| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrea Chicca, Maria Salomé Gachet, Vanessa Petrucci, Wolfgang Schuehly, Roch-Philippe Charles, Jürg Gertsc. 4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation. Journal of neuroinflammation. vol 12. 2016-08-08. PMID:25962384. |
in this study, the exact modulation of mh on cb2 receptor activity was elucidated and its endocannabinoid substrate-specific inhibition (ssi) of cyclooxygenase-2 (cox-2) and cns bioavailability are described for the first time. |
2016-08-08 |
2023-08-13 |
mouse |
| Y M Al Suleimani, A S Al Mahruqi, C R Hile. Mechanisms of vasorelaxation induced by the cannabidiol analogue compound O-1602 in the rat small mesenteric artery. European journal of pharmacology. vol 765. 2016-08-01. PMID:26297305. |
o-1602 mediates its vasorelaxant effects partly by an endothelium-dependent pathway involving rimonabant- and o-1918-sensitive targets that are distinct from the classical cb1 and cb2 cannabinoid receptors and might involve activation of kca. |
2016-08-01 |
2023-08-13 |
human |
| Mingyue Zhang, Kun Wang, Min Ma, Songyu Tian, Na Wei, Guonian Wan. Low-Dose Cannabinoid Type 2 Receptor Agonist Attenuates Tolerance to Repeated Morphine Administration via Regulating μ-Opioid Receptor Expression in Walker 256 Tumor-Bearing Rats. Anesthesia and analgesia. vol 122. issue 4. 2016-07-28. PMID:26720619. |
previous studies have shown that cannabinoid type 2 (cb2) receptor agonists induce morphine analgesia, attenuate morphine tolerance in normal and neuropathic pain animals, induce transcription of the μ-opioid receptor (mor) gene in jurkat t cells, and increase morphine analgesia in cancer pain animals. |
2016-07-28 |
2023-08-13 |
rat |
| Doodipala Samba Reddy, Victoria M Golu. The Pharmacological Basis of Cannabis Therapy for Epilepsy. The Journal of pharmacology and experimental therapeutics. vol 357. issue 1. 2016-07-19. PMID:26787773. |
cbd is anticonvulsant, but it has a low affinity for the cannabinoid receptors cb1 and cb2; therefore the exact mechanism by which it affects seizures remains poorly understood. |
2016-07-19 |
2023-08-13 |
Not clear |
| Rubén García-Cabrerizo, M Julia García-Fuste. Opposite regulation of cannabinoid CB1 and CB2 receptors in the prefrontal cortex of rats treated with cocaine during adolescence. Neuroscience letters. vol 615. 2016-07-14. PMID:26797579. |
opposite regulation of cannabinoid cb1 and cb2 receptors in the prefrontal cortex of rats treated with cocaine during adolescence. |
2016-07-14 |
2023-08-13 |
rat |
| Rubén García-Cabrerizo, M Julia García-Fuste. Opposite regulation of cannabinoid CB1 and CB2 receptors in the prefrontal cortex of rats treated with cocaine during adolescence. Neuroscience letters. vol 615. 2016-07-14. PMID:26797579. |
the endocannabinoid system is implicated in the neurobiology of cocaine addiction, although it is not clear how cocaine regulates brain cb1 and cb2 receptors, especially during adolescence, a critical moment for shaping adult response to drug use. |
2016-07-14 |
2023-08-13 |
rat |
| Eric W Bow, John M Rimold. The Structure-Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation. Perspectives in medicinal chemistry. vol 8. 2016-07-11. PMID:27398024. |
the cannabinoids are members of a deceptively simple class of terpenophenolic secondary metabolites isolated from cannabis sativa highlighted by (-)-Δ(9)-tetrahydrocannabinol (thc), eliciting distinct pharmacological effects mediated largely by cannabinoid receptor (cb1 or cb2) signaling. |
2016-07-11 |
2023-08-13 |
Not clear |
| Eric W Bow, John M Rimold. The Structure-Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation. Perspectives in medicinal chemistry. vol 8. 2016-07-11. PMID:27398024. |
cumulative structure-activity relationship studies to date have helped define the critical structural elements required for potency and selectivity toward cb1 and cb2 and, more importantly, ushered the discovery and development of contemporary nonclassical cannabinoid modulators with enhanced physicochemical and pharmacological profiles. |
2016-07-11 |
2023-08-13 |
Not clear |
| Ahmet Altun, Kemal Yildirim, Ercan Ozdemir, Ihsan Bagcivan, Sinan Gursoy, Nedim Durmu. Attenuation of morphine antinociceptive tolerance by cannabinoid CB1 and CB2 receptor antagonists. The journal of physiological sciences : JPS. vol 65. issue 5. 2016-07-01. PMID:25894754. |
attenuation of morphine antinociceptive tolerance by cannabinoid cb1 and cb2 receptor antagonists. |
2016-07-01 |
2023-08-13 |
rat |
| Ahmet Altun, Kemal Yildirim, Ercan Ozdemir, Ihsan Bagcivan, Sinan Gursoy, Nedim Durmu. Attenuation of morphine antinociceptive tolerance by cannabinoid CB1 and CB2 receptor antagonists. The journal of physiological sciences : JPS. vol 65. issue 5. 2016-07-01. PMID:25894754. |
cannabinoid cb1 and cb2 receptor antagonists may be useful for their potential to increase or prolong opioid analgesia while attenuating the development of opioid tolerance. |
2016-07-01 |
2023-08-13 |
rat |
| Jessica Margaret Sido, Prakash S Nagarkatti, Mitzi Nagarkatt. Role of Endocannabinoid Activation of Peripheral CB1 Receptors in the Regulation of Autoimmune Disease. International reviews of immunology. vol 34. issue 5. 2016-06-30. PMID:24911431. |
the impact of the endogenous cannabinoids (aea, 2-ag, pea, and virodamine) on the immune cell expressed cannabinoid receptors (cb1, cb2, trpv-1, and gpr55) and consequent regulation of immune function is an exciting area of research with potential implications in the prevention and treatment of inflammatory and autoimmune diseases. |
2016-06-30 |
2023-08-13 |
Not clear |
| Michael Milne, John C Ashto. Effect of cannabinoids on CGRP release in the isolated rat lumbar spinal cord. Neuroscience letters. vol 614. 2016-06-29. PMID:26762784. |
previous studies have reported that cannabinoids, particularly cb2 receptor agonists, can modulate cgrp release in the isolated rat spinal cord. |
2016-06-29 |
2023-08-13 |
rat |
| Marjan Nikan, Seyed Mohammad Nabavi, Azadeh Manay. Ligands for cannabinoid receptors, promising anticancer agents. Life sciences. vol 146. 2016-06-13. PMID:26764235. |
these compounds along with endocannabinoids, a group of neuromodulator compounds in the body especially in brain, express their effects by activation of g-protein-coupled cannabinoid receptors, cb1 and cb2. |
2016-06-13 |
2023-08-13 |
Not clear |
| K R Patil, S N Goyal, C Sharma, C R Patil, S Ojh. Phytocannabinoids for Cancer Therapeutics: Recent Updates and Future Prospects. Current medicinal chemistry. vol 22. issue 30. 2016-06-07. PMID:26179998. |
the ecs includes two g-protein-coupled receptors; the cannabinoid receptors-1 and -2 (cb1 and cb2) for marijuana's psychoactive principle Δ(9)-tetrahydrocannabinol (Δ(9)-thc), their endogenous small lipid ligands; namely anandamide (aea) and 2-arachidonoylglycerol (2-ag), also known as endocannabinoids and the enzymes for endocannabinoid biosynthesis and degradation such as fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl). |
2016-06-07 |
2023-08-13 |
Not clear |
| K R Patil, S N Goyal, C Sharma, C R Patil, S Ojh. Phytocannabinoids for Cancer Therapeutics: Recent Updates and Future Prospects. Current medicinal chemistry. vol 22. issue 30. 2016-06-07. PMID:26179998. |
hence, targeting the cb2 receptors or the endocannabinoid metabolizing enzymes by pcbs obtained from plants lacking psychotropic adverse reactions has garnered interest in drug discovery. |
2016-06-07 |
2023-08-13 |
Not clear |
| Yolanda Gómez-Gálvez, Cristina Palomo-Garo, Javier Fernández-Ruiz, Concepción Garcí. Potential of the cannabinoid CB(2) receptor as a pharmacological target against inflammation in Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 64. 2016-05-31. PMID:25863279. |
the cannabinoid type-2 (cb2) receptor has been investigated as a potential anti-inflammatory and neuroprotective target in different neurodegenerative disorders, but still limited evidence has been collected in pd. |
2016-05-31 |
2023-08-13 |
mouse |
| Chaela S Presley, Suni M Mustafa, Ammaar H Abidi, Bob M Moor. Synthesis and biological evaluation of (3',5'-dichloro-2,6-dihydroxy-biphenyl-4-yl)-aryl/alkyl-methanone selective CB2 inverse agonist. Bioorganic & medicinal chemistry. vol 23. issue 17. 2016-05-26. PMID:26275680. |
in process of designing new cannabinoid ligands we discovered that the 2,6-dihydroxy-biphenyl-aryl methanone scaffold imparts inverse agonist activity at cb2 receptor without functional activity at cb1. |
2016-05-26 |
2023-08-13 |
Not clear |
| Torsten Lowin, Rainer H Strau. Cannabinoid-based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis. Arthritis research & therapy. vol 17. 2016-05-20. PMID:26343051. |
in this review, we focus on cb1 and transient receptor potential vanilloid 1 (trpv1)-mediated effects on ra since most anti-inflammatory mechanisms induced by cannabinoids are attributed to cannabinoid receptor type 2 (cb2) activation. |
2016-05-20 |
2023-08-13 |
Not clear |
| Shu-Kun Jiang, Miao Zhang, Zhi-Ling Tian, Meng Wang, Rui Zhao, Lin-Lin Wang, Shan-Shan Li, Min Liu, Jiao-Yong Li, Meng-Zhou Zhang, Da-Wei Gua. The monoacylglycerol lipase inhibitor JZL184 decreases inflammatory response in skeletal muscle contusion in rats. European journal of pharmacology. vol 761. 2016-05-17. PMID:25912803. |
furthermore, 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-n-morpholin-4-ylpyrazole-3-carboxamide (am281, a selective cannabinoid cb1 receptor antagonist) and [6-iodo-2-methyl-1-(2-morpholin-4-ylethyl)indol-3-yl]-(4-methoxyphenyl)methanone (am630, a selective cannabinoid cb2 receptor antagonist) treatment alleviated the anti-inflammatory effect of jzl184. |
2016-05-17 |
2023-08-13 |
mouse |
| Shu-Kun Jiang, Miao Zhang, Zhi-Ling Tian, Meng Wang, Rui Zhao, Lin-Lin Wang, Shan-Shan Li, Min Liu, Jiao-Yong Li, Meng-Zhou Zhang, Da-Wei Gua. The monoacylglycerol lipase inhibitor JZL184 decreases inflammatory response in skeletal muscle contusion in rats. European journal of pharmacology. vol 761. 2016-05-17. PMID:25912803. |
our findings demonstrate that jzl184 is able to inhibit the inflammatory response and interfere with contused muscle healing, in which the anti-inflammatory action may be mediated through cannabinoid cb1 and cb2 receptors. |
2016-05-17 |
2023-08-13 |
mouse |