| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew R D Brown, W Paul Farquhar-Smit. Cannabinoids and cancer pain: A new hope or a false dawn? European journal of internal medicine. vol 49. 2018-10-25. PMID:29482740. |
the efficacy of cannabinoids seems to have been 'lost in translation' which may in part be related to using extracts of herbal cannabis rather than targeted selective full agonists at the cannabinoid cb1 and cb2 receptors. |
2018-10-25 |
2023-08-13 |
Not clear |
| Bihua Bie, Jiang Wu, Joseph F Foss, Mohamed Nagui. An overview of the cannabinoid type 2 receptor system and its therapeutic potential. Current opinion in anaesthesiology. vol 31. issue 4. 2018-10-24. PMID:29794855. |
this narrative review summarizes recent insights into the role of the cannabinoid type 2 (cb2) receptor as potential therapeutic target in neuropathic pain and neurodegenerative conditions. |
2018-10-24 |
2023-08-13 |
Not clear |
| Changfeng Lu, Xun Sun, Chong Wang, Yu Wang, Jiang Pen. Mechanisms and treatment of painful neuromas. Reviews in the neurosciences. vol 29. issue 5. 2018-10-23. PMID:29306933. |
several pathophysiological mechanisms have been proposed to explain this type of neuropathic pain, including peripheral and central sensitisation and the involvement of nerve growth factor, α-smooth muscle actin, the cannabinoid cb2 receptor and structural changes in neuroma fibres. |
2018-10-23 |
2023-08-13 |
Not clear |
| Djalma Medeiros, Laíz da Costa Silva-Gonçalves, Annielle Mendes Brito da Silva, Marcia Perez Dos Santos Cabrera, Manoel Arcisio-Mirand. Membrane-mediated action of the endocannabinoid anandamide on membrane proteins: implications for understanding the receptor-independent mechanism. Scientific reports. vol 7. 2018-10-22. PMID:28128290. |
antagonists and knockdown of the classical cb1 and cb2 cannabinoid receptors do not completely abolish many endocannabinoid activities, supporting the idea of a mechanism independent of receptors whose mode of action remains unclear. |
2018-10-22 |
2023-08-13 |
Not clear |
| Sung Dae Kim, Kang Jun Cho, Joon Chul Ki. Expression of cannabinoid 1 and, 2 receptors and the effects of cannabinoid 1 and, 2 receptor agonists on detrusor overactivity associated with bladder outlet obstruction in rats. BMC urology. vol 17. issue 1. 2018-10-05. PMID:29284441. |
this study investigated changes in the expression of cannabinoid (cb) receptors and the effects of cb1 and cb2 agonists on detrusor overactivity (do) associated with bladder outlet obstruction (boo) in rats. |
2018-10-05 |
2023-08-13 |
rat |
| S Ückert, G la Croce, A Bettiga, K Albrecht, R Buono, F Benigni, M A Kuczyk, P Hedlun. Expression and distribution of key proteins of the endocannabinoid system in the human seminal vesicles. Andrologia. vol 50. issue 2. 2018-09-18. PMID:28786134. |
as information is scarce on the expression of the ecs in human male reproductive tissues, this study aimed to investigate by means of molecular biology (rt-pcr) and immunohistochemistry/immunofluorescence the expression and distribution of cb1 and cb2, gpr55 (an orphan g protein-coupled receptor that recognises cannabinoid ligands) and faah (isoforms 1 and 2) in the human seminal vesicles (sv). |
2018-09-18 |
2023-08-13 |
human |
| C Pirino, M G Cappai, M Maranesi, D Tomassoni, A Giontella, W Pinna, C Boiti, J Kamphues, C Dall'Agli. The presence and distribution of cannabinoid type 1 and 2 receptors in the mandibular gland: The influence of different physical forms of diets on their expression in piglets. Journal of animal physiology and animal nutrition. vol 102. issue 2. 2018-09-11. PMID:29218862. |
we explored the expression and cell type distribution of cannabinoid receptors type 1 (cb1) and cannabinoid receptors type 2 (cb2) in the mandibular glands of pigs in relation to different physical forms of the diet. |
2018-09-11 |
2023-08-13 |
Not clear |
| Gianfranca Carta, Laura Poddighe, Maria Pina Serra, Marianna Boi, Tiziana Melis, Sara Lisai, Elisabetta Murru, Laura Muredda, Maria Collu, Sebastiano Banni, Marina Quart. Preventive Effects of Resveratrol on Endocannabinoid System and Synaptic Protein Modifications in Rat Cerebral Cortex Challenged by Bilateral Common Carotid Artery Occlusion and Reperfusion. International journal of molecular sciences. vol 19. issue 2. 2018-09-07. PMID:29385102. |
in the frontal cortex, rvt pre-treatment prevented the bccao/r-induced increase of lipoperoxides, augmented concentrations of palmitoylethanolamide and docosahexaenoic acid, increased relative levels of the cannabinoid receptors type 1 (cb1) and 2 (cb2), and peroxisome-proliferator-activated-receptor (ppar)-α proteins. |
2018-09-07 |
2023-08-13 |
rat |
| Agata Czarnywojtek, Magdalena Borowska, Nadia Sawicka-Gutaj, Kosma Woliński, Maria Teresa Płazińska, Ewa Florek, Marek Ruchał. [The impact of cannabinoids on the endocrine system]. Przeglad lekarski. vol 73. issue 10. 2018-09-07. PMID:29689684. |
marijuanaacts through cannabinoid receptorscb 1 and cb2. |
2018-09-07 |
2023-08-13 |
Not clear |
| Agata Czarnywojtek, Magdalena Borowska, Nadia Sawicka-Gutaj, Kosma Woliński, Maria Teresa Płazińska, Ewa Florek, Marek Ruchał. [The impact of cannabinoids on the endocrine system]. Przeglad lekarski. vol 73. issue 10. 2018-09-07. PMID:29689684. |
cb2 cannabinoid receptorsare located in the peripheral nervoussystem (at the ends of peripheralnerves), and on the surfaces of thecells of the immunological system.the discovery of endogenous cannabinoidshas contributed to a betterunderstanding of their role in the regulationof the intake of food, energetichomeostasis and their significant influenceon the endocrine system. |
2018-09-07 |
2023-08-13 |
Not clear |
| Shao-Liu Wang, Wen-Jing Qian, Xiao-Han Wang, Shu-Yue Wang, Wei Yang, Chuan-Qiang Zhang, Zhong-Feng Wan. [Cannabinoid receptor system regulates ion channels and synaptic transmission in retinal cells]. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 5. 2018-08-29. PMID:29063116. |
there are two types of cannabinoid receptors, cb1 and cb2. |
2018-08-29 |
2023-08-13 |
Not clear |
| Shao-Liu Wang, Wen-Jing Qian, Xiao-Han Wang, Shu-Yue Wang, Wei Yang, Chuan-Qiang Zhang, Zhong-Feng Wan. [Cannabinoid receptor system regulates ion channels and synaptic transmission in retinal cells]. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 5. 2018-08-29. PMID:29063116. |
in this review, incorporating our results, we discuss the modulation of cannabinoid cb1 and cb2 receptors on retinal neuronal and glial ion channels and retinal synaptic transmission. |
2018-08-29 |
2023-08-13 |
Not clear |
| Dan Zhou, Yue Li, Tian Tian, Wei Quan, Lei Wang, Qing Shao, Lian-Qiang Fu, Xiao-Hong Zhang, Xiao-Ye Wang, Hui Zhang, Yan-Min M. Role of the endocannabinoid system in the formation and development of depression. Die Pharmazie. vol 72. issue 8. 2018-08-24. PMID:29441900. |
two types of cannabinoid (cb) receptors have been described in the human body: cb1 and cb2 receptors. |
2018-08-24 |
2023-08-13 |
human |
| Dongxing Ji, Zhiyong Liang, Guixin Liu, Guangzong Zhao, Jun Fan. Bufalin attenuates cancer-induced pain and bone destruction in a model of bone cancer. Naunyn-Schmiedeberg's archives of pharmacology. vol 390. issue 12. 2018-07-23. PMID:28840279. |
cannabinoid 2 receptor (cb2) inverse agonist am630 was administrated to mice with bone cancer together with bufalin. |
2018-07-23 |
2023-08-13 |
mouse |
| Anna Konermann, Andreas Jäger, Stefanie A E Held, P Brossart, Anne Schmöl. In vivo and In vitro Identification of Endocannabinoid Signaling in Periodontal Tissues and Their Potential Role in Local Pathophysiology. Cellular and molecular neurobiology. vol 37. issue 8. 2018-07-13. PMID:28289947. |
the endocannabinoid system (ecs) with its binding receptors cb1 and cb2 impacts multiple pathophysiologies not only limited to neuronal psychoactivity. |
2018-07-13 |
2023-08-13 |
human |
| Pablo Nicolás Surkin, Sofia Ludmila Gallino, Valeria Luce, Fernando Correa, Javier Fernandez-Solari, Andrea De Laurentii. Pharmacological augmentation of endocannabinoid signaling reduces the neuroendocrine response to stress. Psychoneuroendocrinology. vol 87. 2018-07-13. PMID:29065362. |
at hypothalamic level both cannabinoid receptors (cb1 and cb2) are involved, while in the adrenal gland, anandamide has a very potent effect in suppressing acth-induced corticosterone release that is mainly mediated by vanilloid trpv1 receptors. |
2018-07-13 |
2023-08-13 |
rat |
| Fang Gao, Hong-Chun Xiang, Hong-Ping Li, Min Jia, Xiao-Li Pan, Hui-Lin Pan, Man L. Electroacupuncture inhibits NLRP3 inflammasome activation through CB2 receptors in inflammatory pain. Brain, behavior, and immunity. vol 67. 2018-07-11. PMID:28782714. |
the inflammasome promotes the maturation of the inflammatory cytokines, and ea can stimulate cannabinoid cb2 receptors in inflamed tissues. |
2018-07-11 |
2023-08-13 |
mouse |
| Marta Kruk-Slomka, Agnieszka Dzik, Barbara Budzynska, Grazyna Bial. Endocannabinoid System: the Direct and Indirect Involvement in the Memory and Learning Processes-a Short Review. Molecular neurobiology. vol 54. issue 10. 2018-07-02. PMID:27924524. |
the endocannabinoid system via cannabinoid (cb: cb1 and cb2) receptors and their endogenous ligands is directly and indirectly involved in many physiological functions, especially in memory and learning processes. |
2018-07-02 |
2023-08-13 |
Not clear |
| Thanh C Ho, Naoyuki Shimada, Marcus A Tius, Spyros P Nikas, Wen Zhang, Alexandros Makriyanni. C1'-Azacycloalkyl Hexahydrocannabinols. The Journal of organic chemistry. vol 82. issue 15. 2018-06-19. PMID:28677397. |
the c1'-n-methylazetidinyl and c1'-n-methylpyrrolidinyl analogues were found to be high affinity ligands for the cb1 and cb2 cannabinoid receptors. |
2018-06-19 |
2023-08-13 |
Not clear |
| Eleonora Patsenker, Andrea Chicca, Vanessa Petrucci, Sheida Moghadamrad, Andrea de Gottardi, Jochen Hampe, Jürg Gertsch, Nasser Semmo, Felix Sticke. 4-O'-methylhonokiol protects from alcohol/carbon tetrachloride-induced liver injury in mice. Journal of molecular medicine (Berlin, Germany). vol 95. issue 10. 2018-06-19. PMID:28689299. |
the endocannabinoid system contributes to the development of chronic liver diseases, where cannabinoid receptor 2 (cb2) has been shown to have a protecting role. |
2018-06-19 |
2023-08-13 |
mouse |