| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lu Wang, Wakana Mori, Ran Cheng, Joji Yui, Akiko Hatori, Longle Ma, Yiding Zhang, Benjamin H Rotstein, Masayuki Fujinaga, Yoko Shimoda, Tomoteru Yamasaki, Lin Xie, Yuji Nagai, Takafumi Minamimoto, Makoto Higuchi, Neil Vasdev, Ming-Rong Zhang, Steven H Lian. Synthesis and Preclinical Evaluation of Sulfonamido-based [(11)C-Carbonyl]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase. Theranostics. vol 6. issue 8. 2017-10-16. PMID:27279908. |
the most potent compounds were a novel magl inhibitor, n-((1-(1h-1,2,4-triazole-1-carbonyl)piperidin-4-yl) methyl)-4-chlorobenzenesulfonamide (tzpu; ic50 = 35.9 nm), and the known inhibitor 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(((4-chlorophenyl)sulfonamido) methyl)piperidine-1-carboxylate (sar127303; ic50 = 39.3 nm), which were also shown to be selective for magl over fatty acid amide hydrolase (faah), and cannabinoid receptors (cb1 & cb2). |
2017-10-16 |
2023-08-13 |
rat |
| Yasmine Zehani, Lucas Lemaire, Regis Millet, Emmanuelle Lipk. Small scale separation of isoxazole structurally related analogues by chiral supercritical fluid chromatography. Journal of chromatography. A. vol 1505. 2017-10-16. PMID:28527527. |
supercritical fluid chromatography has many advantages over liquid chromatography and was therefore chosen for the small scale enantioseparation of four original 3-carboxamido-5-aryl isoxazole molecules, ligands of the cb2 cannabinoid receptors. |
2017-10-16 |
2023-08-13 |
Not clear |
| Concepción García, Cristina Palomo-Garo, Yolanda Gómez-Gálvez, Javier Fernández-Rui. Cannabinoid-dopamine interactions in the physiology and physiopathology of the basal ganglia. British journal of pharmacology. vol 173. issue 13. 2017-10-12. PMID:26059564. |
additional evidence suggests that cb2 receptors may be located in nigrostriatal dopaminergic neurons, and that certain eicosanoid-related cannabinoids may directly activate trpv1 receptors, which have been found in nigrostriatal dopaminergic neurons, thus allowing in both cases a direct regulation of dopamine transmission by specific cannabinoids. |
2017-10-12 |
2023-08-13 |
Not clear |
| Mellar P Davi. Cannabinoids for Symptom Management and Cancer Therapy: The Evidence. Journal of the National Comprehensive Cancer Network : JNCCN. vol 14. issue 7. 2017-10-04. PMID:27407130. |
cannabinoids bind not only to classical receptors (cb1 and cb2) but also to certain orphan receptors (gpr55 and gpr119), ion channels (transient receptor potential vanilloid), and peroxisome proliferator-activated receptors. |
2017-10-04 |
2023-08-13 |
Not clear |
| Daniel J Foster, Jermaine M Wilson, Daniel H Remke, M Suhaib Mahmood, M Jashim Uddin, Jürgen Wess, Sachin Patel, Lawrence J Marnett, Colleen M Niswender, Carrie K Jones, Zixiu Xiang, Craig W Lindsley, Jerri M Rook, P Jeffrey Con. Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release. Neuron. vol 91. issue 6. 2017-10-03. PMID:27618677. |
furthermore, both the m4-mediated sustained inhibition of dopamine release and the antipsychotic-like efficacy of m4 activators were found to require intact signaling through cb2 cannabinoid receptors. |
2017-10-03 |
2023-08-13 |
Not clear |
| Marta Kruk-Slomka, Izabela Banaszkiewicz, Grazyna Bial. The Impact of CB2 Receptor Ligands on the MK-801-Induced Hyperactivity in Mice. Neurotoxicity research. vol 31. issue 3. 2017-10-02. PMID:28138895. |
however, an acute injection of both cb2 receptor ligands (agonist and antagonist), jwh 133, at the non-effective dose of 2.0 mg/kg and am 630 at the non-effective dose of 2.0 mg/kg, potentiated the mk-801-induced hyperactivity.the present findings have confirmed that endocannabinoid system, not only via cb1, but also via cb2 receptors, may be involved in the schizophrenia-like responses, including hyperlocomotion in mice. |
2017-10-02 |
2023-08-13 |
mouse |
| Jessica Freundt-Revilla, Kristel Kegler, Wolfgang Baumgärtner, Andrea Tipol. Spatial distribution of cannabinoid receptor type 1 (CB1) in normal canine central and peripheral nervous system. PloS one. vol 12. issue 7. 2017-09-27. PMID:28700706. |
the endocannabinoid system is a regulatory pathway consisting of two main types of cannabinoid receptors (cb1 and cb2) and their endogenous ligands, the endocannabinoids. |
2017-09-27 |
2023-08-13 |
dog |
| Carmen Rodríguez-Cueto, Mariluz Hernández-Gálvez, Cecilia J Hillard, Patricia Maciel, Sara Valdeolivas, José A Ramos, María Gómez-Ruiz, Javier Fernández-Rui. Altered striatal endocannabinoid signaling in a transgenic mouse model of spinocerebellar ataxia type-3. PloS one. vol 12. issue 4. 2017-09-07. PMID:28448548. |
in terms of endocannabinoid signaling, no changes in cb2 receptors were evident, yet an important reduction in cb1 receptors was detected by qpcr and immunostaining. |
2017-09-07 |
2023-08-13 |
mouse |
| Orla Haugh, June Penman, Andrew J Irving, Veronica A Campbel. The Emerging Role of the Cannabinoid Receptor Family in Peripheral and Neuro-immune Interactions. Current drug targets. vol 17. issue 16. 2017-08-30. PMID:26758668. |
the classical endogenous cannabinoid (cb) system is composed of the endocannabinoid signalling molecules, 2-arachidonoyl glycerol (2-ag) and anandamide (aea) and their g-protein coupled receptors (gpcr), cb1 and cb2 which together constitutes the endocannabinoid system (ecs). |
2017-08-30 |
2023-08-13 |
Not clear |
| Sergio Martín-Saldaña, Almudena Trinidad, Elvira Ramil, Antonio J Sánchez-López, Maria José Coronado, Esther Martínez-Martínez, José Miguel García, José Ramón García-Berrocal, Rafael Ramírez-Camach. Spontaneous Cannabinoid Receptor 2 (CB2) Expression in the Cochlea of Adult Albino Rat and Its Up-Regulation after Cisplatin Treatment. PloS one. vol 11. issue 8. 2017-08-18. PMID:27564061. |
we provide evidence for the presence of cannabinoid cb2 receptors in some cellular types of the cochlea of the adult albino rat. |
2017-08-18 |
2023-08-13 |
rat |
| Pasquale Annunziata, Chiara Cioni, Claudia Mugnaini, Federico Corell. Potent immunomodulatory activity of a highly selective cannabinoid CB2 agonist on immune cells from healthy subjects and patients with multiple sclerosis. Journal of neuroimmunology. vol 303. 2017-08-14. PMID:28041663. |
potent immunomodulatory activity of a highly selective cannabinoid cb2 agonist on immune cells from healthy subjects and patients with multiple sclerosis. |
2017-08-14 |
2023-08-13 |
human |
| Pasquale Annunziata, Chiara Cioni, Claudia Mugnaini, Federico Corell. Potent immunomodulatory activity of a highly selective cannabinoid CB2 agonist on immune cells from healthy subjects and patients with multiple sclerosis. Journal of neuroimmunology. vol 303. 2017-08-14. PMID:28041663. |
these findings demonstrate that cor167 exerts potent immunomodulatory effects and confirm the cannabinoid cb2 receptor as a novel pharmacological target to counteract neuroinflammation. |
2017-08-14 |
2023-08-13 |
human |
| Safa Almaghrabi, Dominic Geraghty, Kiran Ahuja, Murray Adam. Inhibition of platelet aggregation by vanilloid-like agents is not mediated by transient receptor potential vanilloid-1 channels or cannabinoid receptors. Clinical and experimental pharmacology & physiology. vol 43. issue 6. 2017-08-07. PMID:26991025. |
this research is extended to investigate the effect of these vanilloid-like-agents on platelet count, and to test whether the effect of these agents is mediated through trpv1 and/or cannabinoid (cb1 and cb2) receptors in the presence of other agonists, including collagen and arachidonic acid. |
2017-08-07 |
2023-08-13 |
Not clear |
| Andrew L Ninnemann, Hye Jeong Choi, Gregory L Stuart, Jeff R Templ. Longitudinal Predictors of Synthetic Cannabinoid Use in Adolescents. Pediatrics. vol 139. issue 4. 2017-08-03. PMID:28289139. |
many scs are high-efficacy full agonists of the cb1 and/or cb2 cannabinoid receptors, resulting in a potent group of chemicals with a variety of negative health effects, including death. |
2017-08-03 |
2023-08-13 |
Not clear |
| Ming-Hua Li, Katherine L Suchland, Susan L Ingra. Compensatory Activation of Cannabinoid CB2 Receptor Inhibition of GABA Release in the Rostral Ventromedial Medulla in Inflammatory Pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 3. 2017-08-01. PMID:28100744. |
compensatory activation of cannabinoid cb2 receptor inhibition of gaba release in the rostral ventromedial medulla in inflammatory pain. |
2017-08-01 |
2023-08-13 |
rat |
| M Mecha, F J Carrillo-Salinas, A Feliú, L Mestre, C Guaz. Microglia activation states and cannabinoid system: Therapeutic implications. Pharmacology & therapeutics. vol 166. 2017-07-31. PMID:27373505. |
the expression of cannabinoid receptors - mainly cb2 - and the production of ecbs have been related to the activation profile of these cells and therefore, the microglial phenotype, emerging as one of the mechanisms by which microglia becomes alternatively activated. |
2017-07-31 |
2023-08-13 |
Not clear |
| Igor Blaha, Paz Recio, María Pilar Martínez, María Elvira López-Oliva, Ana S F Ribeiro, Ángel Agis-Torres, Ana Cristina Martínez, Sara Benedito, Albino García-Sacristán, Vítor S Fernandes, Medardo Hernánde. Impaired Excitatory Neurotransmission in the Urinary Bladder from the Obese Zucker Rat: Role of Cannabinoid Receptors. PloS one. vol 11. issue 6. 2017-07-18. PMID:27285468. |
this study investigates whether functional and expression changes of cannabinoid cb1 and cb2 receptors are involved in the bladder dysfunction in an obese rat model with insulin resistance. |
2017-07-18 |
2023-08-13 |
rat |
| Igor Blaha, Paz Recio, María Pilar Martínez, María Elvira López-Oliva, Ana S F Ribeiro, Ángel Agis-Torres, Ana Cristina Martínez, Sara Benedito, Albino García-Sacristán, Vítor S Fernandes, Medardo Hernánde. Impaired Excitatory Neurotransmission in the Urinary Bladder from the Obese Zucker Rat: Role of Cannabinoid Receptors. PloS one. vol 11. issue 6. 2017-07-18. PMID:27285468. |
these results suggest that a diminished function and expression of neuronal cannabinoid cb1 and cb2 receptors, as well as a lower nerve fiber density is involved in the impaired excitatory neurotransmission of the urinary bladder from the ozr. |
2017-07-18 |
2023-08-13 |
rat |
| Marta Kruk-Slomka, Barbara Budzynska, Tomasz Slomka, Izabela Banaszkiewicz, Grazyna Bial. The Influence of the CB1 Receptor Ligands on the Schizophrenia-Like Effects in Mice Induced by MK-801. Neurotoxicity research. vol 30. issue 4. 2017-07-18. PMID:27577742. |
for example, the endocannabinoid system, via cannabinoid cb (cb1 and cb2) receptors, is able to control the function of many receptors, such as n-methyl-d-aspartate (nmda) receptors connected strictly with psychosis or other schizophrenia-associated symptoms. |
2017-07-18 |
2023-08-13 |
mouse |
| Michał Biernacki, Elżbieta Skrzydlewsk. Metabolism of endocannabinoids. Postepy higieny i medycyny doswiadczalnej (Online). vol 70. issue 0. 2017-07-17. PMID:27516570. |
endocannabinoids belong to a group of ester, ether and amide derivatives of fatty acids, which are endogenous ligands of receptors cb1, cb2, trpv1 and gpr55 that are included in the endocannabinoid system of the animal organism. |
2017-07-17 |
2023-08-13 |
Not clear |