| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francisco Navarrete, Marta Rodríguez-Arias, Elena Martín-García, Daniela Navarro, María S García-Gutiérrez, María A Aguilar, Auxiliadora Aracil-Fernández, Pere Berbel, José Miñarro, Rafael Maldonado, Jorge Manzanare. Role of CB2 cannabinoid receptors in the rewarding, reinforcing, and physical effects of nicotine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 12. 2014-06-03. PMID:23817165. |
this study was aimed to evaluate the involvement of cb2 cannabinoid receptors (cb2r) in the rewarding, reinforcing and motivational effects of nicotine. |
2014-06-03 |
2023-08-12 |
mouse |
| Ariane Mallat, Fatima Teixeira-Clerc, Sophie Lotersztaj. Cannabinoid signaling and liver therapeutics. Journal of hepatology. vol 59. issue 4. 2014-06-02. PMID:23567085. |
over the last decade, the endocannabinoid system has emerged as a pivotal mediator of acute and chronic liver injury, with the description of the role of cb1 and cb2 receptors and their endogenous lipidic ligands in various aspects of liver pathophysiology. |
2014-06-02 |
2023-08-12 |
Not clear |
| Sonja Kallendrusch, Stine Kremzow, Marcin Nowicki, Urszula Grabiec, Ria Winkelmann, Alexander Benz, Robert Kraft, Ingo Bechmann, Faramarz Dehghani, Marco Koc. The G protein-coupled receptor 55 ligand l-α-lysophosphatidylinositol exerts microglia-dependent neuroprotection after excitotoxic lesion. Glia. vol 61. issue 11. 2014-05-19. PMID:24038453. |
cannabinoids limit neurodegeneration by activation of neuronal g protein-coupled cannabinoid receptor 1 (cb1 ) and microglial g protein-coupled cannabinoid receptor 2 (cb2 ). |
2014-05-19 |
2023-08-12 |
mouse |
| Bogna M Ignatowska-Jankowska, Pretal P Muldoon, Aron H Lichtman, M Imad Dama. The cannabinoid CB2 receptor is necessary for nicotine-conditioned place preference, but not other behavioral effects of nicotine in mice. Psychopharmacology. vol 229. issue 4. 2014-05-06. PMID:23652588. |
the cannabinoid cb2 receptor is necessary for nicotine-conditioned place preference, but not other behavioral effects of nicotine in mice. |
2014-05-06 |
2023-08-12 |
mouse |
| Bogna M Ignatowska-Jankowska, Pretal P Muldoon, Aron H Lichtman, M Imad Dama. The cannabinoid CB2 receptor is necessary for nicotine-conditioned place preference, but not other behavioral effects of nicotine in mice. Psychopharmacology. vol 229. issue 4. 2014-05-06. PMID:23652588. |
whereas cannabinoid cb1 receptors have long been known to contribute to the rewarding effects and dependence liability of many drugs of abuse, recent studies have implicated the involvement of cannabinoid cb2 receptors. |
2014-05-06 |
2023-08-12 |
mouse |
| Pritesh Kumar, Zhao-Hui Son. CB2 cannabinoid receptor is a novel target for third-generation selective estrogen receptor modulators bazedoxifene and lasofoxifene. Biochemical and biophysical research communications. vol 443. issue 1. 2014-05-06. PMID:24275139. |
furthermore, bazedoxifene and lasofoxifene caused parallel, rightward shifts of the cp-55,940, hu-210, and win55,212-2 concentration-response curves without altering the efficacy of these cannabinoid agonists on cb2, which indicates that bazedoxifene- and lasofoxifene-induced cb2 antagonism is most likely competitive in nature. |
2014-05-06 |
2023-08-12 |
Not clear |
| Fiorella Descalzi, Valentina Ulivi, Ranieri Cancedda, Fabiana Piscitelli, Livio Luongo, Francesca Guida, Luisa Gatta, Sabatino Maione, Vincenzo Di Marz. Platelet-rich plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism. Tissue engineering. Part A. vol 19. issue 19-20. 2014-05-02. PMID:23578218. |
in all conditions, antagonists of endocannabinoid cb1 and cb2 receptors, injected in the paw, abrogated the antinociceptive effects strongly suggesting for this preparation a peripheral mechanism of action. |
2014-05-02 |
2023-08-12 |
mouse |
| Cássia C Coelhoso, Douglas S Engelke, Renato Filev, Dartiu X Silveira, Luiz E Mello, Jair G Santos-Junio. Temporal and behavioral variability in cannabinoid receptor expression in outbred mice submitted to ethanol-induced locomotor sensitization paradigm. Alcoholism, clinical and experimental research. vol 37. issue 9. 2014-04-22. PMID:23647533. |
this study investigated possible differential expression of cannabinoid receptors cb1 (cb1r) and cb2 (cb2r) in an outbred mice strain displaying behavioral variability to ethanol (etoh)-induced locomotor sensitization. |
2014-04-22 |
2023-08-12 |
mouse |
| Stephen D Skaper, Laura Facci, Pietro Giust. Glia and mast cells as targets for palmitoylethanolamide, an anti-inflammatory and neuroprotective lipid mediator. Molecular neurobiology. vol 48. issue 2. 2014-04-21. PMID:23813098. |
these actions may be mediated by pea acting through "receptor pleiotropism," i.e., both direct and indirect interactions of pea with different receptor targets, e.g., cannabinoid cb2 and peroxisome proliferator-activated receptor-alpha. |
2014-04-21 |
2023-08-12 |
mouse |
| Mahmoud A Elsohly, Waseem Gul, Amira S Wanas, Mohamed M Radwa. Synthetic cannabinoids: analysis and metabolites. Life sciences. vol 97. issue 1. 2014-04-15. PMID:24412391. |
cannabimimetics (commonly referred to as synthetic cannabinoids), a group of compounds encompassing a wide range of chemical structures, have been developed by scientists with the hope of achieving selectivity toward one or the other of the cannabinoid receptors cb1 and cb2. |
2014-04-15 |
2023-08-12 |
Not clear |
| Erika Cottone, Valentina Pomatto, Fulvio Cerri, Ezio Campantico, Ken Mackie, Massimiliano Delpero, Alda Guastalla, Claudio Dati, Patrizia Bovolin, Maria Fosca Franzon. Cannabinoid receptors are widely expressed in goldfish: molecular cloning of a CB2-like receptor and evaluation of CB1 and CB2 mRNA expression profiles in different organs. Fish physiology and biochemistry. vol 39. issue 5. 2014-04-07. PMID:23504102. |
cannabinoid receptors are widely expressed in goldfish: molecular cloning of a cb2-like receptor and evaluation of cb1 and cb2 mrna expression profiles in different organs. |
2014-04-07 |
2023-08-12 |
zebrafish |
| Erika Cottone, Valentina Pomatto, Fulvio Cerri, Ezio Campantico, Ken Mackie, Massimiliano Delpero, Alda Guastalla, Claudio Dati, Patrizia Bovolin, Maria Fosca Franzon. Cannabinoid receptors are widely expressed in goldfish: molecular cloning of a CB2-like receptor and evaluation of CB1 and CB2 mRNA expression profiles in different organs. Fish physiology and biochemistry. vol 39. issue 5. 2014-04-07. PMID:23504102. |
cannabinoids, the bioactive constituents of cannabis sativa, and endocannabinoids, among which the most important are anandamide and 2-arachidonoylglycerol, control various biological processes by binding to specific g protein-coupled receptors, namely cb1 and cb2 cannabinoid receptors. |
2014-04-07 |
2023-08-12 |
zebrafish |
| H Ikeda, M Ikegami, M Kai, M Ohsawa, J Kame. Activation of spinal cannabinoid CB2 receptors inhibits neuropathic pain in streptozotocin-induced diabetic mice. Neuroscience. vol 250. 2014-04-04. PMID:23892011. |
activation of spinal cannabinoid cb2 receptors inhibits neuropathic pain in streptozotocin-induced diabetic mice. |
2014-04-04 |
2023-08-12 |
mouse |
| H Ikeda, M Ikegami, M Kai, M Ohsawa, J Kame. Activation of spinal cannabinoid CB2 receptors inhibits neuropathic pain in streptozotocin-induced diabetic mice. Neuroscience. vol 250. 2014-04-04. PMID:23892011. |
the selective cannabinoid cb2 receptor agonist l-759,656 (19 and 38 μg, i.t.) |
2014-04-04 |
2023-08-12 |
mouse |
| H Ikeda, M Ikegami, M Kai, M Ohsawa, J Kame. Activation of spinal cannabinoid CB2 receptors inhibits neuropathic pain in streptozotocin-induced diabetic mice. Neuroscience. vol 250. 2014-04-04. PMID:23892011. |
the protein levels of cannabinoid cb1 receptors, cb2 receptors and diacylglycerol lipase α (dgl-α), the enzyme that synthesizes endocannabinoid 2-arachidonoylglycerol, in the spinal cord were examined using western blotting. |
2014-04-04 |
2023-08-12 |
mouse |
| H Ikeda, M Ikegami, M Kai, M Ohsawa, J Kame. Activation of spinal cannabinoid CB2 receptors inhibits neuropathic pain in streptozotocin-induced diabetic mice. Neuroscience. vol 250. 2014-04-04. PMID:23892011. |
the protein levels of both cannabinoid cb1 and cb2 receptors were increased in stz-induced diabetic mice, whereas the protein level of dgl-α was significantly decreased. |
2014-04-04 |
2023-08-12 |
mouse |
| H Ikeda, M Ikegami, M Kai, M Ohsawa, J Kame. Activation of spinal cannabinoid CB2 receptors inhibits neuropathic pain in streptozotocin-induced diabetic mice. Neuroscience. vol 250. 2014-04-04. PMID:23892011. |
these results indicate that spinal cannabinoid systems are changed in diabetic mice and suggest that cannabinoid cb2 receptor agonists might have an ability to recover diabetic neuropathic pain. |
2014-04-04 |
2023-08-12 |
mouse |
| Maurizio Baldassarre, Ferdinando A Giannone, Lucia Napoli, Alessandra Tovoli, Carmen S Ricci, Manuel Tufoni, Paolo Caracen. The endocannabinoid system in advanced liver cirrhosis: pathophysiological implication and future perspectives. Liver international : official journal of the International Association for the Study of the Liver. vol 33. issue 9. 2014-03-31. PMID:23890208. |
endogenous cannabinoids (ec) are ubiquitous lipid signalling molecules providing different central and peripheral effects that are mediated mostly by the specific receptors cb1 and cb2. |
2014-03-31 |
2023-08-12 |
Not clear |
| Aymen I Idri. The promise and dilemma of cannabinoid therapy: lessons from animal studies of bone disease. BoneKEy reports. vol 1. 2014-03-24. PMID:24363927. |
although no distinct abnormalities in bone development were observed in healthy adult mice deficient in cannabinoid type 2 receptors (cb2), pharmacological blockage of this receptor was effective in suppressing bone loss associated with increased bone turnover, particularly in mouse models of osteoporosis, arthritis and osteolytic bone disease. |
2014-03-24 |
2023-08-12 |
mouse |
| M Álvaro-Bartolomé, J A García-Sevill. Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents. Neuroscience. vol 247. 2014-03-18. PMID:23727505. |
this study evaluated the status of cannabinoid (cb) cb1 and cb2 receptors, the endocytic cycle of cb1 receptors, g protein-coupled receptor regulatory kinases (grk), and associated signaling (mammalian target of rapamicin (mtor) and 70kda ribosomal protein s6 kinase (p70s6k)) in brain cortices of drug abusers and cocaine- and cannabinoid-treated rodents. |
2014-03-18 |
2023-08-12 |
mouse |