| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Berhanu Geresu, Ana Canseco-Alba, Branden Sanabria, Zhicheng Lin, Qing-Rong Liu, Emmanuel S Onaivi, Ephrem Engidawor. Involvement of CB2 Receptors in the Neurobehavioral Effects of Molecules (Basel, Switzerland). vol 24. issue 17. 2020-01-22. PMID:31480324. |
involvement of cb2 receptors in the neurobehavioral effects of there is behavioral evidence for the interaction between crude khat extract and the endocannabinoid system, whereby the endocannabinoid system alters khat extract-mediated behavioral effects through modulation of the monoaminergic system. |
2020-01-22 |
2023-08-13 |
mouse |
| Mario García-Domínguez, Alina Aguirre, Ana Lastra, Agustín Hidalgo, Ana Baamonde, Luis Menénde. The Systemic Administration of the Chemokine CCL1 Evokes Thermal Analgesia in Mice Through the Activation of the Endocannabinoid System. Cellular and molecular neurobiology. vol 39. issue 8. 2020-01-20. PMID:31203533. |
furthermore, whereas the antinociceptive effect of ccl1 was unaffected after the treatment with either the antagonist of opioid receptors naloxone or the cannabinoid type 1 receptor blocker am251, it was dose-dependently inhibited after the administration of the cb2 receptor antagonist sr144528 (0.1-1 mg/kg). |
2020-01-20 |
2023-08-13 |
mouse |
| Murat Çakır, Suat Tekin, Züleyha Doğanyiğit, Pınar Çakan, Emin Kayma. The protective effect of cannabinoid type 2 receptor activation on renal ischemia-reperfusion injury. Molecular and cellular biochemistry. vol 462. issue 1-2. 2020-01-14. PMID:31446615. |
the relation of cannabinoid type 2 (cb2) receptor with inflammatory and apoptotic process has been determined. |
2020-01-14 |
2023-08-13 |
human |
| Oindrila Rahaman, Roopkatha Bhattacharya, Chinky Shiu Chen Liu, Deblina Raychaudhuri, Amrit Raj Ghosh, Purbita Bandopadhyay, Santu Pal, Rudra Prasad Goswami, Geetabali Sircar, Parasar Ghosh, Dipyaman Gangul. Cutting Edge: Dysregulated Endocannabinoid-Rheostat for Plasmacytoid Dendritic Cell Activation in a Systemic Lupus Endophenotype. Journal of immunology (Baltimore, Md. : 1950). vol 202. issue 6. 2020-01-10. PMID:30728209. |
we discovered a regulatory role of abhd6 in human pdcs through modulating the local abundance of its substrate, the endocannabinoid 2-arachidonyl glycerol (2-ag), and elucidated a hitherto unknown cannabinoid receptor 2 (cb2)-mediated regulatory role of 2-ag on ifn-α induction by pdcs. |
2020-01-10 |
2023-08-13 |
human |
| Sirichai Chayasirisobho. Cannabis and Neuropsychiatric Disorders: An Updated Review. Acta neurologica Taiwanica. vol 28(2). 2019-12-31. PMID:31867704. |
there are at least two types of endocannabinoid receptors (cb1 and cb2) which are g-protein coupled receptors. |
2019-12-31 |
2023-08-13 |
Not clear |
| Zyanya P Espinosa-Riquer, Alfredo Ibarra-Sánchez, Shamila Vibhushan, Manuela Bratti, Nicolas Charles, Ulrich Blank, Gabriela Rodríguez-Manzo, Claudia González-Espinos. TLR4 Receptor Induces 2-AG-Dependent Tolerance to Lipopolysaccharide and Trafficking of CB2 Receptor in Mast Cells. Journal of immunology (Baltimore, Md. : 1950). vol 202. issue 8. 2019-12-27. PMID:30814309. |
in this study, we demonstrate that the endocannabinoid 2-arachidonoylglycerol (2-ag) and its receptor, cannabinoid receptor 2 (cb2), play a role in the establishment of et in bone marrow-derived mcs from c57bl/6j mice. |
2019-12-27 |
2023-08-13 |
mouse |
| Juan A Páez, Nuria E Campill. Innovative Therapeutic Potential of Cannabinoid Receptors as Targets in Alzheimer's Disease and Less Well-Known Diseases. Current medicinal chemistry. vol 26. issue 18. 2019-12-02. PMID:29484980. |
the discovery of cannabinoid receptors at the beginning of the 1990s, cb1 cloned in 1990 and cb2 cloned in 1993, and the availability of selective and potent cannabimimetics could only be justified by the existence of endogenous ligands that are capable of binding to them. |
2019-12-02 |
2023-08-13 |
Not clear |
| Juan A Páez, Nuria E Campill. Innovative Therapeutic Potential of Cannabinoid Receptors as Targets in Alzheimer's Disease and Less Well-Known Diseases. Current medicinal chemistry. vol 26. issue 18. 2019-12-02. PMID:29484980. |
the therapeutic applications will be addressed through the study of cannabinoid agonists acting as single drugs and multi-target drugs highlighting the cb2 receptor agonist. |
2019-12-02 |
2023-08-13 |
Not clear |
| Annukka Kallinen, Rochelle Boyd, Samuel Lane, Rajiv Bhalla, Karine Mardon, Damion H R Stimson, Eryn L Werry, Roger Fulton, Mark Connor, Michael Kassio. Synthesis and in vitro evaluation of fluorine-18 benzimidazole sulfones as CB2 PET-radioligands. Organic & biomolecular chemistry. vol 17. issue 20. 2019-12-02. PMID:31070218. |
cannabinoid type 2 receptor (cb2) is up-regulated on activated microglial cells and can potentially be used as a biomarker for pet-imaging of neuroinflammation. |
2019-12-02 |
2023-08-13 |
Not clear |
| Zhenhua Shao, Jie Yin, Karen Chapman, Magdalena Grzemska, Lindsay Clark, Junmei Wang, Daniel M Rosenbau. High-resolution crystal structure of the human CB1 cannabinoid receptor. Nature. vol 540. issue 7634. 2019-11-20. PMID:27851727. |
the human cannabinoid g-protein-coupled receptors (gpcrs) cb1 and cb2 mediate the functional responses to the endocannabinoids anandamide and 2-arachidonyl glycerol (2-ag) and to the widely consumed plant phytocannabinoid Δ |
2019-11-20 |
2023-08-13 |
human |
| Omer Iqba. Endocannabinoid system and pathophysiology of adipogenesis: current management of obesity. Personalized medicine. vol 4. issue 3. 2019-11-20. PMID:29788669. |
the endocannabinoid system consists primarily of two receptors, cannabinoid (cb)1 and cb2, their endogenous ligands termed endocannabinoids and the enzymes responsible for ligand biosynthesis and degradation. |
2019-11-20 |
2023-08-13 |
human |
| Aya E Ghonim, Alessia Ligresti, Alessandro Rabbito, Ali Mokhtar Mahmoud, Vincenzo Di Marzo, Noha A Osman, Ashraf H Abad. Structure-activity relationships of thiazole and benzothiazole derivatives as selective cannabinoid CB2 agonists with in vivo anti-inflammatory properties. European journal of medicinal chemistry. vol 180. 2019-11-04. PMID:31302448. |
structure-activity relationships of thiazole and benzothiazole derivatives as selective cannabinoid cb2 agonists with in vivo anti-inflammatory properties. |
2019-11-04 |
2023-08-13 |
Not clear |
| Pauline S Santos, Thaisa C Oliveira, Luís Mário R Júnior, Ana Figueiras, Lívio C C Nune. β-caryophyllene Delivery Systems: Enhancing the Oral Pharmacokinetic and Stability. Current pharmaceutical design. vol 24. issue 29. 2019-10-24. PMID:30207226. |
the β-caryophyllene (bcp), a phytocannabinoid present in various essential oils, demonstrated selective action on the cb2 endocannabinoid receptor and attracted considerable attention because of its several pharmacological activities. |
2019-10-24 |
2023-08-13 |
Not clear |
| Emily Lorenzen, Thomas P Sakma. Receptor Structures for a Caldron of Cannabinoids. Cell. vol 176. issue 3. 2019-10-23. PMID:30682366. |
structures of the cannabinoid receptor 1 (cb1) in complex with an "ultrapotent" synthetic cannabinoid and its g protein (krishna kumar et al., 2019) and cb2 in complex with a new rationally designed inverse agonist (li et al., 2019) provide unique snapshots of the molecular pharmacology of cannabinoids. |
2019-10-23 |
2023-08-13 |
Not clear |
| Chihiro Nozaki, Elisa Nent, Andras Bilkei-Gorzo, Andreas Zimme. Involvement of leptin signaling in the development of cannabinoid CB2 receptor-dependent mirror image pain. Scientific reports. vol 8. issue 1. 2019-10-21. PMID:30018366. |
involvement of leptin signaling in the development of cannabinoid cb2 receptor-dependent mirror image pain. |
2019-10-21 |
2023-08-13 |
mouse |
| Shakiru O Alapafuja, Michael S Malamas, Vidyanand Shukla, Alexander Zvonok, Sally Miller, Laura Daily, Girija Rajarshi, Christina Yume Miyabe, Honrao Chandrashekhar, JodiAnne Wood, Sergiy Tyukhtenko, Alex Straiker, Alexandros Makriyanni. Synthesis and evaluation of potent and selective MGL inhibitors as a glaucoma treatment. Bioorganic & medicinal chemistry. vol 27. issue 1. 2019-10-17. PMID:30446439. |
the new inhibitors showed potent nanomolar inhibitory activity against recombinant human and purified rat mgl, were selective (>1000-fold) against serine hydrolases faah and abhd6 and lacked any affinity for the cannabinoid receptors cb1 and cb2. |
2019-10-17 |
2023-08-13 |
human |
| Raquel Guillamat-Prats, Martina Rami, Stephan Herzig, Sabine Steffen. Endocannabinoid Signalling in Atherosclerosis and Related Metabolic Complications. Thrombosis and haemostasis. vol 119. issue 4. 2019-09-12. PMID:30769363. |
endocannabinoids are a group of arachidonic acid-derived lipid mediators binding to cannabinoid receptors cb1 and cb2. |
2019-09-12 |
2023-08-13 |
Not clear |
| Francesco Spinelli, Linjing Mu, Simon M Ametame. Radioligands for positron emission tomography imaging of cannabinoid type 2 receptor. Journal of labelled compounds & radiopharmaceuticals. vol 61. issue 3. 2019-09-11. PMID:29110331. |
the cannabinoid type 2 (cb2) receptor is an immunomodulatory receptor mainly expressed in peripheral cells and organs of the immune system. |
2019-09-11 |
2023-08-13 |
Not clear |
| Thangesweran Ayakannu, Anthony H Taylor, Justin C Konj. Cannabinoid receptor expression in estrogen-dependent and estrogen-independent endometrial cancer. Journal of receptor and signal transduction research. vol 38. issue 5-6. 2019-09-04. PMID:30569804. |
previous studies on the expression of the classical cannabinoid receptors, cb1 and cb2, suggest these could provide good diagnostic/prognostic biomarkers for ec but those observations have been contradictory. |
2019-09-04 |
2023-08-13 |
Not clear |
| Marco Gentili, Simona Ronchetti, Erika Ricci, Rosanna Di Paola, Enrico Gugliandolo, Salvatore Cuzzocrea, Oxana Bereshchenko, Graziella Migliorati, Carlo Riccard. Selective CB2 inverse agonist JTE907 drives T cell differentiation towards a Treg cell phenotype and ameliorates inflammation in a mouse model of inflammatory bowel disease. Pharmacological research. vol 141. 2019-09-03. PMID:30552973. |
cb2 is the cannabinoid receptor that is expressed primarily on hematopoietic cells and mediates the immunoregulatory functions of cannabinoids. |
2019-09-03 |
2023-08-13 |
mouse |