| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Tang, Qianwei Chen, Jing Guo, Liming Yang, Yihao Tao, Lin Li, Hongping Miao, Hua Feng, Zhi Chen, Gang Zh. Minocycline Attenuates Neonatal Germinal-Matrix-Hemorrhage-Induced Neuroinflammation and Brain Edema by Activating Cannabinoid Receptor 2. Molecular neurobiology. vol 53. issue 3. 2016-12-13. PMID:25833102. |
a cannabinoid cb2 agonist (jwh133) was used to strengthen the hypothesis, which showed the identical neuroprotective effects of minocycline. |
2016-12-13 |
2023-08-13 |
rat |
| Yong Li, Jimok Ki. Deletion of CB2 cannabinoid receptors reduces synaptic transmission and long-term potentiation in the mouse hippocampus. Hippocampus. vol 26. issue 3. 2016-11-14. PMID:26663094. |
deletion of cb2 cannabinoid receptors reduces synaptic transmission and long-term potentiation in the mouse hippocampus. |
2016-11-14 |
2023-08-13 |
mouse |
| Yong Li, Jimok Ki. Deletion of CB2 cannabinoid receptors reduces synaptic transmission and long-term potentiation in the mouse hippocampus. Hippocampus. vol 26. issue 3. 2016-11-14. PMID:26663094. |
the effects of cannabinoids are mostly mediated by two types of cannabinoid receptors--cb1 receptors in the nervous system and cb2 receptors in the immune system. |
2016-11-14 |
2023-08-13 |
mouse |
| Yong Li, Jimok Ki. Deletion of CB2 cannabinoid receptors reduces synaptic transmission and long-term potentiation in the mouse hippocampus. Hippocampus. vol 26. issue 3. 2016-11-14. PMID:26663094. |
however, cb2 cannabinoid receptors have recently been discovered in the brain and also implicated in neurophysiological functions. |
2016-11-14 |
2023-08-13 |
mouse |
| Yong Li, Jimok Ki. Deletion of CB2 cannabinoid receptors reduces synaptic transmission and long-term potentiation in the mouse hippocampus. Hippocampus. vol 26. issue 3. 2016-11-14. PMID:26663094. |
this study provides insights into the role of cb2 cannabinoid receptors in regulating cognitive functions such as long-term memory. |
2016-11-14 |
2023-08-13 |
mouse |
| Christopher J Coke, Kisha A Scarlett, Mahandranauth A Chetram, Kia J Jones, Brittney J Sandifer, Ahriea S Davis, Adam I Marcus, Cimona V Hinto. Simultaneous Activation of Induced Heterodimerization between CXCR4 Chemokine Receptor and Cannabinoid Receptor 2 (CB2) Reveals a Mechanism for Regulation of Tumor Progression. The Journal of biological chemistry. vol 291. issue 19. 2016-11-08. PMID:26841863. |
given that treatment with cannabinoids has been shown to reduce invasiveness of cancer cells as well as cxcr4-mediated migration of immune cells, it is plausible that cxcr4 signaling can be silenced through a physical heterodimeric association with cb2, thereby inhibiting subsequent functions of cxcr4. |
2016-11-08 |
2023-08-13 |
human |
| Valeria Deiana, María Gómez-Cañas, M Ruth Pazos, Javier Fernández-Ruiz, Battistina Asproni, Elena Cichero, Paola Fossa, Eduardo Muñoz, Francesco Deligia, Gabriele Murineddu, Moisés García-Arencibia, Gerard A Pinn. Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties. European journal of medicinal chemistry. vol 112. 2016-11-07. PMID:26890113. |
previous studies have investigated the relevance and structure-activity relationships (sars) of pyrazole derivatives in relation with cannabinoid receptors, and the series of tricyclic 1,4-dihydroindeno[1,2-c]pyrazoles emerged as potent cb2 receptor ligands. |
2016-11-07 |
2023-08-13 |
human |
| Yong Li, Jimok Ki. CB2 Cannabinoid Receptor Knockout in Mice Impairs Contextual Long-Term Memory and Enhances Spatial Working Memory. Neural plasticity. vol 2016. 2016-11-04. PMID:26819779. |
however, recent discoveries of cb2 cannabinoid receptors in the brain demand accurate determination of whether and how cb2 receptors are involved in the cognitive effects of cannabinoids. |
2016-11-04 |
2023-08-13 |
mouse |
| Yong Li, Jimok Ki. CB2 Cannabinoid Receptor Knockout in Mice Impairs Contextual Long-Term Memory and Enhances Spatial Working Memory. Neural plasticity. vol 2016. 2016-11-04. PMID:26819779. |
cb2 cannabinoid receptors are primarily involved in immune functions, but also implicated in psychiatric disorders such as schizophrenia and depression. |
2016-11-04 |
2023-08-13 |
mouse |
| Yong Li, Jimok Ki. CB2 Cannabinoid Receptor Knockout in Mice Impairs Contextual Long-Term Memory and Enhances Spatial Working Memory. Neural plasticity. vol 2016. 2016-11-04. PMID:26819779. |
our results suggest that cb2 cannabinoid receptors play diverse roles in regulating memory depending on memory types and/or brain areas. |
2016-11-04 |
2023-08-13 |
mouse |
| Partha Mukhopadhyay, Marc Baggelaar, Katalin Erdelyi, Zongxian Cao, Resat Cinar, Filomena Fezza, Bogna Ignatowska-Janlowska, Jenny Wilkerson, Noortje van Gils, Thomas Hansen, Marc Ruben, Marjolein Soethoudt, Laura Heitman, George Kunos, Mauro Maccarrone, Aron Lichtman, Pál Pacher, Mario Van der Stel. The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity. British journal of pharmacology. vol 173. issue 3. 2016-11-01. PMID:26398481. |
the novel, orally available and peripherally restricted selective cannabinoid cb2 receptor agonist lei-101 prevents cisplatin-induced nephrotoxicity. |
2016-11-01 |
2023-08-13 |
Not clear |
| Partha Mukhopadhyay, Marc Baggelaar, Katalin Erdelyi, Zongxian Cao, Resat Cinar, Filomena Fezza, Bogna Ignatowska-Janlowska, Jenny Wilkerson, Noortje van Gils, Thomas Hansen, Marc Ruben, Marjolein Soethoudt, Laura Heitman, George Kunos, Mauro Maccarrone, Aron Lichtman, Pál Pacher, Mario Van der Stel. The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity. British journal of pharmacology. vol 173. issue 3. 2016-11-01. PMID:26398481. |
here, we have characterized 3-cyclopropyl-1-(4-(6-((1,1-dioxidothiomorpholino)methyl)-5-fluoropyridin-2-yl)benzyl)imidazolidine-2,4-dione hydrochloride (lei-101) as a novel, peripherally restricted cannabinoid cb2 receptor agonist, using both in vitro and in vivo models. |
2016-11-01 |
2023-08-13 |
Not clear |
| Hui-Chen Lu, Ken Macki. An Introduction to the Endogenous Cannabinoid System. Biological psychiatry. vol 79. issue 7. 2016-10-28. PMID:26698193. |
the most abundant cannabinoid receptors are the cb1 cannabinoid receptors; however, cb2 cannabinoid receptors, transient receptor potential channels, and peroxisome proliferator activated receptors are also engaged by some cannabinoids. |
2016-10-28 |
2023-08-13 |
Not clear |
| Marta Kruk-Slomka, Grażyna Bial. CB1 receptors in the formation of the different phases of memory-related processes in the inhibitory avoidance test in mice. Behavioural brain research. vol 301. 2016-10-20. PMID:26711911. |
the endocannabinoid system, through the cannabinoid type 1 (cb1) and 2 (cb2) receptors modulates many physiological functions, including different aspects of memory-related processes. |
2016-10-20 |
2023-08-13 |
mouse |
| Mojgan Aghazadeh Tabrizi, Pier Giovanni Baraldi, Pier Andrea Borea, Katia Varan. Medicinal Chemistry, Pharmacology, and Potential Therapeutic Benefits of Cannabinoid CB2 Receptor Agonists. Chemical reviews. vol 116. issue 2. 2016-10-20. PMID:26741146. |
medicinal chemistry, pharmacology, and potential therapeutic benefits of cannabinoid cb2 receptor agonists. |
2016-10-20 |
2023-08-13 |
Not clear |
| Luca Carnevali, Federica Vacondio, Stefano Rossi, Emilio Macchi, Gilberto Spadoni, Annalida Bedini, Inga D Neumann, Silvia Rivara, Marco Mor, Andrea Sgoif. Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety. Scientific reports. vol 5. 2016-10-13. PMID:26656183. |
the anti-arrhythmic effect of urb694 was prevented by pharmacological blockade of the cannabinoid type 1 (cb1), but not of the cb2, receptor. |
2016-10-13 |
2023-08-13 |
rat |
| Gemma Navarro, Paula Morales, Carmen Rodríguez-Cueto, Javier Fernández-Ruiz, Nadine Jagerovic, Rafael Franc. Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders. Frontiers in neuroscience. vol 10. 2016-09-28. PMID:27679556. |
targeting cannabinoid cb2 receptors in the central nervous system. |
2016-09-28 |
2023-08-13 |
human |
| Gemma Navarro, Paula Morales, Carmen Rodríguez-Cueto, Javier Fernández-Ruiz, Nadine Jagerovic, Rafael Franc. Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders. Frontiers in neuroscience. vol 10. 2016-09-28. PMID:27679556. |
endocannabinoids activate two types of specific g-protein-coupled receptors (gpcrs), namely cannabinoid cb1 and cb2. |
2016-09-28 |
2023-08-13 |
human |
| Dai Lu, Rachel Dopart, Debra A Kendal. Controlled downregulation of the cannabinoid CB1 receptor provides a promising approach for the treatment of obesity and obesity-derived type 2 diabetes. Cell stress & chaperones. vol 21. issue 1. 2016-09-26. PMID:26498013. |
the endocannabinoid system is composed of at least two gprotein-coupled receptors (gpcrs), the cannabinoid receptor type 1 (cb1), and the cannabinoid receptor type 2 (cb2). |
2016-09-26 |
2023-08-13 |
Not clear |
| Y Li, J Ki. Neuronal expression of CB2 cannabinoid receptor mRNAs in the mouse hippocampus. Neuroscience. vol 311. 2016-09-14. PMID:26515747. |
in the brain, cb1 cannabinoid receptors primarily mediate the effects of cannabinoids, but cb2 cannabinoid receptors (cb2rs) have recently been discovered in the nervous system and also implicated in neuromodulatory roles. |
2016-09-14 |
2023-08-13 |
mouse |