| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lauren Van Hove, Kirsten R Kim, Denise M Arrick, William G Mayha. A cannabinoid type 2 (CB2) receptor agonist augments NOS-dependent responses of cerebral arterioles during type 1 diabetes. Microvascular research. vol 133. 2021-02-17. PMID:32979391. |
while activation of cannabinoid (cb2) receptors has been shown to be neuroprotective, no studies have examined whether this neuroprotection is directed at cerebral arterioles and no studies have examined whether activation of cb2 receptors can rescue cerebrovascular dysfunction during a chronic disease state such as type 1 diabetes (t1d). |
2021-02-17 |
2023-08-13 |
rat |
| Dongchen An, Steve Peigneur, Louise Antonia Hendrickx, Jan Tytga. Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products. International journal of molecular sciences. vol 21. issue 14. 2021-02-16. PMID:32709050. |
cannabinoid receptors (cb1 and cb2), as part of the endocannabinoid system, play a critical role in numerous human physiological and pathological conditions. |
2021-02-16 |
2023-08-13 |
human |
| Dongchen An, Steve Peigneur, Louise Antonia Hendrickx, Jan Tytga. Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products. International journal of molecular sciences. vol 21. issue 14. 2021-02-16. PMID:32709050. |
thus, considerable efforts have been made to develop ligands for cb1 and cb2, resulting in hundreds of phyto- and synthetic cannabinoids which have shown varying affinities relevant for the treatment of various diseases. |
2021-02-16 |
2023-08-13 |
human |
| Laila Asth, Aline C Santos, Fabrício A Moreir. The endocannabinoid system and drug-associated contextual memories. Behavioural pharmacology. 2021-02-12. PMID:33491992. |
in targeting the endocannabinoid system for developing new treatments for drug addiction, future research should focus on 'neutral' cb1 receptor antagonists and cb2 receptor agonists. |
2021-02-12 |
2023-08-13 |
Not clear |
| Aboagyewaah Oppong-Damoah, Brenda Marie Gannon, Kevin Sean Murnan. The Endocannabinoid System and Alcohol Dependence: Will Cannabinoid Receptor 2 Agonism be More Fruitful than Cannabinoid Receptor 1 Antagonism? CNS & neurological disorders drug targets. 2021-02-12. PMID:33573565. |
this has redirected the field to focus on alternative components of the endocannabinoid system, including cannabinoid type 2 (cb2) receptor agonists as a potential therapeutic target for aud. |
2021-02-12 |
2023-08-13 |
Not clear |
| María de Los Ángeles Nuñez-Lumbreras, José Luis Castañeda-Cabral, María Guadalupe Valle-Dorado, Vicente Sánchez-Valle, Sandra Orozco-Suárez, Rosalinda Guevara-Guzmán, Iris Martínez-Juárez, Mario Alonso-Vanegas, Fruzsina Walter, Maria A Deli, Francia Carmona-Cruz, Luisa Roch. Drug-Resistant Temporal Lobe Epilepsy Alters the Expression and Functional Coupling to Gαi/o Proteins of CB1 and CB2 Receptors in the Microvasculature of the Human Brain. Frontiers in behavioral neuroscience. vol 14. 2021-02-10. PMID:33551765. |
cannabinoid receptors 1 and 2 (cb1 and cb2, respectively) play an important role in maintaining the integrity of the blood-brain barrier (bbb). |
2021-02-10 |
2023-08-13 |
human |
| Mohammad Nasehi, Ensiyeh Forouzanmehr, Fatemeh Khakpai, Mohammad-Reza Zarrindas. Possible interaction between the ventral hippocampal cannabinoid CB2 and muscarinic acetylcholine receptors on the modulation of memory consolidation in mice. Neuroreport. vol 31. issue 2. 2021-02-03. PMID:31876680. |
possible interaction between the ventral hippocampal cannabinoid cb2 and muscarinic acetylcholine receptors on the modulation of memory consolidation in mice. |
2021-02-03 |
2023-08-13 |
mouse |
| Mohammad Nasehi, Ensiyeh Forouzanmehr, Fatemeh Khakpai, Mohammad-Reza Zarrindas. Possible interaction between the ventral hippocampal cannabinoid CB2 and muscarinic acetylcholine receptors on the modulation of memory consolidation in mice. Neuroreport. vol 31. issue 2. 2021-02-03. PMID:31876680. |
to clarify possible interaction between the ventral hippocampal cannabinoid cb2 receptors and the cholinergic system in control of the memory process, the effects of cannabinoid and acetylcholine receptor agents on memory consolidation have been investigated in mice. |
2021-02-03 |
2023-08-13 |
mouse |
| Mohammad Nasehi, Ensiyeh Forouzanmehr, Fatemeh Khakpai, Mohammad-Reza Zarrindas. Possible interaction between the ventral hippocampal cannabinoid CB2 and muscarinic acetylcholine receptors on the modulation of memory consolidation in mice. Neuroreport. vol 31. issue 2. 2021-02-03. PMID:31876680. |
posttraining application of cannabinoid cb2 receptor antagonist, am630 (1, 10 and 100 µg/mouse; intra-ca3) alone had no significant influence on memory performance, but its coinjection with significant dose of scopolamine (1 µg/mouse) decreased memory consolidation. |
2021-02-03 |
2023-08-13 |
mouse |
| Mohammad Nasehi, Ensiyeh Forouzanmehr, Fatemeh Khakpai, Mohammad-Reza Zarrindas. Possible interaction between the ventral hippocampal cannabinoid CB2 and muscarinic acetylcholine receptors on the modulation of memory consolidation in mice. Neuroreport. vol 31. issue 2. 2021-02-03. PMID:31876680. |
moreover, posttraining injection of gp1a, cannabinoid cb2 receptor agonist, (10 and 100 µg/mouse; intra-ca3) decreased memory consolidation. |
2021-02-03 |
2023-08-13 |
mouse |
| Mohammad Nasehi, Ensiyeh Forouzanmehr, Fatemeh Khakpai, Mohammad-Reza Zarrindas. Possible interaction between the ventral hippocampal cannabinoid CB2 and muscarinic acetylcholine receptors on the modulation of memory consolidation in mice. Neuroreport. vol 31. issue 2. 2021-02-03. PMID:31876680. |
consequently, these results propose that a probable interaction between the ca3 cannabinoid cb2 receptors and muscarinic acetylcholine receptors (machr) modulates memory consolidation process in mice. |
2021-02-03 |
2023-08-13 |
mouse |
| Emily M Cravens, Jay S Kirkwood, Lisa M Wolfe, Rebecca A Packer, Lawrence R Whalen, Samantha J Wojda, Jessica E Prenni, Gregory L Florant, Seth W Donahu. The effects of neurectomy and hibernation on bone properties and the endocannabinoid system in marmots (Marmota flaviventris). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 241. 2021-02-02. PMID:31783174. |
cannabinoid receptors (cb1 and cb2) have divergent localization in bone. |
2021-02-02 |
2023-08-13 |
Not clear |
| David Ruano-Ordás, Lindsey Burggraaff, Rongfang Liu, Cas van der Horst, Laura H Heitman, Michael T M Emmerich, Jose R Mendez, Iryna Yevseyeva, Gerard J P van Weste. A multiple classifier system identifies novel cannabinoid CB2 receptor ligands. Journal of cheminformatics. vol 11. issue 1. 2021-01-15. PMID:33430920. |
a multiple classifier system identifies novel cannabinoid cb2 receptor ligands. |
2021-01-15 |
2023-08-13 |
Not clear |
| David Ruano-Ordás, Lindsey Burggraaff, Rongfang Liu, Cas van der Horst, Laura H Heitman, Michael T M Emmerich, Jose R Mendez, Iryna Yevseyeva, Gerard J P van Weste. A multiple classifier system identifies novel cannabinoid CB2 receptor ligands. Journal of cheminformatics. vol 11. issue 1. 2021-01-15. PMID:33430920. |
we applied our technique to a dataset of cannabinoid cb2 ligands obtained from the chembl database. |
2021-01-15 |
2023-08-13 |
Not clear |
| Peggy Rentsch, Sandy Stayte, Timothy Egan, Ian Clark, Bryce Visse. Targeting the cannabinoid receptor CB2 in a mouse model of l-dopa induced dyskinesia. Neurobiology of disease. vol 134. 2021-01-13. PMID:31669673. |
here we investigate the effect of hu-308, a cannabinoid cb2 receptor agonist, on lids. |
2021-01-13 |
2023-08-13 |
mouse |
| Qi-Wen Han, Yu-He Yuan, Nai-Hong Che. The therapeutic role of cannabinoid receptors and its agonists or antagonists in Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 96. 2021-01-04. PMID:31442553. |
recent studies have found that the endocannabinoid signaling system in particular the comprised two receptors, cb1 and cb2 receptors, has a significant regulatory function in basal ganglia and is involved in the pathogenesis of pd. |
2021-01-04 |
2023-08-13 |
Not clear |
| Glauce Crivelaro do Nascimento, Daniele Pereira Ferrari, Francisco Silveira Guimaraes, Elaine Aparecida Del Bel, Mariza Bortolanza, Nilson Carlos Ferreira-Junio. Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease. Neuropharmacology. vol 163. 2021-01-04. PMID:31706993. |
further, we investigated the pathway involved in the analgesic effect of the cbd through the co-administration with a fatty acid amide hydrolase (faah) inhibitor, increasing the endogenous anandamide levels, and possible targets from anandamide, i.e., the cannabinoid receptors subtype 1 and 2 (cb1 and cb2) and the transient receptor potential vanilloid type 1 (trpv1). |
2021-01-04 |
2023-08-13 |
mouse |
| Ahmed Haider, Luca Gobbi, Julian Kretz, Christoph Ullmer, Andreas Brink, Michael Honer, Thomas J Woltering, Dieter Muri, Hans Iding, Markus Bürkler, Martin Binder, Christian Bartelmus, Irene Knuesel, Pal Pacher, Adrienne Müller Herde, Francesco Spinelli, Hazem Ahmed, Kenneth Atz, Claudia Keller, Markus Weber, Roger Schibli, Linjing Mu, Uwe Grether, Simon M Ametame. Identification and Preclinical Development of a 2,5,6-Trisubstituted Fluorinated Pyridine Derivative as a Radioligand for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors. Journal of medicinal chemistry. vol 63. issue 18. 2021-01-04. PMID:32787079. |
despite the broad implications of the cannabinoid type 2 receptor (cb2) in neuroinflammatory processes, a suitable cb2-targeted probe is currently lacking in clinical routine. |
2021-01-04 |
2023-08-13 |
Not clear |
| Aurora Musa, Nicola Simola, Gessica Piras, Francesca Caria, Emmanuel Shan Onaivi, Maria Antonietta De Luc. Neurochemical and Behavioral Characterization after Acute and Repeated Exposure to Novel Synthetic Cannabinoid Agonist 5-MDMB-PICA. Brain sciences. vol 10. issue 12. 2020-12-31. PMID:33353194. |
5f-mdmb-pica has been recently detected and classified as a highly potent agonist of cb1 and cb2 cannabinoid receptors. |
2020-12-31 |
2023-08-13 |
mouse |
| Beatrice Polini, Chiara Cervetto, Sara Carpi, Simone Pelassa, Francesca Gado, Rebecca Ferrisi, Simone Bertini, Paola Nieri, Manuela Marcoli, Clementina Maner. Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist. Life (Basel, Switzerland). vol 10. issue 12. 2020-12-29. PMID:33302569. |
positive allosteric modulation of cb1 and cb2 cannabinoid receptors enhances the neuroprotective activity of a dual cb1r/cb2r orthosteric agonist. |
2020-12-29 |
2023-08-13 |
Not clear |