| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiuyuan Zhang, Shan Gao, Jinfeng Niu, Pan Li, Juan Deng, Shixin Xu, Zhihong Wang, Weiwei Wang, Deling Kong, Chen L. Cannabinoid 2 Receptor Agonist Improves Systemic Sensitivity to Insulin in High-Fat Diet/Streptozotocin-Induced Diabetic Mice. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 40. issue 5. 2017-02-06. PMID:27960161. |
previous studies have suggested that the cannabinoid 2 (cb2) receptor may play a regulatory role on insulin secretion, immune modulation and insulin resistance. |
2017-02-06 |
2023-08-13 |
mouse |
| Mohammad Hosein Farzaei, Roodabeh Bahramsoltani, Roja Rahimi, Faezeh Abbasabadi, Mohammad Abdollah. A Systematic Review of Plant-Derived Natural Compounds for Anxiety Disorders. Current topics in medicinal chemistry. vol 16. issue 17. 2017-02-01. PMID:26845556. |
the involved mechanisms include interaction with γ-aminobutyric acid (gaba)a receptors at benzodiazepine (bzd) and non-bzd sites with various affinity to different subunits, serotonergic 5-hydrodytryptamine (5-ht)1a and 5-ht2a/c receptors, noradrenergic and dopaminergic systems, glycine and glutamate receptors, and κ-opioid receptor as well as cannabinoid (cb)1 and cb2 receptors. |
2017-02-01 |
2023-08-13 |
human |
| Lisheng Jiang, Yingmin Chen, Xiaojing Huang, Ancai Yuan, Qin Shao, Jun Pu, Ben H. Selective activation of CB2 receptor improves efferocytosis in cultured macrophages. Life sciences. vol 161. 2017-01-30. PMID:27474129. |
the cannabinoid type 2 receptor (cb2), has recently been emerging as a new target to reduce vulnerability and promote stability of plaques, however, the underlying mechanisms have not been studied in detail. |
2017-01-30 |
2023-08-13 |
Not clear |
| Amgad I M Khedr, Sabrin R M Ibrahim, Gamal A Mohamed, Hany E A Ahmed, Amany S Ahmad, Mahmoud A Ramadan, Atef E Abd El-Baky, Koji Yamada, Samir A Ros. New ursane triterpenoids from Ficus pandurata and their binding affinity for human cannabinoid and opioid receptors. Archives of pharmacal research. vol 39. issue 7. 2017-01-27. PMID:27350550. |
furthermore, the binding mode of the active compounds in the active site of the cb2 cannabinoid receptors was investigated through molecular modelling. |
2017-01-27 |
2023-08-13 |
human |
| Claudius Füllhase, Andrea Schreiber, Armin Giese, Michael Schmidt, Francesco Montorsi, Christian Gratzke, Giovanni La Croce, Fabio Castiglione, Christian Stief, Petter Hedlun. Spinal neuronal cannabinoid receptors mediate urodynamic effects of systemic fatty acid amide hydrolase (FAAH) inhibition in rats. Neurourology and urodynamics. vol 35. issue 4. 2017-01-09. PMID:25788026. |
to test if urodynamic effects from systemic fatty acid amide hydrolase (faah) inhibition involve sacral spinal cannabinoid type 1 (cb1) or type 2 (cb2) receptors. |
2017-01-09 |
2023-08-13 |
rat |
| Joseph Bouskila, Vanessa Harrar, Pasha Javadi, Amy Beierschmitt, Roberta Palmour, Christian Casanova, Jean-François Bouchard, Maurice Ptit. Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys. Neural plasticity. vol 2016. 2016-12-30. PMID:27069692. |
cannabinoid receptors cb1 and cb2 modulate the electroretinographic waves in vervet monkeys. |
2016-12-30 |
2023-08-13 |
monkey |
| Shan-Shan Li, Lin-Lin Wang, Min Liu, Shu-Kun Jiang, Miao Zhang, Zhi-Ling Tian, Meng Wang, Jiao-Yong Li, Rui Zhao, Da-Wei Gua. Cannabinoid CB₂ receptors are involved in the regulation of fibrogenesis during skin wound repair in mice. Molecular medicine reports. vol 13. issue 4. 2016-12-28. PMID:26935001. |
studies have shown that cannabinoid cb2 receptors are involved in wound repair, however, its physiological roles in fibrogenesis remain to be elucidated. |
2016-12-28 |
2023-08-13 |
mouse |
| Shan-Shan Li, Lin-Lin Wang, Min Liu, Shu-Kun Jiang, Miao Zhang, Zhi-Ling Tian, Meng Wang, Jiao-Yong Li, Rui Zhao, Da-Wei Gua. Cannabinoid CB₂ receptors are involved in the regulation of fibrogenesis during skin wound repair in mice. Molecular medicine reports. vol 13. issue 4. 2016-12-28. PMID:26935001. |
in the present study, the capacity of cannabinoid cb2 receptors in the regulation of skin fibrogenesis during skin wound healing was investigated. |
2016-12-28 |
2023-08-13 |
mouse |
| Shan-Shan Li, Lin-Lin Wang, Min Liu, Shu-Kun Jiang, Miao Zhang, Zhi-Ling Tian, Meng Wang, Jiao-Yong Li, Rui Zhao, Da-Wei Gua. Cannabinoid CB₂ receptors are involved in the regulation of fibrogenesis during skin wound repair in mice. Molecular medicine reports. vol 13. issue 4. 2016-12-28. PMID:26935001. |
to assess the function of cannabinoid cb2 receptors, skin excisional balb/c mice were treated with either the cannabinoid cb2 receptor selective agonist, gp1a, or antagonist, am630. |
2016-12-28 |
2023-08-13 |
mouse |
| Shan-Shan Li, Lin-Lin Wang, Min Liu, Shu-Kun Jiang, Miao Zhang, Zhi-Ling Tian, Meng Wang, Jiao-Yong Li, Rui Zhao, Da-Wei Gua. Cannabinoid CB₂ receptors are involved in the regulation of fibrogenesis during skin wound repair in mice. Molecular medicine reports. vol 13. issue 4. 2016-12-28. PMID:26935001. |
these results indicated that cannabinoid cb2 receptors modulate fibrogenesis and the tgf‑β/smad profibrotic signaling pathway during skin wound repair in the mouse. |
2016-12-28 |
2023-08-13 |
mouse |
| Jakub Wojcieszak, Wojciech Krzemień, Jolanta B Zawilsk. JWH-133, a Selective Cannabinoid CB₂ Receptor Agonist, Exerts Toxic Effects on Neuroblastoma SH-SY5Y Cells. Journal of molecular neuroscience : MN. vol 58. issue 4. 2016-12-26. PMID:26842917. |
although cannabinoid type 2 receptors (cb2) are involved in the modulation of immune system in peripheral tissues, recent findings demonstrated that they are also expressed in the central nervous system and could constitute a new target for the treatment of neurodegenerative disorders. |
2016-12-26 |
2023-08-13 |
Not clear |
| María S Aymerich, Estefanía Rojo-Bustamante, Carmen Molina, Marta Celorrio, Juan A Sánchez-Arias, Rafael Franc. Neuroprotective Effect of JZL184 in MPP(+)-Treated SH-SY5Y Cells Through CB2 Receptors. Molecular neurobiology. vol 53. issue 4. 2016-12-26. PMID:25976369. |
furthermore, sh-sy5y cells express both cannabinoid receptors, cb1 and cb2. |
2016-12-26 |
2023-08-13 |
mouse |
| Mohammed I Khan, Anna A Sobocińska, Anna M Czarnecka, Magdalena Król, Bruno Botta, Cezary Szczyli. The Therapeutic Aspects of the Endocannabinoid System (ECS) for Cancer and their Development: From Nature to Laboratory. Current pharmaceutical design. vol 22. issue 12. 2016-12-21. PMID:26654588. |
for instance, the cb1 and cb2 receptors are assumed to play an important role inside the endocannabinoid system. |
2016-12-21 |
2023-08-13 |
human |
| Ewa Kozela, Christeene Haj, Lumir Hanuš, Mukesh Chourasia, Avital Shurki, Ana Juknat, Nathali Kaushansky, Raphael Mechoulam, Zvi Voge. HU-446 and HU-465, Derivatives of the Non-psychoactive Cannabinoid Cannabidiol, Decrease the Activation of Encephalitogenic T Cells. Chemical biology & drug design. vol 87. issue 1. 2016-12-13. PMID:26259697. |
binding assays followed by molecular modeling revealed that hu-446 has negligible affinity toward the cannabinoid cb1 and cb2 receptors while hu-465 binds to both cb1 and cb2 receptors at the high nanomolar concentrations (ki = 76.7 ± 5.8 nm and 12.1 ± 2.3 nm, respectively). |
2016-12-13 |
2023-08-13 |
mouse |
| M Carnovali, R Ottria, S Pasqualetti, G Banfi, P Ciuffreda, M Mariott. Effects of bioactive fatty acid amide derivatives in zebrafish scale model of bone metabolism and disease. Pharmacological research. vol 104. 2016-12-13. PMID:26707833. |
putative orthologues and paralogs of endocannabinoid genes have recently been identified in zebrafish, demonstrating the presence of cannabinoid type 1 (cb1) and type 2 (cb2) receptors with affinity to endocannabinoid ligands. |
2016-12-13 |
2023-08-13 |
zebrafish |
| Andrea Ossato, Isabella Canazza, Claudio Trapella, Fabrizio Vincenzi, Maria Antonietta De Luca, Claudia Rimondo, Katia Varani, Pier Andrea Borea, Giovanni Serpelloni, Matteo Mart. Effect of JWH-250, JWH-073 and their interaction on "tetrad", sensorimotor, neurological and neurochemical responses in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 67. 2016-12-13. PMID:26780169. |
jwh-250 and jwh-073 are two synthetic cannabinoid agonists with nanomolar affinity at cb1 and cb2 receptors. |
2016-12-13 |
2023-08-13 |
mouse |
| Katarzyna Fijał, Małgorzata Fili. Clinical/Therapeutic Approaches for Cannabinoid Ligands in Central and Peripheral Nervous System Diseases: Mini Review. Clinical neuropharmacology. vol 39. issue 2. 2016-12-13. PMID:26818043. |
cannabinoids, the components of cannabis sativa linnaeus, interact with cb1 and cb2 receptors, which are located both in the central nervous system and in the periphery and thus may exert a widespread biological activity in the body. |
2016-12-13 |
2023-08-13 |
Not clear |
| Ji Jia, Jie Peng, Zhaoju Li, Youping Wu, Qunlin Wu, Weifeng Tu, Mingchun W. Cannabinoid CB2 Receptor Mediates Nicotine-Induced Anti-Inflammation in N9 Microglial Cells Exposed to β Amyloid via Protein Kinase C. Mediators of inflammation. vol 2016. 2016-12-13. PMID:26884647. |
cannabinoid cb2 receptor mediates nicotine-induced anti-inflammation in n9 microglial cells exposed to β amyloid via protein kinase c. reducing β amyloid- (aβ-) induced microglial activation is considered to be effective in treating alzheimer's disease (ad). |
2016-12-13 |
2023-08-13 |
Not clear |
| Ji Jia, Jie Peng, Zhaoju Li, Youping Wu, Qunlin Wu, Weifeng Tu, Mingchun W. Cannabinoid CB2 Receptor Mediates Nicotine-Induced Anti-Inflammation in N9 Microglial Cells Exposed to β Amyloid via Protein Kinase C. Mediators of inflammation. vol 2016. 2016-12-13. PMID:26884647. |
in this investigation, we hypothesized that nicotine attenuates aβ-induced microglial activation by shifting microglial m1 to m2 state, and cannabinoid cb2 receptor and protein kinase c mediate the process. |
2016-12-13 |
2023-08-13 |
Not clear |
| Stefania Petrosino, Aniello Schiano Moriello, Santiago Cerrato, Mariella Fusco, Anna Puigdemont, Luciano De Petrocellis, Vincenzo Di Marz. The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels. British journal of pharmacology. vol 173. issue 7. 2016-12-13. PMID:25598150. |
palmitoylethanolamide (pea) is an endogenous congener of anandamide and potentiates its actions at cannabinoid cb1 and cb2 receptors, and at transient receptor potential vanilloid type-1 (trpv1) channels. |
2016-12-13 |
2023-08-13 |
Not clear |