| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Nowińska, M Niezgoda, N Domian, I Kasack. Altered cannabinoid receptor expression in pancreatic islets in experimental model of uraemia. Folia morphologica. vol 79. issue 3. 2021-10-15. PMID:31625133. |
the aim of the present study was the immunohistochemical localisation and evaluation of cannabinoid receptors (cb1, cb2), insulin and glucagon in the pancreatic islets of uraemic rats. |
2021-10-15 |
2023-08-13 |
rat |
| Sirichai Chayasirisobho. Mechanisms of Action and Pharmacokinetics of Cannabis. The Permanente journal. vol 25. 2021-10-15. PMID:33635755. |
thc and cbd bind with cannabinoid receptors (cb1 and cb2), which are present in the brain and many organs. |
2021-10-15 |
2023-08-13 |
Not clear |
| Mostafa Rastegar, Saeed Samadizadeh, Mohammad Yasaghi, Abdolvahab Moradi, Alijan Tabarraei, Vahid Salimi, Alireza Tahamta. Functional variation (Q63R) in the cannabinoid CB2 receptor may affect the severity of COVID-19: a human study and molecular docking. Archives of virology. vol 166. issue 11. 2021-10-15. PMID:34514519. |
functional variation (q63r) in the cannabinoid cb2 receptor may affect the severity of covid-19: a human study and molecular docking. |
2021-10-15 |
2023-08-13 |
human |
| Mostafa Rastegar, Saeed Samadizadeh, Mohammad Yasaghi, Abdolvahab Moradi, Alijan Tabarraei, Vahid Salimi, Alireza Tahamta. Functional variation (Q63R) in the cannabinoid CB2 receptor may affect the severity of COVID-19: a human study and molecular docking. Archives of virology. vol 166. issue 11. 2021-10-15. PMID:34514519. |
variation in the cannabinoid cb2 receptor gene (cnr2) could affect the regulatory action of endocannabinoids on the immune system, resulting in an increased risk of various inflammatory diseases. |
2021-10-15 |
2023-08-13 |
human |
| Juan Carlos Ledesma, Marta Rodríguez-Arias, Ana L Gavito, Ana M Sánchez-Pérez, José Viña, Dina Medina Vera, Fernando Rodríguez de Fonseca, José Miñarr. Adolescent binge-ethanol accelerates cognitive impairment and β-amyloid production and dysregulates endocannabinoid signaling in the hippocampus of APP/PSE mice. Addiction biology. vol 26. issue 1. 2021-10-05. PMID:32043730. |
at 6 and 12 months of age, we evaluated hippocampal-dependent learning and memory: β-amyloid concentrations and rna and protein levels of cannabinoid type-2 receptors (cb2), diacylglycerol lipase-α (daglα), and monoacylglycerol lipase (magl) in the hippocampus. |
2021-10-05 |
2023-08-13 |
mouse |
| Xiang-Hu He, Ewa Galaj, Guo-Hua Bi, Yi He, Briana Hempel, Yan-Lin Wang, Eliot L Gardner, Zheng-Xiong X. β-caryophyllene, an FDA-Approved Food Additive, Inhibits Methamphetamine-Taking and Methamphetamine-Seeking Behaviors Possibly Frontiers in pharmacology. vol 12. 2021-09-29. PMID:34566647. |
β-caryophyllene, an fda-approved food additive, inhibits methamphetamine-taking and methamphetamine-seeking behaviors possibly recent research indicates that brain cannabinoid cb2 receptors are involved in drug reward and addiction. |
2021-09-29 |
2023-08-13 |
Not clear |
| Alba Angelina, Mario Pérez-Diego, Jacobo López-Abente, Beate Rückert, Ivan Nombela, Mübeccel Akdis, Mar Martín-Fontecha, Cezmi Akdis, Oscar Palomare. Cannabinoids induce functional Tregs by promoting tolerogenic DCs via autophagy and metabolic reprograming. Mucosal immunology. 2021-09-22. PMID:34548620. |
dendritic cells (dcs) express the endocannabinoid system, including the cannabinoid receptors cb1 and cb2. |
2021-09-22 |
2023-08-13 |
human |
| Ana Canseco-Alba, Norman Schanz, Hiroki Ishiguro, Qing-Rong Liu, Emmanuel S Onaiv. Behavioral Evaluation of Seeking and Preference of Alcohol in Mice Subjected to Stress. Bio-protocol. vol 8. issue 20. 2021-09-17. PMID:30505884. |
the alcohol preference model was combined with the conditioned place preference paradigm to determine alcohol conditioning and preference following the deletion of cb2 cannabinoid receptors in dopaminergic neurons in the dat- |
2021-09-17 |
2023-08-13 |
mouse |
| Ewa Galaj, Zheng-Xiong X. Possible Receptor Mechanisms Underlying Cannabidiol Effects on Addictive-like Behaviors in Experimental Animals. International journal of molecular sciences. vol 22. issue 1. 2021-09-13. PMID:33374481. |
both in vivo and in vitro receptor mechanism studies indicate that cbd may act as a negative allosteric modulator of type 1 cannabinoid (cb1) receptor and an agonist of type 2 cannabinoid (cb2), transient receptor potential vanilloid 1 (trpv1), and serotonin 5-ht |
2021-09-13 |
2023-08-13 |
Not clear |
| Aylar Alenabi, Hassan Malekineja. Cannabinoids pharmacological effects are beyond the palliative effects: CB2 cannabinoid receptor agonist induced cytotoxicity and apoptosis in human colorectal cancer cells (HT-29). Molecular and cellular biochemistry. vol 476. issue 9. 2021-09-06. PMID:33886060. |
cannabinoids pharmacological effects are beyond the palliative effects: cb2 cannabinoid receptor agonist induced cytotoxicity and apoptosis in human colorectal cancer cells (ht-29). |
2021-09-06 |
2023-08-13 |
human |
| Xiaoting Li, Ling Shen, Tian Hua, Zhi-Jie Li. Structural and Functional Insights into Cannabinoid Receptors. Trends in pharmacological sciences. vol 41. issue 9. 2021-08-31. PMID:32739033. |
cannabinoid receptors type 1 (cb1) and 2 (cb2) are widely expressed in the human body, and are attractive drug targets in the prevention and management of central nervous system (cns) and immune system dysfunction, respectively. |
2021-08-31 |
2023-08-13 |
human |
| Aurélien Laguerre, Kaya Keutler, Sebastian Hauke, Carsten Schult. Regulation of Calcium Oscillations in β-Cells by Co-activated Cannabinoid Receptors. Cell chemical biology. vol 28. issue 1. 2021-08-26. PMID:33147441. |
pharmacological treatment of pancreatic β cells targeting cannabinoid receptors 1 and 2 (cb1 and cb2) has been shown to result in significant effects on insulin release, possibly by modulating intracellular calcium levels ([ca |
2021-08-26 |
2023-08-13 |
Not clear |
| Thanh C Ho, Marcus A Tius, Spyros P Nikas, Ngan K Tran, Fei Tong, Han Zhou, Nikolai Zvonok, Alexandros Makriyanni. Oxa-adamantyl cannabinoids. Bioorganic & medicinal chemistry letters. vol 38. 2021-08-25. PMID:33636308. |
the novel oxa-adamantyl cannabinoids reported here were found to be high affinity ligands for the cb1 and cb2 cannabinoid receptors. |
2021-08-25 |
2023-08-13 |
Not clear |
| Xiaoqiang Cheng, Jiayi Lin, Zhanghuan Chen, Yubo Mao, Xiexin Wu, Congxin Xu, Jiacheng Du, Zhongchen Dong, Huilin Yang, Feng Zhou, Dechun Gen. CB2-mediated attenuation of nucleus pulposus degeneration via the amelioration of inflammation and oxidative stress in vivo and in vitro. Molecular medicine (Cambridge, Mass.). vol 27. issue 1. 2021-08-25. PMID:34412587. |
cannabinoid type 2 receptor (cb2) has been shown to be involved in the pathological mechanism of a variety of diseases due to its anti-inflammatory effects and antioxidative stress capacity. |
2021-08-25 |
2023-08-13 |
Not clear |
| Priodarshi Roychoudhury, Astha Koolwal Kapoor, Declan Walsh, Henry Cortes, Hance Clark. State of the science: cannabis and cannabinoids in palliative medicine-the potential. BMJ supportive & palliative care. vol 11. issue 3. 2021-08-23. PMID:33903260. |
within palliative medicine, cannabinoid receptors (cb1 and cb2) may modulate some cancer symptoms: appetite, chemotherapy-induced nausea and vomiting, and mood, pain and sleep disorders. |
2021-08-23 |
2023-08-13 |
Not clear |
| Inês Correia-Sá, Cláudia Carvalho, Vera A Machado, Sofia Carvalho, Paula Serrão, Marisa Marques, Maria A Vieira-Coelh. Targeting cannabinoid receptor 2 (CB2) limits collagen production-An in vitro study in a primary culture of human fibroblasts. Fundamental & clinical pharmacology. 2021-08-20. PMID:34259358. |
previous studies showed that cannabinoid 2 (cb2) receptor is involved in skin inflammation, fibrogenesis and re-epithelialization in mice, indicating that this receptor may be implicated in wound healing. |
2021-08-20 |
2023-08-13 |
mouse |
| Si-Jing Hu, Chen-Xia Lian, Tao Yu, Qi Zahng, Quan-Long Zhang, Qiao-Yan Zhang, Lu-Ping Qi. [Research progress on natural cannabinoid receptor type 2( CB2R)regulators and their effects on bone metabolism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 14. 2021-08-18. PMID:34402276. |
cannabinoids in cannabis sativa can cause psychoactive effects despite various pharmacological actions they exerted by targeting cb2 r. therefore,it is of great significance to discover cb2 r regulators in non-cannabis plants for finding new lead compounds without psychoactive effects and elucidating the action mechanism of plant drugs. |
2021-08-18 |
2023-08-13 |
Not clear |
| Hebaallah Mamdouh Hashiesh, Charu Sharma, Sameer N Goyal, Niraj Kumar Jha, Shreesh Ojh. Pharmacological Properties, Therapeutic Potential and Molecular Mechanisms of JWH133, a CB2 Receptor-Selective Agonist. Frontiers in pharmacology. vol 12. 2021-08-17. PMID:34393784. |
cannabinoid (cb2)-selective agonists have been the focus of pharmacological studies because modulation of the cb2 receptor (cb2r) can be useful in the treatment of pain, inflammation, arthritis, addiction, and cancer among other possible therapeutic applications while circumventing cns-related adverse effects. |
2021-08-17 |
2023-08-13 |
Not clear |
| Hajar Miranzadeh Mahabadi, Haseeb Bhatti, Robert B Laprairie, Changiz Taghibiglo. Cannabinoid receptors distribution in mouse cortical plasma membrane compartments. Molecular brain. vol 14. issue 1. 2021-08-12. PMID:34099009. |
the type 1 and type 2 cannabinoid receptors (cb1 and cb2 receptors) are class a g protein-coupled receptors (gpcrs) that are activated by endogenous lipids called endocannabinoids to modulate neuronal excitability and synaptic transmission in neurons throughout the central nervous system (cns), and inflammatory processes throughout the body. |
2021-08-12 |
2023-08-13 |
mouse |
| Nicholas John Sadgrove, Monique S J Simmond. Topical and nutricosmetic products for healthy hair and dermal antiaging using "dual-acting" (2 for 1) plant-based peptides, hormones, and cannabinoids. FASEB bioAdvances. vol 3. issue 8. 2021-08-12. PMID:34377956. |
because of crosstalk between adenosine and cannabinoid receptors it makes sense to try combinations of specific cb2 agonists and cytokinins (or phytoestrogens). |
2021-08-12 |
2023-08-13 |
Not clear |