| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sean D McAllister, Liliana Soroceanu, Pierre-Yves Despre. The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 10. issue 2. 2016-04-01. PMID:25916739. |
as a therapeutic agent, most people are familiar with the palliative effects of the primary psychoactive constituent of cannabis sativa (cs), Δ(9)-tetrahydrocannabinol (thc), a molecule active at both the cannabinoid 1 (cb1) and cannabinoid 2 (cb2) receptor subtypes. |
2016-04-01 |
2023-08-13 |
Not clear |
| Guy A Cabral, Thomas J Rogers, Aron H Lichtma. Turning Over a New Leaf: Cannabinoid and Endocannabinoid Modulation of Immune Function. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 10. issue 2. 2016-04-01. PMID:26054900. |
the major psychoactive phytocannabinoid found in cannabis ∆(9)-tetrahydrocannabinol (thc) produces the majority of its pharmacological effects through two cannabinoid receptors, termed cb1 and cb2. |
2016-04-01 |
2023-08-13 |
human |
| C R Hutch, C J Hillard, C Jia, C C Heg. An endocannabinoid system is present in the mouse olfactory epithelium but does not modulate olfaction. Neuroscience. vol 300. 2016-03-29. PMID:26037800. |
we found the presence of cannabinoid type 1 (cb1) and cannabinoid type 2 (cb2) receptor protein and mrna in the olfactory epithelium. |
2016-03-29 |
2023-08-13 |
mouse |
| Tyrell Simkins, Robert B Crawford, John L Goudreau, Keith J Lookingland, Barbara L F Kapla. Enhanced humoral immunity in mice lacking CB1 and CB2 receptors (Cnr1-/-/Cnr2-/- mice) is not due to increased splenic noradrenergic neuronal activity. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 9. issue 4. 2016-03-28. PMID:24870806. |
cannabinoids are immunosuppressive, and mice lacking cb1 and cb2 receptors (cnr1(-/-)/cnr2(-/-) mice) have augmented cell-mediated immune responses. |
2016-03-28 |
2023-08-13 |
mouse |
| Vishnudutt Purohit, Rao S Rapaka, Joni Rutte. Cannabinoid receptor-2 and HIV-associated neurocognitive disorders. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 9. issue 4. 2016-03-28. PMID:25015040. |
in this regard, cannabinoid receptor-2(cb2) activation is a promising means to attenuate hand by inhibiting hiv replication, down regulating inflammation, and suppressing chemokine-like activity of viral neurotoxic proteins (for example, tat and hiv-1gp120), and thereby prevent neuronal and synaptic loss. |
2016-03-28 |
2023-08-13 |
Not clear |
| Julia Kremshofer, Monika Siwetz, Veronika M Berghold, Ingrid Lang, Berthold Huppertz, Martin Gauste. A role for GPR55 in human placental venous endothelial cells. Histochemistry and cell biology. vol 144. issue 1. 2016-03-22. PMID:25869640. |
g protein-coupled receptor 55 (gpr55) was previously postulated to be another cannabinoid receptor, since specific cannabinoids were shown to act independently of the classical cannabinoid receptors cb1 or cb2. |
2016-03-22 |
2023-08-13 |
human |
| Natalia Malek, Katarzyna Popiolek-Barczyk, Joanna Mika, Barbara Przewlocka, Katarzyna Starowic. Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures. Neural plasticity. vol 2015. 2016-03-09. PMID:26090232. |
anandamide as an immune modulator in the central nervous system acts via not only cannabinoid receptors (cb1 and cb2) but also other targets (e.g., gpr18/gpr55). |
2016-03-09 |
2023-08-13 |
rat |
| Farinaz Nasirinezhad, Stanislava Jergova, James P Pearson, Jacqueline Sage. Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy. Neuropharmacology. vol 95. 2016-03-08. PMID:25486617. |
to assess the contribution of cannabinoid receptors in these antinociceptive effects, cb1 antagonist am251 or cb2 antagonist sr144528 were tested in conjunction with faah inhibitors. |
2016-03-08 |
2023-08-13 |
rat |
| Robert P Picone, Debra A Kendal. Minireview: From the bench, toward the clinic: therapeutic opportunities for cannabinoid receptor modulation. Molecular endocrinology (Baltimore, Md.). vol 29. issue 6. 2016-02-22. PMID:25866875. |
the effects of cannabinoids have been known for centuries and over the past several decades two g protein-coupled receptors, cb1 and cb2, that are responsible for their activity have been identified. |
2016-02-22 |
2023-08-13 |
human |
| Christopher J Fowle. The potential of inhibitors of endocannabinoid metabolism as anxiolytic and antidepressive drugs--A practical view. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 6. 2016-02-16. PMID:25791296. |
the endocannabinoid system, comprising cannabinoid cb1 and cb2 receptors, their endogenous ligands anandamide and 2-arachidonoylglyerol, and their synthetic and metabolic enzymes, are involved in many biological processes in the body, ranging from appetite to bone turnover. |
2016-02-16 |
2023-08-13 |
Not clear |
| Huan Gui, Qiang Tong, Wenchun Qu, Chen-Mei Mao, Sheng-Ming Da. The endocannabinoid system and its therapeutic implications in rheumatoid arthritis. International immunopharmacology. vol 26. issue 1. 2016-02-16. PMID:25791728. |
increasing evidence suggests that the endocannabinoid system, especially cannabinoid receptor 2 (cb2), has an important role in the pathophysiology of ra. |
2016-02-16 |
2023-08-13 |
Not clear |
| Panagiotis Zogopoulos, Penelope Korkolopoulou, Efstratios Patsouris, Stamatios Theochari. The antitumor action of cannabinoids on glioma tumorigenesis. Histology and histopathology. vol 30. issue 6. 2016-02-09. PMID:25472761. |
cannabinoids are a class of chemical compounds with a wide spectrum of pharmacological effects, mediated by two specific plasma membrane receptors (cb1 and cb2). |
2016-02-09 |
2023-08-13 |
human |
| Jiong-jiong Chen, Shuang Han, Yang Cao, Jian-zhong Che. The agonist binding mechanism of human CB2 receptor studied by molecular dynamics simulation, free energy calculation and 3D-QSAR studies. Yao xue xue bao = Acta pharmaceutica Sinica. vol 48. issue 9. 2016-02-02. PMID:24358778. |
however, the lack of experimental data of the 3d structures of human cannabinoid receptors hampers the understanding of the binding modes between ligands and cb2 by traditional methods. |
2016-02-02 |
2023-08-12 |
human |
| Antonia Sophocleous, Silvia Marino, John G Logan, Patrick Mollat, Stuart H Ralston, Aymen I Idri. Bone Cell-autonomous Contribution of Type 2 Cannabinoid Receptor to Breast Cancer-induced Osteolysis. The Journal of biological chemistry. vol 290. issue 36. 2016-02-01. PMID:26195631. |
the cannabinoid type 2 receptor (cb2) has previously been implicated as a regulator of tumor growth, bone remodeling, and bone pain. |
2016-02-01 |
2023-08-13 |
mouse |
| Adriana M Godin, Débora P Araújo, Isabela C César, Raquel R Menezes, Ana Mercy S Brito, Ivo S F Melo, Giovanna M E Coura, Leandro F S Bastos, Mariana O Almeida, Ricardo M D Byrro, Tamires C Matsui, Carla R A Batista, Gerson A Pianetti, Ângelo de Fátima, Renes R Machado, Márcio M Coelh. Activities of 2-phthalimidethyl nitrate and 2-phthalimidethanol in the models of nociceptive response and edema induced by formaldehyde in mice and preliminary investigation of the underlying mechanisms. European journal of pharmacology. vol 756. 2016-01-28. PMID:25794846. |
the antiedematogenic activities of both analogs were not affected by the cb2 cannabinoid antagonist am630 (4 or 8 mg/kg, i.p., -30 min). |
2016-01-28 |
2023-08-13 |
mouse |
| Rentian Feng, Qin Tong, Zhaojun Xie, Haizi Cheng, Lirong Wang, Suzanne Lentzsch, G David Roodman, Xiang-Qun Xi. Targeting cannabinoid receptor-2 pathway by phenylacetylamide suppresses the proliferation of human myeloma cells through mitotic dysregulation and cytoskeleton disruption. Molecular carcinogenesis. vol 54. issue 12. 2016-01-22. PMID:25640641. |
cannabinoid receptor-2 (cb2) is expressed dominantly in the immune system, especially on plasma cells. |
2016-01-22 |
2023-08-13 |
human |
| Ching-Heng Ting, Chin-Wen Chi, Chung-Pin Li, Chih-Yen Che. Differential modulation of endogenous cannabinoid CB1 and CB2 receptors in spontaneous and splice variants of ghrelin-induced food intake in conscious rats. Nutrition (Burbank, Los Angeles County, Calif.). vol 31. issue 1. 2016-01-11. PMID:25466669. |
differential modulation of endogenous cannabinoid cb1 and cb2 receptors in spontaneous and splice variants of ghrelin-induced food intake in conscious rats. |
2016-01-11 |
2023-08-13 |
rat |
| Michael W Calik, David W Carle. Cannabinoid type 1 and type 2 receptor antagonists prevent attenuation of serotonin-induced reflex apneas by dronabinol in Sprague-Dawley rats. PloS one. vol 9. issue 10. 2016-01-08. PMID:25350456. |
vagal afferent neurons are inhibited by cannabinoid type 1 (cb1) or cannabinoid type 2 (cb2) receptors in animal models of vagally-mediated behaviors. |
2016-01-08 |
2023-08-13 |
rat |
| L Jean-Gilles, M Braitch, M L Latif, J Aram, A J Fahey, L J Edwards, R A Robins, R Tanasescu, P J Tighe, B Gran, L C Showe, S P Alexander, V Chapman, D A Kendall, C S Constantinesc. Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells. Acta physiologica (Oxford, England). vol 214. issue 1. 2016-01-06. PMID:25704169. |
effects of pro-inflammatory cytokines on cannabinoid cb1 and cb2 receptors in immune cells. |
2016-01-06 |
2023-08-13 |
Not clear |
| L Jean-Gilles, M Braitch, M L Latif, J Aram, A J Fahey, L J Edwards, R A Robins, R Tanasescu, P J Tighe, B Gran, L C Showe, S P Alexander, V Chapman, D A Kendall, C S Constantinesc. Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells. Acta physiologica (Oxford, England). vol 214. issue 1. 2016-01-06. PMID:25704169. |
to investigate the regulation of cannabinoid receptors cb1 and cb2 on immune cells by pro-inflammatory cytokines and its potential relevance to the inflammatory neurological disease, multiple sclerosis (ms). |
2016-01-06 |
2023-08-13 |
Not clear |