| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Prabhuanand Selvaraj, Jie Wen, Mikiei Tanaka, Yumin Zhan. Therapeutic Effect of a Novel Fatty Acid Amide Hydrolase Inhibitor PF04457845 in the Repetitive Closed Head Injury Mouse Model. Journal of neurotrauma. vol 36. issue 10. 2020-09-11. PMID:30526351. |
the improved locomotor function and working memory were partially mediated by activation of both cannabinoid (cb)1 and cb2 receptors, whereas the improvement on spatial learning and memory seemed to be cb1 receptor dependent. |
2020-09-11 |
2023-08-13 |
mouse |
| Tian Hua, Xiaoting Li, Lijie Wu, Christos Iliopoulos-Tsoutsouvas, Yuxia Wang, Meng Wu, Ling Shen, Christina A Brust, Spyros P Nikas, Feng Song, Xiyong Song, Shuguang Yuan, Qianqian Sun, Yiran Wu, Shan Jiang, Travis W Grim, Othman Benchama, Edward L Stahl, Nikolai Zvonok, Suwen Zhao, Laura M Bohn, Alexandros Makriyannis, Zhi-Jie Li. Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-G Cell. vol 180. issue 4. 2020-08-24. PMID:32004463. |
activation and signaling mechanism revealed by cannabinoid receptor-g human endocannabinoid systems modulate multiple physiological processes mainly through the activation of cannabinoid receptors cb1 and cb2. |
2020-08-24 |
2023-08-13 |
human |
| Jiang Wu, Mark Hocevar, Bihua Bie, Joseph F Foss, Mohamed Nagui. Cannabinoid Type 2 Receptor System Modulates Paclitaxel-Induced Microglial Dysregulation and Central Sensitization in Rats. The journal of pain. vol 20. issue 5. 2020-08-19. PMID:30414958. |
mda7, 1-([3-benzyl-3-methyl-2,3-dihydro-1-benzofuran-6-yl]carbonyl) piperidine, is a novel highly selective cannabinoid type 2 (cb2) agonist. |
2020-08-19 |
2023-08-13 |
rat |
| Jin Cheng, Siyi Wang, Weiwei Lin, Nan Wu, Yuanqiang Wang, Maozi Chen, Xiang-Qun Xie, Zhiwei Fen. Computational Systems Pharmacology-Target Mapping for Fentanyl-Laced Cocaine Overdose. ACS chemical neuroscience. vol 10. issue 8. 2020-08-18. PMID:31257858. |
finally, we looked into the detail of jwh133, an agonist of cannabinoid 2-receptor (cb2) with potential as a therapy for cocaine and fentanyl overdose. |
2020-08-18 |
2023-08-13 |
Not clear |
| Maryna Rodrigues Gonçalves, Milena Santana da Conceição, Carlos Henrique Alves Jesus, Aléxia Thamara Gasparin, Evelize Stacoviaki Rosa, Joice Maria da Cunh. Spinal cannabinoid CB1 or CB2 receptors activation attenuates mechanical allodynia in streptozotocin-induced diabetic rats. Behavioural pharmacology. 2020-08-17. PMID:32804775. |
spinal cannabinoid cb1 or cb2 receptors activation attenuates mechanical allodynia in streptozotocin-induced diabetic rats. |
2020-08-17 |
2023-08-13 |
rat |
| Maryna Rodrigues Gonçalves, Milena Santana da Conceição, Carlos Henrique Alves Jesus, Aléxia Thamara Gasparin, Evelize Stacoviaki Rosa, Joice Maria da Cunh. Spinal cannabinoid CB1 or CB2 receptors activation attenuates mechanical allodynia in streptozotocin-induced diabetic rats. Behavioural pharmacology. 2020-08-17. PMID:32804775. |
cannabinoid receptor antagonists cb1 am251 or cb2 am630 (1 mg/kg) were given before treatment with respective agonists to confirm the involvement of cannabinoid cb1 or cb2 receptors. |
2020-08-17 |
2023-08-13 |
rat |
| Christina Miyabe Shields, Nikolai Zvonok, Alexander Zvonok, Alexandros Makriyanni. Biochemical and Proteomic Characterization of Recombinant Human α/β Hydrolase Domain 6. Scientific reports. vol 9. issue 1. 2020-08-12. PMID:30696836. |
human alpha/beta hydrolase domain 6 (habhd6) is an enzyme that hydrolyzes 2-arachidonoylglycerol (2-ag), a potent agonist at both cannabinoid cb1 and cb2 receptors. |
2020-08-12 |
2023-08-13 |
human |
| Sriity Melley Sadanandan, Tabita Kreko-Pierce, Shailesh N Khatri, Jason R Pug. Cannabinoid type 2 receptors inhibit GABAA receptor-mediated currents in cerebellar Purkinje cells of juvenile mice. PloS one. vol 15. issue 5. 2020-07-31. PMID:32437355. |
however, most studies have focused on signaling through cannabinoid type 1 (cb1) receptors, while relatively little is known about signaling through type 2 (cb2) receptors. |
2020-07-31 |
2023-08-13 |
mouse |
| Jadna B Lopes, Juliana R Bastos, Rayssa B Costa, Daniele C Aguiar, Fabrício A Moreir. The roles of cannabinoid CB1 and CB2 receptors in cocaine-induced behavioral sensitization and conditioned place preference in mice. Psychopharmacology. vol 237. issue 2. 2020-07-28. PMID:31667531. |
the roles of cannabinoid cb1 and cb2 receptors in cocaine-induced behavioral sensitization and conditioned place preference in mice. |
2020-07-28 |
2023-08-13 |
mouse |
| Erkan Kilinc, Seyit Ankarali, Ibrahim Ethem Torun, Yasar Dagista. Receptor mechanisms mediating the anti-neuroinflammatory effects of endocannabinoid system modulation in a rat model of migraine. The European journal of neuroscience. 2020-07-25. PMID:32639078. |
we used methanandamide (cannabinoid agonist), rimonabant (cannabinoid receptor-1 cb1 antagonist), sr144528 (cb2 antagonist) and capsazepine (transient receptor potential vanilloid-1 trpv1 antagonist) to explore effects of endocannabinoid system modulation on the neurogenic inflammation, and possible involvement of cb1, cb2 and trpv1 receptors during endocannabinoid effects. |
2020-07-25 |
2023-08-13 |
rat |
| Ryan M Wyatt, Ian Fraser, Natalie Welty, Brian Lord, Michelle Wennerholm, Steven Sutton, Michael K Ameriks, Christine Dugovic, Sujin Yun, Allison White, Leslie Nguyen, Tatiana Koudriakova, Gaochao Tian, Javier Suarez, Lawrence Szewczuk, William Bonnette, Kay Ahn, Brahma Ghosh, Christopher M Flores, Peter J Connolly, Bin Zhu, Mark J Macielag, Michael R Brandt, Kristen Chevalier, Sui-Po Zhang, Timothy Lovenberg, Pascal Bonaventur. Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor. The Journal of pharmacology and experimental therapeutics. vol 372. issue 3. 2020-07-06. PMID:31818916. |
inhibition of 2-ag degradation leads to elevation of 2-ag, the most abundant endogenous agonist of the cannabinoid receptors (cbs) cb1 and cb2. |
2020-07-06 |
2023-08-13 |
human |
| Sarah-Lena Puh. Cannabinoid-sensitive receptors in cardiac physiology and ischaemia. Biochimica et biophysica acta. Molecular cell research. vol 1867. issue 3. 2020-07-01. PMID:30890410. |
the classical cannabinoid receptors cb1 and cb2 as well as the cannabinoid-sensitive receptor gpr55 are widely distributed throughout the mammalian body. |
2020-07-01 |
2023-08-13 |
Not clear |
| Giselle Castaneira, Kelley Rojas, Yehuda Galili, Zachary Field, Ariel Perez-Perez, Mario Madruga, Steve J Carla. Idiopathic Thrombocytopenic Purpura Induced by Synthetic Cannabinoid. Journal of addiction medicine. vol 13. issue 3. 2020-06-25. PMID:30531235. |
k2/spice, or synthetic marijuana, acts on cannabinoid receptors cb1 (cannabinoid type-1) and cb2 (cannabinoid type-2) with increased binding capacity compared to marijuana. |
2020-06-25 |
2023-08-13 |
Not clear |
| Georg D Duerr, Jan C Heinemann, Julian Kley, Lars Eichhorn, Stilla Frede, Christina Weisheit, Sven Wehner, Laura Bindila, Beat Lutz, Andreas Zimmer, Oliver Dewal. Myocardial maladaptation to pressure overload in CB2 receptor-deficient mice. Journal of molecular and cellular cardiology. vol 133. 2020-06-25. PMID:31181227. |
since the endocannabinoid system and the cb2 receptor provide cardioprotection and modulate immune response in experimental ischemia, we investigated the role of cb2 in a mouse model of cardiac pressure overload. |
2020-06-25 |
2023-08-13 |
mouse |
| Ahmed Haider, Julian Kretz, Luca Gobbi, Hazem Ahmed, Kenneth Atz, Markus Bürkler, Christian Bartelmus, Jürgen Fingerle, Wolfgang Guba, Christoph Ullmer, Michael Honer, Irene Knuesel, Markus Weber, Andreas Brink, Adrienne Müller Herde, Claudia Keller, Roger Schibli, Linjing Mu, Uwe Grether, Simon M Ametame. Structure-Activity Relationship Studies of Pyridine-Based Ligands and Identification of a Fluorinated Derivative for Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors. Journal of medicinal chemistry. vol 62. issue 24. 2020-06-22. PMID:31751140. |
the cannabinoid type 2 (cb2) receptor has emerged as a valuable target for therapy and imaging of immune-mediated pathologies. |
2020-06-22 |
2023-08-13 |
Not clear |
| Ronald Chow, Crystal Valdez, Natalie Chow, Daniel Zhang, James Im, Emily Sodhi, Michael Loc. Oral cannabinoid for the prophylaxis of chemotherapy-induced nausea and vomiting-a systematic review and meta-analysis. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. vol 28. issue 5. 2020-06-08. PMID:31916006. |
evidence suggests that cannabinoid cb2 receptors are present in brainstem neurons, and thus, there may exist a role for cannabinoids to counter cinv. |
2020-06-08 |
2023-08-13 |
Not clear |
| Evelyn Gaffal, Andrea M Kemter, Stefanie Scheu, Rafael Leite Dantas, Jens Vogt, Bernhard Baune, Thomas Tüting, Andreas Zimmer, Judith Alferin. Cannabinoid Receptor 2 Modulates Maturation of Dendritic Cells and Their Capacity to Induce Hapten-Induced Contact Hypersensitivity. International journal of molecular sciences. vol 21. issue 2. 2020-06-03. PMID:31940843. |
the cannabinoid receptors 1 (cb1) and 2 (cb2) modulate dc functions and inflammatory skin responses, but their influence on the capacity of haptenized dcs to induce chs is still unknown. |
2020-06-03 |
2023-08-13 |
mouse |
| Francesca Gado, Serena Meini, Simone Bertini, Maria Digiacomo, Marco Macchia, Clementina Maner. Allosteric modulators targeting cannabinoid cb1 and cb2 receptors: implications for drug discovery. Future medicinal chemistry. vol 11. issue 15. 2020-05-20. PMID:31517528. |
allosteric modulators targeting cannabinoid cb1 and cb2 receptors: implications for drug discovery. |
2020-05-20 |
2023-08-13 |
Not clear |
| Sarah Al Fawaz, Mohammad Al Deeb, James L Huffman, Naji A Al Kholaif, Fiona Garlich, Ryan Chuan. A Case of Status Epilepticus and Transient Stress Cardiomyopathy Associated with Smoking the Synthetic Psychoactive Cannabinoid, UR-144. The American journal of case reports. vol 20. 2020-05-13. PMID:31857571. |
background synthetic cannabinoids have a higher affinity for the cannabinoid receptors cb1 and cb2 than natural cannabinoids. |
2020-05-13 |
2023-08-13 |
Not clear |
| Lara Milian, Manuel Mata, Javier Alcacer, María Oliver, María Sancho-Tello, José Javier Martín de Llano, Carlos Camps, José Galbis, Julian Carretero, Carmen Card. Cannabinoid receptor expression in non-small cell lung cancer. Effectiveness of tetrahydrocannabinol and cannabidiol inhibiting cell proliferation and epithelial-mesenchymal transition in vitro. PloS one. vol 15. issue 2. 2020-05-05. PMID:32049991. |
this necessitates the development of new complementary drugs, e.g., cannabinoid receptors (cb1 and cb2) agonists including tetrahydrocannabinol (thc) and cannabidiol (cbd). |
2020-05-05 |
2023-08-13 |
Not clear |