| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sriity Melley Sadanandan, Tabita Kreko-Pierce, Shailesh N Khatri, Jason R Pug. Cannabinoid type 2 receptors inhibit GABAA receptor-mediated currents in cerebellar Purkinje cells of juvenile mice. PloS one. vol 15. issue 5. 2020-07-31. PMID:32437355. |
however, most studies have focused on signaling through cannabinoid type 1 (cb1) receptors, while relatively little is known about signaling through type 2 (cb2) receptors. |
2020-07-31 |
2023-08-13 |
mouse |
| Jadna B Lopes, Juliana R Bastos, Rayssa B Costa, Daniele C Aguiar, Fabrício A Moreir. The roles of cannabinoid CB1 and CB2 receptors in cocaine-induced behavioral sensitization and conditioned place preference in mice. Psychopharmacology. vol 237. issue 2. 2020-07-28. PMID:31667531. |
the roles of cannabinoid cb1 and cb2 receptors in cocaine-induced behavioral sensitization and conditioned place preference in mice. |
2020-07-28 |
2023-08-13 |
mouse |
| Erkan Kilinc, Seyit Ankarali, Ibrahim Ethem Torun, Yasar Dagista. Receptor mechanisms mediating the anti-neuroinflammatory effects of endocannabinoid system modulation in a rat model of migraine. The European journal of neuroscience. 2020-07-25. PMID:32639078. |
we used methanandamide (cannabinoid agonist), rimonabant (cannabinoid receptor-1 cb1 antagonist), sr144528 (cb2 antagonist) and capsazepine (transient receptor potential vanilloid-1 trpv1 antagonist) to explore effects of endocannabinoid system modulation on the neurogenic inflammation, and possible involvement of cb1, cb2 and trpv1 receptors during endocannabinoid effects. |
2020-07-25 |
2023-08-13 |
rat |
| Ryan M Wyatt, Ian Fraser, Natalie Welty, Brian Lord, Michelle Wennerholm, Steven Sutton, Michael K Ameriks, Christine Dugovic, Sujin Yun, Allison White, Leslie Nguyen, Tatiana Koudriakova, Gaochao Tian, Javier Suarez, Lawrence Szewczuk, William Bonnette, Kay Ahn, Brahma Ghosh, Christopher M Flores, Peter J Connolly, Bin Zhu, Mark J Macielag, Michael R Brandt, Kristen Chevalier, Sui-Po Zhang, Timothy Lovenberg, Pascal Bonaventur. Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor. The Journal of pharmacology and experimental therapeutics. vol 372. issue 3. 2020-07-06. PMID:31818916. |
inhibition of 2-ag degradation leads to elevation of 2-ag, the most abundant endogenous agonist of the cannabinoid receptors (cbs) cb1 and cb2. |
2020-07-06 |
2023-08-13 |
human |
| Sarah-Lena Puh. Cannabinoid-sensitive receptors in cardiac physiology and ischaemia. Biochimica et biophysica acta. Molecular cell research. vol 1867. issue 3. 2020-07-01. PMID:30890410. |
the classical cannabinoid receptors cb1 and cb2 as well as the cannabinoid-sensitive receptor gpr55 are widely distributed throughout the mammalian body. |
2020-07-01 |
2023-08-13 |
Not clear |
| Giselle Castaneira, Kelley Rojas, Yehuda Galili, Zachary Field, Ariel Perez-Perez, Mario Madruga, Steve J Carla. Idiopathic Thrombocytopenic Purpura Induced by Synthetic Cannabinoid. Journal of addiction medicine. vol 13. issue 3. 2020-06-25. PMID:30531235. |
k2/spice, or synthetic marijuana, acts on cannabinoid receptors cb1 (cannabinoid type-1) and cb2 (cannabinoid type-2) with increased binding capacity compared to marijuana. |
2020-06-25 |
2023-08-13 |
Not clear |
| Georg D Duerr, Jan C Heinemann, Julian Kley, Lars Eichhorn, Stilla Frede, Christina Weisheit, Sven Wehner, Laura Bindila, Beat Lutz, Andreas Zimmer, Oliver Dewal. Myocardial maladaptation to pressure overload in CB2 receptor-deficient mice. Journal of molecular and cellular cardiology. vol 133. 2020-06-25. PMID:31181227. |
since the endocannabinoid system and the cb2 receptor provide cardioprotection and modulate immune response in experimental ischemia, we investigated the role of cb2 in a mouse model of cardiac pressure overload. |
2020-06-25 |
2023-08-13 |
mouse |
| Ahmed Haider, Julian Kretz, Luca Gobbi, Hazem Ahmed, Kenneth Atz, Markus Bürkler, Christian Bartelmus, Jürgen Fingerle, Wolfgang Guba, Christoph Ullmer, Michael Honer, Irene Knuesel, Markus Weber, Andreas Brink, Adrienne Müller Herde, Claudia Keller, Roger Schibli, Linjing Mu, Uwe Grether, Simon M Ametame. Structure-Activity Relationship Studies of Pyridine-Based Ligands and Identification of a Fluorinated Derivative for Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors. Journal of medicinal chemistry. vol 62. issue 24. 2020-06-22. PMID:31751140. |
the cannabinoid type 2 (cb2) receptor has emerged as a valuable target for therapy and imaging of immune-mediated pathologies. |
2020-06-22 |
2023-08-13 |
Not clear |
| Ronald Chow, Crystal Valdez, Natalie Chow, Daniel Zhang, James Im, Emily Sodhi, Michael Loc. Oral cannabinoid for the prophylaxis of chemotherapy-induced nausea and vomiting-a systematic review and meta-analysis. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. vol 28. issue 5. 2020-06-08. PMID:31916006. |
evidence suggests that cannabinoid cb2 receptors are present in brainstem neurons, and thus, there may exist a role for cannabinoids to counter cinv. |
2020-06-08 |
2023-08-13 |
Not clear |
| Evelyn Gaffal, Andrea M Kemter, Stefanie Scheu, Rafael Leite Dantas, Jens Vogt, Bernhard Baune, Thomas Tüting, Andreas Zimmer, Judith Alferin. Cannabinoid Receptor 2 Modulates Maturation of Dendritic Cells and Their Capacity to Induce Hapten-Induced Contact Hypersensitivity. International journal of molecular sciences. vol 21. issue 2. 2020-06-03. PMID:31940843. |
the cannabinoid receptors 1 (cb1) and 2 (cb2) modulate dc functions and inflammatory skin responses, but their influence on the capacity of haptenized dcs to induce chs is still unknown. |
2020-06-03 |
2023-08-13 |
mouse |
| Francesca Gado, Serena Meini, Simone Bertini, Maria Digiacomo, Marco Macchia, Clementina Maner. Allosteric modulators targeting cannabinoid cb1 and cb2 receptors: implications for drug discovery. Future medicinal chemistry. vol 11. issue 15. 2020-05-20. PMID:31517528. |
allosteric modulators targeting cannabinoid cb1 and cb2 receptors: implications for drug discovery. |
2020-05-20 |
2023-08-13 |
Not clear |
| Sarah Al Fawaz, Mohammad Al Deeb, James L Huffman, Naji A Al Kholaif, Fiona Garlich, Ryan Chuan. A Case of Status Epilepticus and Transient Stress Cardiomyopathy Associated with Smoking the Synthetic Psychoactive Cannabinoid, UR-144. The American journal of case reports. vol 20. 2020-05-13. PMID:31857571. |
background synthetic cannabinoids have a higher affinity for the cannabinoid receptors cb1 and cb2 than natural cannabinoids. |
2020-05-13 |
2023-08-13 |
Not clear |
| Lara Milian, Manuel Mata, Javier Alcacer, María Oliver, María Sancho-Tello, José Javier Martín de Llano, Carlos Camps, José Galbis, Julian Carretero, Carmen Card. Cannabinoid receptor expression in non-small cell lung cancer. Effectiveness of tetrahydrocannabinol and cannabidiol inhibiting cell proliferation and epithelial-mesenchymal transition in vitro. PloS one. vol 15. issue 2. 2020-05-05. PMID:32049991. |
this necessitates the development of new complementary drugs, e.g., cannabinoid receptors (cb1 and cb2) agonists including tetrahydrocannabinol (thc) and cannabidiol (cbd). |
2020-05-05 |
2023-08-13 |
Not clear |
| Adriana Díaz-Rivera, Alejandra Meza-Ríos, Victoria Chagoya de Sánchez, Gabriela Velasco-Loyden, Leonel García-Benavides, Luis F Jave-Suarez, Hugo Christian Monroy-Ramirez, Arturo Santos-García, Juan Armendáriz-Borunda, Ana Sandoval-Rodrígue. Hydrodynamics-based liver transfection achieves gene silencing of CB1 using short hairpin RNA plasmid in cirrhotic rats. PloS one. vol 15. issue 2. 2020-05-04. PMID:32053633. |
there is a correlation between the endocannabinoid system and hepatic fibrosis based on the activation of cb1 and cb2 receptors; where cb1 has profibrogenic effects. |
2020-05-04 |
2023-08-13 |
rat |
| Joshua Z Seither, Lisa J Reidy, Diane M Bolan. Identification and Quantification of 5-Fluoro ADB and the 5-Fluoro ADB Ester Hydrolysis Metabolite in Postmortem Blood Samples by LC-MS/MS. Journal of analytical toxicology. vol 44. issue 2. 2020-04-29. PMID:31274144. |
5-fluoro adb, also known as 5-fluoro mdmb-pinaca, is a potent synthetic cannabinoid that is an agonist to the human cannabinoid cb1 and cb2 receptors. |
2020-04-29 |
2023-08-13 |
human |
| Mariana M Almeida, Camilla P Dias-Rocha, Clara F Reis-Gomes, Haimei Wang, Georgia C Atella, Aline Cordeiro, Carmen C Pazos-Moura, Lisa Joss-Moore, Isis H Trevenzol. Maternal high-fat diet impairs leptin signaling and up-regulates type-1 cannabinoid receptor with sex-specific epigenetic changes in the hypothalamus of newborn rats. Psychoneuroendocrinology. vol 103. 2020-04-23. PMID:30776574. |
the ecs mainly consists of endocannabinoids derived from n-6 fatty acids and cannabinoid receptors (cb1 coded by cnr1 and cb2 coded by cnr2). |
2020-04-23 |
2023-08-13 |
rat |
| Mengjuan Lin, Lei Chen, Yong Xiao, Baoping Y. Activation of cannabinoid 2 receptor relieves colonic hypermotility in a rat model of irritable bowel syndrome. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 31. issue 6. 2020-04-17. PMID:30793435. |
we aimed to determine whether cannabinoid 2 (cb2) receptor modulates intestinal motility associated with stress-induced ibs. |
2020-04-17 |
2023-08-13 |
rat |
| Lin Cheng, Jinsi Li, Yi Zhou, Qixue Zheng, Xin Ming, Sha Li. N-Linoleyltyrosine Protects against Transient Cerebral Ischemia in Gerbil via CB2 Receptor Involvement in PI3K/Akt Signaling Pathway. Biological & pharmaceutical bulletin. vol 42. issue 11. 2020-04-16. PMID:31484847. |
anandamide (aea) played potent neuroprotective activities via cannabinoid type 1 (cb1) and 2 (cb2) receptor. |
2020-04-16 |
2023-08-13 |
mouse |
| Maura Argenziano, Chiara Tortora, Giulia Bellini, Alessandra Di Paola, Francesca Punzo, Francesca Ross. The Endocannabinoid System in Pediatric Inflammatory and Immune Diseases. International journal of molecular sciences. vol 20. issue 23. 2020-04-13. PMID:31771129. |
endocannabinoid system consists of cannabinoid type 1 (cb1) and cannabinoid type 2 (cb2) receptors, their endogenous ligands, and the enzymes responsible for their synthesis and degradation. |
2020-04-13 |
2023-08-13 |
Not clear |
| Chiara Cioni, Maristella Tassi, Giuseppe Marotta, Claudia Mugnaini, Federico Corelli, Pasquale Annunziat. A Novel Highly Selective Cannabinoid CB2 Agonist Reduces in vitro Growth and TGF-beta Release of Human Glial Cell Tumors. Central nervous system agents in medicinal chemistry. vol 19. issue 3. 2020-04-09. PMID:31549596. |
a novel highly selective cannabinoid cb2 agonist reduces in vitro growth and tgf-beta release of human glial cell tumors. |
2020-04-09 |
2023-08-13 |
human |