| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N A Balenga, E Martínez-Pinilla, J Kargl, R Schröder, M Peinhaupt, W Platzer, Z Bálint, M Zamarbide, I G Dopeso-Reyes, A Ricobaraza, J M Pérez-Ortiz, E Kostenis, M Waldhoer, A Heinemann, R Franc. Heteromerization of GPR55 and cannabinoid CB2 receptors modulates signalling. British journal of pharmacology. vol 171. issue 23. 2015-08-14. PMID:25048571. |
heteromerization of gpr55 and cannabinoid cb2 receptors modulates signalling. |
2015-08-14 |
2023-08-13 |
human |
| Iryna A Khasabova, Xu Yao, Justin Paz, Cutler T Lewandowski, Amy E Lindberg, Lia Coicou, Natasha Burlakova, Don A Simone, Virginia S Seybol. JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy. Pharmacological research. vol 90. 2015-08-13. PMID:25304184. |
acute injection of a cannabinoid (cb)-1 but not a cb2 receptor antagonist reversed the anti-hyperalgesic effect of jzl184 indicating that downstream activation of cb1 receptors suppressed the expression of mechanical hyperalgesia. |
2015-08-13 |
2023-08-13 |
Not clear |
| D I Abrams, M Guzma. Cannabis in cancer care. Clinical pharmacology and therapeutics. vol 97. issue 6. 2015-08-12. PMID:25777363. |
cannabinoids, the active components of cannabis sativa, mimic the effects of the endogenous cannabinoids (endocannabinoids), activating specific cannabinoid receptors, particularly cb1 found predominantly in the central nervous system and cb2 found predominantly in cells involved with immune function. |
2015-08-12 |
2023-08-13 |
Not clear |
| V Kiran Vemuri, A Makriyanni. Medicinal chemistry of cannabinoids. Clinical pharmacology and therapeutics. vol 97. issue 6. 2015-08-12. PMID:25801236. |
the endocannabinoid system comprises the two well characterized gi/o -protein coupled receptors (cannabinoid receptor 1 (cb1) and cb2), their endogenous lipid ligands, and the enzymes involved in their biosynthesis and biotransformation. |
2015-08-12 |
2023-08-13 |
Not clear |
| Ruth M Concannon, Bright N Okine, David P Finn, Eilís Dow. Differential upregulation of the cannabinoid CB₂ receptor in neurotoxic and inflammation-driven rat models of Parkinson's disease. Experimental neurology. vol 269. 2015-08-11. PMID:25895887. |
the cannabinoid cb2 receptor has recently emerged as a potential anti-inflammatory target to break the self-sustaining cycle of neuroinflammation and neurodegeneration that is associated with neurodegenerative diseases. |
2015-08-11 |
2023-08-13 |
rat |
| Liting Deng, Benjamin L Cornett, Ken Mackie, Andrea G Hohman. CB1 Knockout Mice Unveil Sustained CB2-Mediated Antiallodynic Effects of the Mixed CB1/CB2 Agonist CP55,940 in a Mouse Model of Paclitaxel-Induced Neuropathic Pain. Molecular pharmacology. vol 88. issue 1. 2015-08-11. PMID:25904556. |
cannabinoids suppress neuropathic pain through activation of cannabinoid cb1 and/or cb2 receptors; however, unwanted cb1-mediated cannabimimetic effects limit clinical use. |
2015-08-11 |
2023-08-13 |
mouse |
| Liting Deng, Benjamin L Cornett, Ken Mackie, Andrea G Hohman. CB1 Knockout Mice Unveil Sustained CB2-Mediated Antiallodynic Effects of the Mixed CB1/CB2 Agonist CP55,940 in a Mouse Model of Paclitaxel-Induced Neuropathic Pain. Molecular pharmacology. vol 88. issue 1. 2015-08-11. PMID:25904556. |
we asked whether cp55,940 [(-)-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-4-(3-hydroxypropyl)cyclohexanol], a potent cannabinoid that binds with similar affinity to cb1 and cb2 in vitro, produces functionally separable cb1- and cb2-mediated pharmacological effects in vivo. |
2015-08-11 |
2023-08-13 |
mouse |
| Liting Deng, Benjamin L Cornett, Ken Mackie, Andrea G Hohman. CB1 Knockout Mice Unveil Sustained CB2-Mediated Antiallodynic Effects of the Mixed CB1/CB2 Agonist CP55,940 in a Mouse Model of Paclitaxel-Induced Neuropathic Pain. Molecular pharmacology. vol 88. issue 1. 2015-08-11. PMID:25904556. |
our study highlights the therapeutic potential of targeting cannabinoid cb2 receptors to bypass unwanted central effects associated with cb1 receptor activation. |
2015-08-11 |
2023-08-13 |
mouse |
| Hiroko Ikeda, Megumi Ikegami, Misa Kai, Junzo Kame. Cannabinoid functions in the amygdala contribute to conditioned fear memory in streptozotocin-induced diabetic mice: Interaction with glutamatergic functions. Experimental neurology. vol 269. 2015-08-11. PMID:25929688. |
this effect was significantly inhibited by the cannabinoid cb1 receptor antagonist am 251 (3mg/kg, s.c.), but not by the cannabinoid cb2 receptor antagonist am 630 (1mg/kg, s.c.). |
2015-08-11 |
2023-08-13 |
mouse |
| Hiroko Ikeda, Megumi Ikegami, Misa Kai, Junzo Kame. Cannabinoid functions in the amygdala contribute to conditioned fear memory in streptozotocin-induced diabetic mice: Interaction with glutamatergic functions. Experimental neurology. vol 269. 2015-08-11. PMID:25929688. |
in contrast, the protein levels of cannabinoid cb2 receptors and diacylglycerol lipase α, the enzyme that synthesizes endocannabinoid 2-arachidonoylglycerol, in the amygdala did not differ between non-diabetic and stz-induced diabetic mice. |
2015-08-11 |
2023-08-13 |
mouse |
| María Concepción García, Valentina Cinquina, Cristina Palomo-Garo, Alberto Rábano, Javier Fernández-Rui. Identification of CB₂ receptors in human nigral neurons that degenerate in Parkinson's disease. Neuroscience letters. vol 587. 2015-08-10. PMID:25481767. |
it is well-demonstrated that cannabinoid cb2 receptors located in glial cells are up-regulated in neurodegenerative disorders serving as a target to control glial influences to neurons. |
2015-08-10 |
2023-08-13 |
human |
| Tian-Cheng Wang, Jing Wang, Xu Xu, Jing-Lin Ma, Xue-Feng Wan. Tonic modulation of nociceptive behavior and allodynia by cannabinoid receptors in formalin test in rats. The Chinese journal of physiology. vol 58. issue 1. 2015-08-06. PMID:25687494. |
the current study investigated the role of cannabinoid (cb1 and cb2) receptors in modulating formalin-induced nociceptive behavior and mechanical allodynia in the rat. |
2015-08-06 |
2023-08-13 |
rat |
| Ramy Khella, Jennifer L Short, Daniel T Malon. CB2 receptor agonism reverses MK-801-induced disruptions of prepulse inhibition in mice. Psychopharmacology. vol 231. issue 16. 2015-08-04. PMID:24705902. |
whilst cannabinoid cb2 receptors were thought to exist predominantly in immune cells in the periphery, the recent discovery of cb2 receptors in the brain has led to an increased interest in the role of these central cb2 receptors. |
2015-08-04 |
2023-08-13 |
mouse |
| Joëlle Nader, Cinzia Rapino, Benjamin Gennequin, Francois Chavant, Maureen Francheteau, Alexandros Makriyannis, Andrea Duranti, Mauro Maccarrone, Marcello Solinas, Nathalie Thirie. Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors. Neuropharmacology. vol 87. 2015-08-04. PMID:24709540. |
prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of cb2 receptors. |
2015-08-04 |
2023-08-13 |
Not clear |
| Joëlle Nader, Cinzia Rapino, Benjamin Gennequin, Francois Chavant, Maureen Francheteau, Alexandros Makriyannis, Andrea Duranti, Mauro Maccarrone, Marcello Solinas, Nathalie Thirie. Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors. Neuropharmacology. vol 87. 2015-08-04. PMID:24709540. |
Δ(9)-tetrahydrocannabinol (thc), a cannabis-derived agonist of both cb1 and cb2 cannabinoid receptors, or inhibitors of the main enzymes responsible for the degradation of aea and 2-ag (urb597 and jzl184, respectively), blunted the decrease in striatal protein levels of tyrosine hydroxylase induced by methamphetamine. |
2015-08-04 |
2023-08-13 |
Not clear |
| Alexander I Bondarenk. Endothelial atypical cannabinoid receptor: do we have enough evidence? British journal of pharmacology. vol 171. issue 24. 2015-07-28. PMID:25073723. |
more studies are needed to differentiate gi/o protein-dependent endothelial cannabinoid signalling from that involving the classical cb1 and cb2 receptors as well as its relevance for pathophysiological conditions. |
2015-07-28 |
2023-08-13 |
human |
| Stephen G Woodhams, Devi Rani Sagar, James J Burston, Victoria Chapma. The role of the endocannabinoid system in pain. Handbook of experimental pharmacology. vol 227. 2015-07-27. PMID:25846617. |
the ec system is composed of two main cannabinoid receptors (cb1 and cb2) and two main classes of endogenous ligands or endocannabinoids (ecs). |
2015-07-27 |
2023-08-13 |
Not clear |
| Anna Maria Malfitano, Sreemanti Basu, Katarzyna Maresz, Maurizio Bifulco, Bonnie N Ditte. What we know and do not know about the cannabinoid receptor 2 (CB2). Seminars in immunology. vol 26. issue 5. 2015-07-15. PMID:24877594. |
it has been well appreciated that the endocannabinoid system can regulate immune responses via the cannabinoid receptor 2 (cb2), which is primarily expressed by cells of the hematopoietic system. |
2015-07-15 |
2023-08-13 |
mouse |
| Anna Maria Malfitano, Sreemanti Basu, Katarzyna Maresz, Maurizio Bifulco, Bonnie N Ditte. What we know and do not know about the cannabinoid receptor 2 (CB2). Seminars in immunology. vol 26. issue 5. 2015-07-15. PMID:24877594. |
along with endocannabinoids, both plant-derived and synthetic cannabinoids have been shown to bind to and signal through cb2 via g proteins leading to both inhibitory and stimulatory signals depending on the biological process. |
2015-07-15 |
2023-08-13 |
mouse |
| Anna Maria Malfitano, Sreemanti Basu, Katarzyna Maresz, Maurizio Bifulco, Bonnie N Ditte. What we know and do not know about the cannabinoid receptor 2 (CB2). Seminars in immunology. vol 26. issue 5. 2015-07-15. PMID:24877594. |
because no cannabinoid ligand has been identified that only binds to cb2, the generation of mice deficient in cb2 has greatly expanded our knowledge of how cb2 contributes to immune cell development and function in health and disease. |
2015-07-15 |
2023-08-13 |
mouse |