| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Timothy J England, William H Hind, Nadiah A Rasid, Saoirse E O'Sulliva. Cannabinoids in experimental stroke: a systematic review and meta-analysis. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 3. 2015-04-20. PMID:25492113. |
cannabinoids reduced infarct volume in transient (smd -1.41 (95% ci -1.71), -1.11) p<0.00001) and permanent (-1.67 (-2.08, -1.27), p<0.00001) ischemia and in all subclasses: endocannabinoids (-1.72 (-2.62, -0.82), p=0.0002), cb1/cb2 ligands (-1.75 (-2.19, -1.31), p<0.00001), cb2 ligands (-1.65 (-2.09, -1.22), p<0.00001), cannabidiol (-1.20 (-1.63, -0.77), p<0.00001), Δ(9)-tetrahydrocannabinol (-1.43 (-2.01, -0.86), p<0.00001), and hu-211 (-2.90 (-4.24, -1.56), p<0.0001). |
2015-04-20 |
2023-08-13 |
Not clear |
| Lih-Chu Chiou, Sherry Shu-Jung Hu, Yu-Cheng H. Targeting the cannabinoid system for pain relief? Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists. vol 51. issue 4. 2015-04-13. PMID:24529672. |
it is mainly mediated by its constituents, cannabinoids, through activating central cannabinoid 1 (cb1) receptors, as well as peripheral cb1 and cb2 receptors. |
2015-04-13 |
2023-08-12 |
Not clear |
| Esther Martínez-Martínez, Irene Gómez, Paloma Martín, Antonio Sánchez, Laura Román, Eva Tejerina, Félix Bonilla, Antonio García Merino, Antonio García de Herreros, Mariano Provencio, Jose M Garcí. Cannabinoids receptor type 2, CB2, expression correlates with human colon cancer progression and predicts patient survival. Oncoscience. vol 2. issue 2. 2015-04-10. PMID:25859556. |
cannabinoids receptor type 2, cb2, expression correlates with human colon cancer progression and predicts patient survival. |
2015-04-10 |
2023-08-13 |
human |
| Luara A Batista, Pedro H Gobira, Thercia G Viana, Daniele C Aguiar, Fabricio A Moreir. Inhibition of endocannabinoid neuronal uptake and hydrolysis as strategies for developing anxiolytic drugs. Behavioural pharmacology. vol 25. issue 5-6. 2015-03-31. PMID:25083569. |
the endocannabinoid system comprises the cb1 and cb2 receptors (the targets of the cannabis sativa compound delta-9-tetrahydrocannabinol), the endogenous ligands (endocannabinoids) arachidonoyl ethanolamide (anandamide) and 2-arachidonoyl glycerol, their synthesizing machinery and membrane transport system, and the hydrolyzing enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), respectively. |
2015-03-31 |
2023-08-13 |
Not clear |
| Giovanni Pinna, Giovanni Loriga, Paolo Lazzari, Stefania Ruiu, Matteo Falzoi, Simona Frau, Amedeo Pau, Gabriele Murineddu, Battistina Asproni, Gerard A Pinn. Tricyclic pyrazoles. Part 6. Benzofuro[3,2-c]pyrazole: a versatile architecture for CB2 selective ligands. European journal of medicinal chemistry. vol 82. 2015-03-30. PMID:24922543. |
the novel compounds (15-24) were evaluated for their affinity to cb2 and cb1 cannabinoid receptors. |
2015-03-30 |
2023-08-13 |
Not clear |
| Longhe Yang, Yanting Li, Jie Ren, Chenggang Zhu, Jin Fu, Donghai Lin, Yan Qi. Celastrol attenuates inflammatory and neuropathic pain mediated by cannabinoid receptor type 2. International journal of molecular sciences. vol 15. issue 8. 2015-03-30. PMID:25101848. |
), a specific cannabinoid receptor-2 (cb2) receptor antagonist, but not by sr141716 (1 mg/kg, i.p. |
2015-03-30 |
2023-08-13 |
mouse |
| Maria Haustein, Robert Ramer, Michael Linnebacher, Katrin Manda, Burkhard Hin. Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. Biochemical pharmacology. vol 92. issue 2. 2015-03-20. PMID:25069049. |
increased cancer cell lysis by cbd was likewise abrogated when cbd-induced icam-1 expression was blocked by specific sirna or by antagonists to cannabinoid receptors (cb1, cb2) and to transient receptor potential vanilloid 1. |
2015-03-20 |
2023-08-13 |
Not clear |
| Elad Wasserman, Joseph Tam, Raphael Mechoulam, Andreas Zimmer, Gila Maor, Itai Ba. CB1 cannabinoid receptors mediate endochondral skeletal growth attenuation by Δ9-tetrahydrocannabinol. Annals of the New York Academy of Sciences. vol 1335. 2015-03-20. PMID:25573322. |
we show that cb1 and cb2 cannabinoid receptors are expressed specifically in hypertrophic chondrocytes of the epiphyseal growth cartilage (egc), which drives vertebrate growth. |
2015-03-20 |
2023-08-13 |
mouse |
| Mellar P Davi. Cannabinoids in pain management: CB1, CB2 and non-classic receptor ligands. Expert opinion on investigational drugs. vol 23. issue 8. 2015-03-10. PMID:24836296. |
cannabinoids in pain management: cb1, cb2 and non-classic receptor ligands. |
2015-03-10 |
2023-08-13 |
human |
| Obaid Afzal, Suresh Kumar, Rajiv Kumar, Ahmad Firoz, Manu Jaggi, Sandhya Baw. Docking based virtual screening and molecular dynamics study to identify potential monoacylglycerol lipase inhibitors. Bioorganic & medicinal chemistry letters. vol 24. issue 16. 2015-03-06. PMID:25011912. |
it hydrolyzes one of the major endocannabinoid, 2-arachidonoylglycerol (2-ag), an endogenous full agonist at g protein coupled cannabinoid receptors cb1 and cb2. |
2015-03-06 |
2023-08-13 |
human |
| Andrea Chicca, Diego Caprioglio, Alberto Minassi, Vanessa Petrucci, Giovanni Appendino, Orazio Taglialatela-Scafati, Jürg Gertsc. Functionalization of β-caryophyllene generates novel polypharmacology in the endocannabinoid system. ACS chemical biology. vol 9. issue 7. 2015-02-26. PMID:24831513. |
the widespread dietary plant sesquiterpene hydrocarbon β-caryophyllene (1) is a cb2 cannabinoid receptor-specific agonist showing anti-inflammatory and analgesic effects in vivo. |
2015-02-26 |
2023-08-13 |
Not clear |
| Andrea Chicca, Diego Caprioglio, Alberto Minassi, Vanessa Petrucci, Giovanni Appendino, Orazio Taglialatela-Scafati, Jürg Gertsc. Functionalization of β-caryophyllene generates novel polypharmacology in the endocannabinoid system. ACS chemical biology. vol 9. issue 7. 2015-02-26. PMID:24831513. |
while most changes on this element were detrimental for activity, ring-opening cross metathesis of 1 with ethyl acrylate followed by amide functionalization generated a series of new monocyclic amides (11a, 11b, 11c) that not only retained the cb2 receptor functional agonism of 1 but also reversibly inhibited fatty acid amide hydrolase (faah), the major endocannabinoid degrading enzyme, without affecting monoacylglycerol lipase (magl) and α,β hydrolases 6 and 12. |
2015-02-26 |
2023-08-13 |
Not clear |
| R Ribeiro, F Yu, J Wen, A Vana, Y Zhan. Therapeutic potential of a novel cannabinoid agent CB52 in the mouse model of experimental autoimmune encephalomyelitis. Neuroscience. vol 254. 2015-02-23. PMID:24036373. |
the protective mechanisms of cannabinoids are thought to be mediated by the activation of the cannabinoid type 1 (cb1) and type 2 (cb2) receptors expressed primarily in neurons and immune cells, respectively. |
2015-02-23 |
2023-08-12 |
mouse |
| R Ribeiro, F Yu, J Wen, A Vana, Y Zhan. Therapeutic potential of a novel cannabinoid agent CB52 in the mouse model of experimental autoimmune encephalomyelitis. Neuroscience. vol 254. 2015-02-23. PMID:24036373. |
although cb1 and cb2 receptors are expressed in oligodendrocytes, the myelin producing cells in the central nervous system, the role of cannabinoids in oligodendrocyte survival has not been well investigated. |
2015-02-23 |
2023-08-12 |
mouse |
| R Ribeiro, F Yu, J Wen, A Vana, Y Zhan. Therapeutic potential of a novel cannabinoid agent CB52 in the mouse model of experimental autoimmune encephalomyelitis. Neuroscience. vol 254. 2015-02-23. PMID:24036373. |
these effects are reversed by the cb1 receptor antagonist, but not by the cb2 receptor antagonist, suggesting that the activation of cb1 receptors contributes significantly to the anti-inflammatory and neuroprotective effects of cannabinoids on ms. |
2015-02-23 |
2023-08-12 |
mouse |
| Joseph Bouskila, Pasha Javadi, Christian Casanova, Maurice Ptito, Jean-François Bouchar. Rod photoreceptors express GPR55 in the adult vervet monkey retina. PloS one. vol 8. issue 11. 2015-02-23. PMID:24244730. |
cannabinoids exert their actions mainly through two receptors, the cannabinoid cb1 receptor (cb1r) and cannabinoid cb2 receptor (cb2r). |
2015-02-23 |
2023-08-12 |
monkey |
| S Vlachou, G Panagi. Regulation of brain reward by the endocannabinoid system: a critical review of behavioral studies in animals. Current pharmaceutical design. vol 20. issue 13. 2015-02-20. PMID:23829366. |
the effects of cannabinoid 1 (cb1) and cannabinoid 2 (cb2) receptor agonists, antagonists and endocannabinoid modulators in these procedures are examined. |
2015-02-20 |
2023-08-12 |
mouse |
| Zhiyuan Wu, Pin Shao, Shaojuan Zhang, Xiaoxi Ling, Mingfeng Ba. Molecular imaging of human tumor cells that naturally overexpress type 2 cannabinoid receptors using a quinolone-based near-infrared fluorescent probe. Journal of biomedical optics. vol 19. issue 7. 2015-02-20. PMID:25036213. |
cannabinoid cb2 receptors (cb2r) hold promise as therapeutic targets for treating diverse diseases, such as cancers, neurodegenerative diseases, pain, inflammation, osteoporosis, psychiatric disorders, addiction, and immune disorders. |
2015-02-20 |
2023-08-13 |
human |
| Katia Befor. Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies. Frontiers in pharmacology. vol 6. 2015-02-20. PMID:25698968. |
the endogenous cannabinoid system comprises lipid neuromodulators (endocannabinoids), enzymes for their synthesis and their degradation and two well-characterized receptors, cannabinoid receptors cb1 and cb2. |
2015-02-20 |
2023-08-13 |
mouse |
| Daniela Muhl, Markus Kathmann, Carolin Hoyer, Laura Kranaster, Martin Hellmich, Christoph W Gerth, Johannes Faulhaber, Eberhard Schlicker, F Markus Lewek. Increased CB2 mRNA and anandamide in human blood after cessation of cannabis abuse. Naunyn-Schmiedeberg's archives of pharmacology. vol 387. issue 7. 2015-02-19. PMID:24788457. |
in previous studies, long-term cannabis use led to alterations of the endocannabinoid system including an increase in cb1 and/or cb2 receptor messenger rna (mrna) in blood cells and an increase in the serum level of the endocannabinoid 2-arachidonoyl glycerol. |
2015-02-19 |
2023-08-13 |
human |