| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dacai Xu, Jianglin Wang, Zhenkang Zhou, Zhiwei He, Qing Zha. Cannabinoid WIN55, 212-2 induces cell cycle arrest and inhibits the proliferation and migration of human BEL7402 hepatocellular carcinoma cells. Molecular medicine reports. vol 12. issue 6. 2016-09-09. PMID:26500101. |
the results demonstrated that win55, 212‑2 induced cell cycle arrest of the bel7402 cells at the g0/g1 phase via cannabinoid receptor 2 (cb2)‑mediated downregulation of phosphorylated-extracellular signal-regulated kinases (erk)1/2, upregulation of p27, and downregulation of cyclin d1 and cyclin‑dependent kinase 4. |
2016-09-09 |
2023-08-13 |
human |
| Ana Belen Lopez-Rodriguez, Virginia Mela, Estefania Acaz-Fonseca, Luis Miguel Garcia-Segura, Maria-Paz Vivero. CB2 cannabinoid receptor is involved in the anti-inflammatory effects of leptin in a model of traumatic brain injury. Experimental neurology. vol 279. 2016-09-06. PMID:27006282. |
in addition, the possible implication of cb2 cannabinoid receptor in leptin actions has been explored, since it is known that the endocannabinoid system interacts with leptin and actively participates in brain recovery after lesions. |
2016-09-06 |
2023-08-13 |
mouse |
| Roberto Di Maio, Jason R Cannon, J Timothy Greenamyr. Post-status epilepticus treatment with the cannabinoid agonist WIN 55,212-2 prevents chronic epileptic hippocampal damage in rats. Neurobiology of disease. vol 73. 2016-08-29. PMID:25447228. |
g-protein-coupled cannabinoid receptors (cb1 and cb2 receptors) regulate neuronal excitability and have been shown to mediate acute anticonvulsant effects of cannabinoids in animal models. |
2016-08-29 |
2023-08-13 |
rat |
| Eleftheria Lakiotaki, Constantinos Giaginis, Maria Tolia, Paraskevi Alexandrou, Ioanna Delladetsima, Ioanna Giannopoulou, George Kyrgias, Efstratios Patsouris, Stamatios Theochari. Clinical Significance of Cannabinoid Receptors CB1 and CB2 Expression in Human Malignant and Benign Thyroid Lesions. BioMed research international. vol 2015. 2016-08-19. PMID:26539529. |
clinical significance of cannabinoid receptors cb1 and cb2 expression in human malignant and benign thyroid lesions. |
2016-08-19 |
2023-08-13 |
human |
| Eleftheria Lakiotaki, Constantinos Giaginis, Maria Tolia, Paraskevi Alexandrou, Ioanna Delladetsima, Ioanna Giannopoulou, George Kyrgias, Efstratios Patsouris, Stamatios Theochari. Clinical Significance of Cannabinoid Receptors CB1 and CB2 Expression in Human Malignant and Benign Thyroid Lesions. BioMed research international. vol 2015. 2016-08-19. PMID:26539529. |
the endocannabinoid system is comprised of cannabinoid receptors (cb1 and cb2), their endogenous ligands (endocannabinoids), and proteins responsible for their metabolism participate in many different functions indispensable to homeostatic regulation in several tissues, exerting also antitumorigenic effects. |
2016-08-19 |
2023-08-13 |
human |
| Zoltán Benyó, Éva Ruisanchez, Miriam Leszl-Ishiguro, Péter Sándor, Pál Pache. Endocannabinoids in cerebrovascular regulation. American journal of physiology. Heart and circulatory physiology. vol 310. issue 7. 2016-08-19. PMID:26825517. |
all major cell types involved in cerebrovascular control pathways (i.e., smooth muscle, endothelium, neurons, astrocytes, pericytes, microglia, and leukocytes) are capable of synthesizing endocannabinoids and/or express some or several of their target proteins [i.e., the cannabinoid 1 and 2 (cb1 and cb2) receptors and the transient receptor potential vanilloid type 1 ion channel]. |
2016-08-19 |
2023-08-13 |
Not clear |
| Salvador Sierra, Natasha Luquin, Alberto J Rico, Virginia Gómez-Bautista, Elvira Roda, Iria G Dopeso-Reyes, Alfonso Vázquez, Eva Martínez-Pinilla, José L Labandeira-García, Rafael Franco, José L Lancieg. Detection of cannabinoid receptors CB1 and CB2 within basal ganglia output neurons in macaques: changes following experimental parkinsonism. Brain structure & function. vol 220. issue 5. 2016-08-19. PMID:24972960. |
detection of cannabinoid receptors cb1 and cb2 within basal ganglia output neurons in macaques: changes following experimental parkinsonism. |
2016-08-19 |
2023-08-13 |
Not clear |
| Hayate Javed, Sheikh Azimullah, M Emdadul Haque, Shreesh K Ojh. Cannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson's Disease. Frontiers in neuroscience. vol 10. 2016-08-17. PMID:27531971. |
cannabinoid type 2 (cb2) receptors activation protects against oxidative stress and neuroinflammation associated dopaminergic neurodegeneration in rotenone model of parkinson's disease. |
2016-08-17 |
2023-08-13 |
rat |
| Hayate Javed, Sheikh Azimullah, M Emdadul Haque, Shreesh K Ojh. Cannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson's Disease. Frontiers in neuroscience. vol 10. 2016-08-17. PMID:27531971. |
the cannabinoid type two receptors (cb2), an important component of the endocannabinoid system, have recently emerged as neuromodulators and therapeutic targets for neurodegenerative diseases including parkinson's disease (pd). |
2016-08-17 |
2023-08-13 |
rat |
| Stefanie C Hofer, William T Ralvenius, M Salomé Gachet, Jean-Marc Fritschy, Hanns Ulrich Zeilhofer, Jürg Gertsc. Localization and production of peptide endocannabinoids in the rodent CNS and adrenal medulla. Neuropharmacology. vol 98. 2016-08-12. PMID:25839900. |
the endocannabinoid system (ecs) comprises the cannabinoid receptors cb1 and cb2 and their endogenous arachidonic acid-derived agonists 2-arachidonoyl glycerol and anandamide, which play important neuromodulatory roles. |
2016-08-12 |
2023-08-13 |
Not clear |
| María Victoria Bariani, Ana Paula Domínguez Rubio, Maximiliano Cella, Juliana Burdet, Ana María Franchi, Julieta Aisember. Role of the endocannabinoid system in the mechanisms involved in the LPS-induced preterm labor. Reproduction (Cambridge, England). vol 150. issue 6. 2016-08-10. PMID:26347521. |
anandamide (aea) is an endogenous ligand for the cannabinoid receptors cb1 and cb2. |
2016-08-10 |
2023-08-13 |
mouse |
| María Victoria Bariani, Ana Paula Domínguez Rubio, Maximiliano Cella, Juliana Burdet, Ana María Franchi, Julieta Aisember. Role of the endocannabinoid system in the mechanisms involved in the LPS-induced preterm labor. Reproduction (Cambridge, England). vol 150. issue 6. 2016-08-10. PMID:26347521. |
in addition, we also found that lps modulated uterine cannabinoid receptors expression by downregulating cb2 mrna levels and upregulating cb1 protein expression. |
2016-08-10 |
2023-08-13 |
mouse |
| Andrea Chicca, Maria Salomé Gachet, Vanessa Petrucci, Wolfgang Schuehly, Roch-Philippe Charles, Jürg Gertsc. 4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation. Journal of neuroinflammation. vol 12. 2016-08-08. PMID:25962384. |
mh was reported to modulate cannabinoid cb2 receptors as an inverse agonist for camp production and an agonist for intracellular [ca2+]. |
2016-08-08 |
2023-08-13 |
mouse |
| Andrea Chicca, Maria Salomé Gachet, Vanessa Petrucci, Wolfgang Schuehly, Roch-Philippe Charles, Jürg Gertsc. 4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation. Journal of neuroinflammation. vol 12. 2016-08-08. PMID:25962384. |
in this study, the exact modulation of mh on cb2 receptor activity was elucidated and its endocannabinoid substrate-specific inhibition (ssi) of cyclooxygenase-2 (cox-2) and cns bioavailability are described for the first time. |
2016-08-08 |
2023-08-13 |
mouse |
| Y M Al Suleimani, A S Al Mahruqi, C R Hile. Mechanisms of vasorelaxation induced by the cannabidiol analogue compound O-1602 in the rat small mesenteric artery. European journal of pharmacology. vol 765. 2016-08-01. PMID:26297305. |
o-1602 mediates its vasorelaxant effects partly by an endothelium-dependent pathway involving rimonabant- and o-1918-sensitive targets that are distinct from the classical cb1 and cb2 cannabinoid receptors and might involve activation of kca. |
2016-08-01 |
2023-08-13 |
human |
| Mingyue Zhang, Kun Wang, Min Ma, Songyu Tian, Na Wei, Guonian Wan. Low-Dose Cannabinoid Type 2 Receptor Agonist Attenuates Tolerance to Repeated Morphine Administration via Regulating μ-Opioid Receptor Expression in Walker 256 Tumor-Bearing Rats. Anesthesia and analgesia. vol 122. issue 4. 2016-07-28. PMID:26720619. |
previous studies have shown that cannabinoid type 2 (cb2) receptor agonists induce morphine analgesia, attenuate morphine tolerance in normal and neuropathic pain animals, induce transcription of the μ-opioid receptor (mor) gene in jurkat t cells, and increase morphine analgesia in cancer pain animals. |
2016-07-28 |
2023-08-13 |
rat |
| Doodipala Samba Reddy, Victoria M Golu. The Pharmacological Basis of Cannabis Therapy for Epilepsy. The Journal of pharmacology and experimental therapeutics. vol 357. issue 1. 2016-07-19. PMID:26787773. |
cbd is anticonvulsant, but it has a low affinity for the cannabinoid receptors cb1 and cb2; therefore the exact mechanism by which it affects seizures remains poorly understood. |
2016-07-19 |
2023-08-13 |
Not clear |
| Rubén García-Cabrerizo, M Julia García-Fuste. Opposite regulation of cannabinoid CB1 and CB2 receptors in the prefrontal cortex of rats treated with cocaine during adolescence. Neuroscience letters. vol 615. 2016-07-14. PMID:26797579. |
opposite regulation of cannabinoid cb1 and cb2 receptors in the prefrontal cortex of rats treated with cocaine during adolescence. |
2016-07-14 |
2023-08-13 |
rat |
| Rubén García-Cabrerizo, M Julia García-Fuste. Opposite regulation of cannabinoid CB1 and CB2 receptors in the prefrontal cortex of rats treated with cocaine during adolescence. Neuroscience letters. vol 615. 2016-07-14. PMID:26797579. |
the endocannabinoid system is implicated in the neurobiology of cocaine addiction, although it is not clear how cocaine regulates brain cb1 and cb2 receptors, especially during adolescence, a critical moment for shaping adult response to drug use. |
2016-07-14 |
2023-08-13 |
rat |
| Eric W Bow, John M Rimold. The Structure-Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation. Perspectives in medicinal chemistry. vol 8. 2016-07-11. PMID:27398024. |
the cannabinoids are members of a deceptively simple class of terpenophenolic secondary metabolites isolated from cannabis sativa highlighted by (-)-Δ(9)-tetrahydrocannabinol (thc), eliciting distinct pharmacological effects mediated largely by cannabinoid receptor (cb1 or cb2) signaling. |
2016-07-11 |
2023-08-13 |
Not clear |