| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew L Ninnemann, Hye Jeong Choi, Gregory L Stuart, Jeff R Templ. Longitudinal Predictors of Synthetic Cannabinoid Use in Adolescents. Pediatrics. vol 139. issue 4. 2017-08-03. PMID:28289139. |
many scs are high-efficacy full agonists of the cb1 and/or cb2 cannabinoid receptors, resulting in a potent group of chemicals with a variety of negative health effects, including death. |
2017-08-03 |
2023-08-13 |
Not clear |
| Ming-Hua Li, Katherine L Suchland, Susan L Ingra. Compensatory Activation of Cannabinoid CB2 Receptor Inhibition of GABA Release in the Rostral Ventromedial Medulla in Inflammatory Pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 3. 2017-08-01. PMID:28100744. |
compensatory activation of cannabinoid cb2 receptor inhibition of gaba release in the rostral ventromedial medulla in inflammatory pain. |
2017-08-01 |
2023-08-13 |
rat |
| M Mecha, F J Carrillo-Salinas, A Feliú, L Mestre, C Guaz. Microglia activation states and cannabinoid system: Therapeutic implications. Pharmacology & therapeutics. vol 166. 2017-07-31. PMID:27373505. |
the expression of cannabinoid receptors - mainly cb2 - and the production of ecbs have been related to the activation profile of these cells and therefore, the microglial phenotype, emerging as one of the mechanisms by which microglia becomes alternatively activated. |
2017-07-31 |
2023-08-13 |
Not clear |
| Igor Blaha, Paz Recio, María Pilar Martínez, María Elvira López-Oliva, Ana S F Ribeiro, Ángel Agis-Torres, Ana Cristina Martínez, Sara Benedito, Albino García-Sacristán, Vítor S Fernandes, Medardo Hernánde. Impaired Excitatory Neurotransmission in the Urinary Bladder from the Obese Zucker Rat: Role of Cannabinoid Receptors. PloS one. vol 11. issue 6. 2017-07-18. PMID:27285468. |
this study investigates whether functional and expression changes of cannabinoid cb1 and cb2 receptors are involved in the bladder dysfunction in an obese rat model with insulin resistance. |
2017-07-18 |
2023-08-13 |
rat |
| Igor Blaha, Paz Recio, María Pilar Martínez, María Elvira López-Oliva, Ana S F Ribeiro, Ángel Agis-Torres, Ana Cristina Martínez, Sara Benedito, Albino García-Sacristán, Vítor S Fernandes, Medardo Hernánde. Impaired Excitatory Neurotransmission in the Urinary Bladder from the Obese Zucker Rat: Role of Cannabinoid Receptors. PloS one. vol 11. issue 6. 2017-07-18. PMID:27285468. |
these results suggest that a diminished function and expression of neuronal cannabinoid cb1 and cb2 receptors, as well as a lower nerve fiber density is involved in the impaired excitatory neurotransmission of the urinary bladder from the ozr. |
2017-07-18 |
2023-08-13 |
rat |
| Marta Kruk-Slomka, Barbara Budzynska, Tomasz Slomka, Izabela Banaszkiewicz, Grazyna Bial. The Influence of the CB1 Receptor Ligands on the Schizophrenia-Like Effects in Mice Induced by MK-801. Neurotoxicity research. vol 30. issue 4. 2017-07-18. PMID:27577742. |
for example, the endocannabinoid system, via cannabinoid cb (cb1 and cb2) receptors, is able to control the function of many receptors, such as n-methyl-d-aspartate (nmda) receptors connected strictly with psychosis or other schizophrenia-associated symptoms. |
2017-07-18 |
2023-08-13 |
mouse |
| Michał Biernacki, Elżbieta Skrzydlewsk. Metabolism of endocannabinoids. Postepy higieny i medycyny doswiadczalnej (Online). vol 70. issue 0. 2017-07-17. PMID:27516570. |
endocannabinoids belong to a group of ester, ether and amide derivatives of fatty acids, which are endogenous ligands of receptors cb1, cb2, trpv1 and gpr55 that are included in the endocannabinoid system of the animal organism. |
2017-07-17 |
2023-08-13 |
Not clear |
| Małgorzata Pokrywka, Joanna Góralska, Bogdan Solnic. Cannabinoids - a new weapon against cancer? Postepy higieny i medycyny doswiadczalnej (Online). vol 70. issue 0. 2017-07-17. PMID:28100841. |
the isolation and characterization of the structure of one of the main active ingredients of cannabis - Δ9 - tetrahydrocannabinol as well the discovery of its cannabinoid binding receptors cb1 and cb2, has been a milestone in the study of the possibilities of the uses of cannabis sativa and related products in modern medicine. |
2017-07-17 |
2023-08-13 |
Not clear |
| Clementina Manera, Chiara Arena, Andrea Chicc. Synthetic Cannabinoid Receptor Agonists and Antagonists: Implication in CNS Disorders. Recent patents on CNS drug discovery. vol 10. issue 2. 2017-07-11. PMID:27193072. |
the cannabinoid cb1 and cb2 receptor synthetic ligands reported in this review have been collected by a wide research of scientific literature in particular in public database for patents and clinical trials. |
2017-07-11 |
2023-08-13 |
Not clear |
| Agnieszka Zakrzeska, Tomasz Grędziński, Wioleta Kisiel, Ewa Chabielsk. Cannabinoids and haemostasis. Postepy higieny i medycyny doswiadczalnej (Online). vol 70. issue 0. 2017-07-10. PMID:27383573. |
elements of the endocannabinoid system (cannabinoid receptors cb1, cb2, cbpt and cbed, endocannabinoids, enzymes involved in the synthesis and metabolism of endocannabinoids) are located on the structures involved in the process of hemostasis. |
2017-07-10 |
2023-08-13 |
Not clear |
| Agnieszka Zakrzeska, Tomasz Grędziński, Wioleta Kisiel, Ewa Chabielsk. Cannabinoids and haemostasis. Postepy higieny i medycyny doswiadczalnej (Online). vol 70. issue 0. 2017-07-10. PMID:27383573. |
the mechanisms of action of cannabinoids on homeostasis depend on the cannabinoid receptors cb1, cb2, cbpt and cbed, receptors of other systems stimulated by endocannabinoids, as well as metabolites of endocannabinoids and nitrogen oxide. |
2017-07-10 |
2023-08-13 |
Not clear |
| Rareş-Petru Moldovan, Rodrigo Teodoro, Yongjun Gao, Winnie Deuther-Conrad, Mathias Kranz, Yuchuan Wang, Hiroto Kuwabara, Masayoshi Nakano, Heather Valentine, Steffen Fischer, Martin G Pomper, Dean F Wong, Robert F Dannals, Peter Brust, Andrew G Hort. Development of a High-Affinity PET Radioligand for Imaging Cannabinoid Subtype 2 Receptor. Journal of medicinal chemistry. vol 59. issue 17. 2017-07-10. PMID:27500461. |
cannabinoid receptors type 2 (cb2) represent a target with increasing importance for neuroimaging due to its upregulation under various pathological conditions. |
2017-07-10 |
2023-08-13 |
mouse |
| Rita Maccarone, Cinzia Rapino, Darin Zerti, Monia di Tommaso, Natalia Battista, Stefano Di Marco, Silvia Bisti, Mauro Maccarron. Modulation of Type-1 and Type-2 Cannabinoid Receptors by Saffron in a Rat Model of Retinal Neurodegeneration. PloS one. vol 11. issue 11. 2017-06-26. PMID:27861558. |
these data suggest that bcl modulates only distinct ecs elements like cb1 and cb2, and that saffron and cannabinoid receptors could share the same mechanism in order to afford retinal protection. |
2017-06-26 |
2023-08-13 |
rat |
| Javier Romero-Parra, Hery Chung, Ricardo A Tapia, Mario Faúndez, Cesar Morales-Verdejo, Marcos Lorca, Carlos F Lagos, Vincenzo Di Marzo, C David Pessoa-Mahana, Jaime Mell. Combined CoMFA and CoMSIA 3D-QSAR study of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 101. 2017-06-21. PMID:28137469. |
the preceding years have brought an exponential increase in our understanding of the endocannabinoid system (ecs), including the knowledge of cb1 and cb2 cannabinoid receptors, endocannabinoids, and the enzymes that synthesize and degrade endocannabinoids. |
2017-06-21 |
2023-08-13 |
human |
| Nagendra S Punyamurthula, Tushar Hingorani, Goutham Adelli, Waseem Gul, Mahmoud A ElSohly, Michael A Repka, Soumyajit Majumda. Controlled release tablet formulation containing natural Δ(9)-tetrahydrocannabinol. Drug development and industrial pharmacy. vol 42. issue 7. 2017-06-19. PMID:26585693. |
cannabinoids are increasingly being used in the treatment of chemotherapy-induced nausea and vomiting (cinv) because of their action on the cannabinoid receptors, cb1 and cb2. |
2017-06-19 |
2023-08-13 |
Not clear |
| S C Dyall, H K Mandhair, R E A Fincham, D M Kerr, M Roche, F Molina-Holgad. Distinctive effects of eicosapentaenoic and docosahexaenoic acids in regulating neural stem cell fate are mediated via endocannabinoid signalling pathways. Neuropharmacology. vol 107. 2017-06-19. PMID:27044662. |
epa, but not dha, significantly increased proliferation of nscs compared to controls, an effect associated with enhanced levels of the endocannabinoid 2-arachidonylglycerol (2-ag) and p-p38 mapk, effects attenuated by pre-treatment with cb1 (am251) or cb2 (am630) receptor antagonists. |
2017-06-19 |
2023-08-13 |
mouse |
| Roger Slavik, Adrienne Müller Herde, Ahmed Haider, Stefanie D Krämer, Markus Weber, Roger Schibli, Simon M Ametamey, Linjing M. Discovery of a fluorinated 4-oxo-quinoline derivative as a potential positron emission tomography radiotracer for imaging cannabinoid receptor type 2. Journal of neurochemistry. vol 138. issue 6. 2017-06-13. PMID:27385045. |
the cannabinoid receptor type 2 (cb2) is part of the endocannabinoid system and has gained growing attention in recent years because of its important role in neuroinflammatory/neurodegenerative diseases. |
2017-06-13 |
2023-08-13 |
mouse |
| Paula Morales, María Gómez-Cañas, Gemma Navarro, Dow P Hurst, Francisco J Carrillo-Salinas, Laura Lagartera, Ruth Pazos, Pilar Goya, Patricia H Reggio, Carmen Guaza, Rafael Franco, Javier Fernández-Ruiz, Nadine Jagerovi. Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis. Journal of medicinal chemistry. vol 59. issue 14. 2017-06-09. PMID:27309150. |
a combination of molecular modeling and structure-activity relationship studies has been used to fine-tune cb2 selectivity in the chromenopyrazole ring, a versatile cb1/cb2 cannabinoid scaffold. |
2017-06-09 |
2023-08-13 |
Not clear |
| Irene M Wohlman, Gabriella M Composto, Diane E Heck, Ned D Heindel, C Jeffrey Lacey, Christophe D Guillon, Robert P Casillas, Claire R Croutch, Donald R Gerecke, Debra L Laskin, Laurie B Joseph, Jeffrey D Laski. Mustard vesicants alter expression of the endocannabinoid system in mouse skin. Toxicology and applied pharmacology. vol 303. 2017-05-23. PMID:27125198. |
their activity is mediated by binding to cannabinoid receptors 1 and 2 (cb1 and cb2), as well as peroxisome proliferator-activated receptor alpha (pparα). |
2017-05-23 |
2023-08-13 |
mouse |
| Keith A Sharkey, John W Wile. The Role of the Endocannabinoid System in the Brain-Gut Axis. Gastroenterology. vol 151. issue 2. 2017-05-23. PMID:27133395. |
the endocannabinoid system (ecs) consists of the naturally occurring ligands n-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol (2-ag), their biosynthetic and degradative enzymes, and the cannabinoid (cb) receptors cb1 and cb2. |
2017-05-23 |
2023-08-13 |
Not clear |