| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Małgorzata Pokrywka, Joanna Góralska, Bogdan Solnic. Cannabinoids - a new weapon against cancer? Postepy higieny i medycyny doswiadczalnej (Online). vol 70. issue 0. 2017-07-17. PMID:28100841. |
the isolation and characterization of the structure of one of the main active ingredients of cannabis - Δ9 - tetrahydrocannabinol as well the discovery of its cannabinoid binding receptors cb1 and cb2, has been a milestone in the study of the possibilities of the uses of cannabis sativa and related products in modern medicine. |
2017-07-17 |
2023-08-13 |
Not clear |
| Clementina Manera, Chiara Arena, Andrea Chicc. Synthetic Cannabinoid Receptor Agonists and Antagonists: Implication in CNS Disorders. Recent patents on CNS drug discovery. vol 10. issue 2. 2017-07-11. PMID:27193072. |
the cannabinoid cb1 and cb2 receptor synthetic ligands reported in this review have been collected by a wide research of scientific literature in particular in public database for patents and clinical trials. |
2017-07-11 |
2023-08-13 |
Not clear |
| Agnieszka Zakrzeska, Tomasz Grędziński, Wioleta Kisiel, Ewa Chabielsk. Cannabinoids and haemostasis. Postepy higieny i medycyny doswiadczalnej (Online). vol 70. issue 0. 2017-07-10. PMID:27383573. |
elements of the endocannabinoid system (cannabinoid receptors cb1, cb2, cbpt and cbed, endocannabinoids, enzymes involved in the synthesis and metabolism of endocannabinoids) are located on the structures involved in the process of hemostasis. |
2017-07-10 |
2023-08-13 |
Not clear |
| Agnieszka Zakrzeska, Tomasz Grędziński, Wioleta Kisiel, Ewa Chabielsk. Cannabinoids and haemostasis. Postepy higieny i medycyny doswiadczalnej (Online). vol 70. issue 0. 2017-07-10. PMID:27383573. |
the mechanisms of action of cannabinoids on homeostasis depend on the cannabinoid receptors cb1, cb2, cbpt and cbed, receptors of other systems stimulated by endocannabinoids, as well as metabolites of endocannabinoids and nitrogen oxide. |
2017-07-10 |
2023-08-13 |
Not clear |
| Rareş-Petru Moldovan, Rodrigo Teodoro, Yongjun Gao, Winnie Deuther-Conrad, Mathias Kranz, Yuchuan Wang, Hiroto Kuwabara, Masayoshi Nakano, Heather Valentine, Steffen Fischer, Martin G Pomper, Dean F Wong, Robert F Dannals, Peter Brust, Andrew G Hort. Development of a High-Affinity PET Radioligand for Imaging Cannabinoid Subtype 2 Receptor. Journal of medicinal chemistry. vol 59. issue 17. 2017-07-10. PMID:27500461. |
cannabinoid receptors type 2 (cb2) represent a target with increasing importance for neuroimaging due to its upregulation under various pathological conditions. |
2017-07-10 |
2023-08-13 |
mouse |
| Rita Maccarone, Cinzia Rapino, Darin Zerti, Monia di Tommaso, Natalia Battista, Stefano Di Marco, Silvia Bisti, Mauro Maccarron. Modulation of Type-1 and Type-2 Cannabinoid Receptors by Saffron in a Rat Model of Retinal Neurodegeneration. PloS one. vol 11. issue 11. 2017-06-26. PMID:27861558. |
these data suggest that bcl modulates only distinct ecs elements like cb1 and cb2, and that saffron and cannabinoid receptors could share the same mechanism in order to afford retinal protection. |
2017-06-26 |
2023-08-13 |
rat |
| Javier Romero-Parra, Hery Chung, Ricardo A Tapia, Mario Faúndez, Cesar Morales-Verdejo, Marcos Lorca, Carlos F Lagos, Vincenzo Di Marzo, C David Pessoa-Mahana, Jaime Mell. Combined CoMFA and CoMSIA 3D-QSAR study of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 101. 2017-06-21. PMID:28137469. |
the preceding years have brought an exponential increase in our understanding of the endocannabinoid system (ecs), including the knowledge of cb1 and cb2 cannabinoid receptors, endocannabinoids, and the enzymes that synthesize and degrade endocannabinoids. |
2017-06-21 |
2023-08-13 |
human |
| Nagendra S Punyamurthula, Tushar Hingorani, Goutham Adelli, Waseem Gul, Mahmoud A ElSohly, Michael A Repka, Soumyajit Majumda. Controlled release tablet formulation containing natural Δ(9)-tetrahydrocannabinol. Drug development and industrial pharmacy. vol 42. issue 7. 2017-06-19. PMID:26585693. |
cannabinoids are increasingly being used in the treatment of chemotherapy-induced nausea and vomiting (cinv) because of their action on the cannabinoid receptors, cb1 and cb2. |
2017-06-19 |
2023-08-13 |
Not clear |
| S C Dyall, H K Mandhair, R E A Fincham, D M Kerr, M Roche, F Molina-Holgad. Distinctive effects of eicosapentaenoic and docosahexaenoic acids in regulating neural stem cell fate are mediated via endocannabinoid signalling pathways. Neuropharmacology. vol 107. 2017-06-19. PMID:27044662. |
epa, but not dha, significantly increased proliferation of nscs compared to controls, an effect associated with enhanced levels of the endocannabinoid 2-arachidonylglycerol (2-ag) and p-p38 mapk, effects attenuated by pre-treatment with cb1 (am251) or cb2 (am630) receptor antagonists. |
2017-06-19 |
2023-08-13 |
mouse |
| Roger Slavik, Adrienne Müller Herde, Ahmed Haider, Stefanie D Krämer, Markus Weber, Roger Schibli, Simon M Ametamey, Linjing M. Discovery of a fluorinated 4-oxo-quinoline derivative as a potential positron emission tomography radiotracer for imaging cannabinoid receptor type 2. Journal of neurochemistry. vol 138. issue 6. 2017-06-13. PMID:27385045. |
the cannabinoid receptor type 2 (cb2) is part of the endocannabinoid system and has gained growing attention in recent years because of its important role in neuroinflammatory/neurodegenerative diseases. |
2017-06-13 |
2023-08-13 |
mouse |
| Paula Morales, María Gómez-Cañas, Gemma Navarro, Dow P Hurst, Francisco J Carrillo-Salinas, Laura Lagartera, Ruth Pazos, Pilar Goya, Patricia H Reggio, Carmen Guaza, Rafael Franco, Javier Fernández-Ruiz, Nadine Jagerovi. Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis. Journal of medicinal chemistry. vol 59. issue 14. 2017-06-09. PMID:27309150. |
a combination of molecular modeling and structure-activity relationship studies has been used to fine-tune cb2 selectivity in the chromenopyrazole ring, a versatile cb1/cb2 cannabinoid scaffold. |
2017-06-09 |
2023-08-13 |
Not clear |
| Irene M Wohlman, Gabriella M Composto, Diane E Heck, Ned D Heindel, C Jeffrey Lacey, Christophe D Guillon, Robert P Casillas, Claire R Croutch, Donald R Gerecke, Debra L Laskin, Laurie B Joseph, Jeffrey D Laski. Mustard vesicants alter expression of the endocannabinoid system in mouse skin. Toxicology and applied pharmacology. vol 303. 2017-05-23. PMID:27125198. |
their activity is mediated by binding to cannabinoid receptors 1 and 2 (cb1 and cb2), as well as peroxisome proliferator-activated receptor alpha (pparα). |
2017-05-23 |
2023-08-13 |
mouse |
| Keith A Sharkey, John W Wile. The Role of the Endocannabinoid System in the Brain-Gut Axis. Gastroenterology. vol 151. issue 2. 2017-05-23. PMID:27133395. |
the endocannabinoid system (ecs) consists of the naturally occurring ligands n-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol (2-ag), their biosynthetic and degradative enzymes, and the cannabinoid (cb) receptors cb1 and cb2. |
2017-05-23 |
2023-08-13 |
Not clear |
| Eman Soliman, Rukiyah Van Dros. Anandamide-induced endoplasmic reticulum stress and apoptosis are mediated by oxidative stress in non-melanoma skin cancer: Receptor-independent endocannabinoid signaling. Molecular carcinogenesis. vol 55. issue 11. 2017-05-17. PMID:26513129. |
the g-protein coupled cannabinoid receptors (cb1 and cb2) and the trpv1 ion channel were reported to mediate the antiproliferative activity of endocannabinoids. |
2017-05-17 |
2023-08-13 |
Not clear |
| Amey Dhopeshwarkar, Natalia Murataeva, Alex Makriyannis, Alex Straiker, Ken Macki. Two Janus Cannabinoids That Are Both CB2 Agonists and CB1 Antagonists. The Journal of pharmacology and experimental therapeutics. vol 360. issue 2. 2017-05-16. PMID:27927913. |
two janus cannabinoids that are both cb2 agonists and cb1 antagonists. |
2017-05-16 |
2023-08-13 |
Not clear |
| Takayo Haruna, Masahiko Soga, Yasuhide Morioka, Kinichi Imura, Yoko Furue, Mina Yamamoto, Jun Hayakawa, Masashi Deguchi, Akinori Arimura, Kiyoshi Yasu. The Inhibitory Effect of S-777469, a Cannabinoid Type 2 Receptor Agonist, on Skin Inflammation in Mice. Pharmacology. vol 99. issue 5-6. 2017-05-16. PMID:28214870. |
we investigated the effects of s-777469 (1-[[6-ethyl-1-[4-fluorobenzyl]-5-methyl-2-oxo-1, 2-dihydropyridine-3-carbonyl]amino]-cyclohexanecarboxylic acid), a novel cannabinoid type 2 receptor (cb2) agonist, on 1-fluoro-2,4-dinitrobenzene (dnfb)-induced ear inflammation and mite antigen-induced dermatitis in mice. |
2017-05-16 |
2023-08-13 |
mouse |
| Sabrina Giacoppo, Agnese Gugliandolo, Oriana Trubiani, Federica Pollastro, Gianpaolo Grassi, Placido Bramanti, Emanuela Mazzo. Cannabinoid CB2 receptors are involved in the protection of RAW264.7 macrophages against the oxidative stress: an in vitro study. European journal of histochemistry : EJH. vol 61. issue 1. 2017-05-15. PMID:28348416. |
cannabinoid cb2 receptors are involved in the protection of raw264.7 macrophages against the oxidative stress: an in vitro study. |
2017-05-15 |
2023-08-13 |
Not clear |
| Cecilia Dall'Aglio, Angela Polisca, Maria Grazia Cappai, Francesca Mercati, Alessandro Troisi, Carolina Pirino, Paola Scocco, Margherita Maranes. Immunohistochemistry detected and localized cannabinoid receptor type 2 in bovine fetal pancreas at late gestation. European journal of histochemistry : EJH. vol 61. issue 1. 2017-05-15. PMID:28348424. |
characteristically, also the epithelium of the excretory ducts and the smooth muscle layers of the smaller arteries, in the interlobular glandular septa, tested positive for the cb2 endocannabinoid receptor. |
2017-05-15 |
2023-08-13 |
human |
| Ruth M Concannon, Bright N Okine, David P Finn, Eilís Dow. Upregulation of the cannabinoid CB2 receptor in environmental and viral inflammation-driven rat models of Parkinson's disease. Experimental neurology. vol 283. issue Pt A. 2017-05-05. PMID:27317300. |
upregulation of the cannabinoid cb2 receptor in environmental and viral inflammation-driven rat models of parkinson's disease. |
2017-05-05 |
2023-08-13 |
rat |
| Víctor Manuel Rivera-Olmos, Marisela C Parra-Berna. [Cannabis: Effects in the Central Nervous System. Therapeutic, societal and legal consequences]. Revista medica del Instituto Mexicano del Seguro Social. vol 54. issue 5. 2017-05-03. PMID:27428345. |
their psychological stimulatory effect is widely recognized; their biochemical and molecular components interact with cb1 and cb2 (endocannabinoid system) receptors in various central nervous system structures (cns) and immune cells. |
2017-05-03 |
2023-08-13 |
Not clear |