| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Agustín Riquelme-Sandoval, Caio O de Sá-Ferreira, Leo M Miyakoshi, Cecilia Hedin-Pereir. New Insights Into Peptide Cannabinoids: Structure, Biosynthesis and Signaling. Frontiers in pharmacology. vol 11. 2020-12-29. PMID:33362550. |
classically, the endocannabinoid system (ecs) consists of endogenous lipids, of which the best known are anandamide (aea) and 2 arachidonoylglycerol (2-ag), their enzyme machinery for synthesis and degradation and their specific receptors, cannabinoid receptor one (cb1) and cannabinoid receptor two (cb2). |
2020-12-29 |
2023-08-13 |
Not clear |
| Marisol Maya-López, Leonardo C Rubio-López, Ivana V Rodríguez-Alvarez, Julián Orduño-Piceno, Yuliza Flores-Valdivia, Aline Colonnello, Edgar Rangel-López, Isaac Túnez, Oscar Prospéro-García, Abel Santamarí. A Cannabinoid Receptor-Mediated Mechanism Participates in the Neuroprotective Effects of Oleamide Against Excitotoxic Damage in Rat Brain Synaptosomes and Cortical Slices. Neurotoxicity research. vol 37. issue 1. 2020-12-21. PMID:31286434. |
here, we investigated the protective properties of oda against the excitotoxic damage induced by quin in rat brain synaptosomes and cortical slices, and whether these effects are linked to the stimulation of the endocannabinoid system via cb1 and/or cb2 receptor activation. |
2020-12-21 |
2023-08-13 |
rat |
| Isadora L Cortez, Naielly Rodrigues da Silva, Francisco S Guimarães, Felipe V Gome. Are CB2 Receptors a New Target for Schizophrenia Treatment? Frontiers in psychiatry. vol 11. 2020-12-18. PMID:33329132. |
although initially described as present mostly in the periphery, cannabinoid type-2 (cb2) receptors are now proposed to play a role in several brain processes related to schizophrenia, such as modulation of dopaminergic neurotransmission, microglial activation, and neuroplastic changes induced by stress. |
2020-12-18 |
2023-08-13 |
Not clear |
| Alexandre C Buffon, Marcelo A Javornik, Ana C Heymanns, Daiana C Salm, VerÔnica V Horewicz, Daniel F Martins, Anna P Pioveza. Role of the endocannabinoid system on the antihyperalgesic action of gabapentin in animal model of neuropathic pain induced by partial sciatic nerve ligation. Anais da Academia Brasileira de Ciencias. vol 92. issue 4. 2020-12-18. PMID:33331440. |
the results show that endocannabinoid system contributes to the antihyperalgesic action of gabapetin in neuropathic pain by psl, suggesting participation in the medullary and peripheral levels of cb1 receptors, and the peripheral performance of cb2 receptors. |
2020-12-18 |
2023-08-13 |
mouse |
| Christian Boyer, Laura Cussonneau, Charlotte Brun, Christiane Deval, Jean-Paul Pais de Barros, Stéphanie Chanon, Nathalie Bernoud-Hubac, Patricia Daira, Alina L Evans, Jon M Arnemo, Jon E Swenson, Guillemette Gauquelin-Koch, Chantal Simon, Stéphane Blanc, Lydie Combaret, Fabrice Bertile, Etienne Lefa. Specific shifts in the endocannabinoid system in hibernating brown bears. Frontiers in zoology. vol 17. issue 1. 2020-12-12. PMID:33292302. |
in adipose and muscle tissues of hibernating bears, we found significant lower concentrations of 2-arachidonoylglycerol (2-ag), a major ligand of cannabinoid receptors 1 (cb1) and 2 (cb2). |
2020-12-12 |
2023-08-13 |
Not clear |
| J Maia, B M Fonseca, N Teixeira, G Correia-da-Silv. The fundamental role of the endocannabinoid system in endometrium and placenta: implications in pathophysiological aspects of uterine and pregnancy disorders. Human reproduction update. vol 26. issue 4. 2020-12-08. PMID:32347309. |
the endocannabinoid system (ecs) consists of the cannabinoid receptors cb1 and cb2, the main endocannabinoids anandamide (aea) and 2-arachidonoylglycerol (2-ag) and their metabolic enzymes n-acylphosphatidylethanolamine-specific phospholipase d, fatty acid amide hydrolase, diacylglycerol lipase and monoacylglycerol lipase. |
2020-12-08 |
2023-08-13 |
Not clear |
| Joseph Bouskila, Catarina Micaelo-Fernandes, Roberta M Palmour, Jean-François Bouchard, Maurice Ptit. Transient receptor potential vanilloid type 1 is expressed in the horizontal pathway of the vervet monkey retina. Scientific reports. vol 10. issue 1. 2020-12-04. PMID:32694518. |
the ubiquitous distribution of the classic endocannabinoid system (cannabinoid receptors cb1 and cb2) has been demonstrated within the monkey nervous system, including the retina. |
2020-12-04 |
2023-08-13 |
monkey |
| Mohammad Zakir Hossain, Hiroshi Ando, Shumpei Unno, Junichi Kitagaw. Targeting Peripherally Restricted Cannabinoid Receptor 1, Cannabinoid Receptor 2, and Endocannabinoid-Degrading Enzymes for the Treatment of Neuropathic Pain Including Neuropathic Orofacial Pain. International journal of molecular sciences. vol 21. issue 4. 2020-11-19. PMID:32093166. |
cannabinoids mainly act on cannabinoid 1 (cb1) and 2 (cb2) receptors, and the former is widely distributed in the brain. |
2020-11-19 |
2023-08-13 |
mouse |
| Tim Ruhl, Niklas Karthaus, Bong-Sung Kim, Justus P Beie. The endocannabinoid receptors CB1 and CB2 affect the regenerative potential of adipose tissue MSCs. Experimental cell research. vol 389. issue 1. 2020-11-13. PMID:32006556. |
the endocannabinoid receptors cb1 and cb2 affect the regenerative potential of adipose tissue mscs. |
2020-11-13 |
2023-08-13 |
human |
| Tim Ruhl, Niklas Karthaus, Bong-Sung Kim, Justus P Beie. The endocannabinoid receptors CB1 and CB2 affect the regenerative potential of adipose tissue MSCs. Experimental cell research. vol 389. issue 1. 2020-11-13. PMID:32006556. |
adipose tissue secrets various soluble factors including endocannabinoids, and atmscs express the cannabinoid receptors cb1 and cb2. |
2020-11-13 |
2023-08-13 |
human |
| Sait Bayram, Ali Parlar, Seyfullah Oktay Arsla. The curative effect of cannabinoid 2 receptor agonist on functional failure and disruptive inflammation caused by intestinal ischemia and reperfusion. Fundamental & clinical pharmacology. vol 34. issue 1. 2020-10-23. PMID:31373049. |
the aim of this study was to reveal whether therapeutic value of cannabinoid 2 (cb2) receptor activity in the intestinal i/r, via to the exogenous administration of cb2 agonist (am-1241). |
2020-10-23 |
2023-08-13 |
rat |
| Qinggang Liu, Zonglong Wu, Yaxiao Liu, Lipeng Chen, Hongda Zhao, Hongda Guo, Kejia Zhu, Wenfu Wang, Shouzhen Chen, Nan Zhou, Yan Li, Benkang Sh. Cannabinoid receptor 2 activation decreases severity of cyclophosphamide-induced cystitis via regulating autophagy. Neurourology and urodynamics. vol 39. issue 1. 2020-10-23. PMID:31729056. |
cannabinoids have been shown to exert analgesic and anti-inflammatory effects, and the effects of cannabinoids are mediated primarily by cannabinoid receptors 1 and 2 (cb1 and cb2). |
2020-10-23 |
2023-08-13 |
Not clear |
| Murat Çakır, Suat Tekin, Aslı Okan, Pınar Çakan, Züleyha Doğanyiği. The ameliorating effect of cannabinoid type 2 receptor activation on brain, lung, liver and heart damage in cecal ligation and puncture-induced sepsis model in rats. International immunopharmacology. vol 78. 2020-10-21. PMID:31767546. |
it is already known that cannabinoid type 2 (cb2) receptors, which are commonly expressed in immune cells and in many other tissues, have an effect on the regulation of immune response. |
2020-10-21 |
2023-08-13 |
rat |
| Elisa Nent, Chihiro Nozaki, Anne-Caroline Schmöle, David Otte, Andreas Zimme. CB2 receptor deletion on myeloid cells enhanced mechanical allodynia in a mouse model of neuropathic pain. Scientific reports. vol 9. issue 1. 2020-10-14. PMID:31097758. |
mechanisms leading to mirror-image pain are not completely understood, but cannabinoid cb2 receptors have been implicated. |
2020-10-14 |
2023-08-13 |
mouse |
| Alireza Tahamtan, Shahrzad Rezaiy, Saeed Samadizadeh, Abdolvahab Moradi, Alijan Tabarraei, Naeme Javid, Morteza Oladnabi, Mohammad Hosein Naeim. Cannabinoid CB2 Receptor Functional Variation (Q63R) Is Associated with Multiple Sclerosis in Iranian Subjects. Journal of molecular neuroscience : MN. vol 70. issue 1. 2020-10-08. PMID:31407233. |
cannabinoid cb2 receptor functional variation (q63r) is associated with multiple sclerosis in iranian subjects. |
2020-10-08 |
2023-08-13 |
human |
| Alireza Tahamtan, Shahrzad Rezaiy, Saeed Samadizadeh, Abdolvahab Moradi, Alijan Tabarraei, Naeme Javid, Morteza Oladnabi, Mohammad Hosein Naeim. Cannabinoid CB2 Receptor Functional Variation (Q63R) Is Associated with Multiple Sclerosis in Iranian Subjects. Journal of molecular neuroscience : MN. vol 70. issue 1. 2020-10-08. PMID:31407233. |
variations in the cannabinoid cb2 receptor gene (cnr2) could affect intracellular signaling and reduce system function, which has been associated with an unbalanced immune response and increased risk of a variety of autoimmune inflammatory disorders. |
2020-10-08 |
2023-08-13 |
human |
| Ilaria Ceccarelli, Paolo Fiorenzani, Federica Pessina, Jessica Pinassi, Margherita Aglianò, Vincenzo Miragliotta, Anna Maria Alois. The CB2 Agonist β-Caryophyllene in Male and Female Rats Exposed to a Model of Persistent Inflammatory Pain. Frontiers in neuroscience. vol 14. 2020-10-06. PMID:33013287. |
cannabinoids help in pain treatment through their action on cb1 and cb2 receptors. |
2020-10-06 |
2023-08-13 |
rat |
| Muneer Ahamed, Daisy van Veghel, Christoph Ullmer, Koen Van Laere, Alfons Verbruggen, Guy M Borman. Synthesis, Biodistribution and Frontiers in neuroscience. vol 10. 2020-10-01. PMID:27713686. |
synthesis, biodistribution and the type 2 cannabinoid receptor (cb2) is a member of the endocannabinoid system and is known for its important role in (neuro)inflammation. |
2020-10-01 |
2023-08-13 |
Not clear |
| Maria Notarnicola, Valeria Tutino, Angela Tafaro, Giusy Bianco, Emilia Guglielmi, Maria Gabriella Carus. Dietary olive oil induces cannabinoid CB2 receptor expression in adipose tissue of Apc Nutrition and healthy aging. vol 4. issue 1. 2020-10-01. PMID:28035344. |
dietary olive oil induces cannabinoid cb2 receptor expression in adipose tissue of apc |
2020-10-01 |
2023-08-13 |
Not clear |
| Marc-Alain Babi, Christopher P Robinson, Carolina B Macie. A spicy status: Synthetic cannabinoid (spice) use and new-onset refractory status epilepticus-A case report and review of the literature. SAGE open medical case reports. vol 5. 2020-10-01. PMID:29238581. |
synthetic cannabinoids refer to a wide variety of chemicals engineered to bind cannabinoid receptors (cb1 and cb2) and mimic the effects of delta-9-tetrahydrocanabinol. |
2020-10-01 |
2023-08-13 |
Not clear |