| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John M McPartland, Geoffrey W Guy, Vincenzo Di Marz. Care and feeding of the endocannabinoid system: a systematic review of potential clinical interventions that upregulate the endocannabinoid system. PloS one. vol 9. issue 3. 2015-05-29. PMID:24622769. |
the "classic" endocannabinoid (ecb) system includes the cannabinoid receptors cb1 and cb2, the ecb ligands anandamide (aea) and 2-arachidonoylglycerol (2-ag), and their metabolic enzymes. |
2015-05-29 |
2023-08-12 |
Not clear |
| Ming-wei Liu, Mei-xian Su, Yun-hui Wang, Wei Wei, Lan-fang Qin, Xu Liu, Mao-li Tian, Chuan-yun Qia. Effect of melilotus extract on lung injury by upregulating the expression of cannabinoid CB2 receptors in septic rats. BMC complementary and alternative medicine. vol 14. 2015-05-27. PMID:24612782. |
effect of melilotus extract on lung injury by upregulating the expression of cannabinoid cb2 receptors in septic rats. |
2015-05-27 |
2023-08-12 |
rat |
| Mukesh K Pandey, Timothy R DeGrado, Kun Qian, Mark S Jacobson, Clinton E Hagen, Richard I Duclos, S John Gatle. Synthesis and preliminary evaluation of N-(16-18F-fluorohexadecanoyl)ethanolamine (18F-FHEA) as a PET probe of N-acylethanolamine metabolism in mouse brain. ACS chemical neuroscience. vol 5. issue 9. 2015-05-26. PMID:25003845. |
the best-known mammalian compound of this class is anandamide, n-arachidonoylethanolamine, one of the endogenous ligands of cannabinoid cb1 and cb2 receptors. |
2015-05-26 |
2023-08-13 |
mouse |
| Jenny L Wiley, Timothy W Lefever, Ricardo A Cortes, Julie A Marusic. Cross-substitution of Δ9-tetrahydrocannabinol and JWH-018 in drug discrimination in rats. Pharmacology, biochemistry, and behavior. vol 124. 2015-05-19. PMID:24887450. |
synthetic indole-derived cannabinoids, originally developed to probe cannabinoid cb1 and cb2 receptors, have become widely abused for their marijuana-like intoxicating properties. |
2015-05-19 |
2023-08-13 |
rat |
| Shamma Al Mansouri, Shreesh Ojha, Elyazia Al Maamari, Mouza Al Ameri, Syed M Nurulain, Amine Bah. The cannabinoid receptor 2 agonist, β-caryophyllene, reduced voluntary alcohol intake and attenuated ethanol-induced place preference and sensitivity in mice. Pharmacology, biochemistry, and behavior. vol 124. 2015-05-19. PMID:24999220. |
several recent studies have suggested that brain cb2 cannabinoid receptors play a major role in alcohol reward. |
2015-05-19 |
2023-08-13 |
mouse |
| Jiao Zhang, San-Yi Wang, Jing-Jing Zhou, Yan Wei, Qian Li, Jing Yang, Yi Zhan. Inhibitory effects of endocannabinoid on the action potential of pacemaker cells in sinoatrial nodes of rabbits. Sheng li xue bao : [Acta physiologica Sinica]. vol 65. issue 2. 2015-05-16. PMID:23598867. |
for some san samples, cannabinoid type 1 (cb1) receptor antagonist am251, cannabinoid type 2 (cb2) receptor antagonist am630, potassium channel blocker tetraethylammonium (tea) and nitric oxide (no) synthase inhibitor l-nitro-arginine methylester (l-name) were used before aea treatment, respectively. |
2015-05-16 |
2023-08-12 |
Not clear |
| I Zofková, P Matuch. New insights into the physiology of bone regulation: the role of neurohormones. Physiological research. vol 63. issue 4. 2015-05-15. PMID:24702491. |
on the other hand, both cannabinoid systems (cb1 receptors in the brain and cb2 in bone tissue) are unambiguously osteo-protective, especially with regard to the aging skeleton. |
2015-05-15 |
2023-08-13 |
Not clear |
| Rebecca A Kohnz, Daniel K Nomur. Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids. Chemical Society reviews. vol 43. issue 19. 2015-05-14. PMID:24676249. |
while thc and its derivatives have garnered notoriety in the eyes of the public, the endocannabinoid system consists of two endogenous signaling lipids, 2-arachidonoylglycerol (2-ag) and n-arachidonoylethanolamine (anandamide), which activate cannabinoid receptors cb1 and cb2 in the nervous system and peripheral tissues. |
2015-05-14 |
2023-08-12 |
Not clear |
| Jeremy Koppel, Valerie Vingtdeux, Philippe Marambaud, Cristina d'Abramo, Heidy Jimenez, Mark Stauber, Rachel Friedman, Peter Davie. CB2 receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease. Molecular medicine (Cambridge, Mass.). vol 20. 2015-05-11. PMID:24722782. |
the endocannabinoid cb2 receptor system has been implicated in the neuropathology of alzheimer's disease (ad). |
2015-05-11 |
2023-08-13 |
mouse |
| Jeremy Koppel, Valerie Vingtdeux, Philippe Marambaud, Cristina d'Abramo, Heidy Jimenez, Mark Stauber, Rachel Friedman, Peter Davie. CB2 receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease. Molecular medicine (Cambridge, Mass.). vol 20. 2015-05-11. PMID:24722782. |
the results confirm the constitutive role of the cb2 receptor system both in reducing amyloid plaque pathology in ad and also support tehpotential of cannabinoid therapies targeting cb2 to reduce aβ; however, the results suggest that interventions may have a divergent effect on tau pathology. |
2015-05-11 |
2023-08-13 |
mouse |
| Raffaele Capasso, Pierangelo Orlando, Ester Pagano, Teresa Aveta, Lorena Buono, Francesca Borrelli, Vincenzo Di Marzo, Angelo A Izz. Palmitoylethanolamide normalizes intestinal motility in a model of post-inflammatory accelerated transit: involvement of CB₁ receptors and TRPV1 channels. British journal of pharmacology. vol 171. issue 17. 2015-05-11. PMID:24818658. |
palmitoylethanolamide (pea), a naturally occurring acylethanolamide chemically related to the endocannabinoid anandamide, interacts with targets that have been identified in peripheral nerves controlling gastrointestinal motility, such as cannabinoid cb1 and cb2 receptors, trpv1 channels and pparα. |
2015-05-11 |
2023-08-13 |
mouse |
| Miles D Thompson, David E C Cole, Valerie Capra, Katherine A Siminovitch, G Enrico Rovati, W McIntyre Burnham, Brinda K Ran. Pharmacogenetics of the G protein-coupled receptors. Methods in molecular biology (Clifton, N.J.). vol 1175. 2015-05-11. PMID:25150871. |
in this chapter, pharmacogenetic and genomic studies on gpcr variants are reviewed with respect to a subset of gpcr systems, including the adrenergic, calcium sensing, cysteinyl leukotriene, cannabinoid cb1 and cb2 receptors, and the de-orphanized receptors such as gpr55. |
2015-05-11 |
2023-08-13 |
Not clear |
| Lei Ma, Ji Jia, Xiangyu Liu, Fuhai Bai, Qiang Wang, Lize Xion. Activation of murine microglial N9 cells is attenuated through cannabinoid receptor CB2 signaling. Biochemical and biophysical research communications. vol 458. issue 1. 2015-05-06. PMID:25637536. |
activation of microglial cannabinoid cb2 receptor induces anti-inflammatory effects, and the mechanism, however, is still elusive. |
2015-05-06 |
2023-08-13 |
Not clear |
| Lei Ma, Ji Jia, Xiangyu Liu, Fuhai Bai, Qiang Wang, Lize Xion. Activation of murine microglial N9 cells is attenuated through cannabinoid receptor CB2 signaling. Biochemical and biophysical research communications. vol 458. issue 1. 2015-05-06. PMID:25637536. |
in this study, we used lipopolysaccharide (lps) plus interferon-γ (ifnγ) to activate n9 microglia and hypothesized the pretreatment with cannabinoid cb2 receptor agonist am1241 attenuates microglial activation by shifting microglial m1 to m2 state. |
2015-05-06 |
2023-08-13 |
Not clear |
| Lei Ma, Ji Jia, Xiangyu Liu, Fuhai Bai, Qiang Wang, Lize Xion. Activation of murine microglial N9 cells is attenuated through cannabinoid receptor CB2 signaling. Biochemical and biophysical research communications. vol 458. issue 1. 2015-05-06. PMID:25637536. |
however, these effects induced by am1241 pretreatment were significantly reversed in the presence of 10 μm cannabinoid cb2 receptor antagonist am630 or 10 μm protein kinase c (pkc) inhibitor chelerythrine. |
2015-05-06 |
2023-08-13 |
Not clear |
| Rosanna Chianese, Vincenza Ciaramella, Silvia Fasano, Riccardo Pierantoni, Rosaria Meccariell. Hypothalamus-pituitary axis: an obligatory target for endocannabinoids to inhibit steroidogenesis in frog testis. General and comparative endocrinology. vol 205. 2015-05-04. PMID:24566122. |
endocannabinoids - primarily anandamide (aea) and 2-arachidonoylglycerol (2-ag) - are lipophilic molecules that bind to cannabinoid receptors (cb1 and cb2). |
2015-05-04 |
2023-08-12 |
Not clear |
| Derek M Shore, Patricia H Reggi. The therapeutic potential of orphan GPCRs, GPR35 and GPR55. Frontiers in pharmacology. vol 6. 2015-04-30. PMID:25926795. |
however, the gpr55 endogenous ligand has been found to be a non-cannabinoid, lysophophatidylinositol (lpi) and subsequent high throughput assays have identified other gpr55 ligands that are not cannabinoids and do not bind to either the cannabinoid cb1 and cb2 receptors. |
2015-04-30 |
2023-08-13 |
Not clear |
| Megan J Dowie, Natasha L Grimsey, Therri Hoffman, Richard L M Faull, Michelle Glas. Cannabinoid receptor CB2 is expressed on vascular cells, but not astroglial cells in the post-mortem human Huntington's disease brain. Journal of chemical neuroanatomy. vol 59-60. 2015-04-23. PMID:24978314. |
cannabinoid cb2 receptors are localised and up-regulated on a number of peripheral immune cell types following inflammation and injury. |
2015-04-23 |
2023-08-13 |
human |
| Hai-Ying Zhang, Ming Gao, Qing-Rong Liu, Guo-Hua Bi, Xia Li, Hong-Ju Yang, Eliot L Gardner, Jie Wu, Zheng-Xiong X. Cannabinoid CB2 receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 46. 2015-04-23. PMID:25368177. |
cannabinoid cb2 receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice. |
2015-04-23 |
2023-08-13 |
mouse |
| Hai-Ying Zhang, Ming Gao, Qing-Rong Liu, Guo-Hua Bi, Xia Li, Hong-Ju Yang, Eliot L Gardner, Jie Wu, Zheng-Xiong X. Cannabinoid CB2 receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 46. 2015-04-23. PMID:25368177. |
cannabinoid cb2 receptors (cb2rs) have been recently reported to modulate brain dopamine (da)-related behaviors; however, the cellular mechanisms underlying these actions are unclear. |
2015-04-23 |
2023-08-13 |
mouse |