| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nora Helmrich, Martin Roderfeld, Anne Baier, Anita Windhorst, Diran Herebian, Ertan Mayatepek, Christian Dierkes, Matthias Ocker, Dieter Glebe, Bruno Christ, Yuri Churin, Karuna Irungbam, Elke Roe. Pharmacological antagonization of cannabinoid receptor 1 improves cholestasis in Abcb4 Cellular and molecular gastroenterology and hepatology. 2021-12-26. PMID:34954190. |
pharmacological antagonization of cannabinoid receptor 1 improves cholestasis in abcb4 the endocannabinoid system is involved in the modulation of inflammatory, fibrotic, metabolic, and carcinogenesis-associated signaling pathways via the cannabinoid receptors 1 and 2 (cb1 and cb2). |
2021-12-26 |
2023-08-13 |
Not clear |
| Vickram Ramkumar, Debashree Mukherjea, Asmita Dhukhwa, Leonard P Ryba. Oxidative Stress and Inflammation Caused by Cisplatin Ototoxicity. Antioxidants (Basel, Switzerland). vol 10. issue 12. 2021-12-24. PMID:34943021. |
these include adenosine a1 receptors, cannabinoid 2 receptors (cb2) and the sphingosine 1-phosphate receptor 2 (s1pr2). |
2021-12-24 |
2023-08-13 |
Not clear |
| Armin Aryannejad, Nafise Noroozi, Seyed Mohammad Tavangar, Samira Ramezani, Amir Rashidian, Reza Laripour, Mojtaba Yousefi Zoshk, Ahmad Reza Dehpour, Mohsen Chamanar. Involvement of cannabinoid type 2 (CB2) receptors in the favorable effects of sumatriptan on the random-pattern skin flap survival in rats: a novel potential target. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes. 2021-12-20. PMID:34929701. |
involvement of cannabinoid type 2 (cb2) receptors in the favorable effects of sumatriptan on the random-pattern skin flap survival in rats: a novel potential target. |
2021-12-20 |
2023-08-13 |
rat |
| Armin Aryannejad, Nafise Noroozi, Seyed Mohammad Tavangar, Samira Ramezani, Amir Rashidian, Reza Laripour, Mojtaba Yousefi Zoshk, Ahmad Reza Dehpour, Mohsen Chamanar. Involvement of cannabinoid type 2 (CB2) receptors in the favorable effects of sumatriptan on the random-pattern skin flap survival in rats: a novel potential target. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes. 2021-12-20. PMID:34929701. |
recent investigations have indicated the potential therapeutic role of cannabinoid type 2 (cb2) receptors in various inflammatory-related disorders. |
2021-12-20 |
2023-08-13 |
rat |
| Sai Varshini Magham, Praveen Thaggikuppe Krishnamurthy, Neenu Shaji, Lalithkumar Mani, Shivaramakrishnan Balasubramania. Cannabinoid receptor 2 selective agonists and Alzheimer's disease: An insight into the therapeutic potentials. Journal of neuroscience research. vol 99. issue 11. 2021-12-11. PMID:34486749. |
endocannabinoid system has been extensively studied in recent decades, particularly the cannabinoid receptors cb1 and cb2, due to their important role in neuroinflammation. |
2021-12-11 |
2023-08-13 |
Not clear |
| Antonia Sophocleous, Michael Yiallourides, Feier Zeng, Pantelis Pantelas, Eleni Stylianou, Boya Li, Giovana Carrasco, Aymen I Idri. Association of cannabinoid receptor modulation with normal and abnormal skeletal remodelling: A systematic review and meta-analysis of in vitro, in vivo and human studies. Pharmacological research. vol 175. 2021-12-11. PMID:34800625. |
to address the inconsistent findings from studies that used different models to explore the role of classical cannabinoid type 1 (cb1) and 2 (cb2) receptors in skeletal remodelling, we searched medline, web of science and embase for relevant studies from inception to june 23, 2020. |
2021-12-11 |
2023-08-13 |
mouse |
| Qingling Kong, Songyu Tian, Chao Ma, Guonian Wang, Mingyue Zhan. Cannabinoid Receptor Type 2 Agonist Reduces Morphine Tolerance via Mitogen Activated Protein Kinase Phosphatase Induction and Mitogen Activated Protein Kinase Dephosphorylation. Neuroscience. vol 480. 2021-12-10. PMID:34774714. |
our previous study showed that a cannabinoid type 2 (cb2) receptor agonist attenuated morphine tolerance. |
2021-12-10 |
2023-08-13 |
Not clear |
| H V Sudeep, K Venkatakrishna, Amritharaj, K Gouthamchandra, B Reethi, P Naveen, H B Lingaraju, K Shyamprasa. A standardized black pepper seed extract containing β-caryophyllene improves cognitive function in scopolamine-induced amnesia model mice via regulation of brain-derived neurotrophic factor and MAPK proteins. Journal of food biochemistry. vol 45. issue 12. 2021-12-10. PMID:34778972. |
β-caryophyllene (bcp), a natural sesquiterpene present in plants, is a selective agonist of cannabinoid receptor type-2 (cb2) of the endocannabinoid system. |
2021-12-10 |
2023-08-13 |
mouse |
| Mariana Macedo Almeida, Camilla Pereira Dias-Rocha, Camila Calviño, Isis Hara Trevenzol. Lipid endocannabinoids in energy metabolism, stress and developmental programming. Molecular and cellular endocrinology. vol 542. 2021-12-10. PMID:34843899. |
the ecs comprises mainly the bioactive lipid ligands anandamide (aea) and 2-aracdonoylglycerol (2-ag), cannabinoid receptors 1 and 2 (cb1 and cb2), and several metabolizing enzymes. |
2021-12-10 |
2023-08-13 |
Not clear |
| Vivek S Kumawat, Ginpreet Kau. CB2 receptor agonist and L- arginine combination attenuates diabetic cardiomyopathy in rats via NF-ĸβ inhibition. Canadian journal of physiology and pharmacology. 2021-12-03. PMID:34860602. |
beta-caryophyllene (bcp), a cannabinoid 2 receptor (cb2) agonist has recently been found to have cardioprotective activity as an anti-inflammatory and antioxidant molecule. |
2021-12-03 |
2023-08-13 |
rat |
| Shogo Kasuda, Takeshi Kondo, Ikuko Terazawa, Mami Morimoto, Katsuya Yuui, Risa Kud. Cardiac sudden death in a young cannabis user. Legal medicine (Tokyo, Japan). vol 53. 2021-11-25. PMID:34438239. |
both cannabinoid receptors (cb1 and cb2) were expressed in the atherosclerotic lesions. |
2021-11-25 |
2023-08-13 |
Not clear |
| Alba García-Baos, Laia Alegre-Zurano, Lídia Cantacorps, Ana Martín-Sánchez, Olga Valverd. Role of cannabinoids in alcohol-induced neuroinflammation. Progress in neuro-psychopharmacology & biological psychiatry. vol 104. 2021-11-22. PMID:32758518. |
indeed, specific modulations of the expanded endocannabinoid system have been proved to exert anti-inflammatory effects, primarily through the cb2 and pparγ signalling. |
2021-11-22 |
2023-08-13 |
Not clear |
| Mukuo Wang, Shujing Hou, Ye Liu, Dongmei Li, Jianping Li. Identification of Novel Antagonists Targeting Cannabinoid Receptor 2 Using a Multi-Step Virtual Screening Strategy. Molecules (Basel, Switzerland). vol 26. issue 21. 2021-11-18. PMID:34771087. |
the endocannabinoid system plays an essential role in the regulation of analgesia and human immunity, and cannabinoid receptor 2 (cb2) has been proved to be an ideal target for the treatment of liver diseases and some cancers. |
2021-11-18 |
2023-08-13 |
human |
| Marcia G Honig, Nobel A Del Mar, Desmond L Henderson, Dylan O'Neal, John B Doty, Rachel Cox, Chunyan Li, Aaron M Perry, Bob M Moore, Anton Reine. Raloxifene Modulates Microglia and Rescues Visual Deficits and Pathology After Impact Traumatic Brain Injury. Frontiers in neuroscience. vol 15. 2021-11-17. PMID:34776838. |
the upregulation of cannabinoid type-2 receptors (cb2) when microglia become activated allows cb2-binding drugs to selectively target microglia. |
2021-11-17 |
2023-08-13 |
mouse |
| O'Llenecia S Walker, Harmeet Gurm, Reeti Sharma, Navkiran Verma, Linda L May, Sandeep Rah. Delta-9-tetrahydrocannabinol inhibits invasion of HTR8/SVneo human extravillous trophoblast cells and negatively impacts mitochondrial function. Scientific reports. vol 11. issue 1. 2021-11-15. PMID:33597628. |
we also demonstrate that these changes in htr8/svneo biology may be variably mediated by cannabinoid receptors cb1 and cb2. |
2021-11-15 |
2023-08-13 |
human |
| Tim Ruhl, Ella F Lippold, Tim Christer, Benedikt Schaefer, Bong-Sung Kim, Justus P Beie. Genetic deletion of the cannabinoid receptors CB1 and CB2 enhances inflammation with diverging effects on skin wound healing in mice. Life sciences. vol 285. 2021-11-15. PMID:34624321. |
genetic deletion of the cannabinoid receptors cb1 and cb2 enhances inflammation with diverging effects on skin wound healing in mice. |
2021-11-15 |
2023-08-13 |
mouse |
| Tim Ruhl, Ella F Lippold, Tim Christer, Benedikt Schaefer, Bong-Sung Kim, Justus P Beie. Genetic deletion of the cannabinoid receptors CB1 and CB2 enhances inflammation with diverging effects on skin wound healing in mice. Life sciences. vol 285. 2021-11-15. PMID:34624321. |
it mediates several effects through the cannabinoid receptors cb1 and cb2. |
2021-11-15 |
2023-08-13 |
mouse |
| Yane Costa Chaves, Karina Genaro, José Alexandre Crippa, Joice Maria da Cunha, Janaína Menezes Zanovel. Cannabidiol induces antidepressant and anxiolytic-like effects in experimental type-1 diabetic animals by multiple sites of action. Metabolic brain disease. vol 36. issue 4. 2021-11-12. PMID:33464458. |
although the underlying mechanism remains unknown, the type-1a serotonin receptor (5-ht1a) and cannabinoids type-1 (cb1) and type-2 (cb2) receptors seem to play a central role in mediating the beneficial effects on emotional responses. |
2021-11-12 |
2023-08-13 |
rat |
| Nicholas Dopkins, Kathryn Miranda, Kiesha Wilson, Bryan L Holloman, Prakash Nagarkatti, Mitzi Nagarkatt. Effects of Orally Administered Cannabidiol on Neuroinflammation and Intestinal Inflammation in the Attenuation of Experimental Autoimmune Encephalomyelitis. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2021-11-10. PMID:34757526. |
cbd inhibited il-1β production independent of the classical cannabinoid receptors, cb1 and cb2. |
2021-11-10 |
2023-08-13 |
mouse |
| Chawon Yun, Meraaj S Haleem, Soyeon Jeong, Mark A Oyer, Adam J Driscoll, Kevin Y Chang, Jonghwa Yun, Jonathan Paul, Ryan J Lubbe, Stuart R Stock, Wellington K Hsu, Erin L Hs. Effect of Postoperative Analgesic Exposure to the Cannabinoid Receptor Agonist WIN55 on Osteogenic Differentiation and Spinal Fusion in Rats. The Journal of bone and joint surgery. American volume. vol 103. issue 11. 2021-11-08. PMID:33759484. |
as an alternative, the endocannabinoid system has been shown to have antinociceptive activity, while contributing to bone homeostasis via the cb1 and cb2 cannabinoid receptors. |
2021-11-08 |
2023-08-13 |
rat |