| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Satoru Yamagishi, Yurika Iga, Masato Nakamura, Chika Takizawa, Dai Fukumoto, Takeharu Kakiuchi, Shingo Nishiyama, Hiroyuki Ohba, Hideo Tsukada, Kohji Sato, Yasuomi Ouch. Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study. Journal of neuroinflammation. vol 16. issue 1. 2020-04-02. PMID:31707986. |
type 2 endocannabinoid receptors (cb2) and translocator protein 18 kd (tspo) are considered to reflect distinct aspects of microglia-related neuroinflammatory responses in the brain. |
2020-04-02 |
2023-08-13 |
mouse |
| Wei Huang, Yaqin Xiong, Yali Chen, Yan Cheng, Rurong Wan. NOX2 is involved in CB2-mediated protection against lung ischemia-reperfusion injury in mice. International journal of clinical and experimental pathology. vol 13. issue 2. 2020-03-28. PMID:32211110. |
activation of the cannabinoid 2 (cb2) receptor limits tissue injury in some ischemia-reperfusion (i/r) models. |
2020-03-28 |
2023-08-13 |
mouse |
| Yuemin Bian, Yankang Jing, Lirong Wang, Shifan Ma, Jaden Jungho Jun, Xiang-Qun Xi. Prediction of Orthosteric and Allosteric Regulations on Cannabinoid Receptors Using Supervised Machine Learning Classifiers. Molecular pharmaceutics. vol 16. issue 6. 2020-03-16. PMID:31013097. |
in this study, supervised machine learning classifiers were built for two subtypes of cannabinoid receptors, cb1 and cb2. |
2020-03-16 |
2023-08-13 |
Not clear |
| Marta Kruk-Slomka, Izabela Banaszkiewicz, Tomasz Slomka, Grazyna Bial. Effects of Fatty Acid Amide Hydrolase Inhibitors Acute Administration on the Positive and Cognitive Symptoms of Schizophrenia in Mice. Molecular neurobiology. vol 56. issue 11. 2020-03-13. PMID:31004320. |
the ecs is composed of two types cannabinoid (cb: cb1 and cb2) receptors and their endogenous ligands, endocannabinoids. |
2020-03-13 |
2023-08-13 |
mouse |
| David Schubert, Devin Kepchia, Zhibin Liang, Richard Dargusch, Joshua Goldberg, Pamela Mahe. Efficacy of Cannabinoids in a Pre-Clinical Drug-Screening Platform for Alzheimer's Disease. Molecular neurobiology. vol 56. issue 11. 2020-03-12. PMID:31104297. |
nine of the 11 cannabinoids have the ability to protect cells in four distinct phenotypic neurodegeneration screening assays, including those using neurons that lack cb1 and cb2 receptors. |
2020-03-12 |
2023-08-13 |
Not clear |
| Ana Martín-Sánchez, Vincent Warnault, Sandra Montagud-Romero, Antoni Pastor, Neus Mondragón, Rafael De La Torre, Olga Valverd. Alcohol-induced conditioned place preference is modulated by CB2 cannabinoid receptors and modifies levels of endocannabinoids in the mesocorticolimbic system. Pharmacology, biochemistry, and behavior. vol 183. 2020-03-10. PMID:31220547. |
alcohol-induced conditioned place preference is modulated by cb2 cannabinoid receptors and modifies levels of endocannabinoids in the mesocorticolimbic system. |
2020-03-10 |
2023-08-13 |
mouse |
| Han Zhou, Xingrong Peng, Tao Hou, Nan Zhao, Minghua Qiu, Xiuli Zhang, Xinmiao Lian. Identification of novel phytocannabinoids from Ganoderma by label-free dynamic mass redistribution assay. Journal of ethnopharmacology. vol 246. 2020-02-27. PMID:31494202. |
located throughout the body, cannabinoid receptors (cb1 and cb2) are therapeutic targets for obesity/metabolic diseases, neurological/mental disorders, and immune modulation. |
2020-02-27 |
2023-08-13 |
Not clear |
| Zhigang Wang, Min Lu, Jie Ren, Xiaoxue Wu, Man Long, Longyun Chen, Zebin Che. Electroacupuncture inhibits mast cell degranulation via cannabinoid CB2 receptors in a rat model of allergic contact dermatitis. Acupuncture in medicine : journal of the British Medical Acupuncture Society. vol 37. issue 6. 2020-02-24. PMID:31429590. |
electroacupuncture inhibits mast cell degranulation via cannabinoid cb2 receptors in a rat model of allergic contact dermatitis. |
2020-02-24 |
2023-08-13 |
rat |
| Zhigang Wang, Min Lu, Jie Ren, Xiaoxue Wu, Man Long, Longyun Chen, Zebin Che. Electroacupuncture inhibits mast cell degranulation via cannabinoid CB2 receptors in a rat model of allergic contact dermatitis. Acupuncture in medicine : journal of the British Medical Acupuncture Society. vol 37. issue 6. 2020-02-24. PMID:31429590. |
cannabinoid cb2 receptors (cb2rs) are mainly present on immune cells including mast cells, which participate in 2,4-dinitrofluorobenzene (dnfb)-induced allergic contact dermatitis (acd). |
2020-02-24 |
2023-08-13 |
rat |
| Marcia G Honig, Nobel A Del Mar, Desmond L Henderson, Tyler D Ragsdale, John B Doty, Jake H Driver, Chunyan Li, Andrew P Fortugno, William M Mitchell, Aaron M Perry, Bob M Moore, Anton Reine. Amelioration of visual deficits and visual system pathology after mild TBI via the cannabinoid Type-2 receptor inverse agonism of raloxifene. Experimental neurology. vol 322. 2020-02-24. PMID:31518568. |
we have found that treatment with the cannabinoid type-2 receptor (cb2) inverse agonist smm-189 for 2 weeks after closed-head blast tbi greatly attenuates the visual deficits and retinal pathology this otherwise produces in mice, by modulating the deleterious role of microglia in the injury process after trauma. |
2020-02-24 |
2023-08-13 |
mouse |
| Mellar P Davis, Bertrand Behm, Zankhana Mehta, Carlos Fernande. The Potential Benefits of Palmitoylethanolamide in Palliation: A Qualitative Systematic Review. The American journal of hospice & palliative care. vol 36. issue 12. 2020-02-20. PMID:31113223. |
palmitoylethanolamide targets nonclassical cannabinoid receptors rather than cb1 and cb2 receptors. |
2020-02-20 |
2023-08-13 |
Not clear |
| Eva Danner, Frauke Hoffmann, Seo-Youn Lee, Fabian Cordes, Sabine Orban, Katrin Dauber, Doreen Chudziak, Gabriele Spohn, Eliza Wiercinska, Benjamin Tast, Darja Karpova, Halvard Boni. Modest and nonessential roles of the endocannabinoid system in immature hematopoiesis of mice. Experimental hematology. vol 78. 2020-02-18. PMID:31562901. |
the endocannabinoid receptor cb2 is expressed on blood cells, including stem cells, and mediates the effects of cannabinoids on the immune system. |
2020-02-18 |
2023-08-13 |
mouse |
| Natalie M Guley, Nobel A Del Mar, Tyler Ragsdale, Chunyan Li, Aaron M Perry, Bob M Moore, Marcia G Honig, Anton Reine. Amelioration of visual deficits and visual system pathology after mild TBI with the cannabinoid type-2 receptor inverse agonist SMM-189. Experimental eye research. vol 182. 2020-02-17. PMID:30922891. |
using our focal cranial blast mouse model of closed-skull mild tbi, we evaluated the ability of the cannabinoid type-2 (cb2) receptor inverse agonist smm-189, which biases microglia from the harmful m1 state to the beneficial m2 state, to mitigate visual system dysfunction and injury after tbi. |
2020-02-17 |
2023-08-13 |
mouse |
| Berhanu Geresu, Ana Canseco-Alba, Branden Sanabria, Zhicheng Lin, Qing-Rong Liu, Emmanuel S Onaivi, Ephrem Engidawor. Involvement of CB2 Receptors in the Neurobehavioral Effects of Molecules (Basel, Switzerland). vol 24. issue 17. 2020-01-22. PMID:31480324. |
involvement of cb2 receptors in the neurobehavioral effects of there is behavioral evidence for the interaction between crude khat extract and the endocannabinoid system, whereby the endocannabinoid system alters khat extract-mediated behavioral effects through modulation of the monoaminergic system. |
2020-01-22 |
2023-08-13 |
mouse |
| Mario García-Domínguez, Alina Aguirre, Ana Lastra, Agustín Hidalgo, Ana Baamonde, Luis Menénde. The Systemic Administration of the Chemokine CCL1 Evokes Thermal Analgesia in Mice Through the Activation of the Endocannabinoid System. Cellular and molecular neurobiology. vol 39. issue 8. 2020-01-20. PMID:31203533. |
furthermore, whereas the antinociceptive effect of ccl1 was unaffected after the treatment with either the antagonist of opioid receptors naloxone or the cannabinoid type 1 receptor blocker am251, it was dose-dependently inhibited after the administration of the cb2 receptor antagonist sr144528 (0.1-1 mg/kg). |
2020-01-20 |
2023-08-13 |
mouse |
| Murat Çakır, Suat Tekin, Züleyha Doğanyiğit, Pınar Çakan, Emin Kayma. The protective effect of cannabinoid type 2 receptor activation on renal ischemia-reperfusion injury. Molecular and cellular biochemistry. vol 462. issue 1-2. 2020-01-14. PMID:31446615. |
the relation of cannabinoid type 2 (cb2) receptor with inflammatory and apoptotic process has been determined. |
2020-01-14 |
2023-08-13 |
human |
| Oindrila Rahaman, Roopkatha Bhattacharya, Chinky Shiu Chen Liu, Deblina Raychaudhuri, Amrit Raj Ghosh, Purbita Bandopadhyay, Santu Pal, Rudra Prasad Goswami, Geetabali Sircar, Parasar Ghosh, Dipyaman Gangul. Cutting Edge: Dysregulated Endocannabinoid-Rheostat for Plasmacytoid Dendritic Cell Activation in a Systemic Lupus Endophenotype. Journal of immunology (Baltimore, Md. : 1950). vol 202. issue 6. 2020-01-10. PMID:30728209. |
we discovered a regulatory role of abhd6 in human pdcs through modulating the local abundance of its substrate, the endocannabinoid 2-arachidonyl glycerol (2-ag), and elucidated a hitherto unknown cannabinoid receptor 2 (cb2)-mediated regulatory role of 2-ag on ifn-α induction by pdcs. |
2020-01-10 |
2023-08-13 |
human |
| Sirichai Chayasirisobho. Cannabis and Neuropsychiatric Disorders: An Updated Review. Acta neurologica Taiwanica. vol 28(2). 2019-12-31. PMID:31867704. |
there are at least two types of endocannabinoid receptors (cb1 and cb2) which are g-protein coupled receptors. |
2019-12-31 |
2023-08-13 |
Not clear |
| Zyanya P Espinosa-Riquer, Alfredo Ibarra-Sánchez, Shamila Vibhushan, Manuela Bratti, Nicolas Charles, Ulrich Blank, Gabriela Rodríguez-Manzo, Claudia González-Espinos. TLR4 Receptor Induces 2-AG-Dependent Tolerance to Lipopolysaccharide and Trafficking of CB2 Receptor in Mast Cells. Journal of immunology (Baltimore, Md. : 1950). vol 202. issue 8. 2019-12-27. PMID:30814309. |
in this study, we demonstrate that the endocannabinoid 2-arachidonoylglycerol (2-ag) and its receptor, cannabinoid receptor 2 (cb2), play a role in the establishment of et in bone marrow-derived mcs from c57bl/6j mice. |
2019-12-27 |
2023-08-13 |
mouse |
| Juan A Páez, Nuria E Campill. Innovative Therapeutic Potential of Cannabinoid Receptors as Targets in Alzheimer's Disease and Less Well-Known Diseases. Current medicinal chemistry. vol 26. issue 18. 2019-12-02. PMID:29484980. |
the discovery of cannabinoid receptors at the beginning of the 1990s, cb1 cloned in 1990 and cb2 cloned in 1993, and the availability of selective and potent cannabimimetics could only be justified by the existence of endogenous ligands that are capable of binding to them. |
2019-12-02 |
2023-08-13 |
Not clear |