| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cristina Palomo-Garo, Yolanda Gómez-Gálvez, Concepción García, Javier Fernández-Rui. Targeting the cannabinoid CB2 receptor to attenuate the progression of motor deficits in LRRK2-transgenic mice. Pharmacological research. vol 110. 2017-12-21. PMID:27063942. |
we designed a long-term study with these animals aimed at: (i) elucidating the changes experienced by the endocannabinoid signaling system in the basal ganglia during the progression of the disease in these mice, paying emphasis in the cb2 receptor, which has emerged as a promising target in pd, and (ii) evaluating the potential of compounds selectively activating this cb2 receptor, as disease-modifying agents in these mice. |
2017-12-21 |
2023-08-13 |
mouse |
| Cristina Palomo-Garo, Yolanda Gómez-Gálvez, Concepción García, Javier Fernández-Rui. Targeting the cannabinoid CB2 receptor to attenuate the progression of motor deficits in LRRK2-transgenic mice. Pharmacological research. vol 110. 2017-12-21. PMID:27063942. |
furthermore, there were no changes in the status of the cb2 receptor, as well as in other elements of the endocannabinoid signaling, in the basal ganglia, but, paradoxically, the selective activation of this receptor partially reversed the deficits in the hanging-wire test of lrrk2 transgenic mice. |
2017-12-21 |
2023-08-13 |
mouse |
| Natalia Murataeva, Amey Dhopeshwarkar, Danielle Yin, José Mitjavila, Heather Bradshaw, Alex Straiker, Ken Macki. Where's my entourage? The curious case of 2-oleoylglycerol, 2-linolenoylglycerol, and 2-palmitoylglycerol. Pharmacological research. vol 110. 2017-12-21. PMID:27117667. |
2-arachidonoylglycerol (2-ag) is the most abundant endogenous cannabinoid in the brain and an agonist at two cannabinoid receptors (cb1 and cb2). |
2017-12-21 |
2023-08-13 |
Not clear |
| Tiziana Bisogno, Sergio Oddi, Alessandra Piccoli, Domenico Fazio, Mauro Maccarron. Type-2 cannabinoid receptors in neurodegeneration. Pharmacological research. vol 111. 2017-12-19. PMID:27450295. |
based on its wide expression in immune cells, type-2 cannabinoid (cb2) receptors were traditionally thought to act as "peripheral receptors" with an almost exclusively immunomodulatory function. |
2017-12-19 |
2023-08-13 |
Not clear |
| Sevil Köse, Fatima Aerts-Kaya, Çağla Zübeyde Köprü, Emirhan Nemutlu, Barış Kuşkonmaz, Beren Karaosmanoğlu, Ekim Zihni Taşkıran, Belgin Altun, Duygu Uçkan Çetinkaya, Petek Korkusu. Human bone marrow mesenchymal stem cells secrete endocannabinoids that stimulate in vitro hematopoietic stem cell migration effectively comparable to beta-adrenergic stimulation. Experimental hematology. vol 57. 2017-12-19. PMID:29030083. |
endocannabinoids (ecbs) are endogenous lipid mediators generated in the brain and peripheral tissues and activate the cannabinoid receptors cb1 and cb2. |
2017-12-19 |
2023-08-13 |
human |
| Mariana M Almeida, Camilla P Dias-Rocha, André S Souza, Mariana F Muros, Leonardo S Mendonca, Carmen C Pazos-Moura, Isis H Trevenzol. Perinatal maternal high-fat diet induces early obesity and sex-specific alterations of the endocannabinoid system in white and brown adipose tissue of weanling rat offspring. The British journal of nutrition. vol 118. issue 10. 2017-12-13. PMID:29110748. |
the ecs consists of endocannabinoids, cannabinoid receptors (cannabinoid type-1 receptor (cb1) and cannabinoid type-2 receptor (cb2)) and metabolising enzymes. |
2017-12-13 |
2023-08-13 |
human |
| Maria Grazia Cascio, Pietro Marini, Roger G Pertwe. The Displacement Binding Assay Using Human Cannabinoid CB2 Receptor-Transfected Cells. Methods in molecular biology (Clifton, N.J.). vol 1412. 2017-12-07. PMID:27245891. |
the displacement binding assay using human cannabinoid cb2 receptor-transfected cells. |
2017-12-07 |
2023-08-13 |
human |
| Maria Grazia Cascio, Pietro Marini, Roger G Pertwe. The Displacement Binding Assay Using Human Cannabinoid CB2 Receptor-Transfected Cells. Methods in molecular biology (Clifton, N.J.). vol 1412. 2017-12-07. PMID:27245891. |
here, we describe the displacement binding assay that is carried out with a radioligand and cho (chinese hamster ovarian) cells stably transfected with the human cannabinoid cb2 receptor. |
2017-12-07 |
2023-08-13 |
human |
| Pietro Marini, Maria Grazia Cascio, Roger G Pertwe. The Cyclic AMP Assay Using Human Cannabinoid CB2 Receptor-Transfected Cells. Methods in molecular biology (Clifton, N.J.). vol 1412. 2017-12-07. PMID:27245894. |
the cyclic amp assay using human cannabinoid cb2 receptor-transfected cells. |
2017-12-07 |
2023-08-13 |
human |
| Pietro Marini, Maria Grazia Cascio, Roger G Pertwe. The Cyclic AMP Assay Using Human Cannabinoid CB2 Receptor-Transfected Cells. Methods in molecular biology (Clifton, N.J.). vol 1412. 2017-12-07. PMID:27245894. |
here, we describe the cyclic amp assay that is carried out with commercially available non-radioligand ready-to-use kits and chinese hamster ovarian (cho) cells stably transfected with the human cannabinoid cb2 receptor. |
2017-12-07 |
2023-08-13 |
human |
| Marjolein Soethoudt, Noortje van Gils, Mario van der Stelt, Laura H Heitma. Protocol to Study β-Arrestin Recruitment by CB1 and CB2 Cannabinoid Receptors. Methods in molecular biology (Clifton, N.J.). vol 1412. 2017-12-07. PMID:27245896. |
protocol to study β-arrestin recruitment by cb1 and cb2 cannabinoid receptors. |
2017-12-07 |
2023-08-13 |
human |
| Marjolein Soethoudt, Noortje van Gils, Mario van der Stelt, Laura H Heitma. Protocol to Study β-Arrestin Recruitment by CB1 and CB2 Cannabinoid Receptors. Methods in molecular biology (Clifton, N.J.). vol 1412. 2017-12-07. PMID:27245896. |
cannabinoid cb1 and cb2 receptors are g-protein-coupled receptors (gpcrs) that recruit β-arrestins upon activation by (partial) agonists. |
2017-12-07 |
2023-08-13 |
human |
| Tiziana Bisogn. Assay of DAGLα/β Activity. Methods in molecular biology (Clifton, N.J.). vol 1412. 2017-12-07. PMID:27245901. |
the endocannabinoid 2-arachidonoylglycerol (2-ag) exerts its physiological action by binding to and functionally activating type-1 (cb1) and type-2 (cb2) cannabinoid receptors. |
2017-12-07 |
2023-08-13 |
Not clear |
| Shalley N Kudalkar, Philip J Kingsley, Lawrence J Marnet. Assay of Endocannabinoid Oxidation by Cyclooxygenase-2. Methods in molecular biology (Clifton, N.J.). vol 1412. 2017-12-07. PMID:27245906. |
the endocannabinoids, 2-arachidonoylglycerol (2-ag) and arachidonylethanolamide (aea), are endogenous ligands for the cannabinoid receptors (cb1 and cb2) and are implicated in a wide array of physiological processes. |
2017-12-07 |
2023-08-13 |
Not clear |
| R B Frei, P Luschnig, G P Parzmair, M Peinhaupt, S Schranz, A Fauland, C E Wheelock, A Heinemann, E M Stur. Cannabinoid receptor 2 augments eosinophil responsiveness and aggravates allergen-induced pulmonary inflammation in mice. Allergy. vol 71. issue 7. 2017-11-21. PMID:26850094. |
the endocannabinoid 2-arachidonoylglycerol (2-ag) has been proposed to elicit eosinophil migration in a cb2 receptor/gi/o -dependent manner. |
2017-11-21 |
2023-08-13 |
mouse |
| Young C Chung, Won-Ho Shin, Jeong Y Baek, Eun J Cho, Hyung H Baik, Sang R Kim, So-Yoon Won, Byung K Ji. CB2 receptor activation prevents glial-derived neurotoxic mediator production, BBB leakage and peripheral immune cell infiltration and rescues dopamine neurons in the MPTP model of Parkinson's disease. Experimental & molecular medicine. vol 48. issue 1. 2017-11-20. PMID:27534533. |
the cannabinoid (cb2) receptor type 2 has been proposed to prevent the degeneration of dopamine neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated mice. |
2017-11-20 |
2023-08-13 |
mouse |
| Elif Bilgic, Elif Guzel, Sevil Kose, Makbule Cisel Aydin, Eda Karaismailoglu, Irem Akar, Alp Usubutun, Petek Korkusu. Endocannabinoids modulate apoptosis in endometriosis and adenomyosis. Acta histochemica. vol 119. issue 5. 2017-11-16. PMID:28549792. |
endocannabinoid receptors cb1 and cb2, their synthesizing and catabolizing enzymes (faah, nape-pld, dagl, magl) and the apoptotic indexes were immunohistochemically assessed in endometriotic and adenomyotic tissues. |
2017-11-16 |
2023-08-13 |
Not clear |
| Leonid N Maslov, Igor Khaliulin, Yi Zhang, Andrey V Krylatov, Natalia V Naryzhnaya, Raphael Mechoulam, Luciano De Petrocellis, James M Downe. Prospects for Creation of Cardioprotective Drugs Based on Cannabinoid Receptor Agonists. Journal of cardiovascular pharmacology and therapeutics. vol 21. issue 3. 2017-11-02. PMID:26487546. |
cannabinoids inhibit na(+)/ca(2+)exchange via peripheral cannabinoid receptor (cb2) activation that may also be related to the antiapoptotic and cardioprotective effects of cannabinoids. |
2017-11-02 |
2023-08-13 |
Not clear |
| A P López-Cardona, M J Sánchez-Calabuig, P Beltran-Breña, N Agirregoitia, D Rizos, E Agirregoitia, A Gutierrez-Adá. Exocannabinoids effect on in vitro bovine oocyte maturation via activation of AKT and ERK1/2. Reproduction (Cambridge, England). vol 152. issue 6. 2017-10-31. PMID:27798282. |
through rt-pcr and immunocytochemistry, this study confirms the presence of cb1 and cb2 cannabinoid receptors in bovine oocytes and shows how exposure to the exogenous cannabinoids hu-210 and thc during their in vitro maturation (ivm) activates the phosphorylation of akt and erk1/2 proteins associated with the resumption of meiosis. |
2017-10-31 |
2023-08-13 |
cattle |
| Fernando Correa, Manuel L Wolfson, Paula Valchi, Julieta Aisemberg, Ana María Franch. Endocannabinoid system and pregnancy. Reproduction (Cambridge, England). vol 152. issue 6. 2017-10-31. PMID:27798285. |
the endocannabinoid system (ecs), is a complex system, comprising the main endogenous ligands anandamide and 2-arachidonoyl glycerol, the cannabinoid receptors cb1 and cb2 and the biosynthetic and degrading enzymes. |
2017-10-31 |
2023-08-13 |
human |