| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carolina Noble, Annelies Cannaert, Kristian Linnet, Christophe P Stov. Application of an activity-based receptor bioassay to investigate the in vitro activity of selected indole- and indazole-3-carboxamide-based synthetic cannabinoids at CB1 and CB2 receptors. Drug testing and analysis. vol 11. issue 3. 2019-08-27. PMID:30280499. |
application of an activity-based receptor bioassay to investigate the in vitro activity of selected indole- and indazole-3-carboxamide-based synthetic cannabinoids at cb1 and cb2 receptors. |
2019-08-27 |
2023-08-13 |
Not clear |
| Rufaida Al-Zoubi, Paula Morales, Patricia H Reggi. Structural Insights into CB1 Receptor Biased Signaling. International journal of molecular sciences. vol 20. issue 8. 2019-08-09. PMID:31013934. |
thus far, two cannabinoid receptors, cb1 and cb2, have been discovered, which are found predominantly in the central nervous system (cb1) or the immune system (cb2), among other organs and tissues. |
2019-08-09 |
2023-08-13 |
Not clear |
| Qing-Rong Liu, Ana Canseco-Alba, Hai-Ying Zhang, Patricia Tagliaferro, Monika Chung, Eugene Dennis, Branden Sanabria, Norman Schanz, Joao Carlos Escosteguy-Neto, Hiroki Ishiguro, Zhicheng Lin, Susan Sgro, Claire M Leonard, Jair Guilherme Santos-Junior, Eliot L Gardner, Josephine M Egan, Jeung Woon Lee, Zheng-Xiong Xi, Emmanuel S Onaiv. Cannabinoid type 2 receptors in dopamine neurons inhibits psychomotor behaviors, alters anxiety, depression and alcohol preference. Scientific reports. vol 7. issue 1. 2019-08-06. PMID:29234141. |
cannabinoid cb2 receptors (cb2rs) are expressed in mouse brain dopamine (da) neurons and are involved in several da-related disorders. |
2019-08-06 |
2023-08-13 |
mouse |
| b' Agnieszka Szuster-Ciesielska, Agnieszka Zwolak, Jadwiga Daniluk, Martyna Kandefer-Szersze\\xc5\\x8. Metformin inhibits both oleic acid-induced and CB1R receptor agonist-induced lipid accumulation in Hep3B cells: The preliminary report. International journal of immunopathology and pharmacology. vol 33. 2019-07-29. PMID:30880507.' |
both endocannabinoids and metformin may modulate hepatosteatosis; therefore, it was interesting to examine whether metformin may affect lipid accumulation in hepatocytes by acting on cannabinoid receptors, cb1 and cb2, in in vitro study. |
2019-07-29 |
2023-08-13 |
Not clear |
| Nida Noreen, Faqir Muhammad, Bushra Akhtar, Farooq Azam, Muhammad Irfan Anwa. Is Cannabidiol a Promising Substance for New Drug Development? A Review of its Potential Therapeutic Applications. Critical reviews in eukaryotic gene expression. vol 28. issue 1. 2019-07-17. PMID:29773016. |
it has wide spectrum of action because it acts through endocannabinoid receptors; cb1 and cb2 and it also acts on other receptors, such as gpr18, gpr55, gpr 119, 5ht1a, and trpv2. |
2019-07-17 |
2023-08-13 |
Not clear |
| Francisco Navarrete, María Salud García-Gutiérrez, Jorge Manzanare. Pharmacological regulation of cannabinoid CB2 receptor modulates the reinforcing and motivational actions of ethanol. Biochemical pharmacology. vol 157. 2019-07-08. PMID:30063884. |
pharmacological regulation of cannabinoid cb2 receptor modulates the reinforcing and motivational actions of ethanol. |
2019-07-08 |
2023-08-13 |
Not clear |
| Maria A Sanchez-Rodriguez, Oscar Gomez, Pedro F Esteban, Daniel Garcia-Ovejero, Eduardo Molina-Holgad. The endocannabinoid 2-arachidonoylglycerol regulates oligodendrocyte progenitor cell migration. Biochemical pharmacology. vol 157. 2019-07-08. PMID:30195734. |
likewise, antagonists of the cb1 and cb2 cannabinoid receptors (am281 and am630, respectively) produced a similar inhibition of opc migration. |
2019-07-08 |
2023-08-13 |
rat |
| Maria A Sanchez-Rodriguez, Oscar Gomez, Pedro F Esteban, Daniel Garcia-Ovejero, Eduardo Molina-Holgad. The endocannabinoid 2-arachidonoylglycerol regulates oligodendrocyte progenitor cell migration. Biochemical pharmacology. vol 157. 2019-07-08. PMID:30195734. |
by contrast, increasing the levels of endogenous 2-ag by blocking its degradation (impairing monoacylglycerol lipase activity with jzl-184) significantly increased opc migration, as did agonists of the cb1, cb2 or cb1/cb2 cannabinoid receptors. |
2019-07-08 |
2023-08-13 |
rat |
| Jorge Manzanares, David Cabañero, Nagore Puente, María S García-Gutiérrez, Pedro Grandes, Rafael Maldonad. Role of the endocannabinoid system in drug addiction. Biochemical pharmacology. vol 157. 2019-07-08. PMID:30217570. |
currently, new research strategies are under development to target the endocannabinoid system for drug addiction avoiding these side effects, which include allosteric negative modulators of cb1 receptors and compounds targeting cb2 receptors. |
2019-07-08 |
2023-08-13 |
Not clear |
| Michael Camiller. Toward an effective peripheral visceral analgesic: responding to the national opioid crisis. American journal of physiology. Gastrointestinal and liver physiology. vol 314. issue 6. 2019-07-03. PMID:29470146. |
other compounds target nonopioid mechanisms, including cannabinoid (cb2), n-methyl-d-aspartate, calcitonin gene-related peptide, estrogen, and adenosine a |
2019-07-03 |
2023-08-13 |
Not clear |
| Han-Jun Kim, Eun-Ji Choi, Hyo Sung Kim, Chan-Woong Choi, Sik-Won Choi, Sun-Lim Kim, Woo-Duck Seo, Sun Hee D. Germinated soy germ extract ameliorates obesity through beige fat activation. Food & function. vol 10. issue 2. 2019-07-01. PMID:30681105. |
furthermore, gene and protein expression levels of endocannabinoid system-related factors such as nape-pld, faah, dagl-α, and cb2 were altered along with browning and beige fat activation by gsge. |
2019-07-01 |
2023-08-13 |
mouse |
| Thangesweran Ayakannu, Anthony H Taylor, Timothy H Marczylo, Justin C Konj. New Insights of Uterine Leiomyoma Pathogenesis: Endocannabinoid System. Medical science monitor basic research. vol 25. 2019-07-01. PMID:30842391. |
components studied included cannabinoid receptors 1 (cb1) and 2 (cb2); the g protein-coupled receptor gpr55; transient potential vanilloid receptor 1 (trpv1) and the endocannabinoid modulating enzymes n-acylphosphatidylethanolamine-specific phospholipase d (nape-pld) and fatty acid amide hydrolase (faah), and their n-acylethanolamine (nae) ligands: n-arachidonylethanolamine (aea), n-oleoylethanolamine (oea), and n-palmityolethanaolamine (pea). |
2019-07-01 |
2023-08-13 |
Not clear |
| Lili Zhou, Shan Zhou, Peng Yang, Yuan Tian, Zhiwei Feng, Xiang-Qun Xie, Youhua Li. Targeted inhibition of the type 2 cannabinoid receptor is a novel approach to reduce renal fibrosis. Kidney international. vol 94. issue 4. 2019-06-24. PMID:30093080. |
the cannabinoid receptor type 2 (cb2) is a g protein-coupled seven transmembrane receptor that transmits endogenous cannabinoid signaling. |
2019-06-24 |
2023-08-13 |
mouse |
| Chris Meleti. The Important Role of the Endocannabinoid System and the Endocannabinoidome in Gut Health. Alternative therapies in health and medicine. vol 25. issue S2. 2019-06-19. PMID:31202201. |
the endocannabinoid system is an endogenous pathway comprised of the cannabinoid receptors 1 and 2 (cb1 and cb2), their endogenous ligands known as endocannabinoids, and the enzymes responsible for their synthesis and degradation. |
2019-06-19 |
2023-08-13 |
Not clear |
| Simran Maggo, John C Ashto. Effect of Cannabinoid Receptor Agonists on Isolated Rat Atria. Journal of cardiovascular pharmacology. vol 72. issue 4. 2019-06-18. PMID:30080756. |
cannabinoid cb2 receptor agonists are under investigation for clinical use. |
2019-06-18 |
2023-08-13 |
rat |
| Simran Maggo, John C Ashto. Effect of Cannabinoid Receptor Agonists on Isolated Rat Atria. Journal of cardiovascular pharmacology. vol 72. issue 4. 2019-06-18. PMID:30080756. |
we therefore tested the effects of cannabinoids on isolated rat atria to test whether activation of myocardial cb1 and cb2 receptors could contribute to tachycardia. |
2019-06-18 |
2023-08-13 |
rat |
| Simran Maggo, John C Ashto. Effect of Cannabinoid Receptor Agonists on Isolated Rat Atria. Journal of cardiovascular pharmacology. vol 72. issue 4. 2019-06-18. PMID:30080756. |
our results indicate that cannabinoid cardiotoxicity may partially involve cb1 receptors in the myocardium, and that cb2 receptor agonists are unlikely to have significant effects on the heart. |
2019-06-18 |
2023-08-13 |
rat |
| Ai-Ling Li, Xiaoyan Lin, Amey S Dhopeshwarkar, Ana Carla Thomaz, Lawrence M Carey, Yingpeng Liu, Spyros P Nikas, Alexandros Makriyannis, Ken Mackie, Andrea G Hohman. Cannabinoid CB2 Agonist AM1710 Differentially Suppresses Distinct Pathological Pain States and Attenuates Morphine Tolerance and Withdrawal. Molecular pharmacology. vol 95. issue 2. 2019-06-14. PMID:30504240. |
cannabinoid cb2 agonist am1710 differentially suppresses distinct pathological pain states and attenuates morphine tolerance and withdrawal. |
2019-06-14 |
2023-08-13 |
mouse |
| Rodolfo Sánchez-Zavaleta, Hernán Cortés, José Arturo Avalos-Fuentes, Ubaldo García, José Segovia Vila, David Erlij, Benjamín Florá. Presynaptic cannabinoid CB2 receptors modulate [ Synapse (New York, N.Y.). vol 72. issue 11. 2019-06-10. PMID:30022523. |
presynaptic cannabinoid cb2 receptors modulate [ recent studies suggested the expression of cb2 receptors in neurons of the cns, however, most of these studies have only explored one aspect of the receptors, i.e., expression of protein, messenger rna, or functional response, and more complete studies appear to be needed to establish adequately their role in the neuronal function. |
2019-06-10 |
2023-08-13 |
Not clear |
| Xue Shen, Hua Duan, Sha Wang, Lu Gan, Qian Xu, Jin-Jiao L. Decreased Expression of Cannabinoid Receptors in the Eutopic and Ectopic Endometrium of Patients with Adenomyosis. BioMed research international. vol 2019. 2019-06-10. PMID:30800671. |
our research aims to analyze the expression patterns of the typical cannabinoid receptors (cb1 and cb2), the main constituents of the endocannabinoid system, in endometrial samples derived from patients diagnosed as adenomyosis or not. |
2019-06-10 |
2023-08-13 |
Not clear |