| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Camilla P Dias-Rocha, Mariana M Almeida, Erika M Santana, Julia C B Costa, Juliana G Franco, Carmen C Pazos-Moura, Isis H Trevenzol. Maternal high-fat diet induces sex-specific endocannabinoid system changes in newborn rats and programs adiposity, energy expenditure and food preference in adulthood. The Journal of nutritional biochemistry. vol 51. 2018-05-09. PMID:29102876. |
the ecs consists mainly of endogenous ligands, cannabinoid receptors (cb1 and cb2), and the enzymes fatty acid anandamide hydrolase (faah) and monoacylglycerol lipase (magl). |
2018-05-09 |
2023-08-13 |
rat |
| Yu Liu, Samuel S McAfee, Natalie M Guley, Nobel Del Mar, Wei Bu, Scott A Heldt, Marcia G Honig, Bob M Moore, Anton Reiner, Detlef H Hec. Abnormalities in Dynamic Brain Activity Caused by Mild Traumatic Brain Injury Are Partially Rescued by the Cannabinoid Type-2 Receptor Inverse Agonist SMM-189. eNeuro. vol 4. issue 4. 2018-05-03. PMID:28828401. |
treatment with the cannabinoid type-2 (cb2) receptor inverse agonist smm-189 has been shown to mitigate functional deficits and neuronal injury after mtbi in mice. |
2018-05-03 |
2023-08-13 |
mouse |
| Paula Morales, Dow P Hurst, Patricia H Reggi. Methods for the Development of In Silico GPCR Models. Methods in enzymology. vol 593. 2018-04-26. PMID:28750813. |
the reggio group has constructed computer models of the inactive and g-protein-activated states of the cannabinoid cb1 and cb2 receptors, as well as, several orphan receptors that recognize a subset of cannabinoid compounds, including gpr55 and gpr18. |
2018-04-26 |
2023-08-13 |
Not clear |
| Hai-Jing Sun, Yan Lu, Hao-Wei Wang, Hao Zhang, Shuang-Ran Wang, Wen-Yun Xu, Hai-Long Fu, Xue-Ya Yao, Feng Yang, Hong-Bin Yua. Activation of Endocannabinoid Receptor 2 as a Mechanism of Propofol Pretreatment-Induced Cardioprotection against Ischemia-Reperfusion Injury in Rats. Oxidative medicine and cellular longevity. vol 2017. 2018-04-23. PMID:28814985. |
we concluded that enhancing endogenous endocannabinoid release and subsequent activation of cb2 receptor signaling represent a major mechanism whereby propofol conditioning confers antioxidative and cardioprotective effects against myocardial i/r injury. |
2018-04-23 |
2023-08-13 |
rat |
| Michael W Calik, David W Carle. Effects of Cannabinoid Agonists and Antagonists on Sleep and Breathing in Sprague-Dawley Rats. Sleep. vol 40. issue 9. 2018-04-23. PMID:28934522. |
in anesthetized rats, dronabinol attenuates reflex apnea via activation of cannabinoid (cb) receptors located on vagal afferents; an effect blocked by cannabinoid type 1 (cb1) and/or type 2 (cb2) receptor antagonists. |
2018-04-23 |
2023-08-13 |
rat |
| Morag Rose Hunter, Natasha Lillia Grimsey, Michelle Glas. Sulfation of the FLAG epitope is affected by co-expression of G protein-coupled receptors in a mammalian cell model. Scientific reports. vol 6. 2018-04-16. PMID:27273047. |
here, we describe the observation that co-expression of either cannabinoid cb1 or cb2 receptors in hek293 decreases the sulfation of a flag epitope appended at the n-terminus of the dopamine d2 receptor. |
2018-04-16 |
2023-08-13 |
Not clear |
| Eric Murillo-Rodriguez, Jose Carlos Pastrana-Trejo, Mireille Salas-Crisóstomo, Miriel de-la-Cru. The Endocannabinoid System Modulating Levels of Consciousness, Emotions and Likely Dream Contents. CNS & neurological disorders drug targets. vol 16. issue 4. 2018-04-16. PMID:28240187. |
the cannabinoid receptors have been described in rat, human and mouse brains and they have been named the cb1 and cb2 cannabinoid receptors. |
2018-04-16 |
2023-08-13 |
mouse |
| Helene Francois, Lola Lecr. The Role of Cannabinoid Receptors in Renal Diseases. Current medicinal chemistry. vol 25. issue 7. 2018-04-03. PMID:28901271. |
the cannabinoid system and more specifically the cannabinoid receptors 1 (cb1) and 2 (cb2) may represent a new therapeutic target in ckd. |
2018-04-03 |
2023-08-13 |
Not clear |
| Anna Lisa Brigida, Stephen Schultz, Mariana Cascone, Nicola Antonucci, Dario Siniscalc. Endocannabinod Signal Dysregulation in Autism Spectrum Disorders: A Correlation Link between Inflammatory State and Neuro-Immune Alterations. International journal of molecular sciences. vol 18. issue 7. 2018-03-30. PMID:28671614. |
the ec system is a complex network of lipid signaling pathways comprised of arachidonic acid-derived compounds (anandamide, aea) and 2-arachidonoyl glycerol (2-ag), their g-protein-coupled receptors (cannabinoid receptors cb1 and cb2) and the associated enzymes. |
2018-03-30 |
2023-08-13 |
Not clear |
| Esther Martínez-Martínez, Asunción Martín-Ruiz, Paloma Martín, Virginia Calvo, Mariano Provencio, José M Garcí. CB2 cannabinoid receptor activation promotes colon cancer progression via AKT/GSK3β signaling pathway. Oncotarget. vol 7. issue 42. 2018-03-22. PMID:27634891. |
taken together, our data show that cb2 activation with sub-micromolar doses of agonists, which could be more similar to endogenous levels of cannabinoids, promote colon cancer progression, implicating that cb2 could have a pro-tumorigenic endogenous role in colon cancer. |
2018-03-22 |
2023-08-13 |
Not clear |
| Jessica Freundt-Revilla, Franciska Heinrich, Alexander Zoerner, Felix Gesell, Martin Beyerbach, Merav Shamir, Anna Oevermann, Wolfgang Baumgärtner, Andrea Tipol. The endocannabinoid system in canine Steroid-Responsive Meningitis-Arteritis and Intraspinal Spirocercosis. PloS one. vol 13. issue 2. 2018-03-09. PMID:29408878. |
activation of cannabinoid type 2 receptors (cb2) is known to diminish the release of pro-inflammatory factors and enhance the secretion of anti-inflammatory cytokines. |
2018-03-09 |
2023-08-13 |
dog |
| Jessica Freundt-Revilla, Franciska Heinrich, Alexander Zoerner, Felix Gesell, Martin Beyerbach, Merav Shamir, Anna Oevermann, Wolfgang Baumgärtner, Andrea Tipol. The endocannabinoid system in canine Steroid-Responsive Meningitis-Arteritis and Intraspinal Spirocercosis. PloS one. vol 13. issue 2. 2018-03-09. PMID:29408878. |
furthermore, the endocannabinoid 2-arachidonoyl glycerol (2-ag) has been proved to induce the migration of eosinophils in a cb2 receptor-dependent manner in peripheral blood and activate neutrophils independent of cb activation in humans. |
2018-03-09 |
2023-08-13 |
dog |
| M E Ferrini, S Hong, A Stierle, D Stierle, N Stella, K Roberts, Z Jaffa. CB2 receptors regulate natural killer cells that limit allergic airway inflammation in a murine model of asthma. Allergy. vol 72. issue 6. 2018-03-07. PMID:27992060. |
endogenously generated cannabinoids acting via cb2 receptors play important roles in both homeostatic and inflammatory processes. |
2018-03-07 |
2023-08-13 |
Not clear |
| Mohamad Elbaz, Dinesh Ahirwar, Janani Ravi, Mohd W Nasser, Ramesh K Ganj. Novel role of cannabinoid receptor 2 in inhibiting EGF/EGFR and IGF-I/IGF-IR pathways in breast cancer. Oncotarget. vol 8. issue 18. 2018-03-05. PMID:27213582. |
cannabinoid receptor 2 (cnr2 or cb2) is an integral part of the endocannabinoid system. |
2018-03-05 |
2023-08-13 |
mouse |
| Teruyo Hosoya, Dai Fukumoto, Takeharu Kakiuchi, Shingo Nishiyama, Shigeyuki Yamamoto, Hiroyuki Ohba, Hideo Tsukada, Takatoshi Ueki, Kohji Sato, Yasuomi Ouch. In vivo TSPO and cannabinoid receptor type 2 availability early in post-stroke neuroinflammation in rats: a positron emission tomography study. Journal of neuroinflammation. vol 14. issue 1. 2018-03-02. PMID:28356120. |
upregulated levels of 18-kda translocator proteins (tspo) and type 2 endocannabinoid receptors (cb2) are considered to reflect different aspects of microglia-related neuroinflammatory responses in the brain. |
2018-03-02 |
2023-08-13 |
rat |
| Olga Seleverstov, Ana Tobiasz, J Scott Jackson, Ryan Sullivan, Dejian Ma, J Pierce Sullivan, Steven Davison, Yada Akkhawattanangkul, Danielle L Tate, Terry Costello, Stacey Barnett, Wei Li, Giancarlo Mari, Alex M Dopico, Anna N Bukiy. Maternal alcohol exposure during mid-pregnancy dilates fetal cerebral arteries via endocannabinoid receptors. Alcohol (Fayetteville, N.Y.). vol 61. 2018-02-27. PMID:28554529. |
in summary, alcohol exposure dilates fetal cerebral arteries via endocannabinoid receptors and results in an increased function of cb2. |
2018-02-27 |
2023-08-13 |
human |
| Attila Köfalvi, Cristina Lemos, Ana M Martín-Moreno, Bárbara S Pinheiro, Luis García-García, Miguel A Pozo, Ângela Valério-Fernandes, Rui O Beleza, Paula Agostinho, Ricardo J Rodrigues, Susana J Pasquaré, Rodrigo A Cunha, María L de Ceballo. Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease. Neuropharmacology. vol 110. issue Pt A. 2018-02-22. PMID:26976670. |
stimulation of brain glucose uptake by cannabinoid cb2 receptors and its therapeutic potential in alzheimer's disease. |
2018-02-22 |
2023-08-13 |
mouse |
| Attila Köfalvi, Cristina Lemos, Ana M Martín-Moreno, Bárbara S Pinheiro, Luis García-García, Miguel A Pozo, Ângela Valério-Fernandes, Rui O Beleza, Paula Agostinho, Ricardo J Rodrigues, Susana J Pasquaré, Rodrigo A Cunha, María L de Ceballo. Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease. Neuropharmacology. vol 110. issue Pt A. 2018-02-22. PMID:26976670. |
cannabinoid cb2 receptors (cb2rs) are emerging as important therapeutic targets in brain disorders that typically involve neurometabolic alterations. |
2018-02-22 |
2023-08-13 |
mouse |
| L N Maslov, R S Karpo. [Prospects for the Use of Cannabinoid Receptor Ligands for the Treatment of Metabolic Syndrome and Atherosclerosis: Analysis of Experimental and Clinical Data]. Vestnik Rossiiskoi akademii meditsinskikh nauk. vol 72. issue 1. 2018-02-20. PMID:29308855. |
to validate the expediency of clinical research of cb2 receptor agonists in patients with atherosclerosis the comparative analysis of antiatherogenic properties of cannabinoids should be performed. |
2018-02-20 |
2023-08-13 |
mouse |
| Ling Yang, Shaojuan Zhang, Xiaoxi Ling, Pin Shao, Ningyang Jia, Mingfeng Ba. Multilayer photodynamic therapy for highly effective and safe cancer treatment. Acta biomaterialia. vol 54. 2018-02-14. PMID:28285077. |
in this study, we target two proteins upregulated in cancers: the cannabinoid cb2 receptor (cb |
2018-02-14 |
2023-08-13 |
Not clear |