| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Maria Malfitano, Sreemanti Basu, Katarzyna Maresz, Maurizio Bifulco, Bonnie N Ditte. What we know and do not know about the cannabinoid receptor 2 (CB2). Seminars in immunology. vol 26. issue 5. 2015-07-15. PMID:24877594. |
here, we review the endocannabinoid system with an emphasis on cb2 and its role in the immune system. |
2015-07-15 |
2023-08-13 |
mouse |
| Federico Carbone, François Mach, Nicolas Vuilleumier, Fabrizio Montecucc. Cannabinoid receptor type 2 activation in atherosclerosis and acute cardiovascular diseases. Current medicinal chemistry. vol 21. issue 35. 2015-07-02. PMID:25245379. |
different from the other cannabinoid receptors in which controversial results are reported, the selective activation of the cannabinoid receptor type 2 (cb2) has been shown to play antiinflammatory and protective actions within atherosclerotic vessels and downstream ischemic peripheral organs. |
2015-07-02 |
2023-08-13 |
human |
| Gilson Gonçalves dos Santos, Elayne Vieira Dias, Juliana Maia Teixeira, Maria Carolina Pedro Athie, Ivan José Magayewski Bonet, Cláudia Herrera Tambeli, Carlos Amilcar Parad. The analgesic effect of dipyrone in peripheral tissue involves two different mechanisms: neuronal K(ATP) channel opening and CB(1) receptor activation. European journal of pharmacology. vol 741. 2015-06-22. PMID:25058903. |
the aim of this study was to investigate the participation of peripheral cb1 and cb2 cannabinoid receptors activation in the anti-hyperalgesic effect of dipyrone, 4-maa or 4-aa. |
2015-06-22 |
2023-08-13 |
rat |
| Richard S Priestley, Sarah A Nickolls, Stephen P H Alexander, David A Kendal. A potential role for cannabinoid receptors in the therapeutic action of fenofibrate. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 4. 2015-06-22. PMID:25550466. |
radio-ligand binding and functional assays were conducted using human recombinant cannabinoid type 1 (cb1) or cannabinoid type 2 (cb2) receptors, as well as the guinea pig isolated ileum, using the full agonist cp55940 as a positive control. |
2015-06-22 |
2023-08-13 |
human |
| Miriam Fishbein-Kaminietsky, Mikhal Gafni, Yosef Sarn. Ultralow doses of cannabinoid drugs protect the mouse brain from inflammation-induced cognitive damage. Journal of neuroscience research. vol 92. issue 12. 2015-06-19. PMID:25042014. |
the protective effect of thc was blocked by the cannabinoid (cb) 1 receptor antagonist sr14176a but not by the cb2 receptor antagonist sr141528 and was mimicked by the cb1 agonist acea but not by the cb2 agonist hu308. |
2015-06-19 |
2023-08-13 |
mouse |
| Yahiya Y Syed, Kate McKeage, Lesley J Scot. Delta-9-tetrahydrocannabinol/cannabidiol (Sativex®): a review of its use in patients with moderate to severe spasticity due to multiple sclerosis. Drugs. vol 74. issue 5. 2015-06-15. PMID:24671907. |
the main active substance, thc, acts as a partial agonist at human cannabinoid receptors (cb1 and cb2), and thus, may modulate the effects of excitatory (glutamate) and inhibitory (gamma-aminobutyric acid) neurotransmitters. |
2015-06-15 |
2023-08-12 |
human |
| Ornelio Rosati, Federica Messina, Azzurra Pelosi, Massimo Curini, Vanessa Petrucci, Jürg Gertsch, Andrea Chicc. One-pot heterogeneous synthesis of Δ(3)-tetrahydrocannabinol analogues and xanthenes showing differential binding to CB(1) and CB(2) receptors. European journal of medicinal chemistry. vol 85. 2015-06-02. PMID:25072877. |
four Δ(3)-thc analogues and corresponding Δ(4a)-tetrahydroxanthenes (Δ(4a)-thxs) were synthesized regioselectively and showed differential binding affinities for cb1 and cb2 cannabinoid receptors. |
2015-06-02 |
2023-08-13 |
Not clear |
| John M McPartland, Geoffrey W Guy, Vincenzo Di Marz. Care and feeding of the endocannabinoid system: a systematic review of potential clinical interventions that upregulate the endocannabinoid system. PloS one. vol 9. issue 3. 2015-05-29. PMID:24622769. |
the "classic" endocannabinoid (ecb) system includes the cannabinoid receptors cb1 and cb2, the ecb ligands anandamide (aea) and 2-arachidonoylglycerol (2-ag), and their metabolic enzymes. |
2015-05-29 |
2023-08-12 |
Not clear |
| Ming-wei Liu, Mei-xian Su, Yun-hui Wang, Wei Wei, Lan-fang Qin, Xu Liu, Mao-li Tian, Chuan-yun Qia. Effect of melilotus extract on lung injury by upregulating the expression of cannabinoid CB2 receptors in septic rats. BMC complementary and alternative medicine. vol 14. 2015-05-27. PMID:24612782. |
effect of melilotus extract on lung injury by upregulating the expression of cannabinoid cb2 receptors in septic rats. |
2015-05-27 |
2023-08-12 |
rat |
| Mukesh K Pandey, Timothy R DeGrado, Kun Qian, Mark S Jacobson, Clinton E Hagen, Richard I Duclos, S John Gatle. Synthesis and preliminary evaluation of N-(16-18F-fluorohexadecanoyl)ethanolamine (18F-FHEA) as a PET probe of N-acylethanolamine metabolism in mouse brain. ACS chemical neuroscience. vol 5. issue 9. 2015-05-26. PMID:25003845. |
the best-known mammalian compound of this class is anandamide, n-arachidonoylethanolamine, one of the endogenous ligands of cannabinoid cb1 and cb2 receptors. |
2015-05-26 |
2023-08-13 |
mouse |
| Jenny L Wiley, Timothy W Lefever, Ricardo A Cortes, Julie A Marusic. Cross-substitution of Δ9-tetrahydrocannabinol and JWH-018 in drug discrimination in rats. Pharmacology, biochemistry, and behavior. vol 124. 2015-05-19. PMID:24887450. |
synthetic indole-derived cannabinoids, originally developed to probe cannabinoid cb1 and cb2 receptors, have become widely abused for their marijuana-like intoxicating properties. |
2015-05-19 |
2023-08-13 |
rat |
| Shamma Al Mansouri, Shreesh Ojha, Elyazia Al Maamari, Mouza Al Ameri, Syed M Nurulain, Amine Bah. The cannabinoid receptor 2 agonist, β-caryophyllene, reduced voluntary alcohol intake and attenuated ethanol-induced place preference and sensitivity in mice. Pharmacology, biochemistry, and behavior. vol 124. 2015-05-19. PMID:24999220. |
several recent studies have suggested that brain cb2 cannabinoid receptors play a major role in alcohol reward. |
2015-05-19 |
2023-08-13 |
mouse |
| Jiao Zhang, San-Yi Wang, Jing-Jing Zhou, Yan Wei, Qian Li, Jing Yang, Yi Zhan. Inhibitory effects of endocannabinoid on the action potential of pacemaker cells in sinoatrial nodes of rabbits. Sheng li xue bao : [Acta physiologica Sinica]. vol 65. issue 2. 2015-05-16. PMID:23598867. |
for some san samples, cannabinoid type 1 (cb1) receptor antagonist am251, cannabinoid type 2 (cb2) receptor antagonist am630, potassium channel blocker tetraethylammonium (tea) and nitric oxide (no) synthase inhibitor l-nitro-arginine methylester (l-name) were used before aea treatment, respectively. |
2015-05-16 |
2023-08-12 |
Not clear |
| I Zofková, P Matuch. New insights into the physiology of bone regulation: the role of neurohormones. Physiological research. vol 63. issue 4. 2015-05-15. PMID:24702491. |
on the other hand, both cannabinoid systems (cb1 receptors in the brain and cb2 in bone tissue) are unambiguously osteo-protective, especially with regard to the aging skeleton. |
2015-05-15 |
2023-08-13 |
Not clear |
| Rebecca A Kohnz, Daniel K Nomur. Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids. Chemical Society reviews. vol 43. issue 19. 2015-05-14. PMID:24676249. |
while thc and its derivatives have garnered notoriety in the eyes of the public, the endocannabinoid system consists of two endogenous signaling lipids, 2-arachidonoylglycerol (2-ag) and n-arachidonoylethanolamine (anandamide), which activate cannabinoid receptors cb1 and cb2 in the nervous system and peripheral tissues. |
2015-05-14 |
2023-08-12 |
Not clear |
| Jeremy Koppel, Valerie Vingtdeux, Philippe Marambaud, Cristina d'Abramo, Heidy Jimenez, Mark Stauber, Rachel Friedman, Peter Davie. CB2 receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease. Molecular medicine (Cambridge, Mass.). vol 20. 2015-05-11. PMID:24722782. |
the endocannabinoid cb2 receptor system has been implicated in the neuropathology of alzheimer's disease (ad). |
2015-05-11 |
2023-08-13 |
mouse |
| Jeremy Koppel, Valerie Vingtdeux, Philippe Marambaud, Cristina d'Abramo, Heidy Jimenez, Mark Stauber, Rachel Friedman, Peter Davie. CB2 receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease. Molecular medicine (Cambridge, Mass.). vol 20. 2015-05-11. PMID:24722782. |
the results confirm the constitutive role of the cb2 receptor system both in reducing amyloid plaque pathology in ad and also support tehpotential of cannabinoid therapies targeting cb2 to reduce aβ; however, the results suggest that interventions may have a divergent effect on tau pathology. |
2015-05-11 |
2023-08-13 |
mouse |
| Raffaele Capasso, Pierangelo Orlando, Ester Pagano, Teresa Aveta, Lorena Buono, Francesca Borrelli, Vincenzo Di Marzo, Angelo A Izz. Palmitoylethanolamide normalizes intestinal motility in a model of post-inflammatory accelerated transit: involvement of CB₁ receptors and TRPV1 channels. British journal of pharmacology. vol 171. issue 17. 2015-05-11. PMID:24818658. |
palmitoylethanolamide (pea), a naturally occurring acylethanolamide chemically related to the endocannabinoid anandamide, interacts with targets that have been identified in peripheral nerves controlling gastrointestinal motility, such as cannabinoid cb1 and cb2 receptors, trpv1 channels and pparα. |
2015-05-11 |
2023-08-13 |
mouse |
| Miles D Thompson, David E C Cole, Valerie Capra, Katherine A Siminovitch, G Enrico Rovati, W McIntyre Burnham, Brinda K Ran. Pharmacogenetics of the G protein-coupled receptors. Methods in molecular biology (Clifton, N.J.). vol 1175. 2015-05-11. PMID:25150871. |
in this chapter, pharmacogenetic and genomic studies on gpcr variants are reviewed with respect to a subset of gpcr systems, including the adrenergic, calcium sensing, cysteinyl leukotriene, cannabinoid cb1 and cb2 receptors, and the de-orphanized receptors such as gpr55. |
2015-05-11 |
2023-08-13 |
Not clear |
| Lei Ma, Ji Jia, Xiangyu Liu, Fuhai Bai, Qiang Wang, Lize Xion. Activation of murine microglial N9 cells is attenuated through cannabinoid receptor CB2 signaling. Biochemical and biophysical research communications. vol 458. issue 1. 2015-05-06. PMID:25637536. |
activation of microglial cannabinoid cb2 receptor induces anti-inflammatory effects, and the mechanism, however, is still elusive. |
2015-05-06 |
2023-08-13 |
Not clear |