| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gabriela Rodríguez-Manzo, Ana Canseco-Alb. Biphasic effects of anandamide on behavioural responses: emphasis on copulatory behaviour. Behavioural pharmacology. vol 26. issue 6. 2016-05-05. PMID:26226145. |
the fatty acid amide, arachidonoylethanolamide (anandamide), is an important endogenous ligand of the g-protein-coupled cannabinoid receptors cb1 and cb2. |
2016-05-05 |
2023-08-13 |
rat |
| Cristina Miliano, Giovanni Serpelloni, Claudia Rimondo, Maddalena Mereu, Matteo Marti, Maria Antonietta De Luc. Neuropharmacology of New Psychoactive Substances (NPS): Focus on the Rewarding and Reinforcing Properties of Cannabimimetics and Amphetamine-Like Stimulants. Frontiers in neuroscience. vol 10. 2016-05-05. PMID:27147945. |
moreover, the review will include recent data from our lab which links jwh-018, a cb1 and cb2 agonist more potent than Δ(9)-thc, to other cannabinoids with known abuse potential, and to other classes of abused drugs that increase dopamine signaling in the nucleus accumbens (nac) shell. |
2016-05-05 |
2023-08-13 |
Not clear |
| Kajetan Juszczak, Piotr Maciukiewic. The role of the peripheral cannabinoid system in the pathogenesis of detrusor overactivity evoked by increased intravesical osmolarity in rats. Canadian journal of physiology and pharmacology. vol 93. issue 8. 2016-05-03. PMID:26243021. |
the cannabinoid receptors cb1 and cb2 are localized in the urinary bladder and play a role in the regulation of its function. |
2016-05-03 |
2023-08-13 |
rat |
| Susan Fung, Allison E Cherry, Cong Xu, Nephi Stell. Alkylindole-sensitive receptors modulate microglial cell migration and proliferation. Glia. vol 63. issue 10. 2016-05-03. PMID:25914169. |
cannabinoids, including the active component of the cannabis plant, tetrahydrocannabinol (thc), and the synthetic alkylindole (ai) compound, win55212-2 (win-2), activate two molecularly identified gpcrs: cb1 and cb2 . |
2016-05-03 |
2023-08-13 |
mouse |
| Ana Belen Lopez-Rodriguez, Estefania Acaz-Fonseca, Maria-Paz Viveros, Luis M Garcia-Segur. Changes in cannabinoid receptors, aquaporin 4 and vimentin expression after traumatic brain injury in adolescent male mice. Association with edema and neurological deficit. PloS one. vol 10. issue 6. 2016-04-27. PMID:26039099. |
the purpose of this study was to assess the contribution of cannabinoid receptors (cb1 and cb2), blood brain barrier proteins (aqp4) and astrogliosis markers (vimentin) to neurological deficit and brain edema formation in a tbi weight drop model in adolescent male mice. |
2016-04-27 |
2023-08-13 |
mouse |
| Johannes Wedel, Prama Pallavi, Eleni Stamellou, Benito A Yar. N-acyl dopamine derivates as lead compound for implementation in transplantation medicine. Transplantation reviews (Orlando, Fla.). vol 29. issue 3. 2016-04-22. PMID:25576467. |
anandamide and 2-arachidonoyl glycerol are the best characterized endocannabinoids activating both cannabinoid receptors (cb1 and cb2) and transient receptor potential vanilloid type 1 (trpv1) channels (anandamide) or activating cannabinoid receptors only (2-arachidonoyl glycerol). |
2016-04-22 |
2023-08-13 |
Not clear |
| Xuhong Lin, Huichao Wang, Yongyu Li, Chunqiu Chen, Yajing Feng, Jakub Fichn. Cannabinoids regulate intestinal motor function and electrophysiological activity of myocytes in rodents. Archives of medical research. vol 46. issue 6. 2016-04-19. PMID:26254701. |
this study aims to investigate the effects of cannabinoid (cb)1 and cb2 receptor ligands on intestinal motor function and muscular electrophysiological activity in rodent gastrointestinal (gi) tract. |
2016-04-19 |
2023-08-13 |
Not clear |
| Alena V Savonenko, Tatiana Melnikova, Yuchuan Wang, Hayden Ravert, Yongjun Gao, Jeremy Koppel, Deidre Lee, Olga Pletnikova, Eugenia Cho, Nuzhat Sayyida, Andrew Hiatt, Juan Troncoso, Peter Davies, Robert F Dannals, Martin G Pomper, Andrew G Hort. Cannabinoid CB2 Receptors in a Mouse Model of Aβ Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of Neuroinflammation. PloS one. vol 10. issue 6. 2016-04-14. PMID:26086915. |
cannabinoid cb2 receptors in a mouse model of aβ amyloidosis: immunohistochemical analysis and suitability as a pet biomarker of neuroinflammation. |
2016-04-14 |
2023-08-13 |
mouse |
| Michael D Roth, Julie T Castaneda, Sylvia M Kiertsche. Exposure to Δ9-Tetrahydrocannabinol Impairs the Differentiation of Human Monocyte-derived Dendritic Cells and their Capacity for T cell Activation. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 10. issue 2. 2016-04-01. PMID:25614186. |
monocytes express intracellular cannabinoid type 1 (cb1) and 2 (cb2) receptors and we demonstrate that exposure to Δ9-tetrahydrocannabinol (thc) inhibits the forskolin-induced generation of cyclic adenosine monophosphate in a cb2-specific manner. |
2016-04-01 |
2023-08-13 |
human |
| Yuri Persidsky, Shongshan Fan, Holly Dykstra, Nancy L Reichenbach, Slava Rom, Servio H Ramire. Activation of Cannabinoid Type Two Receptors (CB2) Diminish Inflammatory Responses in Macrophages and Brain Endothelium. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 10. issue 2. 2016-04-01. PMID:25666933. |
activation of cannabinoid type two receptors (cb2) diminish inflammatory responses in macrophages and brain endothelium. |
2016-04-01 |
2023-08-13 |
human |
| Francisco Espejo-Porras, Fabiana Piscitelli, Roberta Verde, José A Ramos, Vincenzo Di Marzo, Eva de Lago, Javier Fernández-Rui. Changes in the endocannabinoid signaling system in CNS structures of TDP-43 transgenic mice: relevance for a neuroprotective therapy in TDP-43-related disorders. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 10. issue 2. 2016-04-01. PMID:25819934. |
in conclusion, our data support the idea that the endocannabinoid signaling system, in particular the cb2 receptor, may serve for the development of a neuroprotective therapy in tdp-43-related disorders. |
2016-04-01 |
2023-08-13 |
mouse |
| Toby K Eisenstein, Joseph J Meissle. Effects of Cannabinoids on T-cell Function and Resistance to Infection. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 10. issue 2. 2016-04-01. PMID:25876735. |
the overall conclusion of the studies discussed in this review is that cannabinoids that bind to the cb2 receptor, including ∆(9)-thc and cb2 selective agonists are immunosuppressive. |
2016-04-01 |
2023-08-13 |
Not clear |
| Oscar Gomez, Maria A Sanchez-Rodriguez, Silvia Ortega-Gutierrez, Henar Vazquez-Villa, Carmen Guaza, Francisco Molina-Holgado, Eduardo Molina-Holgad. A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 10. issue 2. 2016-04-01. PMID:25900077. |
we found that the blockade of 2-ag synthesizing enzymes, sn-1-diacylglycerol lipases α and β (dagls), with rhc-80267 or the antagonism of either cb1 or cb2 cannabinoid receptors with am281 and am630, respectively, impaired early opc proliferation stimulated by platelet-derived growth factor (pdgf-aa) and basic fibroblast growth factor (bfgf). |
2016-04-01 |
2023-08-13 |
Not clear |
| Sean D McAllister, Liliana Soroceanu, Pierre-Yves Despre. The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 10. issue 2. 2016-04-01. PMID:25916739. |
as a therapeutic agent, most people are familiar with the palliative effects of the primary psychoactive constituent of cannabis sativa (cs), Δ(9)-tetrahydrocannabinol (thc), a molecule active at both the cannabinoid 1 (cb1) and cannabinoid 2 (cb2) receptor subtypes. |
2016-04-01 |
2023-08-13 |
Not clear |
| Guy A Cabral, Thomas J Rogers, Aron H Lichtma. Turning Over a New Leaf: Cannabinoid and Endocannabinoid Modulation of Immune Function. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 10. issue 2. 2016-04-01. PMID:26054900. |
the major psychoactive phytocannabinoid found in cannabis ∆(9)-tetrahydrocannabinol (thc) produces the majority of its pharmacological effects through two cannabinoid receptors, termed cb1 and cb2. |
2016-04-01 |
2023-08-13 |
human |
| C R Hutch, C J Hillard, C Jia, C C Heg. An endocannabinoid system is present in the mouse olfactory epithelium but does not modulate olfaction. Neuroscience. vol 300. 2016-03-29. PMID:26037800. |
we found the presence of cannabinoid type 1 (cb1) and cannabinoid type 2 (cb2) receptor protein and mrna in the olfactory epithelium. |
2016-03-29 |
2023-08-13 |
mouse |
| Tyrell Simkins, Robert B Crawford, John L Goudreau, Keith J Lookingland, Barbara L F Kapla. Enhanced humoral immunity in mice lacking CB1 and CB2 receptors (Cnr1-/-/Cnr2-/- mice) is not due to increased splenic noradrenergic neuronal activity. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 9. issue 4. 2016-03-28. PMID:24870806. |
cannabinoids are immunosuppressive, and mice lacking cb1 and cb2 receptors (cnr1(-/-)/cnr2(-/-) mice) have augmented cell-mediated immune responses. |
2016-03-28 |
2023-08-13 |
mouse |
| Vishnudutt Purohit, Rao S Rapaka, Joni Rutte. Cannabinoid receptor-2 and HIV-associated neurocognitive disorders. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 9. issue 4. 2016-03-28. PMID:25015040. |
in this regard, cannabinoid receptor-2(cb2) activation is a promising means to attenuate hand by inhibiting hiv replication, down regulating inflammation, and suppressing chemokine-like activity of viral neurotoxic proteins (for example, tat and hiv-1gp120), and thereby prevent neuronal and synaptic loss. |
2016-03-28 |
2023-08-13 |
Not clear |
| Julia Kremshofer, Monika Siwetz, Veronika M Berghold, Ingrid Lang, Berthold Huppertz, Martin Gauste. A role for GPR55 in human placental venous endothelial cells. Histochemistry and cell biology. vol 144. issue 1. 2016-03-22. PMID:25869640. |
g protein-coupled receptor 55 (gpr55) was previously postulated to be another cannabinoid receptor, since specific cannabinoids were shown to act independently of the classical cannabinoid receptors cb1 or cb2. |
2016-03-22 |
2023-08-13 |
human |
| Natalia Malek, Katarzyna Popiolek-Barczyk, Joanna Mika, Barbara Przewlocka, Katarzyna Starowic. Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures. Neural plasticity. vol 2015. 2016-03-09. PMID:26090232. |
anandamide as an immune modulator in the central nervous system acts via not only cannabinoid receptors (cb1 and cb2) but also other targets (e.g., gpr18/gpr55). |
2016-03-09 |
2023-08-13 |
rat |