| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marta Kruk-Slomka, Grażyna Bial. CB1 receptors in the formation of the different phases of memory-related processes in the inhibitory avoidance test in mice. Behavioural brain research. vol 301. 2016-10-20. PMID:26711911. |
the endocannabinoid system, through the cannabinoid type 1 (cb1) and 2 (cb2) receptors modulates many physiological functions, including different aspects of memory-related processes. |
2016-10-20 |
2023-08-13 |
mouse |
| Mojgan Aghazadeh Tabrizi, Pier Giovanni Baraldi, Pier Andrea Borea, Katia Varan. Medicinal Chemistry, Pharmacology, and Potential Therapeutic Benefits of Cannabinoid CB2 Receptor Agonists. Chemical reviews. vol 116. issue 2. 2016-10-20. PMID:26741146. |
medicinal chemistry, pharmacology, and potential therapeutic benefits of cannabinoid cb2 receptor agonists. |
2016-10-20 |
2023-08-13 |
Not clear |
| Luca Carnevali, Federica Vacondio, Stefano Rossi, Emilio Macchi, Gilberto Spadoni, Annalida Bedini, Inga D Neumann, Silvia Rivara, Marco Mor, Andrea Sgoif. Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety. Scientific reports. vol 5. 2016-10-13. PMID:26656183. |
the anti-arrhythmic effect of urb694 was prevented by pharmacological blockade of the cannabinoid type 1 (cb1), but not of the cb2, receptor. |
2016-10-13 |
2023-08-13 |
rat |
| Gemma Navarro, Paula Morales, Carmen Rodríguez-Cueto, Javier Fernández-Ruiz, Nadine Jagerovic, Rafael Franc. Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders. Frontiers in neuroscience. vol 10. 2016-09-28. PMID:27679556. |
targeting cannabinoid cb2 receptors in the central nervous system. |
2016-09-28 |
2023-08-13 |
human |
| Gemma Navarro, Paula Morales, Carmen Rodríguez-Cueto, Javier Fernández-Ruiz, Nadine Jagerovic, Rafael Franc. Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders. Frontiers in neuroscience. vol 10. 2016-09-28. PMID:27679556. |
endocannabinoids activate two types of specific g-protein-coupled receptors (gpcrs), namely cannabinoid cb1 and cb2. |
2016-09-28 |
2023-08-13 |
human |
| Dai Lu, Rachel Dopart, Debra A Kendal. Controlled downregulation of the cannabinoid CB1 receptor provides a promising approach for the treatment of obesity and obesity-derived type 2 diabetes. Cell stress & chaperones. vol 21. issue 1. 2016-09-26. PMID:26498013. |
the endocannabinoid system is composed of at least two gprotein-coupled receptors (gpcrs), the cannabinoid receptor type 1 (cb1), and the cannabinoid receptor type 2 (cb2). |
2016-09-26 |
2023-08-13 |
Not clear |
| Y Li, J Ki. Neuronal expression of CB2 cannabinoid receptor mRNAs in the mouse hippocampus. Neuroscience. vol 311. 2016-09-14. PMID:26515747. |
in the brain, cb1 cannabinoid receptors primarily mediate the effects of cannabinoids, but cb2 cannabinoid receptors (cb2rs) have recently been discovered in the nervous system and also implicated in neuromodulatory roles. |
2016-09-14 |
2023-08-13 |
mouse |
| Dacai Xu, Jianglin Wang, Zhenkang Zhou, Zhiwei He, Qing Zha. Cannabinoid WIN55, 212-2 induces cell cycle arrest and inhibits the proliferation and migration of human BEL7402 hepatocellular carcinoma cells. Molecular medicine reports. vol 12. issue 6. 2016-09-09. PMID:26500101. |
the results demonstrated that win55, 212‑2 induced cell cycle arrest of the bel7402 cells at the g0/g1 phase via cannabinoid receptor 2 (cb2)‑mediated downregulation of phosphorylated-extracellular signal-regulated kinases (erk)1/2, upregulation of p27, and downregulation of cyclin d1 and cyclin‑dependent kinase 4. |
2016-09-09 |
2023-08-13 |
human |
| Ana Belen Lopez-Rodriguez, Virginia Mela, Estefania Acaz-Fonseca, Luis Miguel Garcia-Segura, Maria-Paz Vivero. CB2 cannabinoid receptor is involved in the anti-inflammatory effects of leptin in a model of traumatic brain injury. Experimental neurology. vol 279. 2016-09-06. PMID:27006282. |
in addition, the possible implication of cb2 cannabinoid receptor in leptin actions has been explored, since it is known that the endocannabinoid system interacts with leptin and actively participates in brain recovery after lesions. |
2016-09-06 |
2023-08-13 |
mouse |
| Roberto Di Maio, Jason R Cannon, J Timothy Greenamyr. Post-status epilepticus treatment with the cannabinoid agonist WIN 55,212-2 prevents chronic epileptic hippocampal damage in rats. Neurobiology of disease. vol 73. 2016-08-29. PMID:25447228. |
g-protein-coupled cannabinoid receptors (cb1 and cb2 receptors) regulate neuronal excitability and have been shown to mediate acute anticonvulsant effects of cannabinoids in animal models. |
2016-08-29 |
2023-08-13 |
rat |
| Salvador Sierra, Natasha Luquin, Alberto J Rico, Virginia Gómez-Bautista, Elvira Roda, Iria G Dopeso-Reyes, Alfonso Vázquez, Eva Martínez-Pinilla, José L Labandeira-García, Rafael Franco, José L Lancieg. Detection of cannabinoid receptors CB1 and CB2 within basal ganglia output neurons in macaques: changes following experimental parkinsonism. Brain structure & function. vol 220. issue 5. 2016-08-19. PMID:24972960. |
detection of cannabinoid receptors cb1 and cb2 within basal ganglia output neurons in macaques: changes following experimental parkinsonism. |
2016-08-19 |
2023-08-13 |
Not clear |
| Eleftheria Lakiotaki, Constantinos Giaginis, Maria Tolia, Paraskevi Alexandrou, Ioanna Delladetsima, Ioanna Giannopoulou, George Kyrgias, Efstratios Patsouris, Stamatios Theochari. Clinical Significance of Cannabinoid Receptors CB1 and CB2 Expression in Human Malignant and Benign Thyroid Lesions. BioMed research international. vol 2015. 2016-08-19. PMID:26539529. |
clinical significance of cannabinoid receptors cb1 and cb2 expression in human malignant and benign thyroid lesions. |
2016-08-19 |
2023-08-13 |
human |
| Eleftheria Lakiotaki, Constantinos Giaginis, Maria Tolia, Paraskevi Alexandrou, Ioanna Delladetsima, Ioanna Giannopoulou, George Kyrgias, Efstratios Patsouris, Stamatios Theochari. Clinical Significance of Cannabinoid Receptors CB1 and CB2 Expression in Human Malignant and Benign Thyroid Lesions. BioMed research international. vol 2015. 2016-08-19. PMID:26539529. |
the endocannabinoid system is comprised of cannabinoid receptors (cb1 and cb2), their endogenous ligands (endocannabinoids), and proteins responsible for their metabolism participate in many different functions indispensable to homeostatic regulation in several tissues, exerting also antitumorigenic effects. |
2016-08-19 |
2023-08-13 |
human |
| Zoltán Benyó, Éva Ruisanchez, Miriam Leszl-Ishiguro, Péter Sándor, Pál Pache. Endocannabinoids in cerebrovascular regulation. American journal of physiology. Heart and circulatory physiology. vol 310. issue 7. 2016-08-19. PMID:26825517. |
all major cell types involved in cerebrovascular control pathways (i.e., smooth muscle, endothelium, neurons, astrocytes, pericytes, microglia, and leukocytes) are capable of synthesizing endocannabinoids and/or express some or several of their target proteins [i.e., the cannabinoid 1 and 2 (cb1 and cb2) receptors and the transient receptor potential vanilloid type 1 ion channel]. |
2016-08-19 |
2023-08-13 |
Not clear |
| Hayate Javed, Sheikh Azimullah, M Emdadul Haque, Shreesh K Ojh. Cannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson's Disease. Frontiers in neuroscience. vol 10. 2016-08-17. PMID:27531971. |
cannabinoid type 2 (cb2) receptors activation protects against oxidative stress and neuroinflammation associated dopaminergic neurodegeneration in rotenone model of parkinson's disease. |
2016-08-17 |
2023-08-13 |
rat |
| Hayate Javed, Sheikh Azimullah, M Emdadul Haque, Shreesh K Ojh. Cannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson's Disease. Frontiers in neuroscience. vol 10. 2016-08-17. PMID:27531971. |
the cannabinoid type two receptors (cb2), an important component of the endocannabinoid system, have recently emerged as neuromodulators and therapeutic targets for neurodegenerative diseases including parkinson's disease (pd). |
2016-08-17 |
2023-08-13 |
rat |
| Stefanie C Hofer, William T Ralvenius, M Salomé Gachet, Jean-Marc Fritschy, Hanns Ulrich Zeilhofer, Jürg Gertsc. Localization and production of peptide endocannabinoids in the rodent CNS and adrenal medulla. Neuropharmacology. vol 98. 2016-08-12. PMID:25839900. |
the endocannabinoid system (ecs) comprises the cannabinoid receptors cb1 and cb2 and their endogenous arachidonic acid-derived agonists 2-arachidonoyl glycerol and anandamide, which play important neuromodulatory roles. |
2016-08-12 |
2023-08-13 |
Not clear |
| María Victoria Bariani, Ana Paula Domínguez Rubio, Maximiliano Cella, Juliana Burdet, Ana María Franchi, Julieta Aisember. Role of the endocannabinoid system in the mechanisms involved in the LPS-induced preterm labor. Reproduction (Cambridge, England). vol 150. issue 6. 2016-08-10. PMID:26347521. |
anandamide (aea) is an endogenous ligand for the cannabinoid receptors cb1 and cb2. |
2016-08-10 |
2023-08-13 |
mouse |
| María Victoria Bariani, Ana Paula Domínguez Rubio, Maximiliano Cella, Juliana Burdet, Ana María Franchi, Julieta Aisember. Role of the endocannabinoid system in the mechanisms involved in the LPS-induced preterm labor. Reproduction (Cambridge, England). vol 150. issue 6. 2016-08-10. PMID:26347521. |
in addition, we also found that lps modulated uterine cannabinoid receptors expression by downregulating cb2 mrna levels and upregulating cb1 protein expression. |
2016-08-10 |
2023-08-13 |
mouse |
| Andrea Chicca, Maria Salomé Gachet, Vanessa Petrucci, Wolfgang Schuehly, Roch-Philippe Charles, Jürg Gertsc. 4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation. Journal of neuroinflammation. vol 12. 2016-08-08. PMID:25962384. |
mh was reported to modulate cannabinoid cb2 receptors as an inverse agonist for camp production and an agonist for intracellular [ca2+]. |
2016-08-08 |
2023-08-13 |
mouse |