 2 (cb2) receptors are still poorly defined. |
2014-01-24 |
2023-08-12 |
Not clear |
| Rachel Ribeiro, Jie Wen, Shihe Li, Yumin Zhan. Involvement of ERK1/2, cPLA2 and NF-κB in microglia suppression by cannabinoid receptor agonists and antagonists. Prostaglandins & other lipid mediators. vol 100-101. 2014-01-24. PMID:23219970. |
taken together, these results indicate that both cannabinoid receptor agonists and antagonists might suppress microglia activation by cb1 and cb2 receptor independent mechanisms, and provide a new insight into the mechanisms of microglia inhibition by cannabinoids. |
2014-01-24 |
2023-08-12 |
Not clear |
| J M Franklin, T Vasiljevik, T E Prisinzano, G A Carrasc. Cannabinoid 2 receptor- and beta Arrestin 2-dependent upregulation of serotonin 2A receptors. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 7. 2014-01-23. PMID:22841827. |
here, we present experimental evidence that sustained treatment with a non-selective cannabinoid agonist (cp55,940) or selective cb2 receptor agonists (jwh133 or gp1a) upregulate 5-ht(2a) receptors in a neuronal cell line. |
2014-01-23 |
2023-08-12 |
Not clear |
| J M Franklin, T Vasiljevik, T E Prisinzano, G A Carrasc. Cannabinoid 2 receptor- and beta Arrestin 2-dependent upregulation of serotonin 2A receptors. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 7. 2014-01-23. PMID:22841827. |
our results indicate that cannabinoid agonists might upregulate 5-ht(2a) receptors by a mechanism that requires cb2 receptors and β-arrestin 2 in cells that express both cb2 and 5-ht(2a) receptors. |
2014-01-23 |
2023-08-12 |
Not clear |
| Dow P Hurst, Marianne Schmeisser, Patricia H Reggi. Endogenous lipid activated G protein-coupled receptors: emerging structural features from crystallography and molecular dynamics simulations. Chemistry and physics of lipids. vol 169. 2014-01-15. PMID:23485612. |
however, there is a growing sub-group of class a gpcrs that bind lipid-derived endogenous ligands, such as the cannabinoid cb1 and cb2 receptors (with endogenous ligands, n-arachidonoylethanolamine (anandamide) and sn-2-arachidonylglycerol (2-ag)) and the s1p1-5 receptors (with endogenous ligand, sphingosine-1-phosphate). |
2014-01-15 |
2023-08-12 |
Not clear |
| Joseph Bouskila, Pasha Javadi, Christian Casanova, Maurice Ptito, Jean-François Bouchar. Müller cells express the cannabinoid CB2 receptor in the vervet monkey retina. The Journal of comparative neurology. vol 521. issue 11. 2014-01-13. PMID:23630038. |
müller cells express the cannabinoid cb2 receptor in the vervet monkey retina. |
2014-01-13 |
2023-08-12 |
monkey |
| Eduardo Blanco-Calvo, Patricia Rivera, Sergio Arrabal, Antonio Vargas, Francisco Javier Pavón, Antonia Serrano, Estela Castilla-Ortega, Pablo Galeano, Leticia Rubio, Juan Suárez, Fernando Rodriguez de Fonsec. Pharmacological blockade of either cannabinoid CB1 or CB2 receptors prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of cell proliferation in the hippocampus of adult male rat. Frontiers in integrative neuroscience. vol 7. 2014-01-10. PMID:24409127. |
pharmacological blockade of either cannabinoid cb1 or cb2 receptors prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of cell proliferation in the hippocampus of adult male rat. |
2014-01-10 |
2023-08-12 |
rat |
| Eduardo Blanco-Calvo, Patricia Rivera, Sergio Arrabal, Antonio Vargas, Francisco Javier Pavón, Antonia Serrano, Estela Castilla-Ortega, Pablo Galeano, Leticia Rubio, Juan Suárez, Fernando Rodriguez de Fonsec. Pharmacological blockade of either cannabinoid CB1 or CB2 receptors prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of cell proliferation in the hippocampus of adult male rat. Frontiers in integrative neuroscience. vol 7. 2014-01-10. PMID:24409127. |
the endogenous cannabinoid system modulates this proliferative response as demonstrated by the finding that pharmacological activation/blockade of cannabinoid cb1 and cb2 receptors not only modulates neurogenesis but also modulates cell death in the brain. |
2014-01-10 |
2023-08-12 |
rat |
| B S Harvey, L L Nicotra, M Vu, S D Smi. Cannabinoid CB2 receptor activation attenuates cytokine-evoked mucosal damage in a human colonic explant model without changing epithelial permeability. Cytokine. vol 63. issue 2. 2014-01-08. PMID:23706402. |
cannabinoid cb2 receptor activation attenuates cytokine-evoked mucosal damage in a human colonic explant model without changing epithelial permeability. |
2014-01-08 |
2023-08-12 |
human |
| Noriko Shinjyo, Fabiana Piscitelli, Roberta Verde, Vincenzo Di Marz. Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system. Journal of neuroscience research. vol 91. issue 7. 2014-01-03. PMID:23633391. |
neural stem cells express cannabinoid cb1 and cb2 receptors and the enzymes for the biosynthesis and metabolism of endocannabinoids (ecbs). |
2014-01-03 |
2023-08-12 |
Not clear |
| Congxia Zheng, Linjie Chen, Xiaopan Chen, Xiaobai He, Jingwen Yang, Ying Shi, Naiming Zho. The second intracellular loop of the human cannabinoid CB2 receptor governs G protein coupling in coordination with the carboxyl terminal domain. PloS one. vol 8. issue 5. 2013-12-17. PMID:23667597. |
the second intracellular loop of the human cannabinoid cb2 receptor governs g protein coupling in coordination with the carboxyl terminal domain. |
2013-12-17 |
2023-08-12 |
human |
| Congxia Zheng, Linjie Chen, Xiaopan Chen, Xiaobai He, Jingwen Yang, Ying Shi, Naiming Zho. The second intracellular loop of the human cannabinoid CB2 receptor governs G protein coupling in coordination with the carboxyl terminal domain. PloS one. vol 8. issue 5. 2013-12-17. PMID:23667597. |
the major effects of cannabinoids and endocannabinoids are mediated via two g protein-coupled receptors, cb1 and cb2, elucidation of the mechanism and structural determinants of the cb2 receptor coupling with g proteins will have a significant impact on drug discovery. |
2013-12-17 |
2023-08-12 |
human |
| Qian Li, Feng Wang, Yan-Min Zhang, Jing-Jing Zhou, Yi Zhan. Activation of cannabinoid type 2 receptor by JWH133 protects heart against ischemia/reperfusion-induced apoptosis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 31. issue 4-5. 2013-12-17. PMID:23711495. |
cannabinoid type 2 (cb2) receptor agonists can protect myocardium against ischemia/reperfusion (i/r) injury although the underlying mechanism remains unclear. |
2013-12-17 |
2023-08-12 |
Not clear |
| Krzysztof Bilmin, Beata Kopczyńska, Paweł Grie. Influence of serum and albumin on the in vitro anandamide cytotoxicity toward C6 glioma cells assessed by the MTT cell viability assay: implications for the methodology of the MTT tests. Folia neuropathologica. vol 51. issue 1. 2013-12-11. PMID:23553136. |
anandamide (aea), an endogenous ligand of cannabinoid cb1 and cb2 receptors, which also binds transient receptor potential vanilloid type 1 receptor (trpv1), has been shown to display substantial selective cytotoxicity toward some cancer cell lines in vitro, although the relevant data are not consistent. |
2013-12-11 |
2023-08-12 |
rat |
| María Ibáñez, Lubertus Bijlsma, Alexander L N van Nuijs, Juan V Sancho, Gonzalo Haro, Adrian Covaci, Félix Hernánde. Quadrupole-time-of-flight mass spectrometry screening for synthetic cannabinoids in herbal blends. Journal of mass spectrometry : JMS. vol 48. issue 6. 2013-11-18. PMID:23722959. |
the presence in the herbal blends of these synthetic cannabinoids might explain the psychotic and catatonic symptoms observed in the patient, as jwh compounds could act as potent agonists of cb1 and cb2 receptors located in the limbic system and basal ganglia of the human brain. |
2013-11-18 |
2023-08-12 |
human |
| Rodrigo Teodoro, Rareş-Petru Moldovan, Corinna Lueg, Robert Günther, Cornelius K Donat, Friedrich-Alexander Ludwig, Steffen Fischer, Winnie Deuther-Conrad, Bernhard Wünsch, Peter Brus. Radiofluorination and biological evaluation of N-aryl-oxadiazolyl-propionamides as potential radioligands for PET imaging of cannabinoid CB2 receptors. Organic and medicinal chemistry letters. vol 3. issue 1. 2013-11-15. PMID:24063584. |
radiofluorination and biological evaluation of n-aryl-oxadiazolyl-propionamides as potential radioligands for pet imaging of cannabinoid cb2 receptors. |
2013-11-15 |
2023-08-12 |
Not clear |