| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria A Sanchez-Rodriguez, Oscar Gomez, Pedro F Esteban, Daniel Garcia-Ovejero, Eduardo Molina-Holgad. The endocannabinoid 2-arachidonoylglycerol regulates oligodendrocyte progenitor cell migration. Biochemical pharmacology. vol 157. 2019-07-08. PMID:30195734. |
by contrast, increasing the levels of endogenous 2-ag by blocking its degradation (impairing monoacylglycerol lipase activity with jzl-184) significantly increased opc migration, as did agonists of the cb1, cb2 or cb1/cb2 cannabinoid receptors. |
2019-07-08 |
2023-08-13 |
rat |
| Jorge Manzanares, David Cabañero, Nagore Puente, María S García-Gutiérrez, Pedro Grandes, Rafael Maldonad. Role of the endocannabinoid system in drug addiction. Biochemical pharmacology. vol 157. 2019-07-08. PMID:30217570. |
currently, new research strategies are under development to target the endocannabinoid system for drug addiction avoiding these side effects, which include allosteric negative modulators of cb1 receptors and compounds targeting cb2 receptors. |
2019-07-08 |
2023-08-13 |
Not clear |
| Michael Camiller. Toward an effective peripheral visceral analgesic: responding to the national opioid crisis. American journal of physiology. Gastrointestinal and liver physiology. vol 314. issue 6. 2019-07-03. PMID:29470146. |
other compounds target nonopioid mechanisms, including cannabinoid (cb2), n-methyl-d-aspartate, calcitonin gene-related peptide, estrogen, and adenosine a |
2019-07-03 |
2023-08-13 |
Not clear |
| Han-Jun Kim, Eun-Ji Choi, Hyo Sung Kim, Chan-Woong Choi, Sik-Won Choi, Sun-Lim Kim, Woo-Duck Seo, Sun Hee D. Germinated soy germ extract ameliorates obesity through beige fat activation. Food & function. vol 10. issue 2. 2019-07-01. PMID:30681105. |
furthermore, gene and protein expression levels of endocannabinoid system-related factors such as nape-pld, faah, dagl-α, and cb2 were altered along with browning and beige fat activation by gsge. |
2019-07-01 |
2023-08-13 |
mouse |
| Thangesweran Ayakannu, Anthony H Taylor, Timothy H Marczylo, Justin C Konj. New Insights of Uterine Leiomyoma Pathogenesis: Endocannabinoid System. Medical science monitor basic research. vol 25. 2019-07-01. PMID:30842391. |
components studied included cannabinoid receptors 1 (cb1) and 2 (cb2); the g protein-coupled receptor gpr55; transient potential vanilloid receptor 1 (trpv1) and the endocannabinoid modulating enzymes n-acylphosphatidylethanolamine-specific phospholipase d (nape-pld) and fatty acid amide hydrolase (faah), and their n-acylethanolamine (nae) ligands: n-arachidonylethanolamine (aea), n-oleoylethanolamine (oea), and n-palmityolethanaolamine (pea). |
2019-07-01 |
2023-08-13 |
Not clear |
| Lili Zhou, Shan Zhou, Peng Yang, Yuan Tian, Zhiwei Feng, Xiang-Qun Xie, Youhua Li. Targeted inhibition of the type 2 cannabinoid receptor is a novel approach to reduce renal fibrosis. Kidney international. vol 94. issue 4. 2019-06-24. PMID:30093080. |
the cannabinoid receptor type 2 (cb2) is a g protein-coupled seven transmembrane receptor that transmits endogenous cannabinoid signaling. |
2019-06-24 |
2023-08-13 |
mouse |
| Chris Meleti. The Important Role of the Endocannabinoid System and the Endocannabinoidome in Gut Health. Alternative therapies in health and medicine. vol 25. issue S2. 2019-06-19. PMID:31202201. |
the endocannabinoid system is an endogenous pathway comprised of the cannabinoid receptors 1 and 2 (cb1 and cb2), their endogenous ligands known as endocannabinoids, and the enzymes responsible for their synthesis and degradation. |
2019-06-19 |
2023-08-13 |
Not clear |
| Simran Maggo, John C Ashto. Effect of Cannabinoid Receptor Agonists on Isolated Rat Atria. Journal of cardiovascular pharmacology. vol 72. issue 4. 2019-06-18. PMID:30080756. |
cannabinoid cb2 receptor agonists are under investigation for clinical use. |
2019-06-18 |
2023-08-13 |
rat |
| Simran Maggo, John C Ashto. Effect of Cannabinoid Receptor Agonists on Isolated Rat Atria. Journal of cardiovascular pharmacology. vol 72. issue 4. 2019-06-18. PMID:30080756. |
we therefore tested the effects of cannabinoids on isolated rat atria to test whether activation of myocardial cb1 and cb2 receptors could contribute to tachycardia. |
2019-06-18 |
2023-08-13 |
rat |
| Simran Maggo, John C Ashto. Effect of Cannabinoid Receptor Agonists on Isolated Rat Atria. Journal of cardiovascular pharmacology. vol 72. issue 4. 2019-06-18. PMID:30080756. |
our results indicate that cannabinoid cardiotoxicity may partially involve cb1 receptors in the myocardium, and that cb2 receptor agonists are unlikely to have significant effects on the heart. |
2019-06-18 |
2023-08-13 |
rat |
| Ai-Ling Li, Xiaoyan Lin, Amey S Dhopeshwarkar, Ana Carla Thomaz, Lawrence M Carey, Yingpeng Liu, Spyros P Nikas, Alexandros Makriyannis, Ken Mackie, Andrea G Hohman. Cannabinoid CB2 Agonist AM1710 Differentially Suppresses Distinct Pathological Pain States and Attenuates Morphine Tolerance and Withdrawal. Molecular pharmacology. vol 95. issue 2. 2019-06-14. PMID:30504240. |
cannabinoid cb2 agonist am1710 differentially suppresses distinct pathological pain states and attenuates morphine tolerance and withdrawal. |
2019-06-14 |
2023-08-13 |
mouse |
| Rodolfo Sánchez-Zavaleta, Hernán Cortés, José Arturo Avalos-Fuentes, Ubaldo García, José Segovia Vila, David Erlij, Benjamín Florá. Presynaptic cannabinoid CB2 receptors modulate [ Synapse (New York, N.Y.). vol 72. issue 11. 2019-06-10. PMID:30022523. |
presynaptic cannabinoid cb2 receptors modulate [ recent studies suggested the expression of cb2 receptors in neurons of the cns, however, most of these studies have only explored one aspect of the receptors, i.e., expression of protein, messenger rna, or functional response, and more complete studies appear to be needed to establish adequately their role in the neuronal function. |
2019-06-10 |
2023-08-13 |
Not clear |
| Xue Shen, Hua Duan, Sha Wang, Lu Gan, Qian Xu, Jin-Jiao L. Decreased Expression of Cannabinoid Receptors in the Eutopic and Ectopic Endometrium of Patients with Adenomyosis. BioMed research international. vol 2019. 2019-06-10. PMID:30800671. |
our research aims to analyze the expression patterns of the typical cannabinoid receptors (cb1 and cb2), the main constituents of the endocannabinoid system, in endometrial samples derived from patients diagnosed as adenomyosis or not. |
2019-06-10 |
2023-08-13 |
Not clear |
| Irena Kasacka, Żaneta Piotrowska, Anna Filipek, Wojciech Lebkowsk. Comparative evaluation of cannabinoid receptors, apelin and S100A6 protein in the heart of women of different age groups. BMC cardiovascular disorders. vol 18. issue 1. 2019-05-28. PMID:30286717. |
the aim of the study was to compare and evaluate the distribution of cannabinoid receptors (cb1 and cb2), apelin and s100a6 protein in the heart of healthy women in different age groups. |
2019-05-28 |
2023-08-13 |
Not clear |
| Ana Gabriela Silva, Caio Fabio Baeta Lopes, Clóvis Gomes Carvalho Júnior, Ralph Gruppi Thomé, Hélio Batista Dos Santos, Rui Reis, Rosy Iara Maciel de Azambuja Ribeir. WIN55,212-2 induces caspase-independent apoptosis on human glioblastoma cells by regulating HSP70, p53 and Cathepsin D. Toxicology in vitro : an international journal published in association with BIBRA. vol 57. 2019-05-23. PMID:30776504. |
in this sense, cannabinoids highlight as a promising tool, because this tumor overexpresses cb1 and/or cb2 receptors and being, therefore, can be susceptible to cannabinoids treatment. |
2019-05-23 |
2023-08-13 |
human |
| Jiliang Zhang, Shaojuan Zhang, Yang Liu, Meng Su, Xiaoxi Ling, Funan Liu, Yinghui Ge, Mingfeng Ba. Combined CB2 receptor agonist and photodynamic therapy synergistically inhibit tumor growth in triple negative breast cancer. Photodiagnosis and photodynamic therapy. vol 24. 2019-05-17. PMID:30240926. |
this combinatory therapy targets two proteins upregulated in tnbc: the cannabinoid cb2 receptor (cb |
2019-05-17 |
2023-08-13 |
Not clear |
| Ana Canseco-Alba, Norman Schanz, Branden Sanabria, Juan Zhao, Zhicheng Lin, Qing-Rong Liu, Emmanuel S Onaiv. Behavioral effects of psychostimulants in mutant mice with cell-type specific deletion of CB2 cannabinoid receptors in dopamine neurons. Behavioural brain research. vol 360. 2019-05-02. PMID:30508607. |
behavioral effects of psychostimulants in mutant mice with cell-type specific deletion of cb2 cannabinoid receptors in dopamine neurons. |
2019-05-02 |
2023-08-13 |
mouse |
| Dina A Ezzat, Amira A Hammam, Waleed M El-Malah, Rasha A Khattab, Eman M Mangou. Role of Cannabinoid CB2 Receptor Gene (CNR2) Polymorphism in Children with Immune Thrombocytopenic Purpura in Beni-Suef Governorate in Egypt. The Egyptian journal of immunology. vol 24. issue 1. 2019-04-25. PMID:29120578. |
role of cannabinoid cb2 receptor gene (cnr2) polymorphism in children with immune thrombocytopenic purpura in beni-suef governorate in egypt. |
2019-04-25 |
2023-08-13 |
Not clear |
| Dina A Ezzat, Amira A Hammam, Waleed M El-Malah, Rasha A Khattab, Eman M Mangou. Role of Cannabinoid CB2 Receptor Gene (CNR2) Polymorphism in Children with Immune Thrombocytopenic Purpura in Beni-Suef Governorate in Egypt. The Egyptian journal of immunology. vol 24. issue 1. 2019-04-25. PMID:29120578. |
the cb2 is encoded by the cannabinoid cb receptor gene (cnr2) gene. |
2019-04-25 |
2023-08-13 |
Not clear |
| Vanessa Petrucci, Andrea Chicca, Sandra Glasmacher, Janos Paloczi, Zongxian Cao, Pal Pacher, Jürg Gertsc. Pepcan-12 (RVD-hemopressin) is a CB2 receptor positive allosteric modulator constitutively secreted by adrenals and in liver upon tissue damage. Scientific reports. vol 7. issue 1. 2019-04-16. PMID:28842619. |
however, it remains unknown whether pepcans occur in the periphery and interact with peripheral cb2 cannabinoid receptors. |
2019-04-16 |
2023-08-13 |
Not clear |