| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hajar Miranzadeh Mahabadi, Haseeb Bhatti, Robert B Laprairie, Changiz Taghibiglo. Cannabinoid receptors distribution in mouse cortical plasma membrane compartments. Molecular brain. vol 14. issue 1. 2021-08-12. PMID:34099009. |
the type 1 and type 2 cannabinoid receptors (cb1 and cb2 receptors) are class a g protein-coupled receptors (gpcrs) that are activated by endogenous lipids called endocannabinoids to modulate neuronal excitability and synaptic transmission in neurons throughout the central nervous system (cns), and inflammatory processes throughout the body. |
2021-08-12 |
2023-08-13 |
mouse |
| Nicholas John Sadgrove, Monique S J Simmond. Topical and nutricosmetic products for healthy hair and dermal antiaging using "dual-acting" (2 for 1) plant-based peptides, hormones, and cannabinoids. FASEB bioAdvances. vol 3. issue 8. 2021-08-12. PMID:34377956. |
because of crosstalk between adenosine and cannabinoid receptors it makes sense to try combinations of specific cb2 agonists and cytokinins (or phytoestrogens). |
2021-08-12 |
2023-08-13 |
Not clear |
| Olga P Balezina, Ekaterina O Tarasova, Alexander E Gayduko. Noncanonical Activity of Endocannabinoids and Their Receptors in Central and Peripheral Synapses. Biochemistry. Biokhimiia. vol 86. issue 7. 2021-08-04. PMID:34284706. |
this review focuses on new aspects of endocannabinoid functions and mechanisms of activity in central and peripheral synapses, different from the general viewpoint that endocannabinoids are retrograde signaling molecules, which inhibit neurotransmitter release by activating specific presynaptic endocannabinoid receptors cb1 and cb2. |
2021-08-04 |
2023-08-13 |
Not clear |
| Trenton C Simmons, Sara M Freeman, Nicholas S Lackey, Brooke K Dreyer, Devanand S Manoli, Karen L Bale. Cannabinoid receptor Type 1 densities reflect social organization in Microtus. The Journal of comparative neurology. vol 529. issue 5. 2021-08-02. PMID:33460115. |
these processes are mediated through at least two distinct cannabinoid receptors (cb), cb1 and cb2. |
2021-08-02 |
2023-08-13 |
Not clear |
| Valeria Giorgi, Daniela Marotto, Alberto Batticciotto, Fabiola Atzeni, Sara Bongiovanni, Piercarlo Sarzi-Puttin. Cannabis and Autoimmunity: Possible Mechanisms of Action. ImmunoTargets and therapy. vol 10. 2021-07-30. PMID:34322454. |
renewed interest in the medicinal properties of cannabis has led to increasing research into the practical uses of cannabis derivatives, and it has been found that the endocannabinoid system (particularly cb2 receptor activation) is a possible target for the treatment of inflammatory and the autoimmune diseases related to immune cell activation. |
2021-07-30 |
2023-08-13 |
human |
| Hebaallah Mamdouh Hashiesh, Charu Sharma, Sameer N Goyal, Bassem Sadek, Niraj Kumar Jha, Juma Al Kaabi, Shreesh Ojh. A focused review on CB2 receptor-selective pharmacological properties and therapeutic potential of β-caryophyllene, a dietary cannabinoid. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 140. 2021-07-29. PMID:34091179. |
a focused review on cb2 receptor-selective pharmacological properties and therapeutic potential of β-caryophyllene, a dietary cannabinoid. |
2021-07-29 |
2023-08-13 |
human |
| Roger Gregory Biringe. The rise and fall of anandamide: processes that control synthesis, degradation, and storage. Molecular and cellular biochemistry. vol 476. issue 7. 2021-07-27. PMID:33713246. |
its effects are primarily mediated by the cannabinoid receptors cb1 and cb2, and the vanilloid trpv1 receptor. |
2021-07-27 |
2023-08-13 |
Not clear |
| Sandra Glasmacher, Jürg Gertsc. Characterization of pepcan-23 as pro-peptide of RVD-hemopressin (pepcan-12) and stability of hemopressins in mice. Advances in biological regulation. vol 80. 2021-07-21. PMID:33799079. |
rvd-hemopressin (pepcan-12) was shown to act as endogenous allosteric modulator of cannabinoid receptors, with opposite effects on cb1 and cb2, respectively. |
2021-07-21 |
2023-08-13 |
mouse |
| Anna A Karan, Yulia S Spivak, Konstantin A Gerasimov, Elena M Suleymanova, Maria N Volobueva, Alexey A Kvichansky, Lyudmila V Vinogradova, Alexey P Bolshako. CB2 receptors modulate seizure-induced expression of pro-inflammatory cytokines in the hippocampus but not neocortex. Molecular neurobiology. vol 58. issue 8. 2021-07-15. PMID:33907944. |
we compared neuroinflammatory responses induced by nonconvulsive and convulsive seizures and analyzed the role that may be played by cannabinoid cb2 receptors in the neuroinflammatory response induced by generalized tonic-clonic seizures (gtcs). |
2021-07-15 |
2023-08-13 |
Not clear |
| Xinru Tang, Zheng Liu, Xiaoqing Li, Jing Wang, Liliang L. Cannabinoid Receptors in Myocardial Injury: A Brother Born to Rival. International journal of molecular sciences. vol 22. issue 13. 2021-07-12. PMID:34206926. |
cannabinoid receptors typically include type 1 (cb1) and type 2 (cb2), and they have attracted extensive attention in the central nervous system (cns) and immune system. |
2021-07-12 |
2023-08-13 |
Not clear |
| Xinru Tang, Zheng Liu, Xiaoqing Li, Jing Wang, Liliang L. Cannabinoid Receptors in Myocardial Injury: A Brother Born to Rival. International journal of molecular sciences. vol 22. issue 13. 2021-07-12. PMID:34206926. |
herein, we introduce the general differences of cb1 and cb2 cannabinoid receptors, and summarize the functional rivalries between the two brother receptors in the setting of myocardial injuries. |
2021-07-12 |
2023-08-13 |
Not clear |
| Erik L Hodges, Jessica P Marshall, Nicole M Ashpol. Age-dependent hormesis-like effects of the synthetic cannabinoid CP55940 in C57BL/6 mice. NPJ aging and mechanisms of disease. vol 6. 2021-07-07. PMID:32655880. |
these bidirectional effects appear to be mediated via the endocannabinoid cb1 and cb2 receptors. |
2021-07-07 |
2023-08-13 |
mouse |
| Samer Narouz. Antinociception mechanisms of action of cannabinoid-based medicine: an overview for anesthesiologists and pain physicians. Regional anesthesia and pain medicine. vol 46. issue 3. 2021-07-05. PMID:33239391. |
cannabinoids (endogenous and phytocannabinoids) produce analgesia by interacting with cannabinoids receptors type 1 and 2 (cb1 and cb2), as well as putative non-cb1/cb2 receptors; g protein-coupled receptor 55, and transient receptor potential vanilloid type-1. |
2021-07-05 |
2023-08-13 |
human |
| Xuechen Liu, Yiying Wu, Dan Zhou, Yuting Xie, Yi Zhou, Yu Lu, Rui Yang, Sha Li. N‑linoleyltyrosine protects PC12 cells against oxidative damage via autophagy: Possible involvement of CB1 receptor regulation. International journal of molecular medicine. vol 46. issue 5. 2021-07-02. PMID:33000188. |
as the ligand of cannabinoid type 1 (cb1) and 2 (cb2) receptors, anandamide (aea) exerts benign antioxidant activities. |
2021-07-02 |
2023-08-13 |
Not clear |
| Angela Ramírez-López, Antoni Pastor, Rafael de la Torre, Carmen La Porta, Andrés Ozaita, David Cabañero, Rafael Maldonad. Role of the endocannabinoid system in a mouse model of Fragile X undergoing neuropathic pain. European journal of pain (London, England). vol 25. issue 6. 2021-06-25. PMID:33619843. |
the endocannabinoid system modulates pain perception and drugs targeting the cannabinoid receptor type 2 (cb2) devoid of psychoactive side effects could emerge as novel analgesics. |
2021-06-25 |
2023-08-13 |
mouse |
| Narsimha Reddy Penthala, Amal Shoeib, Soma Shekar Dachavaram, Christian V Cabanlong, Jingfang Yang, Chang-Guo Zhan, Paul L Prather, Peter A Crook. 7-Azaindolequinuclidinones (7-AIQD): A novel class of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands. Bioorganic & medicinal chemistry letters. vol 30. issue 22. 2021-06-22. PMID:32882418. |
7-azaindolequinuclidinones (7-aiqd): a novel class of cannabinoid 1 (cb1) and cannabinoid 2 (cb2) receptor ligands. |
2021-06-22 |
2023-08-13 |
Not clear |
| Narsimha Reddy Penthala, Amal Shoeib, Soma Shekar Dachavaram, Christian V Cabanlong, Jingfang Yang, Chang-Guo Zhan, Paul L Prather, Peter A Crook. 7-Azaindolequinuclidinones (7-AIQD): A novel class of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands. Bioorganic & medicinal chemistry letters. vol 30. issue 22. 2021-06-22. PMID:32882418. |
a series of n-benzyl-7-azaindolequinuclidinone (7-aiqd) analogs have been synthesized and evaluated for affinity toward cb1 and cb2 cannabinoid receptors and identified as a novel class of cannabinoid receptor ligands. |
2021-06-22 |
2023-08-13 |
Not clear |
| Erika Cottone, Valentina Pomatto, Stefania Rapelli, Rosaria Scandiffio, Ken Mackie, Patrizia Bovoli. Cannabinoid Receptor Modulation of Neurogenesis: ST14A Striatal Neural Progenitor Cells as a Simplified In Vitro Model. Molecules (Basel, Switzerland). vol 26. issue 5. 2021-06-21. PMID:33800024. |
while cb1 and cb2 receptor blockade did not affect st14a cell number, exogenous administration of the endocannabinoid 2-ag and the synthetic cb2 agonist jwh133 increased st14a cell proliferation. |
2021-06-21 |
2023-08-13 |
Not clear |
| Jing-Fang Yang, Alexander H Williams, Narsimha R Penthala, Paul L Prather, Peter A Crooks, Chang-Guo Zha. Binding Modes and Selectivity of Cannabinoid 1 (CB1) and Cannabinoid 2 (CB2) Receptor Ligands. ACS chemical neuroscience. vol 11. issue 20. 2021-06-18. PMID:32997485. |
binding modes and selectivity of cannabinoid 1 (cb1) and cannabinoid 2 (cb2) receptor ligands. |
2021-06-18 |
2023-08-13 |
Not clear |
| Slavko Komarnytsky, Thirumurugan Rathinasabapathy, Charles Wagner, Brandon Metzger, Carolina Carlisle, Chinmayee Panda, Sara Le Brun-Blashka, John P Troup, Saradhadevi Varadhara. Endocannabinoid System and Its Regulation by Polyunsaturated Fatty Acids and Full Spectrum Hemp Oils. International journal of molecular sciences. vol 22. issue 11. 2021-06-16. PMID:34067450. |
while hemp cannabinoids of thc and cbd groups show distinct but complementary actions through a variety of cannabinoid (cb1 and cb2), adenosine (a2a), and vanilloid (trpv1) receptors, they also modulate pufa metabolism within a wide variety of specialized lipid mediators that promote or resolve inflammation and oxidative stress. |
2021-06-16 |
2023-08-13 |
Not clear |