| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Catherine Dong, Jingwen Chen, Amy Harrington, K Yaragudri Vinod, Muralidhar L Hegde, Venkatesh L Hegd. Cannabinoid exposure during pregnancy and its impact on immune function. Cellular and molecular life sciences : CMLS. vol 76. issue 4. 2019-02-25. PMID:30374520. |
they mediate their effects primarily through g-protein coupled cannabinoid receptors, cb1 and cb2. |
2019-02-25 |
2023-08-13 |
Not clear |
| Jenny L Wilkerson, Zachary A Curry, Pamela D Kinlow, Brittany L Mason, Ku-Lung Hsu, Mario van der Stelt, Benjamin F Cravatt, Aron H Lichtma. Evaluation of different drug classes on transient sciatic nerve injury-depressed marble burying in mice. Pain. vol 159. issue 6. 2019-02-19. PMID:29528965. |
in addition, we tested drugs targeting distinct components of the endocannabinoid system, including agonists at cannabinoid receptors type 1 (cb1) and type 2 (cb2), as well as inhibitors of the endocannabinoid-regulating enzymes fatty acid amide hydrolase and monoacylglycerol lipase. |
2019-02-19 |
2023-08-13 |
mouse |
| Wei Xiang, Rongchen Shi, Xia Kang, Xuan Zhang, Peng Chen, Lili Zhang, Along Hou, Rui Wang, Yuanyin Zhao, Kun Zhao, Yingzhe Liu, Yue Ma, Huan Luo, Shenglan Shang, Jinyu Zhang, Fengtian He, Songtao Yu, Lixia Gan, Chunmeng Shi, Yongsheng Li, Wei Yang, Houjie Liang, Hongming Mia. Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression. Nature communications. vol 9. issue 1. 2019-01-16. PMID:29968710. |
functionally, macrophage mgll inhibits cb2 cannabinoid receptor-dependent tumor progression in inoculated and genetic cancer models. |
2019-01-16 |
2023-08-13 |
Not clear |
| Murat Çakır, Suat Tekin, Züleyha Doğanyiğit, Yavuz Erden, Merve Soytürk, Yılmaz Çiğremiş, Süleyman Sanda. Cannabinoid type 2 receptor agonist JWH-133, attenuates Okadaic acid induced spatial memory impairment and neurodegeneration in rats. Life sciences. vol 217. 2019-01-11. PMID:30500552. |
the presence of cannabinoid type 2 receptor (cb2), a member of the cannabinoid system, was detected in different regions of the brain. |
2019-01-11 |
2023-08-13 |
rat |
| Vincenzo Micale, Filippo Drag. Endocannabinoid system, stress and HPA axis. European journal of pharmacology. vol 834. 2018-12-18. PMID:30036537. |
the endocannabinoid system (ecs), which is composed of the cannabinoid receptors types 1 and 2 (cb1 and cb2) for marijuana's psychoactive ingredient ∆ |
2018-12-18 |
2023-08-13 |
Not clear |
| Claudia Mugnaini, Alessandro Rabbito, Antonella Brizzi, Nastasja Palombi, Stefania Petrosino, Roberta Verde, Vincenzo Di Marzo, Alessia Ligresti, Federico Corell. Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease. European journal of medicinal chemistry. vol 161. 2018-12-18. PMID:30359820. |
selective cannabinoid type 2 (cb2) receptor agonists as potential agents for the treatment of skin inflammatory disease. |
2018-12-18 |
2023-08-13 |
Not clear |
| Julian Jehle, Benedikt Schöne, Sayeh Bagheri, Elina Avraamidou, Melina Danisch, Imke Frank, Philipp Pfeifer, Laura Bindila, Beat Lutz, Dieter Lütjohann, Andreas Zimmer, Georg Nickeni. Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice. PloS one. vol 13. issue 5. 2018-12-11. PMID:29813086. |
the endocannabinoid (ecb) 2-arachidonoylglycerol (2-ag) is a known modulator of inflammation and ligand to both, pro-inflammatory cannabinoid receptor 1 (cb1) and anti-inflammatory cb2. |
2018-12-11 |
2023-08-13 |
mouse |
| Mariana I Holubiec, Juan I Romero, Juan Suárez, Manuel Portavella, Emilio Fernández-Espejo, Eduardo Blanco, Pablo Galeano, Fernando Rodríguez de Fonsec. Palmitoylethanolamide prevents neuroinflammation, reduces astrogliosis and preserves recognition and spatial memory following induction of neonatal anoxia-ischemia. Psychopharmacology. vol 235. issue 10. 2018-12-11. PMID:30058012. |
palmitoylethanolamide (pea) and oleoylethanolamide (oea) are acylethanolamides that do not bind to cb1 or cb2 receptors and thus they do not present cannabinoid activity. |
2018-12-11 |
2023-08-13 |
Not clear |
| Sara Anna Bonini, Marika Premoli, Simone Tambaro, Amit Kumar, Giuseppina Maccarinelli, Maurizio Memo, Andrea Mastin. Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history. Journal of ethnopharmacology. vol 227. 2018-12-11. PMID:30205181. |
n-arachidonoylethanolamine (aea) and 2-arachidonoyl glycerol (2-ag) are the main endocannabinoids ligands present in the animal kingdom, and the main endocannabinoid receptors are cannabinoid type-1 (cb1) receptor and cannabinoid type-2 (cb2) receptor. |
2018-12-11 |
2023-08-13 |
human |
| Sheila Leone, Claudio Ferrante, Lucia Recinella, Annalisa Chiavaroli, Adriano Mollica, Csaba Tömböly, Azzurra Stefanucci, Marilisa Pia Dimmito, Szabolcs Dvorácskó, Vittore Verratti, Luciano De Petrocellis, Giustino Orlando, Luigi Brunett. Effects of RVD-hemopressin (α) on feeding and body weight after standard or cafeteria diet in rats. Neuropeptides. vol 72. 2018-12-11. PMID:30396596. |
hemopressin, a hemoglobin α chain-derived peptide, plays antagonist/inverse agonist role on cannabinoid (cb)1 receptors, while rvd-hemopressin(α)[rvd-hp(α)], a n-terminally extended form of hemopressin, has been reported as an allosteric modulator of cb1 and cb2 receptors. |
2018-12-11 |
2023-08-13 |
rat |
| Georg Daniel Duerr, Andreas Feißt, Katharina Halbach, Luise Verfuerth, Christopher Gestrich, Daniela Wenzel, Andreas Zimmer, Johannes Breuer, Oliver Dewal. CB2-deficiency is associated with a stronger hypertrophy and remodeling of the right ventricle in a murine model of left pulmonary artery occlusion. Life sciences. vol 215. 2018-12-11. PMID:30403990. |
the endocannabinoid receptor cb2 has been associated with protective effects in adaptation and remodeling of the left ventricle after ischemia. |
2018-12-11 |
2023-08-13 |
Not clear |
| Lucia Recinella, Annalisa Chiavaroli, Claudio Ferrante, Adriano Mollica, Giorgia Macedonio, Azzurra Stefanucci, Marilisa Pia Dimmito, Szabolcs Dvorácskó, Csaba Tömböly, Luigi Brunetti, Giustino Orlando, Sheila Leon. Effects of central RVD-hemopressin(α) administration on anxiety, feeding behavior and hypothalamic neuromodulators in the rat. Pharmacological reports : PR. vol 70. issue 4. 2018-11-19. PMID:29902669. |
rvd-hemopressin(α) [rvd-hp(α)], a n-terminally extended form of hemopressin, is a negative allosteric modulator of the cannabinoid (cb) 1 receptor and a positive allosteric modulator of cb2 receptor which has been recently reported to exert anxiolytic/antidepressant and anorexigenic effects after peripheral administration in rats. |
2018-11-19 |
2023-08-13 |
rat |
| Patil Armenian, Michael Darracq, Jirair Gevorkyan, Shane Clark, Bryan Kaye, Nicklaus P Brandehof. Intoxication from the novel synthetic cannabinoids AB-PINACA and ADB-PINACA: A case series and review of the literature. Neuropharmacology. vol 134. issue Pt A. 2018-11-07. PMID:29037744. |
due to full agonism at the cannabinoid receptors cb1 and cb2, clinical effects are more severe than marijuana, which is a partial cannabinoid receptor agonist. |
2018-11-07 |
2023-08-13 |
Not clear |
| Karolina Pekala, Agnieszka Michalak, Marta Kruk-Slomka, Barbara Budzynska, Grazyna Bial. Impacts of cannabinoid receptor ligands on nicotine- and chronic mild stress-induced cognitive and depression-like effects in mice. Behavioural brain research. vol 347. 2018-11-05. PMID:29551733. |
taking into account the rather frequent concomitance of nicotine abuse and stress, we aimed to research memory- and depression-related effects of nicotine administration in combination with chronic mild unpredictable stress (cmus) in mice and an involvement of the endocannabinoid system through cb1 and cb2 receptors. |
2018-11-05 |
2023-08-13 |
mouse |
| Karolina Pekala, Agnieszka Michalak, Marta Kruk-Slomka, Barbara Budzynska, Grazyna Bial. Impacts of cannabinoid receptor ligands on nicotine- and chronic mild stress-induced cognitive and depression-like effects in mice. Behavioural brain research. vol 347. 2018-11-05. PMID:29551733. |
we confirmed the role of the two main subtypes of cannabinoid receptors, termed cb1 and cb2, on stress- and nicotine-related behavioral changes in mice. |
2018-11-05 |
2023-08-13 |
mouse |
| Hiroki Ishiguro, Yasue Horiuchi, Koichi Tabata, Qing-Rong Liu, Tadao Arinami, Emmanuel S Onaiv. Cannabinoid CB2 Receptor Gene and Environmental Interaction in the Development of Psychiatric Disorders. Molecules (Basel, Switzerland). vol 23. issue 8. 2018-11-05. PMID:30042304. |
cannabinoid cb2 receptor gene and environmental interaction in the development of psychiatric disorders. |
2018-11-05 |
2023-08-13 |
mouse |
| Matthew R D Brown, W Paul Farquhar-Smit. Cannabinoids and cancer pain: A new hope or a false dawn? European journal of internal medicine. vol 49. 2018-10-25. PMID:29482740. |
the efficacy of cannabinoids seems to have been 'lost in translation' which may in part be related to using extracts of herbal cannabis rather than targeted selective full agonists at the cannabinoid cb1 and cb2 receptors. |
2018-10-25 |
2023-08-13 |
Not clear |
| Bihua Bie, Jiang Wu, Joseph F Foss, Mohamed Nagui. An overview of the cannabinoid type 2 receptor system and its therapeutic potential. Current opinion in anaesthesiology. vol 31. issue 4. 2018-10-24. PMID:29794855. |
this narrative review summarizes recent insights into the role of the cannabinoid type 2 (cb2) receptor as potential therapeutic target in neuropathic pain and neurodegenerative conditions. |
2018-10-24 |
2023-08-13 |
Not clear |
| Changfeng Lu, Xun Sun, Chong Wang, Yu Wang, Jiang Pen. Mechanisms and treatment of painful neuromas. Reviews in the neurosciences. vol 29. issue 5. 2018-10-23. PMID:29306933. |
several pathophysiological mechanisms have been proposed to explain this type of neuropathic pain, including peripheral and central sensitisation and the involvement of nerve growth factor, α-smooth muscle actin, the cannabinoid cb2 receptor and structural changes in neuroma fibres. |
2018-10-23 |
2023-08-13 |
Not clear |
| Djalma Medeiros, Laíz da Costa Silva-Gonçalves, Annielle Mendes Brito da Silva, Marcia Perez Dos Santos Cabrera, Manoel Arcisio-Mirand. Membrane-mediated action of the endocannabinoid anandamide on membrane proteins: implications for understanding the receptor-independent mechanism. Scientific reports. vol 7. 2018-10-22. PMID:28128290. |
antagonists and knockdown of the classical cb1 and cb2 cannabinoid receptors do not completely abolish many endocannabinoid activities, supporting the idea of a mechanism independent of receptors whose mode of action remains unclear. |
2018-10-22 |
2023-08-13 |
Not clear |