| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eric W Bow, John M Rimold. The Structure-Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation. Perspectives in medicinal chemistry. vol 8. 2016-07-11. PMID:27398024. |
cumulative structure-activity relationship studies to date have helped define the critical structural elements required for potency and selectivity toward cb1 and cb2 and, more importantly, ushered the discovery and development of contemporary nonclassical cannabinoid modulators with enhanced physicochemical and pharmacological profiles. |
2016-07-11 |
2023-08-13 |
Not clear |
| Ahmet Altun, Kemal Yildirim, Ercan Ozdemir, Ihsan Bagcivan, Sinan Gursoy, Nedim Durmu. Attenuation of morphine antinociceptive tolerance by cannabinoid CB1 and CB2 receptor antagonists. The journal of physiological sciences : JPS. vol 65. issue 5. 2016-07-01. PMID:25894754. |
attenuation of morphine antinociceptive tolerance by cannabinoid cb1 and cb2 receptor antagonists. |
2016-07-01 |
2023-08-13 |
rat |
| Ahmet Altun, Kemal Yildirim, Ercan Ozdemir, Ihsan Bagcivan, Sinan Gursoy, Nedim Durmu. Attenuation of morphine antinociceptive tolerance by cannabinoid CB1 and CB2 receptor antagonists. The journal of physiological sciences : JPS. vol 65. issue 5. 2016-07-01. PMID:25894754. |
cannabinoid cb1 and cb2 receptor antagonists may be useful for their potential to increase or prolong opioid analgesia while attenuating the development of opioid tolerance. |
2016-07-01 |
2023-08-13 |
rat |
| Jessica Margaret Sido, Prakash S Nagarkatti, Mitzi Nagarkatt. Role of Endocannabinoid Activation of Peripheral CB1 Receptors in the Regulation of Autoimmune Disease. International reviews of immunology. vol 34. issue 5. 2016-06-30. PMID:24911431. |
the impact of the endogenous cannabinoids (aea, 2-ag, pea, and virodamine) on the immune cell expressed cannabinoid receptors (cb1, cb2, trpv-1, and gpr55) and consequent regulation of immune function is an exciting area of research with potential implications in the prevention and treatment of inflammatory and autoimmune diseases. |
2016-06-30 |
2023-08-13 |
Not clear |
| Michael Milne, John C Ashto. Effect of cannabinoids on CGRP release in the isolated rat lumbar spinal cord. Neuroscience letters. vol 614. 2016-06-29. PMID:26762784. |
previous studies have reported that cannabinoids, particularly cb2 receptor agonists, can modulate cgrp release in the isolated rat spinal cord. |
2016-06-29 |
2023-08-13 |
rat |
| Marjan Nikan, Seyed Mohammad Nabavi, Azadeh Manay. Ligands for cannabinoid receptors, promising anticancer agents. Life sciences. vol 146. 2016-06-13. PMID:26764235. |
these compounds along with endocannabinoids, a group of neuromodulator compounds in the body especially in brain, express their effects by activation of g-protein-coupled cannabinoid receptors, cb1 and cb2. |
2016-06-13 |
2023-08-13 |
Not clear |
| K R Patil, S N Goyal, C Sharma, C R Patil, S Ojh. Phytocannabinoids for Cancer Therapeutics: Recent Updates and Future Prospects. Current medicinal chemistry. vol 22. issue 30. 2016-06-07. PMID:26179998. |
the ecs includes two g-protein-coupled receptors; the cannabinoid receptors-1 and -2 (cb1 and cb2) for marijuana's psychoactive principle Δ(9)-tetrahydrocannabinol (Δ(9)-thc), their endogenous small lipid ligands; namely anandamide (aea) and 2-arachidonoylglycerol (2-ag), also known as endocannabinoids and the enzymes for endocannabinoid biosynthesis and degradation such as fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl). |
2016-06-07 |
2023-08-13 |
Not clear |
| K R Patil, S N Goyal, C Sharma, C R Patil, S Ojh. Phytocannabinoids for Cancer Therapeutics: Recent Updates and Future Prospects. Current medicinal chemistry. vol 22. issue 30. 2016-06-07. PMID:26179998. |
hence, targeting the cb2 receptors or the endocannabinoid metabolizing enzymes by pcbs obtained from plants lacking psychotropic adverse reactions has garnered interest in drug discovery. |
2016-06-07 |
2023-08-13 |
Not clear |
| Yolanda Gómez-Gálvez, Cristina Palomo-Garo, Javier Fernández-Ruiz, Concepción Garcí. Potential of the cannabinoid CB(2) receptor as a pharmacological target against inflammation in Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 64. 2016-05-31. PMID:25863279. |
the cannabinoid type-2 (cb2) receptor has been investigated as a potential anti-inflammatory and neuroprotective target in different neurodegenerative disorders, but still limited evidence has been collected in pd. |
2016-05-31 |
2023-08-13 |
mouse |
| Chaela S Presley, Suni M Mustafa, Ammaar H Abidi, Bob M Moor. Synthesis and biological evaluation of (3',5'-dichloro-2,6-dihydroxy-biphenyl-4-yl)-aryl/alkyl-methanone selective CB2 inverse agonist. Bioorganic & medicinal chemistry. vol 23. issue 17. 2016-05-26. PMID:26275680. |
in process of designing new cannabinoid ligands we discovered that the 2,6-dihydroxy-biphenyl-aryl methanone scaffold imparts inverse agonist activity at cb2 receptor without functional activity at cb1. |
2016-05-26 |
2023-08-13 |
Not clear |
| Torsten Lowin, Rainer H Strau. Cannabinoid-based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis. Arthritis research & therapy. vol 17. 2016-05-20. PMID:26343051. |
in this review, we focus on cb1 and transient receptor potential vanilloid 1 (trpv1)-mediated effects on ra since most anti-inflammatory mechanisms induced by cannabinoids are attributed to cannabinoid receptor type 2 (cb2) activation. |
2016-05-20 |
2023-08-13 |
Not clear |
| Katherine E Hanlon, Alysia N Lozano-Ondoua, Puja J Umaretiya, Ashley M Symons-Liguori, Anupama Chandramouli, Jamie K Moy, William K Kwass, Patrick W Mantyh, Mark A Nelson, Todd W Vandera. Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent. Breast cancer (Dove Medical Press). vol 8. 2016-05-17. PMID:27186076. |
cannabinoid compounds, both nonspecific as well as agonists selective for either cannabinoid receptor 1 (cb1) or cannabinoid receptor 2 (cb2), have been shown to modulate the tumor microenvironment by inducing apoptosis in tumor cells in several model systems. |
2016-05-17 |
2023-08-13 |
Not clear |
| Shu-Kun Jiang, Miao Zhang, Zhi-Ling Tian, Meng Wang, Rui Zhao, Lin-Lin Wang, Shan-Shan Li, Min Liu, Jiao-Yong Li, Meng-Zhou Zhang, Da-Wei Gua. The monoacylglycerol lipase inhibitor JZL184 decreases inflammatory response in skeletal muscle contusion in rats. European journal of pharmacology. vol 761. 2016-05-17. PMID:25912803. |
furthermore, 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-n-morpholin-4-ylpyrazole-3-carboxamide (am281, a selective cannabinoid cb1 receptor antagonist) and [6-iodo-2-methyl-1-(2-morpholin-4-ylethyl)indol-3-yl]-(4-methoxyphenyl)methanone (am630, a selective cannabinoid cb2 receptor antagonist) treatment alleviated the anti-inflammatory effect of jzl184. |
2016-05-17 |
2023-08-13 |
mouse |
| Shu-Kun Jiang, Miao Zhang, Zhi-Ling Tian, Meng Wang, Rui Zhao, Lin-Lin Wang, Shan-Shan Li, Min Liu, Jiao-Yong Li, Meng-Zhou Zhang, Da-Wei Gua. The monoacylglycerol lipase inhibitor JZL184 decreases inflammatory response in skeletal muscle contusion in rats. European journal of pharmacology. vol 761. 2016-05-17. PMID:25912803. |
our findings demonstrate that jzl184 is able to inhibit the inflammatory response and interfere with contused muscle healing, in which the anti-inflammatory action may be mediated through cannabinoid cb1 and cb2 receptors. |
2016-05-17 |
2023-08-13 |
mouse |
| Roman O Iakovenko, Anna N Kazakova, Vasiliy M Muzalevskiy, Alexander Yu Ivanov, Irina A Boyarskaya, Andrea Chicca, Vanessa Petrucci, Jürg Gertsch, Mikhail Krasavin, Galina L Starova, Andrey A Zolotarev, Margarita S Avdontceva, Valentine G Nenajdenko, Aleksander V Vasilye. Reactions of CF3-enones with arenes under superelectrophilic activation: a pathway to trans-1,3-diaryl-1-CF3-indanes, new cannabinoid receptor ligands. Organic & biomolecular chemistry. vol 13. issue 33. 2016-05-16. PMID:26186675. |
the obtained trans-1,3-diaryl-1-trifluoromethyl indanes were investigated as potential ligands for cannabinoid receptors cb1 and cb2 types. |
2016-05-16 |
2023-08-13 |
Not clear |
| Erin M Rock, Cheryl L Limebeer, Jordan M Ward, Arianne Cohen, Katherine Grove, Micah J Niphakis, Benjamin F Cravatt, Linda A Parke. Interference with acute nausea and anticipatory nausea in rats by fatty acid amide hydrolase (FAAH) inhibition through a PPARα and CB1 receptor mechanism, respectively: a double dissociation. Psychopharmacology. vol 232. issue 20. 2016-05-13. PMID:26297326. |
fatty acid amide hydrolase (faah) inhibition elevates anandamide (aea), which acts on cannabinoid (cb1 and cb2) receptors, as well as n-palmitoylethanolamide (pea) and n-oleoylethanolamine (oea), which act on peroxisome proliferator-activated receptor alpha (pparα). |
2016-05-13 |
2023-08-13 |
rat |
| Jack A Prenderville, Áine M Kelly, Eric J Downe. The role of cannabinoids in adult neurogenesis. British journal of pharmacology. vol 172. issue 16. 2016-05-12. PMID:25951750. |
indeed, cannabinoids have clear modulatory roles in adult neurogenesis, probably through activation of both cb1 and cb2 receptors. |
2016-05-12 |
2023-08-13 |
Not clear |
| Torsten Lowin, Georg Pongratz, Rainer H Strau. The synthetic cannabinoid WIN55,212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by activating CB2, TRPV1, TRPA1 and yet unidentified receptor targets. Journal of inflammation (London, England). vol 13. 2016-05-09. PMID:27158245. |
the synthetic cannabinoid win55,212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by activating cb2, trpv1, trpa1 and yet unidentified receptor targets. |
2016-05-09 |
2023-08-13 |
Not clear |
| Torsten Lowin, Georg Pongratz, Rainer H Strau. The synthetic cannabinoid WIN55,212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by activating CB2, TRPV1, TRPA1 and yet unidentified receptor targets. Journal of inflammation (London, England). vol 13. 2016-05-09. PMID:27158245. |
rasfs are sensitive to the action of cannabinoids and they not only express cannabinoid receptors type i and ii (cb1 and cb2) but also transient receptor potential channels type vanilloid (trpv1) and ankyrin (trpa1). |
2016-05-09 |
2023-08-13 |
Not clear |
| Chihiro Nozaki, Astrid Markert, Andreas Zimme. Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 8. 2016-05-06. PMID:25910421. |
we have therefore investigated mice with a genetic deletion of the two main cannabinoid receptors cb1 and cb2, or the main endocannabinoid degrading enzymes, faah and monoacylglycerol lipase (magl), which degrades 2-arachidonoylglycerol (2-ag), in a nitroglycerine-induced animal model of migraine. |
2016-05-06 |
2023-08-13 |
mouse |