| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valerie L Joers, Hannah Staley, Maclean Bassett, Brenda D Moore, Malu Gamez Tanse. The role of cannabinoid receptor 2 in microglial clearance of human tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109165. |
cannabinoid type 2 receptors (cb2) are highly expressed in immune cells and upregulated in activated microglia under conditions of neurologic disease, such as ad. |
2022-02-03 |
2023-08-13 |
human |
| Hagar Bauminger, Hiba Zaidan, Irit Akirav, Inna Gaisler-Salomo. Anandamide Hydrolysis Inhibition Reverses the Long-Term Behavioral and Gene Expression Alterations Induced by MK-801 in Male Rats: Differential CB1 and CB2 Receptor-Mediated Effects. Schizophrenia bulletin. 2022-01-29. PMID:35092675. |
prevention of behavioral and molecular abnormalities by late-adolescence urb597 via cb1 and cb2 receptors suggests that endocannabinoid stimulation may have therapeutic potential in addressing treatment-resistant symptoms. |
2022-01-29 |
2023-08-13 |
rat |
| Berhanu Geresu Kibret, Hiroki Ishiguro, Yasue Horiuchi, Emmanuel S Onaiv. New Insights and Potential Therapeutic Targeting of CB2 Cannabinoid Receptors in CNS Disorders. International journal of molecular sciences. vol 23. issue 2. 2022-01-21. PMID:35055161. |
new insights and potential therapeutic targeting of cb2 cannabinoid receptors in cns disorders. |
2022-01-21 |
2023-08-13 |
human |
| Berhanu Geresu Kibret, Hiroki Ishiguro, Yasue Horiuchi, Emmanuel S Onaiv. New Insights and Potential Therapeutic Targeting of CB2 Cannabinoid Receptors in CNS Disorders. International journal of molecular sciences. vol 23. issue 2. 2022-01-21. PMID:35055161. |
together, the ecs and the expanded endocannabinoidome (ecbome) are composed of genes coding for cb1 and cb2 cannabinoid receptors (cb1r, cb2r), endocannabinoids (ecbs), and the metabolic enzyme machinery for their synthesis and catabolism. |
2022-01-21 |
2023-08-13 |
human |
| Jiayi Yuan, Chen Jiang, Junmei Wang, Chih-Jung Chen, Yixuan Hao, Guangyi Zhao, Zhiwei Feng, Xiang-Qun Xi. In Silico Prediction and Validation of CB2 Allosteric Binding Sites to Aid the Design of Allosteric Modulators. Molecules (Basel, Switzerland). vol 27. issue 2. 2022-01-21. PMID:35056767. |
although the 3d structures of active and inactive cannabinoid receptors type 2 (cb2) are available, neither the x-ray crystal nor the cryo-em structure of cb2-orthosteric ligand-modulator has been resolved, prohibiting the drug discovery and development of cb2 allosteric modulators (ams). |
2022-01-21 |
2023-08-13 |
Not clear |
| Yongmin Liu, Min Jia, Caihua Wu, Hong Zhang, Chao Chen, Wenqiang Ge, Kexing Wan, Yuye Lan, Shiya Liu, Yuanheng Li, Mengyue Fang, Jiexi He, Hui-Lin Pan, Jun-Qiang Si, Man L. Transcriptomic Profiling in Mice With CB1 receptor Deletion in Primary Sensory Neurons Suggests New Analgesic Targets for Neuropathic Pain. Frontiers in pharmacology. vol 12. 2022-01-20. PMID:35046811. |
type 1 and type 2 cannabinoid receptors (cb1 and cb2, respectively) mediate cannabinoid-induced analgesia. |
2022-01-20 |
2023-08-13 |
mouse |
| Xiaoyan Lin, Zhili Xu, Lawrence Carey, Julian Romero, Alexandros Makriyannis, Cecilia J Hillard, Elizabeth Ruggiero, Marilyn Dockum, George Houk, Ken Mackie, Phillip J Albrecht, Frank L Rice, Andrea G Hohman. A peripheral CB2 cannabinoid receptor mechanism suppresses chemotherapy-induced peripheral neuropathy: evidence from a CB2 reporter mouse. Pain. 2022-01-10. PMID:35001054. |
cb2 cannabinoid receptors (cb2) are a promising therapeutic target that lacks unwanted side effects of cb1 activation. |
2022-01-10 |
2023-08-13 |
mouse |
| Szymon Hryhorowicz, Marta Kaczmarek-Ryś, Aleksandra Zielińska, Rodney J Scott, Ryszard Słomski, Andrzej Pławsk. Endocannabinoid System as a Promising Therapeutic Target in Inflammatory Bowel Disease - A Systematic Review. Frontiers in immunology. vol 12. 2022-01-10. PMID:35003109. |
it consists of cannabinoid receptors (cb1 and cb2), transporters for cellular uptake of endocannabinoid ligands, endogenous bioactive lipids (anandamide and 2-arachidonoylglycerol), and the enzymes responsible for their synthesis and degradation (fatty acid amide hydrolase and monoacylglycerol lipase), the manipulation of which through agonists and antagonists of the system, shows a potential therapeutic role for ecs in inflammatory bowel disease. |
2022-01-10 |
2023-08-13 |
Not clear |
| Shrouq I Farah, Samantha Hilston, Ngan Tran, Nikolai Zvonok, Alexandros Makriyanni. 1-, 2- and 3-AG as substrates of the endocannabinoid enzymes and endogenous ligands of the cannabinoid receptor 1. Biochemical and biophysical research communications. vol 591. 2022-01-07. PMID:34995983. |
2-arachidonoylglycerol (2-ag) is the most potent and abundant endocannabinoid that acts as a full agonist at the cannabinoid 1 (cb1) and 2 (cb2) receptors. |
2022-01-07 |
2023-08-13 |
Not clear |
| Hayley Worth, Daniel O'Hara, Neeru Agarwal, David Collister, Frank Brennan, Brendan Smyt. Cannabinoids for Symptom Management in Patients with Kidney Failure. Clinical journal of the American Society of Nephrology : CJASN. 2022-01-06. PMID:34987023. |
cannabinoid receptors, cb1 and cb2, are widely expressed in the body, including within the nervous and immune systems, and exogenous cannabinoids can have anxiolytic, anti-emetic, analgesic and anti-inflammatory effects. |
2022-01-06 |
2023-08-13 |
Not clear |
| Subramaniam Jayanthi, Ritvik Peesapati, Michael T McCoy, Bruce Ladenheim, Jean Lud Cade. Footshock-Induced Abstinence from Compulsive Methamphetamine Self-administration in Rat Model Is Accompanied by Increased Hippocampal Expression of Cannabinoid Receptors (CB1 and CB2). Molecular neurobiology. 2022-01-03. PMID:34978045. |
footshock-induced abstinence from compulsive methamphetamine self-administration in rat model is accompanied by increased hippocampal expression of cannabinoid receptors (cb1 and cb2). |
2022-01-03 |
2023-08-13 |
rat |
| Yan Shi, Mengxi Liu, Xiangjun Li, Niusheng Xu, Shuai Yuan, Zhiguo Yu, Ping Xiang, Hejian W. Simultaneous screening of 239 synthetic cannabinoids and metabolites in blood and urine samples using liquid chromatography-high resolution mass spectrometry. Journal of chromatography. A. vol 1663. 2022-01-02. PMID:34974369. |
synthetic cannabinoids (scs) are new psychoactive substances that function as endocannabinoid cb1 and cb2 receptor agonists. |
2022-01-02 |
2023-08-13 |
Not clear |
| Takashi Tanikawa, Masashi Kitamura, Yasuhiro Hayashi, Takami Yokogawa, Yutaka Inou. Curcumae Longae Rhizoma and Saussureae Radix Inhibit Nitric Oxide Production and Cannabinoid Receptor 2 Down-regulation. In vivo (Athens, Greece). vol 36. issue 1. 2022-01-01. PMID:34972719. |
the cannabinoid 2 (cb2) receptor is an important regulator of immunoinflammatory responses. |
2022-01-01 |
2023-08-13 |
Not clear |
| Nora Helmrich, Martin Roderfeld, Anne Baier, Anita Windhorst, Diran Herebian, Ertan Mayatepek, Christian Dierkes, Matthias Ocker, Dieter Glebe, Bruno Christ, Yuri Churin, Karuna Irungbam, Elke Roe. Pharmacological antagonization of cannabinoid receptor 1 improves cholestasis in Abcb4 Cellular and molecular gastroenterology and hepatology. 2021-12-26. PMID:34954190. |
pharmacological antagonization of cannabinoid receptor 1 improves cholestasis in abcb4 the endocannabinoid system is involved in the modulation of inflammatory, fibrotic, metabolic, and carcinogenesis-associated signaling pathways via the cannabinoid receptors 1 and 2 (cb1 and cb2). |
2021-12-26 |
2023-08-13 |
Not clear |
| Vickram Ramkumar, Debashree Mukherjea, Asmita Dhukhwa, Leonard P Ryba. Oxidative Stress and Inflammation Caused by Cisplatin Ototoxicity. Antioxidants (Basel, Switzerland). vol 10. issue 12. 2021-12-24. PMID:34943021. |
these include adenosine a1 receptors, cannabinoid 2 receptors (cb2) and the sphingosine 1-phosphate receptor 2 (s1pr2). |
2021-12-24 |
2023-08-13 |
Not clear |
| Armin Aryannejad, Nafise Noroozi, Seyed Mohammad Tavangar, Samira Ramezani, Amir Rashidian, Reza Laripour, Mojtaba Yousefi Zoshk, Ahmad Reza Dehpour, Mohsen Chamanar. Involvement of cannabinoid type 2 (CB2) receptors in the favorable effects of sumatriptan on the random-pattern skin flap survival in rats: a novel potential target. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes. 2021-12-20. PMID:34929701. |
involvement of cannabinoid type 2 (cb2) receptors in the favorable effects of sumatriptan on the random-pattern skin flap survival in rats: a novel potential target. |
2021-12-20 |
2023-08-13 |
rat |
| Armin Aryannejad, Nafise Noroozi, Seyed Mohammad Tavangar, Samira Ramezani, Amir Rashidian, Reza Laripour, Mojtaba Yousefi Zoshk, Ahmad Reza Dehpour, Mohsen Chamanar. Involvement of cannabinoid type 2 (CB2) receptors in the favorable effects of sumatriptan on the random-pattern skin flap survival in rats: a novel potential target. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes. 2021-12-20. PMID:34929701. |
recent investigations have indicated the potential therapeutic role of cannabinoid type 2 (cb2) receptors in various inflammatory-related disorders. |
2021-12-20 |
2023-08-13 |
rat |
| Sai Varshini Magham, Praveen Thaggikuppe Krishnamurthy, Neenu Shaji, Lalithkumar Mani, Shivaramakrishnan Balasubramania. Cannabinoid receptor 2 selective agonists and Alzheimer's disease: An insight into the therapeutic potentials. Journal of neuroscience research. vol 99. issue 11. 2021-12-11. PMID:34486749. |
endocannabinoid system has been extensively studied in recent decades, particularly the cannabinoid receptors cb1 and cb2, due to their important role in neuroinflammation. |
2021-12-11 |
2023-08-13 |
Not clear |
| Antonia Sophocleous, Michael Yiallourides, Feier Zeng, Pantelis Pantelas, Eleni Stylianou, Boya Li, Giovana Carrasco, Aymen I Idri. Association of cannabinoid receptor modulation with normal and abnormal skeletal remodelling: A systematic review and meta-analysis of in vitro, in vivo and human studies. Pharmacological research. vol 175. 2021-12-11. PMID:34800625. |
to address the inconsistent findings from studies that used different models to explore the role of classical cannabinoid type 1 (cb1) and 2 (cb2) receptors in skeletal remodelling, we searched medline, web of science and embase for relevant studies from inception to june 23, 2020. |
2021-12-11 |
2023-08-13 |
mouse |
| Qingling Kong, Songyu Tian, Chao Ma, Guonian Wang, Mingyue Zhan. Cannabinoid Receptor Type 2 Agonist Reduces Morphine Tolerance via Mitogen Activated Protein Kinase Phosphatase Induction and Mitogen Activated Protein Kinase Dephosphorylation. Neuroscience. vol 480. 2021-12-10. PMID:34774714. |
our previous study showed that a cannabinoid type 2 (cb2) receptor agonist attenuated morphine tolerance. |
2021-12-10 |
2023-08-13 |
Not clear |