| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marylou V Solbrig, Yijun Fan, Paul Hazelto. Prospects for cannabinoid therapies in viral encephalitis. Brain research. vol 1537. 2014-06-25. PMID:24021420. |
the selective cb2 agonist hu increases brdu(+) cells in prefrontal cortex (pfc), significantly increases brdu(+) cells in striatum, differentially regulates polydendrocytes vs. microglia/macrophages, and reduces immune activation at a time win-treated rats appear tolerant to the anti-inflammatory effect of their cannabinoid treatment. |
2014-06-25 |
2023-08-12 |
rat |
| Marylou V Solbrig, Yijun Fan, Paul Hazelto. Prospects for cannabinoid therapies in viral encephalitis. Brain research. vol 1537. 2014-06-25. PMID:24021420. |
thus, hu-308 action on cb2 receptors, receptors known to be renewed during microglia proliferation and action, is a nontolerizing mechanism of controlling cns inflammation during viral encephalitis by reducing microglia activation, as well as partially limiting viral infection, and uses a nonpsychotropic cannabinoid agonist. |
2014-06-25 |
2023-08-12 |
rat |
| Sofia Sisay, Gareth Pryce, Samuel J Jackson, Carolyn Tanner, Ruth A Ross, Gregory J Michael, David L Selwood, Gavin Giovannoni, David Bake. Genetic background can result in a marked or minimal effect of gene knockout (GPR55 and CB2 receptor) in experimental autoimmune encephalomyelitis models of multiple sclerosis. PloS one. vol 8. issue 10. 2014-06-24. PMID:24130809. |
endocannabinoids and some phytocannabinoids bind to cb1 and cb2 cannabinoid receptors, transient receptor potential vanilloid one (trpv1) receptor and the orphan g protein receptor fifty-five (gpr55). |
2014-06-24 |
2023-08-12 |
mouse |
| Thangesweran Ayakannu, Anthony H Taylor, Timothy H Marczylo, Jonathon M Willets, Justin C Konj. The endocannabinoid system and sex steroid hormone-dependent cancers. International journal of endocrinology. vol 2013. 2014-06-24. PMID:24369462. |
the "endocannabinoid system (ecs)" comprises the endocannabinoids, the enzymes that regulate their synthesis and degradation, the prototypical cannabinoid receptors (cb1 and cb2), some noncannabinoid receptors, and an, as yet, uncharacterised transport system. |
2014-06-24 |
2023-08-12 |
Not clear |
| Ester Aso, Isidre Ferre. Cannabinoids for treatment of Alzheimer's disease: moving toward the clinic. Frontiers in pharmacology. vol 5. 2014-06-24. PMID:24634659. |
the endocannabinoid system is composed by a number of cannabinoid receptors, including the well-characterized cb1 and cb2 receptors, with their endogenous ligands and the enzymes related to the synthesis and degradation of these endocannabinoid compounds. |
2014-06-24 |
2023-08-12 |
Not clear |
| Alexei A Yelisee. Methods for recombinant expression and functional characterization of human cannabinoid receptor CB2. Computational and structural biotechnology journal. vol 6. 2014-06-24. PMID:24688719. |
cb2 is a part of the endocannabinoid system that plays vital role in regulation of immune response, inflammation, pain sensitivity, obesity and other physiological responses. |
2014-06-24 |
2023-08-12 |
human |
| Ismael Galve-Roperh, Valerio Chiurchiù, Javier Díaz-Alonso, Monica Bari, Manuel Guzmán, Mauro Maccarron. Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation. Progress in lipid research. vol 52. issue 4. 2014-06-20. PMID:24076098. |
the latter is an ensemble of endogenous lipids, their receptors [in particular type-1 (cb1) and type-2 (cb2) cannabinoid receptors] and metabolic enzymes. |
2014-06-20 |
2023-08-12 |
human |
| Laurent Hortala, Joëlle Arnaud, Pascale Roux, Didier Oustric, Laurent Boulu, Florence Oury-Donat, Patrick Avenet, Thomas Rooney, David Alagille, Olivier Barret, Gilles Tamagnan, Francis Bart. Synthesis and preliminary evaluation of a new fluorine-18 labelled triazine derivative for PET imaging of cannabinoid CB2 receptor. Bioorganic & medicinal chemistry letters. vol 24. issue 1. 2014-06-12. PMID:24291040. |
synthesis and preliminary evaluation of a new fluorine-18 labelled triazine derivative for pet imaging of cannabinoid cb2 receptor. |
2014-06-12 |
2023-08-12 |
monkey |
| Laurent Hortala, Joëlle Arnaud, Pascale Roux, Didier Oustric, Laurent Boulu, Florence Oury-Donat, Patrick Avenet, Thomas Rooney, David Alagille, Olivier Barret, Gilles Tamagnan, Francis Bart. Synthesis and preliminary evaluation of a new fluorine-18 labelled triazine derivative for PET imaging of cannabinoid CB2 receptor. Bioorganic & medicinal chemistry letters. vol 24. issue 1. 2014-06-12. PMID:24291040. |
cannabinoid cb2 pet tracers are considered as a promising alternative to pbr/tspo tracers for the in-vivo imaging of neuroinflammation. |
2014-06-12 |
2023-08-12 |
monkey |
| Jarogniew J Luszczki, Marta Andres-Mach, Beata Barcicka-Klosowska, Magdalena Florek-Luszczki, Agnieszka Haratym-Maj, Stanislaw J Czuczwa. Effects of WIN 55,212-2 mesylate (a synthetic cannabinoid) on the protective action of clonazepam, ethosuximide, phenobarbital and valproate against pentylenetetrazole-induced clonic seizures in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 8. 2014-06-09. PMID:21777642. |
the aim of this study was to determine the effect of win 55,212-2 mesylate (win - a non-selective cannabinoid cb1 and cb2 receptor agonist) on the protective action of four classical antiepileptic drugs (aeds: clonazepam [czp], ethosuximide [ets], phenobarbital [pb], and valproate [vpa]) in the mouse pentylenetetrazole (ptz)-induced clonic seizure model. |
2014-06-09 |
2023-08-12 |
mouse |
| Mahmoud Fahmi Elsebai, Viktor Rempel, Gregor Schnakenburg, Stefan Kehraus, Christa E Müller, Gabriele M Köni. Identification of a Potent and Selective Cannabinoid CB1 Receptor Antagonist from Auxarthron reticulatum. ACS medicinal chemistry letters. vol 2. issue 11. 2014-06-05. PMID:24900275. |
in radioligand binding studies at human cannabinoid cb1 and cb2 receptors recombinantly expressed in chinese hamster ovary (cho) cells, amauromine (1) was found to exhibit high affinity and selectivity for the cb1 receptor (k i = 178 nm). |
2014-06-05 |
2023-08-13 |
human |
| Viktor Rempel, Alexander Fuchs, Sonja Hinz, Tadeusz Karcz, Matthias Lehr, Uwe Koetter, Christa E Mülle. Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55. ACS medicinal chemistry letters. vol 4. issue 1. 2014-06-05. PMID:24900561. |
magnolia extract, magnolol, and metabolites: activation of cannabinoid cb2 receptors and blockade of the related gpr55. |
2014-06-05 |
2023-08-13 |
Not clear |
| Francisco Navarrete, Marta Rodríguez-Arias, Elena Martín-García, Daniela Navarro, María S García-Gutiérrez, María A Aguilar, Auxiliadora Aracil-Fernández, Pere Berbel, José Miñarro, Rafael Maldonado, Jorge Manzanare. Role of CB2 cannabinoid receptors in the rewarding, reinforcing, and physical effects of nicotine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 12. 2014-06-03. PMID:23817165. |
role of cb2 cannabinoid receptors in the rewarding, reinforcing, and physical effects of nicotine. |
2014-06-03 |
2023-08-12 |
mouse |
| Francisco Navarrete, Marta Rodríguez-Arias, Elena Martín-García, Daniela Navarro, María S García-Gutiérrez, María A Aguilar, Auxiliadora Aracil-Fernández, Pere Berbel, José Miñarro, Rafael Maldonado, Jorge Manzanare. Role of CB2 cannabinoid receptors in the rewarding, reinforcing, and physical effects of nicotine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 12. 2014-06-03. PMID:23817165. |
this study was aimed to evaluate the involvement of cb2 cannabinoid receptors (cb2r) in the rewarding, reinforcing and motivational effects of nicotine. |
2014-06-03 |
2023-08-12 |
mouse |
| Ariane Mallat, Fatima Teixeira-Clerc, Sophie Lotersztaj. Cannabinoid signaling and liver therapeutics. Journal of hepatology. vol 59. issue 4. 2014-06-02. PMID:23567085. |
over the last decade, the endocannabinoid system has emerged as a pivotal mediator of acute and chronic liver injury, with the description of the role of cb1 and cb2 receptors and their endogenous lipidic ligands in various aspects of liver pathophysiology. |
2014-06-02 |
2023-08-12 |
Not clear |
| Sonja Kallendrusch, Stine Kremzow, Marcin Nowicki, Urszula Grabiec, Ria Winkelmann, Alexander Benz, Robert Kraft, Ingo Bechmann, Faramarz Dehghani, Marco Koc. The G protein-coupled receptor 55 ligand l-α-lysophosphatidylinositol exerts microglia-dependent neuroprotection after excitotoxic lesion. Glia. vol 61. issue 11. 2014-05-19. PMID:24038453. |
cannabinoids limit neurodegeneration by activation of neuronal g protein-coupled cannabinoid receptor 1 (cb1 ) and microglial g protein-coupled cannabinoid receptor 2 (cb2 ). |
2014-05-19 |
2023-08-12 |
mouse |
| Bogna M Ignatowska-Jankowska, Pretal P Muldoon, Aron H Lichtman, M Imad Dama. The cannabinoid CB2 receptor is necessary for nicotine-conditioned place preference, but not other behavioral effects of nicotine in mice. Psychopharmacology. vol 229. issue 4. 2014-05-06. PMID:23652588. |
the cannabinoid cb2 receptor is necessary for nicotine-conditioned place preference, but not other behavioral effects of nicotine in mice. |
2014-05-06 |
2023-08-12 |
mouse |
| Bogna M Ignatowska-Jankowska, Pretal P Muldoon, Aron H Lichtman, M Imad Dama. The cannabinoid CB2 receptor is necessary for nicotine-conditioned place preference, but not other behavioral effects of nicotine in mice. Psychopharmacology. vol 229. issue 4. 2014-05-06. PMID:23652588. |
whereas cannabinoid cb1 receptors have long been known to contribute to the rewarding effects and dependence liability of many drugs of abuse, recent studies have implicated the involvement of cannabinoid cb2 receptors. |
2014-05-06 |
2023-08-12 |
mouse |
| Pritesh Kumar, Zhao-Hui Son. CB2 cannabinoid receptor is a novel target for third-generation selective estrogen receptor modulators bazedoxifene and lasofoxifene. Biochemical and biophysical research communications. vol 443. issue 1. 2014-05-06. PMID:24275139. |
furthermore, bazedoxifene and lasofoxifene caused parallel, rightward shifts of the cp-55,940, hu-210, and win55,212-2 concentration-response curves without altering the efficacy of these cannabinoid agonists on cb2, which indicates that bazedoxifene- and lasofoxifene-induced cb2 antagonism is most likely competitive in nature. |
2014-05-06 |
2023-08-12 |
Not clear |
| Fiorella Descalzi, Valentina Ulivi, Ranieri Cancedda, Fabiana Piscitelli, Livio Luongo, Francesca Guida, Luisa Gatta, Sabatino Maione, Vincenzo Di Marz. Platelet-rich plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism. Tissue engineering. Part A. vol 19. issue 19-20. 2014-05-02. PMID:23578218. |
in all conditions, antagonists of endocannabinoid cb1 and cb2 receptors, injected in the paw, abrogated the antinociceptive effects strongly suggesting for this preparation a peripheral mechanism of action. |
2014-05-02 |
2023-08-12 |
mouse |