| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mariana I Holubiec, Juan I Romero, Juan Suárez, Manuel Portavella, Emilio Fernández-Espejo, Eduardo Blanco, Pablo Galeano, Fernando Rodríguez de Fonsec. Palmitoylethanolamide prevents neuroinflammation, reduces astrogliosis and preserves recognition and spatial memory following induction of neonatal anoxia-ischemia. Psychopharmacology. vol 235. issue 10. 2018-12-11. PMID:30058012. |
palmitoylethanolamide (pea) and oleoylethanolamide (oea) are acylethanolamides that do not bind to cb1 or cb2 receptors and thus they do not present cannabinoid activity. |
2018-12-11 |
2023-08-13 |
Not clear |
| Sara Anna Bonini, Marika Premoli, Simone Tambaro, Amit Kumar, Giuseppina Maccarinelli, Maurizio Memo, Andrea Mastin. Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history. Journal of ethnopharmacology. vol 227. 2018-12-11. PMID:30205181. |
n-arachidonoylethanolamine (aea) and 2-arachidonoyl glycerol (2-ag) are the main endocannabinoids ligands present in the animal kingdom, and the main endocannabinoid receptors are cannabinoid type-1 (cb1) receptor and cannabinoid type-2 (cb2) receptor. |
2018-12-11 |
2023-08-13 |
human |
| Sheila Leone, Claudio Ferrante, Lucia Recinella, Annalisa Chiavaroli, Adriano Mollica, Csaba Tömböly, Azzurra Stefanucci, Marilisa Pia Dimmito, Szabolcs Dvorácskó, Vittore Verratti, Luciano De Petrocellis, Giustino Orlando, Luigi Brunett. Effects of RVD-hemopressin (α) on feeding and body weight after standard or cafeteria diet in rats. Neuropeptides. vol 72. 2018-12-11. PMID:30396596. |
hemopressin, a hemoglobin α chain-derived peptide, plays antagonist/inverse agonist role on cannabinoid (cb)1 receptors, while rvd-hemopressin(α)[rvd-hp(α)], a n-terminally extended form of hemopressin, has been reported as an allosteric modulator of cb1 and cb2 receptors. |
2018-12-11 |
2023-08-13 |
rat |
| Georg Daniel Duerr, Andreas Feißt, Katharina Halbach, Luise Verfuerth, Christopher Gestrich, Daniela Wenzel, Andreas Zimmer, Johannes Breuer, Oliver Dewal. CB2-deficiency is associated with a stronger hypertrophy and remodeling of the right ventricle in a murine model of left pulmonary artery occlusion. Life sciences. vol 215. 2018-12-11. PMID:30403990. |
the endocannabinoid receptor cb2 has been associated with protective effects in adaptation and remodeling of the left ventricle after ischemia. |
2018-12-11 |
2023-08-13 |
Not clear |
| Lucia Recinella, Annalisa Chiavaroli, Claudio Ferrante, Adriano Mollica, Giorgia Macedonio, Azzurra Stefanucci, Marilisa Pia Dimmito, Szabolcs Dvorácskó, Csaba Tömböly, Luigi Brunetti, Giustino Orlando, Sheila Leon. Effects of central RVD-hemopressin(α) administration on anxiety, feeding behavior and hypothalamic neuromodulators in the rat. Pharmacological reports : PR. vol 70. issue 4. 2018-11-19. PMID:29902669. |
rvd-hemopressin(α) [rvd-hp(α)], a n-terminally extended form of hemopressin, is a negative allosteric modulator of the cannabinoid (cb) 1 receptor and a positive allosteric modulator of cb2 receptor which has been recently reported to exert anxiolytic/antidepressant and anorexigenic effects after peripheral administration in rats. |
2018-11-19 |
2023-08-13 |
rat |
| Patil Armenian, Michael Darracq, Jirair Gevorkyan, Shane Clark, Bryan Kaye, Nicklaus P Brandehof. Intoxication from the novel synthetic cannabinoids AB-PINACA and ADB-PINACA: A case series and review of the literature. Neuropharmacology. vol 134. issue Pt A. 2018-11-07. PMID:29037744. |
due to full agonism at the cannabinoid receptors cb1 and cb2, clinical effects are more severe than marijuana, which is a partial cannabinoid receptor agonist. |
2018-11-07 |
2023-08-13 |
Not clear |
| Karolina Pekala, Agnieszka Michalak, Marta Kruk-Slomka, Barbara Budzynska, Grazyna Bial. Impacts of cannabinoid receptor ligands on nicotine- and chronic mild stress-induced cognitive and depression-like effects in mice. Behavioural brain research. vol 347. 2018-11-05. PMID:29551733. |
taking into account the rather frequent concomitance of nicotine abuse and stress, we aimed to research memory- and depression-related effects of nicotine administration in combination with chronic mild unpredictable stress (cmus) in mice and an involvement of the endocannabinoid system through cb1 and cb2 receptors. |
2018-11-05 |
2023-08-13 |
mouse |
| Karolina Pekala, Agnieszka Michalak, Marta Kruk-Slomka, Barbara Budzynska, Grazyna Bial. Impacts of cannabinoid receptor ligands on nicotine- and chronic mild stress-induced cognitive and depression-like effects in mice. Behavioural brain research. vol 347. 2018-11-05. PMID:29551733. |
we confirmed the role of the two main subtypes of cannabinoid receptors, termed cb1 and cb2, on stress- and nicotine-related behavioral changes in mice. |
2018-11-05 |
2023-08-13 |
mouse |
| Hiroki Ishiguro, Yasue Horiuchi, Koichi Tabata, Qing-Rong Liu, Tadao Arinami, Emmanuel S Onaiv. Cannabinoid CB2 Receptor Gene and Environmental Interaction in the Development of Psychiatric Disorders. Molecules (Basel, Switzerland). vol 23. issue 8. 2018-11-05. PMID:30042304. |
cannabinoid cb2 receptor gene and environmental interaction in the development of psychiatric disorders. |
2018-11-05 |
2023-08-13 |
mouse |
| Matthew R D Brown, W Paul Farquhar-Smit. Cannabinoids and cancer pain: A new hope or a false dawn? European journal of internal medicine. vol 49. 2018-10-25. PMID:29482740. |
the efficacy of cannabinoids seems to have been 'lost in translation' which may in part be related to using extracts of herbal cannabis rather than targeted selective full agonists at the cannabinoid cb1 and cb2 receptors. |
2018-10-25 |
2023-08-13 |
Not clear |
| Bihua Bie, Jiang Wu, Joseph F Foss, Mohamed Nagui. An overview of the cannabinoid type 2 receptor system and its therapeutic potential. Current opinion in anaesthesiology. vol 31. issue 4. 2018-10-24. PMID:29794855. |
this narrative review summarizes recent insights into the role of the cannabinoid type 2 (cb2) receptor as potential therapeutic target in neuropathic pain and neurodegenerative conditions. |
2018-10-24 |
2023-08-13 |
Not clear |
| Changfeng Lu, Xun Sun, Chong Wang, Yu Wang, Jiang Pen. Mechanisms and treatment of painful neuromas. Reviews in the neurosciences. vol 29. issue 5. 2018-10-23. PMID:29306933. |
several pathophysiological mechanisms have been proposed to explain this type of neuropathic pain, including peripheral and central sensitisation and the involvement of nerve growth factor, α-smooth muscle actin, the cannabinoid cb2 receptor and structural changes in neuroma fibres. |
2018-10-23 |
2023-08-13 |
Not clear |
| Djalma Medeiros, Laíz da Costa Silva-Gonçalves, Annielle Mendes Brito da Silva, Marcia Perez Dos Santos Cabrera, Manoel Arcisio-Mirand. Membrane-mediated action of the endocannabinoid anandamide on membrane proteins: implications for understanding the receptor-independent mechanism. Scientific reports. vol 7. 2018-10-22. PMID:28128290. |
antagonists and knockdown of the classical cb1 and cb2 cannabinoid receptors do not completely abolish many endocannabinoid activities, supporting the idea of a mechanism independent of receptors whose mode of action remains unclear. |
2018-10-22 |
2023-08-13 |
Not clear |
| Sung Dae Kim, Kang Jun Cho, Joon Chul Ki. Expression of cannabinoid 1 and, 2 receptors and the effects of cannabinoid 1 and, 2 receptor agonists on detrusor overactivity associated with bladder outlet obstruction in rats. BMC urology. vol 17. issue 1. 2018-10-05. PMID:29284441. |
this study investigated changes in the expression of cannabinoid (cb) receptors and the effects of cb1 and cb2 agonists on detrusor overactivity (do) associated with bladder outlet obstruction (boo) in rats. |
2018-10-05 |
2023-08-13 |
rat |
| S Ückert, G la Croce, A Bettiga, K Albrecht, R Buono, F Benigni, M A Kuczyk, P Hedlun. Expression and distribution of key proteins of the endocannabinoid system in the human seminal vesicles. Andrologia. vol 50. issue 2. 2018-09-18. PMID:28786134. |
as information is scarce on the expression of the ecs in human male reproductive tissues, this study aimed to investigate by means of molecular biology (rt-pcr) and immunohistochemistry/immunofluorescence the expression and distribution of cb1 and cb2, gpr55 (an orphan g protein-coupled receptor that recognises cannabinoid ligands) and faah (isoforms 1 and 2) in the human seminal vesicles (sv). |
2018-09-18 |
2023-08-13 |
human |
| C Pirino, M G Cappai, M Maranesi, D Tomassoni, A Giontella, W Pinna, C Boiti, J Kamphues, C Dall'Agli. The presence and distribution of cannabinoid type 1 and 2 receptors in the mandibular gland: The influence of different physical forms of diets on their expression in piglets. Journal of animal physiology and animal nutrition. vol 102. issue 2. 2018-09-11. PMID:29218862. |
we explored the expression and cell type distribution of cannabinoid receptors type 1 (cb1) and cannabinoid receptors type 2 (cb2) in the mandibular glands of pigs in relation to different physical forms of the diet. |
2018-09-11 |
2023-08-13 |
Not clear |
| Gianfranca Carta, Laura Poddighe, Maria Pina Serra, Marianna Boi, Tiziana Melis, Sara Lisai, Elisabetta Murru, Laura Muredda, Maria Collu, Sebastiano Banni, Marina Quart. Preventive Effects of Resveratrol on Endocannabinoid System and Synaptic Protein Modifications in Rat Cerebral Cortex Challenged by Bilateral Common Carotid Artery Occlusion and Reperfusion. International journal of molecular sciences. vol 19. issue 2. 2018-09-07. PMID:29385102. |
in the frontal cortex, rvt pre-treatment prevented the bccao/r-induced increase of lipoperoxides, augmented concentrations of palmitoylethanolamide and docosahexaenoic acid, increased relative levels of the cannabinoid receptors type 1 (cb1) and 2 (cb2), and peroxisome-proliferator-activated-receptor (ppar)-α proteins. |
2018-09-07 |
2023-08-13 |
rat |
| Agata Czarnywojtek, Magdalena Borowska, Nadia Sawicka-Gutaj, Kosma Woliński, Maria Teresa Płazińska, Ewa Florek, Marek Ruchał. [The impact of cannabinoids on the endocrine system]. Przeglad lekarski. vol 73. issue 10. 2018-09-07. PMID:29689684. |
marijuanaacts through cannabinoid receptorscb 1 and cb2. |
2018-09-07 |
2023-08-13 |
Not clear |
| Agata Czarnywojtek, Magdalena Borowska, Nadia Sawicka-Gutaj, Kosma Woliński, Maria Teresa Płazińska, Ewa Florek, Marek Ruchał. [The impact of cannabinoids on the endocrine system]. Przeglad lekarski. vol 73. issue 10. 2018-09-07. PMID:29689684. |
cb2 cannabinoid receptorsare located in the peripheral nervoussystem (at the ends of peripheralnerves), and on the surfaces of thecells of the immunological system.the discovery of endogenous cannabinoidshas contributed to a betterunderstanding of their role in the regulationof the intake of food, energetichomeostasis and their significant influenceon the endocrine system. |
2018-09-07 |
2023-08-13 |
Not clear |
| Shao-Liu Wang, Wen-Jing Qian, Xiao-Han Wang, Shu-Yue Wang, Wei Yang, Chuan-Qiang Zhang, Zhong-Feng Wan. [Cannabinoid receptor system regulates ion channels and synaptic transmission in retinal cells]. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 5. 2018-08-29. PMID:29063116. |
there are two types of cannabinoid receptors, cb1 and cb2. |
2018-08-29 |
2023-08-13 |
Not clear |