| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stewart Christie, Vladimir Zagorodnyu. CB2 cannabinoid receptor agonist selectively inhibits the mechanosensitivity of mucosal afferents in the guinea pig bladder. American journal of physiology. Renal physiology. vol 320. issue 5. 2021-05-10. PMID:33749323. |
endocannabinoids are ligands of cannabinoid 1 and 2 (cb1 and cb2) receptors but can influence the activity of a variety of g protein-coupled receptors as well as ligand-gated and voltage-gated channels. |
2021-05-10 |
2023-08-13 |
Not clear |
| Elaine C D Gonçalves, Pollyana M Assis, Laura A Junqueira, Maíra Cola, Adair R S Santos, Nadia R B Raposo, Rafael C Dutr. Citral Inhibits the Inflammatory Response and Hyperalgesia in Mice: The Role of TLR4, TLR2/Dectin-1, and CB2 Cannabinoid Receptor/ATP-Sensitive K Journal of natural products. vol 83. issue 4. 2021-05-05. PMID:32150408. |
citral inhibits the inflammatory response and hyperalgesia in mice: the role of tlr4, tlr2/dectin-1, and cb2 cannabinoid receptor/atp-sensitive k citral ((2 |
2021-05-05 |
2023-08-13 |
mouse |
| Cody G Yokubaitis, Hassan N Jessani, Hongbo Li, Allison K Amodea, Sara Jane War. Effects of Cannabidiol and Beta-Caryophyllene Alone or in Combination in a Mouse Model of Permanent Ischemia. International journal of molecular sciences. vol 22. issue 6. 2021-05-03. PMID:33799861. |
we and others have previously shown that synthetic agonists of the cannabinoid cb2 receptor reduce infarct size and microglial activation in rodent models of stroke. |
2021-05-03 |
2023-08-13 |
mouse |
| Francesca Gado, Kawthar A Mohamed, Serena Meini, Rebecca Ferrisi, Simone Bertini, Maria Digiacomo, Felicia D'Andrea, Lesley A Stevenson, Robert B Laprairie, Roger G Pertwee, Clementina Maner. Variously substituted 2-oxopyridine derivatives: Extending the structure-activity relationships for allosteric modulation of the cannabinoid CB2 receptor. European journal of medicinal chemistry. vol 211. 2021-04-30. PMID:33360803. |
variously substituted 2-oxopyridine derivatives: extending the structure-activity relationships for allosteric modulation of the cannabinoid cb2 receptor. |
2021-04-30 |
2023-08-13 |
mouse |
| Ewa Poleszak, Sylwia Wośko, Karolina Sławińska, Elżbieta Wyska, Aleksandra Szopa, Jan Sobczyński, Andrzej Wróbel, Urszula Doboszewska, Piotr Wlaź, Aleksandra Wlaź, Jarosław Szponar, Piotr Skałecki, Anna Serefk. Ligands of the CB2 cannabinoid receptors augment activity of the conventional antidepressant drugs in the behavioural tests in mice. Behavioural brain research. vol 378. 2021-04-29. PMID:31626848. |
ligands of the cb2 cannabinoid receptors augment activity of the conventional antidepressant drugs in the behavioural tests in mice. |
2021-04-29 |
2023-08-13 |
mouse |
| Ewa Galaj, Guo-Hua Bi, Hong-Ju Yang, Zheng-Xiong X. Cannabidiol attenuates the rewarding effects of cocaine in rats by CB2, 5-HT Neuropharmacology. vol 167. 2021-04-23. PMID:31437433. |
strikingly, this reduction in both cocaine self-administration and bsr was blocked by am630 (a cannabinoid cb2 receptor antagonist), way100135 (a 5-ht |
2021-04-23 |
2023-08-13 |
rat |
| Teresa Chioccarelli, Marina Migliaccio, Antonio Suglia, Francesco Manfrevola, Veronica Porreca, Nadia Diano, Sonia Errico, Silvia Fasano, Gilda Cobelli. Characterization of Estrogenic Activity and Site-Specific Accumulation of Bisphenol-A in Epididymal Fat Pad: Interfering Effects on the Endocannabinoid System and Temporal Progression of Germ Cells. International journal of molecular sciences. vol 22. issue 5. 2021-04-22. PMID:33802611. |
the exposure to bpa affects the expression levels of some ecs components, namely type-1 (cb1) and type-2 cannabinoid (cb2) receptor and monoacylglycerol-lipase (magl). |
2021-04-22 |
2023-08-13 |
Not clear |
| Beihong Ji, Shuhan Liu, Xibing He, Viet Hoang Man, Xiang-Qun Xie, Junmei Wan. Prediction of the Binding Affinities and Selectivity for CB1 and CB2 Ligands Using Homology Modeling, Molecular Docking, Molecular Dynamics Simulations, and MM-PBSA Binding Free Energy Calculations. ACS chemical neuroscience. vol 11. issue 8. 2021-04-14. PMID:32196303. |
there are at least two types of cannabinoid receptors, cb1 and cb2, which belong to the g protein-coupled receptor superfamily and can trigger different signaling pathways to exert their physiological functions. |
2021-04-14 |
2023-08-13 |
Not clear |
| Beihong Ji, Shuhan Liu, Xibing He, Viet Hoang Man, Xiang-Qun Xie, Junmei Wan. Prediction of the Binding Affinities and Selectivity for CB1 and CB2 Ligands Using Homology Modeling, Molecular Docking, Molecular Dynamics Simulations, and MM-PBSA Binding Free Energy Calculations. ACS chemical neuroscience. vol 11. issue 8. 2021-04-14. PMID:32196303. |
in this study, several representative agonists and antagonists of both cb1 and cb2 were systematically studied to predict their binding affinities and selectivity against both cannabinoid receptors using a set of hierarchical molecular modeling and simulation techniques, including homology modeling, molecular docking, molecular dynamics (md) simulations and end point binding free energy calculations using the molecular mechanics/poisson-boltzmann surface area-wsas (mm-pbsa-wsas) method, and molecular mechanics/generalized born surface area (mm-gbsa) free energy decomposition. |
2021-04-14 |
2023-08-13 |
Not clear |
| Piotr Wójcik, Agnieszka Gęgotek, Neven Žarković, Elżbieta Skrzydlewsk. Oxidative Stress and Lipid Mediators Modulate Immune Cell Functions in Autoimmune Diseases. International journal of molecular sciences. vol 22. issue 2. 2021-04-12. PMID:33450863. |
because the anti-inflammatory cb2 receptors are the predominant cannabinoid receptors in leukocytes, endocannabinoids are believed to act as anti-inflammatory factors that regulate compensatory mechanisms in autoimmune diseases. |
2021-04-12 |
2023-08-13 |
Not clear |
| Mohammad-Mahdi Ghanbari, Marzieh Joneidi, Bahere Kiani, Jalal Babaie, Mohammad Sayya. Cannabinoid receptors and the proconvulsant effect of toxoplasmosis in mice. Microbial pathogenesis. vol 144. 2021-04-07. PMID:32315753. |
the mice with acute and/or chronic toxoplasma infection were pretreated (through intracerebroventricular injection) with cb1 and cb2 receptor agonists (acea and hu308) and antagonists (am251 and am630), as well as jzl184 (the irreversible inhibitor of mono acyl glycerol lipase, enzyme degrading the endogenous cannabinoid 2-acyl glycerol). |
2021-04-07 |
2023-08-13 |
mouse |
| Andrea Toschi, Benedetta Tugnoli, Barbara Rossi, Andrea Piva, Ester Grill. Thymol modulates the endocannabinoid system and gut chemosensing of weaning pigs. BMC veterinary research. vol 16. issue 1. 2021-04-06. PMID:32787931. |
gene expression of cannabinoid receptors (cb1 and cb2), transient receptor potential vanilloid 1 (trpv1), the olfactory receptor or1g1, diacylglycerol lipases (dgl-α and dgl-β), fatty acid amine hydrolase (faah), and cytokines was measured, and elisas of pro-inflammatory cytokines levels were performed. |
2021-04-06 |
2023-08-13 |
Not clear |
| Feng Wang, Jing Wang, Tong Zhao, Yi Zhang, Qian L. CB2 Receptor Agonist JWH133 Activates AMPK to Inhibit Growth of C6 Glioma Cells. Open life sciences. vol 14. 2021-04-06. PMID:33817171. |
it has been reported that endocannabinoid receptor type 2 (cb2) agonist jwh133 inhibits the growth of c6 glioma cells, but the underlying mechanism has not yet been fully elucidated. |
2021-04-06 |
2023-08-13 |
Not clear |
| Graziela Vieira, Juliana Cavalli, Elaine C D Gonçalves, Saulo F P Braga, Rafaela S Ferreira, Adair R S Santos, Maíra Cola, Nádia R B Raposo, Raffaele Capasso, Rafael C Dutr. Antidepressant-Like Effect of Terpineol in an Inflammatory Model of Depression: Involvement of the Cannabinoid System and D2 Dopamine Receptor. Biomolecules. vol 10. issue 5. 2021-04-02. PMID:32443870. |
our data showed terpineol antidepressant-like modulation by cb1 and cb2 cannabinoid receptors and d2-dopaminergic receptors to further corroborate our molecular evidence. |
2021-04-02 |
2023-08-13 |
Not clear |
| Asim Kichloo, Michael Albosta, Michael Aljadah, Zain El-Amir, Ghazaleh Goldar, Muhammed Zatmar Khan, Dushyant Singh Dahiya, Srilakshmi Vallabhaneni, Farah Wani, Jagmeet Sing. Marijuana: A systems-based primer of adverse effects associated with use and an overview of its therapeutic utility. SAGE open medicine. vol 9. 2021-04-02. PMID:33786179. |
it also addresses the biochemical and behavioral changes observed with marijuana use, including the location and changes associated with cannabinoid receptors (abbreviated cb1 and cb2). |
2021-04-02 |
2023-08-13 |
Not clear |
| Luana Greco, Valentina Russo, Cinzia Rapino, Clara Di Germanio, Filomena Fezza, Nicola Bernabò, Paolo Berardinelli, Alessia Peserico, Domenico Fazio, Mauro Maccarrone, Mauro Mattioli, Barbara Barbon. Characterization of Endocannabinoid System and Interleukin Profiles in Ovine AEC: Cannabinoid Receptors Type-1 and Type-2 as Key Effectors of Pro-Inflammatory Response. Cells. vol 9. issue 4. 2021-03-29. PMID:32325674. |
then, the role of cannabinoid receptors 1 and 2 (cb1 and cb2) on interleukin expression and release was investigated in middle stage aec using selective agonists and antagonists. |
2021-03-29 |
2023-08-13 |
Not clear |
| He-Kai Shi, Hui-Cai Guo, Hou-Yue Liu, Zi-Lin Zhang, Mei-Yu Hu, Yi Zhang, Qian L. Cannabinoid type 2 receptor agonist JWH133 decreases blood pressure of spontaneously hypertensive rats through relieving inflammation in the rostral ventrolateral medulla of the brain. Journal of hypertension. vol 38. issue 5. 2021-03-24. PMID:32238784. |
the upregulation and activation of the cannabinoid type 2 (cb2) receptor may be part of the active process of limiting or downregulating the inflammatory process. |
2021-03-24 |
2023-08-13 |
rat |
| Piotr Wójcik, Neven Žarković, Agnieszka Gęgotek, Elżbieta Skrzydlewsk. Involvement of Metabolic Lipid Mediators in the Regulation of Apoptosis. Biomolecules. vol 10. issue 3. 2021-03-18. PMID:32150849. |
in contrast, in cells where cb2 receptors dominate, and cells with low cox activity, cannabinoids act in a cytoprotective manner. |
2021-03-18 |
2023-08-13 |
Not clear |
| William R Arnold, Lauren N Carnevale, Zili Xie, Javier L Baylon, Emad Tajkhorshid, Hongzhen Hu, Aditi Da. Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel. Nature communications. vol 12. issue 1. 2021-03-18. PMID:33568652. |
the endocannabinoid system is a promising target to mitigate pain as the endocannabinoids are endogenous ligands of the pain-mediating receptors-cannabinoid receptors 1 and 2 (cb1 and cb2) and trpv1. |
2021-03-18 |
2023-08-13 |
human |
| Kelly F Paton, Rahau Shirazi, Mikhail Vyssotski, Bronwyn M Kivel. N-docosahexaenoyl ethanolamine (synaptamide) has antinociceptive effects in male mice. European journal of pain (London, England). vol 24. issue 10. 2021-03-03. PMID:32852071. |
n-docosahexaenoyl ethanolamine (dhea; also known as synaptamide) binds to both the cannabinoid-1 and 2 (cb1 and cb2) cannabinoid receptors and has anti-inflammatory properties in vitro. |
2021-03-03 |
2023-08-13 |
mouse |