| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elizabeth J Rahn, Liting Deng, Ganesh A Thakur, Kiran Vemuri, Alexander M Zvonok, Yvonne Y Lai, Alexandros Makriyannis, Andrea G Hohman. Prophylactic cannabinoid administration blocks the development of paclitaxel-induced neuropathic nociception during analgesic treatment and following cessation of drug delivery. Molecular pain. vol 10. 2014-10-17. PMID:24742127. |
the impact of chronic drug infusion on transcriptional regulation of mrna markers of astrocytes (gfap), microglia (cd11b) and cannabinoid receptors (cb1, cb2) was assessed in lumbar spinal cords of paclitaxel and vehicle-treated rats. |
2014-10-17 |
2023-08-13 |
rat |
| Pietro Marini, Maria-Grazia Cascio, Angela King, Roger G Pertwee, Ruth A Ros. Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors. British journal of pharmacology. vol 169. issue 4. 2014-10-08. PMID:23711022. |
characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid cb2 receptors. |
2014-10-08 |
2023-08-12 |
mouse |
| Pedro González-Naranjo, Natalia Pérez-Macias, Nuria E Campillo, Concepción Pérez, Vicente J Arán, Rocio Girón, Eva Sánchez-Robles, María Isabel Martín, María Gómez-Cañas, Moisés García-Arencibia, Javier Fernández-Ruiz, Juan A Páe. Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease. European journal of medicinal chemistry. vol 73. 2014-10-07. PMID:24378710. |
in this work, new indazole ethers that possess dual activity as both cannabinoid agonists cb2 and inhibitors of buche have been designed by computational methods. |
2014-10-07 |
2023-08-12 |
Not clear |
| Pedro González-Naranjo, Natalia Pérez-Macias, Nuria E Campillo, Concepción Pérez, Vicente J Arán, Rocio Girón, Eva Sánchez-Robles, María Isabel Martín, María Gómez-Cañas, Moisés García-Arencibia, Javier Fernández-Ruiz, Juan A Páe. Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease. European journal of medicinal chemistry. vol 73. 2014-10-07. PMID:24378710. |
the results of pharmacological tests have revealed that three of these derivatives behave as cb2 cannabinoid agonists and simultaneously show buche inhibition. |
2014-10-07 |
2023-08-12 |
Not clear |
| Jagjeet S Mnpotra, Zhuanhong Qiao, Jian Cai, Diane L Lynch, Alan Grossfield, Nicholas Leioatts, Dow P Hurst, Michael C Pitman, Zhao-Hui Song, Patricia H Reggi. Structural basis of G protein-coupled receptor-Gi protein interaction: formation of the cannabinoid CB2 receptor-Gi protein complex. The Journal of biological chemistry. vol 289. issue 29. 2014-10-06. PMID:24855641. |
structural basis of g protein-coupled receptor-gi protein interaction: formation of the cannabinoid cb2 receptor-gi protein complex. |
2014-10-06 |
2023-08-13 |
Not clear |
| Richard F Cox, Vincent Ras. Characterization of cannabinoid receptors. Current protocols in pharmacology. vol 63. 2014-09-26. PMID:24510753. |
this unit describes the use of cannabinoid radioligands in competitive binding assays for determining affinity parameters (ic50, ki ) of unlabeled compounds at transfected cb1 and cb2 receptors expressed in cell lines. |
2014-09-26 |
2023-08-12 |
Not clear |
| G Cristina Brailoiu, Elena Deliu, Jahan Marcu, Nicholas E Hoffman, Linda Console-Bram, Pingwei Zhao, Muniswamy Madesh, Mary E Abood, Eugen Brailoi. Differential activation of intracellular versus plasmalemmal CB2 cannabinoid receptors. Biochemistry. vol 53. issue 30. 2014-09-26. PMID:25033246. |
differential activation of intracellular versus plasmalemmal cb2 cannabinoid receptors. |
2014-09-26 |
2023-08-13 |
Not clear |
| G Cristina Brailoiu, Elena Deliu, Jahan Marcu, Nicholas E Hoffman, Linda Console-Bram, Pingwei Zhao, Muniswamy Madesh, Mary E Abood, Eugen Brailoi. Differential activation of intracellular versus plasmalemmal CB2 cannabinoid receptors. Biochemistry. vol 53. issue 30. 2014-09-26. PMID:25033246. |
the type 2 receptor for cannabinoids (cb2) has emerged as an important therapeutic target in several pathologies, as it mediates beneficial effects of cannabinoids while having little if any psychotropic activity. |
2014-09-26 |
2023-08-13 |
Not clear |
| Gabriele Murineddu, Francesco Deligia, Antonio Dore, Giovanni Pinna, Battistina Asproni, Gerard A Pinn. Different classes of CB2 ligands potentially useful in the treatment of pain. Recent patents on CNS drug discovery. vol 8. issue 1. 2014-09-25. PMID:23477308. |
in this context, since the modulation of the endocannabinoid system with the non selective phytocannabinoid Δ9-thc produces analgesia and potentiates opioid analgesia in animal models, cb2 ligands studies aimed to explore the involvement of endocannabinoid system in management of pain were started. |
2014-09-25 |
2023-08-12 |
Not clear |
| J J Xu, P Diaz, B Bie, F Astruc-Diaz, J Wu, H Yang, D L Brown, M Nagui. Spinal gene expression profiling and pathways analysis of a CB2 agonist (MDA7)-targeted prevention of paclitaxel-induced neuropathy. Neuroscience. vol 260. 2014-09-25. PMID:24361916. |
we found that a novel selective cannabinoid cb2 receptor agonist (mda7) prevents paclitaxel-induced mechanical allodynia in rats and mice. |
2014-09-25 |
2023-08-12 |
mouse |
| Isabel Devesa, Antonio Ferrer-Montie. Neurotrophins, endocannabinoids and thermo-transient receptor potential: a threesome in pain signalling. The European journal of neuroscience. vol 39. issue 3. 2014-09-25. PMID:24494676. |
although pain is multifactorial at cellular and molecular levels, it is widely accepted that neurotrophin (trka, p75ntr, ret and gfrs), cannabinoid (cb1 and cb2), and thermo-transient receptor potential (trps; trpv1, trpa1 and trpm8) receptors play a pivotal role. |
2014-09-25 |
2023-08-12 |
Not clear |
| Livio Luongo, Sabatino Maione, Vincenzo Di Marz. Endocannabinoids and neuropathic pain: focus on neuron-glia and endocannabinoid-neurotrophin interactions. The European journal of neuroscience. vol 39. issue 3. 2014-09-25. PMID:24494680. |
although originally described as a signalling system encompassing the cannabinoid cb1 and cb2 receptors, their endogenous agonists (the endocannabinoids), and metabolic enzymes regulating the levels of such agonists, the endocannabinoid system is now viewed as being more complex, and including metabolically related endocannabinoid-like mediators and their molecular targets as well. |
2014-09-25 |
2023-08-12 |
Not clear |
| Sherry Shu-Jung Hu, Yu-Cheng Ho, Lih-Chu Chio. No more pain upon Gq-protein-coupled receptor activation: role of endocannabinoids. The European journal of neuroscience. vol 39. issue 3. 2014-09-25. PMID:24494686. |
the analgesic mechanism of its constituents, the cannabinoids, was only revealed after the discovery of cannabinoid receptors (cb1 and cb2) two decades ago. |
2014-09-25 |
2023-08-12 |
Not clear |
| Roger G Pertwe. Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications. The Proceedings of the Nutrition Society. vol 73. issue 1. 2014-09-24. PMID:24135210. |
the endocannabinoid system consists of cannabinoid cb1 and cb2 receptors, of endogenous agonists for these receptors known as 'endocannabinoids', and of processes responsible for endocannabinoid biosynthesis, cellular uptake and metabolism. |
2014-09-24 |
2023-08-12 |
Not clear |
| Francisco León, Jiangtao Gao, Olivia R Dale, Yunshan Wu, Eman Habib, Afeef S Husni, Robert A Hill, Stephen J Cutle. Secondary metabolites from Eupenicillium parvum and their in vitro binding affinity for human opioid and cannabinoid receptors. Planta medica. vol 79. issue 18. 2014-09-23. PMID:24288291. |
several isolated compounds were evaluated for in vitro binding assays using opioid receptors (subtypes δ, κ, and µ) and cannabinoid receptors (cb1 and cb2). |
2014-09-23 |
2023-08-12 |
human |
| Tomohiro Kimura, Krishna Vukoti, Diane L Lynch, Dow P Hurst, Alan Grossfield, Michael C Pitman, Patricia H Reggio, Alexei A Yeliseev, Klaus Gawrisc. Global fold of human cannabinoid type 2 receptor probed by solid-state 13C-, 15N-MAS NMR and molecular dynamics simulations. Proteins. vol 82. issue 3. 2014-09-19. PMID:23999926. |
the global fold of human cannabinoid type 2 (cb2 ) receptor in the agonist-bound active state in lipid bilayers was investigated by solid-state (13)c- and (15)n magic-angle spinning (mas) nmr, in combination with chemical-shift prediction from a structural model of the receptor obtained by microsecond-long molecular dynamics (md) simulations. |
2014-09-19 |
2023-08-12 |
human |
| Ulrike Thieme, Gustav Schelling, Daniela Hauer, Robert Greif, Torsten Dame, Ruediger Paul Laubender, Werner Bernhard, Detlef Thieme, Patrizia Campolongo, Lorenz Theile. Quantification of anandamide and 2-arachidonoylglycerol plasma levels to examine potential influences of tetrahydrocannabinol application on the endocannabinoid system in humans. Drug testing and analysis. vol 6. issue 1-2. 2014-09-15. PMID:24424856. |
the effects of tetrahydrocannabinol (thc) and endogenous cannabinoids (endocannabinoids, ecs) are both mediated by activation of the cannabinoid receptors cb1 and cb2. |
2014-09-15 |
2023-08-12 |
human |
| Guoqiang Xing, Janis Carlton, Xiaolong Jiang, Jillian Wen, Min Jia, He L. Differential Expression of Brain Cannabinoid Receptors between Repeatedly Stressed Males and Females may Play a Role in Age and Gender-Related Difference in Traumatic Brain Injury: Implications from Animal Studies. Frontiers in neurology. vol 5. 2014-09-15. PMID:25221540. |
because females are more likely to develop anxiety after stress and because anxiety is mediated by cannabinoid receptors (cbrs) (cb1 and cb2), there is a need to compare cb1 and cb2 expression in stressed males and females. |
2014-09-15 |
2023-08-13 |
rat |
| Francesca Rossi, Maria Ester Bernardo, Giulia Bellini, Livio Luongo, Antonella Conforti, Iolanda Manzo, Francesca Guida, Luigia Cristino, Roberta Imperatore, Stefania Petrosino, Bruno Nobili, Vincenzo Di Marzo, Franco Locatelli, Sabatino Maion. The cannabinoid receptor type 2 as mediator of mesenchymal stromal cell immunosuppressive properties. PloS one. vol 8. issue 11. 2014-09-11. PMID:24312195. |
we show, for the first time, that cultures of human mesenchymal stromal cells express all of the components of the endocannabinoid system, suggesting a potential role for the cannabinoid cb2 receptor as a mediator of anti-inflammatory properties of human mesenchymal stromal cells, as well as of their survival pathways and their capability to home and migrate towards endocannabinoid sources. |
2014-09-11 |
2023-08-12 |
human |
| Daniel García-Ovejero, Ángel Arévalo-Martín, Beatriz Navarro-Galve, Emmanuel Pinteaux, Eduardo Molina-Holgado, Francisco Molina-Holgad. Neuroimmmune interactions of cannabinoids in neurogenesis: focus on interleukin-1β (IL-1β) signalling. Biochemical Society transactions. vol 41. issue 6. 2014-08-29. PMID:24256257. |
nscs express functional cb1 and cb2 cannabinoid receptors, daglα (diacylglycerol lipase α) and the nsc markers sox-2 and nestin. |
2014-08-29 |
2023-08-12 |
Not clear |