| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jimok Kim, Yong L. Chronic activation of CB2 cannabinoid receptors in the hippocampus increases excitatory synaptic transmission. The Journal of physiology. vol 593. issue 4. 2015-12-04. PMID:25504573. |
the effects of cannabinoids are primarily mediated by two types of cannabinoid receptors, cb1 receptors in the nervous system and cb2 receptors in the immune system. |
2015-12-04 |
2023-08-13 |
Not clear |
| Jimok Kim, Yong L. Chronic activation of CB2 cannabinoid receptors in the hippocampus increases excitatory synaptic transmission. The Journal of physiology. vol 593. issue 4. 2015-12-04. PMID:25504573. |
this study reveals a novel role of cb2 receptors in the brain, which is clearly distinct from that of cb1 receptors, and thus, will help us to understand better the diverse effects of cannabinoids in the nervous system. |
2015-12-04 |
2023-08-13 |
Not clear |
| Ekaitz Agirregoitia, Inés Ibarra-Lecue, Lide Totorikaguena, Rosario Mendoza, Antonia Expósito, Roberto Matorras, Leyre Urigüen, Naiara Agirregoiti. Dynamics of expression and localization of the cannabinoid system in granulosa cells during oocyte nuclear maturation. Fertility and sterility. vol 104. issue 3. 2015-11-23. PMID:26144572. |
to describe the expression of cannabinoid receptors cb1 and cb2 and cannabinoid-degrading enzymes fatty acid amide hydrolase (faah) and monoglyceride lipase (mgll) in human granulosa cells and to investigate their differential distribution with respect to cb1 at various stages during the nuclear maturation of the oocyte. |
2015-11-23 |
2023-08-13 |
human |
| Bandana Chakravarti, Janani Ravi, Ramesh K Ganj. Cannabinoids as therapeutic agents in cancer: current status and future implications. Oncotarget. vol 5. issue 15. 2015-11-20. PMID:25115386. |
there is more focus on cb1 and cb2, the two cannabinoid receptors which are activated by most of the cannabinoids. |
2015-11-20 |
2023-08-13 |
Not clear |
| Christeene G Haj, Percy F Sumariwalla, Lumír Hanuš, Natalya M Kogan, Zhana Yektin, Raphael Mechoulam, Mark Feldmann, Ruth Gallil. HU-444, a Novel, Potent Anti-Inflammatory, Nonpsychotropic Cannabinoid. The Journal of pharmacology and experimental therapeutics. vol 355. issue 1. 2015-11-17. PMID:26272937. |
in contrast to Δ(9)-tetrahydrocannabinol (Δ(9)-thc), it binds very weakly to the cb1 and cb2 cannabinoid receptors. |
2015-11-17 |
2023-08-13 |
mouse |
| Gergely Fügedi, Miklós Molnár, János Rigó, Júlia Schönléber, Ilona Kovalszky, Attila Molvare. Increased placental expression of cannabinoid receptor 1 in preeclampsia: an observational study. BMC pregnancy and childbirth. vol 14. 2015-11-16. PMID:25444073. |
in the present study, we aimed to analyze cannabinoid receptor 1 (cb1), cb2 and fatty acid amid hydrolase (faah) expressions and localization in normal and preeclamptic placenta, in order to determine whether placental endocannabinoid expression pattern differs between normal pregnancy and preeclampsia. |
2015-11-16 |
2023-08-13 |
Not clear |
| Sabrina F Lisboa, Anna A Borges, Priscila Nejo, Aline Fassini, Francisco S Guimarães, Leonardo B Resste. Cannabinoid CB1 receptors in the dorsal hippocampus and prelimbic medial prefrontal cortex modulate anxiety-like behavior in rats: additional evidence. Progress in neuro-psychopharmacology & biological psychiatry. vol 59. 2015-11-16. PMID:25595265. |
endocannabinoids (ecbs) such as anandamide (aea) act by activating cannabinoid type 1 (cb1) or 2 (cb2) receptors. |
2015-11-16 |
2023-08-13 |
rat |
| Georg D Duerr, Jan C Heinemann, Christopher Gestrich, Tobias Heuft, Timo Klaas, Katharina Keppel, Wilhelm Roell, Alexandra Klein, Andreas Zimmer, Markus Velten, Ana Kilic, Laura Bindila, Beat Lutz, Oliver Dewal. Impaired border zone formation and adverse remodeling after reperfused myocardial infarction in cannabinoid CB2 receptor deficient mice. Life sciences. vol 138. 2015-11-09. PMID:25447445. |
impaired border zone formation and adverse remodeling after reperfused myocardial infarction in cannabinoid cb2 receptor deficient mice. |
2015-11-09 |
2023-08-13 |
mouse |
| Jan C Heinemann, Georg D Duerr, Katharina Keppel, Martin Breitbach, Bernd K Fleischmann, Andreas Zimmer, Sven Wehner, Armin Welz, Oliver Dewal. CB2 receptor-mediated effects of pro-inflammatory macrophages influence survival of cardiomyocytes. Life sciences. vol 138. 2015-11-09. PMID:25497711. |
the endocannabinoid system and cannabinoid receptor 2 (cb2 receptor) have been associated with modulation of inflammatory response and myocardial adaptation after ischemic injury. |
2015-11-09 |
2023-08-13 |
Not clear |
| Richard D Ronca, Alyssa M Myers, Doina Ganea, Ronald F Tuma, Ellen A Walker, Sara Jane War. A selective cannabinoid CB2 agonist attenuates damage and improves memory retention following stroke in mice. Life sciences. vol 138. 2015-11-09. PMID:26032254. |
a selective cannabinoid cb2 agonist attenuates damage and improves memory retention following stroke in mice. |
2015-11-09 |
2023-08-13 |
mouse |
| Richard D Ronca, Alyssa M Myers, Doina Ganea, Ronald F Tuma, Ellen A Walker, Sara Jane War. A selective cannabinoid CB2 agonist attenuates damage and improves memory retention following stroke in mice. Life sciences. vol 138. 2015-11-09. PMID:26032254. |
we have recently demonstrated that treatment with a cannabinoid cb2 agonist was protective in a mouse middle cerebral artery occlusion model of cerebral ischemia/reperfusion injury. |
2015-11-09 |
2023-08-13 |
mouse |
| Reem Smoum, Saja Baraghithy, Mukesh Chourasia, Aviva Breuer, Naama Mussai, Malka Attar-Namdar, Natalya M Kogan, Bitya Raphael, Daniele Bolognini, Maria G Cascio, Pietro Marini, Roger G Pertwee, Avital Shurki, Raphael Mechoulam, Itai Ba. CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 28. 2015-10-30. PMID:26124120. |
however, the endogenous cannabinoids, as well as Δ(9)-tetrahydrocannabinol, the main plant psychoactive constituent, activate both cannabinoid receptors, cb1 and cb2. |
2015-10-30 |
2023-08-13 |
mouse |
| Marisol S Castaneto, David A Gorelick, Nathalie A Desrosiers, Rebecca L Hartman, Sandrine Pirard, Marilyn A Huesti. Synthetic cannabinoids: epidemiology, pharmacodynamics, and clinical implications. Drug and alcohol dependence. vol 144. 2015-10-30. PMID:25220897. |
the majority of sc detected in herbal products have greater binding affinity to the cannabinoid cb1 receptor than does Δ(9)-tetrahydrocannabinol (thc), the primary psychoactive compound in the cannabis plant, and greater affinity at the cb1 than the cb2 receptor. |
2015-10-30 |
2023-08-13 |
human |
| Patricia Rivera, Eduardo Blanco, Laura Bindila, Francisco Alen, Antonio Vargas, Leticia Rubio, Francisco J Pavón, Antonia Serrano, Beat Lutz, Fernando Rodríguez de Fonseca, Juan Suáre. Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the adult rat brain. Frontiers in cellular neuroscience. vol 9. 2015-10-20. PMID:26483633. |
we evaluated the protective effects of the selective cb1 receptor agonist acea, the selective cb2 receptor agonist jwh133 and the fatty-acid amide-hydrolase (faah) inhibitor urb597, which enhances endocannabinoid receptor activity, on npc proliferation in rats with forced consumption of ethanol (10%) or sucrose liquid diets for 2 weeks. |
2015-10-20 |
2023-08-13 |
rat |
| Weisi Fu, Bradley K Taylo. Activation of cannabinoid CB2 receptors reduces hyperalgesia in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis. Neuroscience letters. vol 595. 2015-10-20. PMID:25849525. |
activation of cannabinoid cb2 receptors reduces hyperalgesia in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis. |
2015-10-20 |
2023-08-13 |
mouse |
| Esmée Vendel, Elizabeth C M de Lang. Functions of the CB1 and CB 2 receptors in neuroprotection at the level of the blood-brain barrier. Neuromolecular medicine. vol 16. issue 3. 2015-10-15. PMID:24929655. |
cannabinoids and the bbb share the same mechanisms of neuroprotection and both protect against excitotoxicity (cb1), cell death (cb1), inflammation (cb2) and oxidative stress (possibly cb independent)-all processes that also damage the bbb. |
2015-10-15 |
2023-08-13 |
Not clear |
| Zubair Malik, Daniel Baik, Ron Sche. The role of cannabinoids in regulation of nausea and vomiting, and visceral pain. Current gastroenterology reports. vol 17. issue 2. 2015-10-13. PMID:25715910. |
several cannabinoid receptors, which include the cannabinoid receptor 1 (cb1), cb2, and possibly gpr55, have been identified throughout the gi tract. |
2015-10-13 |
2023-08-13 |
Not clear |
| G Bellini, A N Olivieri, A Grandone, M Alessio, M F Gicchino, B Nobili, L Perrone, S Maione, E Miraglia del Giudice, F Ross. Association between cannabinoid receptor type 2 Q63R variant and oligo/polyarticular juvenile idiopathic arthritis. Scandinavian journal of rheumatology. vol 44. issue 4. 2015-10-08. PMID:25974389. |
to investigate whether the functional variant q63r of the cannabinoid 2 (cb2) receptor is associated with susceptibility to oligo/poly-articular juvenile idiopathic arthritis (jia) and with its clinical features. |
2015-10-08 |
2023-08-13 |
Not clear |
| Takayo Haruna, Masahiko Soga, Yasuhide Morioka, Ichiro Hikita, Kinichi Imura, Yoko Furue, Mina Yamamoto, Chihiro Imura, Minoru Ikeda, Akira Yamauchi, Masashi Deguchi, Michitaka Shichijo, Akinori Arimura, Kiyoshi Yasu. S-777469, a novel cannabinoid type 2 receptor agonist, suppresses itch-associated scratching behavior in rodents through inhibition of itch signal transmission. Pharmacology. vol 95. issue 1-2. 2015-10-06. PMID:25721168. |
we have previously reported that s-777469 [1-([6-ethyl-1-(4-fluorobenzyl)-5-methyl-2-oxo-1,2-dihydropyridine-3-carbonyl]amino)-cyclohexanecarboxylic acid], a novel cannabinoid type 2 receptor (cb2) agonist, significantly suppressed compound 48/80-induced scratching behavior in mice in a dose-dependent manner when it was administered orally. |
2015-10-06 |
2023-08-13 |
mouse |
| Oya Yonal, Fatih Eren, Yusuf Yılmaz, Özlen Atuğ, Hülya Hamzaoğlu Öve. No association between the functional cannabinoid receptor type 2 Q63R variants and inflammatory bowel disease in Turkish subjects. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology. vol 25. issue 6. 2015-10-01. PMID:25599774. |
the endocannabinoid system can exert beneficial effects on gastrointestinal inflammation, and cannabinoid receptor-2 (cb2) agonists may represent a new therapeutic approach in inflammatory bowel disease (ibd). |
2015-10-01 |
2023-08-13 |
human |