| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stefania Petrosino, Aniello Schiano Moriello, Santiago Cerrato, Mariella Fusco, Anna Puigdemont, Luciano De Petrocellis, Vincenzo Di Marz. The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels. British journal of pharmacology. vol 173. issue 7. 2016-12-13. PMID:25598150. |
palmitoylethanolamide (pea) is an endogenous congener of anandamide and potentiates its actions at cannabinoid cb1 and cb2 receptors, and at transient receptor potential vanilloid type-1 (trpv1) channels. |
2016-12-13 |
2023-08-13 |
Not clear |
| Jun Tang, Qianwei Chen, Jing Guo, Liming Yang, Yihao Tao, Lin Li, Hongping Miao, Hua Feng, Zhi Chen, Gang Zh. Minocycline Attenuates Neonatal Germinal-Matrix-Hemorrhage-Induced Neuroinflammation and Brain Edema by Activating Cannabinoid Receptor 2. Molecular neurobiology. vol 53. issue 3. 2016-12-13. PMID:25833102. |
a cannabinoid cb2 agonist (jwh133) was used to strengthen the hypothesis, which showed the identical neuroprotective effects of minocycline. |
2016-12-13 |
2023-08-13 |
rat |
| Ewa Kozela, Christeene Haj, Lumir Hanuš, Mukesh Chourasia, Avital Shurki, Ana Juknat, Nathali Kaushansky, Raphael Mechoulam, Zvi Voge. HU-446 and HU-465, Derivatives of the Non-psychoactive Cannabinoid Cannabidiol, Decrease the Activation of Encephalitogenic T Cells. Chemical biology & drug design. vol 87. issue 1. 2016-12-13. PMID:26259697. |
binding assays followed by molecular modeling revealed that hu-446 has negligible affinity toward the cannabinoid cb1 and cb2 receptors while hu-465 binds to both cb1 and cb2 receptors at the high nanomolar concentrations (ki = 76.7 ± 5.8 nm and 12.1 ± 2.3 nm, respectively). |
2016-12-13 |
2023-08-13 |
mouse |
| M Carnovali, R Ottria, S Pasqualetti, G Banfi, P Ciuffreda, M Mariott. Effects of bioactive fatty acid amide derivatives in zebrafish scale model of bone metabolism and disease. Pharmacological research. vol 104. 2016-12-13. PMID:26707833. |
putative orthologues and paralogs of endocannabinoid genes have recently been identified in zebrafish, demonstrating the presence of cannabinoid type 1 (cb1) and type 2 (cb2) receptors with affinity to endocannabinoid ligands. |
2016-12-13 |
2023-08-13 |
zebrafish |
| Andrea Ossato, Isabella Canazza, Claudio Trapella, Fabrizio Vincenzi, Maria Antonietta De Luca, Claudia Rimondo, Katia Varani, Pier Andrea Borea, Giovanni Serpelloni, Matteo Mart. Effect of JWH-250, JWH-073 and their interaction on "tetrad", sensorimotor, neurological and neurochemical responses in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 67. 2016-12-13. PMID:26780169. |
jwh-250 and jwh-073 are two synthetic cannabinoid agonists with nanomolar affinity at cb1 and cb2 receptors. |
2016-12-13 |
2023-08-13 |
mouse |
| Katarzyna Fijał, Małgorzata Fili. Clinical/Therapeutic Approaches for Cannabinoid Ligands in Central and Peripheral Nervous System Diseases: Mini Review. Clinical neuropharmacology. vol 39. issue 2. 2016-12-13. PMID:26818043. |
cannabinoids, the components of cannabis sativa linnaeus, interact with cb1 and cb2 receptors, which are located both in the central nervous system and in the periphery and thus may exert a widespread biological activity in the body. |
2016-12-13 |
2023-08-13 |
Not clear |
| Ji Jia, Jie Peng, Zhaoju Li, Youping Wu, Qunlin Wu, Weifeng Tu, Mingchun W. Cannabinoid CB2 Receptor Mediates Nicotine-Induced Anti-Inflammation in N9 Microglial Cells Exposed to β Amyloid via Protein Kinase C. Mediators of inflammation. vol 2016. 2016-12-13. PMID:26884647. |
cannabinoid cb2 receptor mediates nicotine-induced anti-inflammation in n9 microglial cells exposed to β amyloid via protein kinase c. reducing β amyloid- (aβ-) induced microglial activation is considered to be effective in treating alzheimer's disease (ad). |
2016-12-13 |
2023-08-13 |
Not clear |
| Ji Jia, Jie Peng, Zhaoju Li, Youping Wu, Qunlin Wu, Weifeng Tu, Mingchun W. Cannabinoid CB2 Receptor Mediates Nicotine-Induced Anti-Inflammation in N9 Microglial Cells Exposed to β Amyloid via Protein Kinase C. Mediators of inflammation. vol 2016. 2016-12-13. PMID:26884647. |
in this investigation, we hypothesized that nicotine attenuates aβ-induced microglial activation by shifting microglial m1 to m2 state, and cannabinoid cb2 receptor and protein kinase c mediate the process. |
2016-12-13 |
2023-08-13 |
Not clear |
| Yong Li, Jimok Ki. Deletion of CB2 cannabinoid receptors reduces synaptic transmission and long-term potentiation in the mouse hippocampus. Hippocampus. vol 26. issue 3. 2016-11-14. PMID:26663094. |
deletion of cb2 cannabinoid receptors reduces synaptic transmission and long-term potentiation in the mouse hippocampus. |
2016-11-14 |
2023-08-13 |
mouse |
| Yong Li, Jimok Ki. Deletion of CB2 cannabinoid receptors reduces synaptic transmission and long-term potentiation in the mouse hippocampus. Hippocampus. vol 26. issue 3. 2016-11-14. PMID:26663094. |
the effects of cannabinoids are mostly mediated by two types of cannabinoid receptors--cb1 receptors in the nervous system and cb2 receptors in the immune system. |
2016-11-14 |
2023-08-13 |
mouse |
| Yong Li, Jimok Ki. Deletion of CB2 cannabinoid receptors reduces synaptic transmission and long-term potentiation in the mouse hippocampus. Hippocampus. vol 26. issue 3. 2016-11-14. PMID:26663094. |
however, cb2 cannabinoid receptors have recently been discovered in the brain and also implicated in neurophysiological functions. |
2016-11-14 |
2023-08-13 |
mouse |
| Yong Li, Jimok Ki. Deletion of CB2 cannabinoid receptors reduces synaptic transmission and long-term potentiation in the mouse hippocampus. Hippocampus. vol 26. issue 3. 2016-11-14. PMID:26663094. |
this study provides insights into the role of cb2 cannabinoid receptors in regulating cognitive functions such as long-term memory. |
2016-11-14 |
2023-08-13 |
mouse |
| Christopher J Coke, Kisha A Scarlett, Mahandranauth A Chetram, Kia J Jones, Brittney J Sandifer, Ahriea S Davis, Adam I Marcus, Cimona V Hinto. Simultaneous Activation of Induced Heterodimerization between CXCR4 Chemokine Receptor and Cannabinoid Receptor 2 (CB2) Reveals a Mechanism for Regulation of Tumor Progression. The Journal of biological chemistry. vol 291. issue 19. 2016-11-08. PMID:26841863. |
given that treatment with cannabinoids has been shown to reduce invasiveness of cancer cells as well as cxcr4-mediated migration of immune cells, it is plausible that cxcr4 signaling can be silenced through a physical heterodimeric association with cb2, thereby inhibiting subsequent functions of cxcr4. |
2016-11-08 |
2023-08-13 |
human |
| Valeria Deiana, María Gómez-Cañas, M Ruth Pazos, Javier Fernández-Ruiz, Battistina Asproni, Elena Cichero, Paola Fossa, Eduardo Muñoz, Francesco Deligia, Gabriele Murineddu, Moisés García-Arencibia, Gerard A Pinn. Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties. European journal of medicinal chemistry. vol 112. 2016-11-07. PMID:26890113. |
previous studies have investigated the relevance and structure-activity relationships (sars) of pyrazole derivatives in relation with cannabinoid receptors, and the series of tricyclic 1,4-dihydroindeno[1,2-c]pyrazoles emerged as potent cb2 receptor ligands. |
2016-11-07 |
2023-08-13 |
human |
| Yong Li, Jimok Ki. CB2 Cannabinoid Receptor Knockout in Mice Impairs Contextual Long-Term Memory and Enhances Spatial Working Memory. Neural plasticity. vol 2016. 2016-11-04. PMID:26819779. |
however, recent discoveries of cb2 cannabinoid receptors in the brain demand accurate determination of whether and how cb2 receptors are involved in the cognitive effects of cannabinoids. |
2016-11-04 |
2023-08-13 |
mouse |
| Yong Li, Jimok Ki. CB2 Cannabinoid Receptor Knockout in Mice Impairs Contextual Long-Term Memory and Enhances Spatial Working Memory. Neural plasticity. vol 2016. 2016-11-04. PMID:26819779. |
cb2 cannabinoid receptors are primarily involved in immune functions, but also implicated in psychiatric disorders such as schizophrenia and depression. |
2016-11-04 |
2023-08-13 |
mouse |
| Yong Li, Jimok Ki. CB2 Cannabinoid Receptor Knockout in Mice Impairs Contextual Long-Term Memory and Enhances Spatial Working Memory. Neural plasticity. vol 2016. 2016-11-04. PMID:26819779. |
our results suggest that cb2 cannabinoid receptors play diverse roles in regulating memory depending on memory types and/or brain areas. |
2016-11-04 |
2023-08-13 |
mouse |
| Partha Mukhopadhyay, Marc Baggelaar, Katalin Erdelyi, Zongxian Cao, Resat Cinar, Filomena Fezza, Bogna Ignatowska-Janlowska, Jenny Wilkerson, Noortje van Gils, Thomas Hansen, Marc Ruben, Marjolein Soethoudt, Laura Heitman, George Kunos, Mauro Maccarrone, Aron Lichtman, Pál Pacher, Mario Van der Stel. The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity. British journal of pharmacology. vol 173. issue 3. 2016-11-01. PMID:26398481. |
the novel, orally available and peripherally restricted selective cannabinoid cb2 receptor agonist lei-101 prevents cisplatin-induced nephrotoxicity. |
2016-11-01 |
2023-08-13 |
Not clear |
| Partha Mukhopadhyay, Marc Baggelaar, Katalin Erdelyi, Zongxian Cao, Resat Cinar, Filomena Fezza, Bogna Ignatowska-Janlowska, Jenny Wilkerson, Noortje van Gils, Thomas Hansen, Marc Ruben, Marjolein Soethoudt, Laura Heitman, George Kunos, Mauro Maccarrone, Aron Lichtman, Pál Pacher, Mario Van der Stel. The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity. British journal of pharmacology. vol 173. issue 3. 2016-11-01. PMID:26398481. |
here, we have characterized 3-cyclopropyl-1-(4-(6-((1,1-dioxidothiomorpholino)methyl)-5-fluoropyridin-2-yl)benzyl)imidazolidine-2,4-dione hydrochloride (lei-101) as a novel, peripherally restricted cannabinoid cb2 receptor agonist, using both in vitro and in vivo models. |
2016-11-01 |
2023-08-13 |
Not clear |
| Hui-Chen Lu, Ken Macki. An Introduction to the Endogenous Cannabinoid System. Biological psychiatry. vol 79. issue 7. 2016-10-28. PMID:26698193. |
the most abundant cannabinoid receptors are the cb1 cannabinoid receptors; however, cb2 cannabinoid receptors, transient receptor potential channels, and peroxisome proliferator activated receptors are also engaged by some cannabinoids. |
2016-10-28 |
2023-08-13 |
Not clear |