| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Krishna Ghosh, Guang-Fen Zhang, Hong Chen, Shao-Rui Chen, Hui-Lin Pa. Cannabinoid CB2 receptors are upregulated via bivalent histone modifications and control primary afferent input to the spinal cord in neuropathic pain. The Journal of biological chemistry. 2022-05-02. PMID:35500651. |
type-2 cannabinoid receptors (cb2, encoded by the cnr2 gene) are mainly expressed in immune cells, and cb2 agonists normally have no analgesic effect. |
2022-05-02 |
2023-08-13 |
rat |
| J Maia, B M Fonseca, N Teixeira, G Correia-da-Silv. The endocannabinoids anandamide and 2-arachidonoylglycerol modulate the expression of angiogenic factors on HTR8/SVneo placental cells. Prostaglandins, leukotrienes, and essential fatty acids. vol 180. 2022-05-01. PMID:35490598. |
transcript analysis of angiogenic factors of the vascular endothelial growth factor (vegf) and matrix metalloproteinase (mmp) protein family demonstrated the ability of aea to increase vegf-c and vegfr3 expression via cannabinoid receptors cb1 and cb2 while the placental growth factor (plgf) was increased through cb1. |
2022-05-01 |
2023-08-13 |
human |
| Leila Etemad, Gholamreza Karimi, Mohaddeseh Sadat Alavi, Ali Roohbakhs. Pharmacological effects of cannabidiol by transient receptor potential channels. Life sciences. 2022-04-28. PMID:35483477. |
it has little affinity for classical cannabinoid receptors (cb1 and cb2). |
2022-04-28 |
2023-08-13 |
Not clear |
| Abhishek Mahajan, Pratishtha Sharma, Abhishek K Mishra, Shashikant Gupta, Sarvajeet Yadav, Mukul Anand, Brijesh Yadav, Arun K Madan, Dilip K Swai. Interplay mechanisms between progesterone and endocannabinoid receptors in regulating bull sperm capacitation and acrosome reaction. Journal of cellular physiology. 2022-04-27. PMID:35476800. |
however, it is not known whether there is an interplay between p4 and cannabinoid receptors 1 and 2 (cb1 and cb2), transient receptor potential vanilloid 1 (trpv1), catsper channels, camp, inositol trisphosphate receptor (ip3r), and mitogen-activated protein kinase (mapk); these potential regulators are involved in the regulation of capacitation and the acrosome reaction. |
2022-04-27 |
2023-08-13 |
Not clear |
| Alessia Mariano, Irene Bigioni, Roberto Mattioli, Antonella Di Sotto, Martina Leopizzi, Stefania Garzoli, Pier Francesco Mariani, Pietro Dalla Vedova, Sergio Ammendola, Anna Scotto d'Abusc. Pharmaceuticals (Basel, Switzerland). vol 15. issue 4. 2022-04-23. PMID:35455454. |
the endocannabinoid system is involved in the nociceptive and anti-inflammatory pathways, and a lowered expression of cb2 receptors has been associated with inflammatory conditions, such as osteoarthritis (oa). |
2022-04-23 |
2023-08-13 |
Not clear |
| Francesca Garofano, Amit Sharma, Hinrich Abken, Maria A Gonzalez-Carmona, Ingo G H Schmidt-Wol. A Low Dose of Pure Cannabidiol Is Sufficient to Stimulate the Cytotoxic Function of CIK Cells without Exerting the Downstream Mediators in Pancreatic Cancer Cells. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35409142. |
though research has focused on two cannabinoid receptors (cb1, cb2) activated by most cannabinoids, cb2 holds greater attention due to its expression in cells of the immune system. |
2022-04-12 |
2023-08-13 |
Not clear |
| Hong Zhang, Wei He, Xue-Fei Hu, Yan-Zhen Li, Yong-Min Liu, Wen-Qiang Ge, Ou-Yang Zhanmu, Chao Chen, Yu-Ye Lan, Yang-Shuai Su, Xiang-Hong Jing, Bing Zhu, Hui-Lin Pan, Ling-Ling Yu, Man L. Electroacupuncture Reduces Visceral Pain Via Cannabinoid CB2 Receptors in a Mouse Model of Inflammatory Bowel Disease. Frontiers in pharmacology. vol 13. 2022-04-11. PMID:35401205. |
electroacupuncture reduces visceral pain via cannabinoid cb2 receptors in a mouse model of inflammatory bowel disease. |
2022-04-11 |
2023-08-13 |
mouse |
| Hong Zhang, Wei He, Xue-Fei Hu, Yan-Zhen Li, Yong-Min Liu, Wen-Qiang Ge, Ou-Yang Zhanmu, Chao Chen, Yu-Ye Lan, Yang-Shuai Su, Xiang-Hong Jing, Bing Zhu, Hui-Lin Pan, Ling-Ling Yu, Man L. Electroacupuncture Reduces Visceral Pain Via Cannabinoid CB2 Receptors in a Mouse Model of Inflammatory Bowel Disease. Frontiers in pharmacology. vol 13. 2022-04-11. PMID:35401205. |
cannabinoid cb2 receptor agonists also reduce colonic inflammation in a mouse model of ibd. |
2022-04-11 |
2023-08-13 |
mouse |
| Mansour Hadda. The Impact of CB1 Receptor on Nuclear Receptors in Skeletal Muscle Cells. Pathophysiology : the official journal of the International Society for Pathophysiology. vol 28. issue 4. 2022-04-02. PMID:35366244. |
cannabinoids are abundant signaling compounds; their influence predominantly arises via engagement with the principal two g-protein-coupled cannabinoid receptors, cb1 and cb2. |
2022-04-02 |
2023-08-13 |
Not clear |
| Gitit Kra, Jayasimha Rayalu Daddam, Uzi Moallem, Hadar Kamer, Majdoleen Ahmad, Alina Nemirovski, G Andres Contreras, Joseph Tam, Maya Zachu. Effects of Environmental Heat Load on Endocannabinoid System Components in Adipose Tissue of High Yielding Dairy Cows. Animals : an open access journal from MDPI. vol 12. issue 6. 2022-03-25. PMID:35327191. |
in addition, we examined ecbs in milk, and studied the interaction of ecbs with bovine cannabinoids receptors cb1 and cb2. |
2022-03-25 |
2023-08-13 |
cattle |
| Petr Jirasek, Alexandr Jusku, Vilim Simanek, Jana Frankova, Jan Storch, Jan Vace. Cannabidiol and periodontal inflammatory disease: A critical assessment. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. 2022-03-25. PMID:35332345. |
cannabidiol (cbd), a non-psychotropic cannabinoid produced by the genus cannabis, is a phytoceutical that activates the endocannabinoid system (ecs) through binding to cb1 and cb2 receptors. |
2022-03-25 |
2023-08-13 |
Not clear |
| Sara E Woodman, Sophia R Antonopoulos, Paul L Durha. Inhibition of Nociception in a Preclinical Episodic Migraine Model by Dietary Supplementation of Grape Seed Extract Involves Activation of Endocannabinoid Receptors. Frontiers in pain research (Lausanne, Switzerland). vol 3. 2022-03-17. PMID:35295808. |
to investigate the role of the endocannabinoid receptors in the effect of gse, some animals were injected intracisternally with the cb1 antagonist am 251 or the cb2 antagonist am 630 prior to odor inhalation. |
2022-03-17 |
2023-08-13 |
rat |
| Riccardo Vago, Francesco Fiorio, Francesco Trevisani, Andrea Salonia, Francesco Montorsi, Arianna Bettig. The Mediterranean Diet as a Source of Bioactive Molecules with Cannabinomimetic Activity in Prevention and Therapy Strategy. Nutrients. vol 14. issue 3. 2022-03-12. PMID:35276827. |
while it is known that they do not necessarily act directly on the cannabinoid receptors cb1 and cb2, their ability to regulate their expression levels has already been shown in some disease-related models, as well as their ability to modulate the activity of other components of the system. |
2022-03-12 |
2023-08-13 |
Not clear |
| Yuemin Bian, Xiang-Qun Xi. Artificial Intelligent Deep Learning Molecular Generative Modeling of Scaffold-Focused and Cannabinoid CB2 Target-Specific Small-Molecule Sublibraries. Cells. vol 11. issue 5. 2022-03-10. PMID:35269537. |
artificial intelligent deep learning molecular generative modeling of scaffold-focused and cannabinoid cb2 target-specific small-molecule sublibraries. |
2022-03-10 |
2023-08-13 |
Not clear |
| Greg Maguire, Christy Eubanks, George Ayou. Neuroprotection of retinal ganglion cells Neuronal signaling. vol 6. issue 1. 2022-03-02. PMID:35233292. |
the present study tests the putative neuroprotective effect mediated by cannabinoids at the cb1 and cb2 receptors. |
2022-03-02 |
2023-08-13 |
mouse |
| Ana Canseco-Alba, Branden Sanabria, Mariam Hammouda, Rollanda Bernadin, Marizel Mina, Qing-Rong Liu, Emmanuel S Onaiv. Cell-Type Specific Deletion of CB2 Cannabinoid Receptors in Dopamine Neurons Induced Hyperactivity Phenotype: Possible Relevance to Attention-Deficit Hyperactivity Disorder. Frontiers in psychiatry. vol 12. 2022-02-25. PMID:35211038. |
cell-type specific deletion of cb2 cannabinoid receptors in dopamine neurons induced hyperactivity phenotype: possible relevance to attention-deficit hyperactivity disorder. |
2022-02-25 |
2023-08-13 |
Not clear |
| Antonio Bruno, Ettore Dolcetti, Diego Centonz. Theoretical and Therapeutic Implications of the Spasticity-Plus Syndrome Model in Multiple Sclerosis. Frontiers in neurology. vol 12. 2022-02-24. PMID:35197915. |
muscle tone, sleep, bladder function, and the pain pathway are controlled by cannabinoid cb1 (cb1r) and cb2 receptors (cb2r) that are particularly enriched in the brainstem. |
2022-02-24 |
2023-08-13 |
Not clear |
| Ricardo Lacava Bailone, Hirla Costa Silva Fukushima, Luis Kluwe de Aguiar, Ricardo Carneiro Borr. The endocannabinoid system in zebrafish and its potential to study the effects of Cannabis in humans. Laboratory animal research. vol 38. issue 1. 2022-02-23. PMID:35193700. |
particular attention is paid to endocannabinoid system (ecb) and its main receptors (cb1 and cb2). |
2022-02-23 |
2023-08-13 |
human |
| Kyung-Hwa Jeon, Sang-Hyuck Park, Woong Jin Bae, Sae Woong Kim, Hyo Jung Park, Soomin Kim, Tae Hyung Kim, Seung Hwan Jeon, Ilbum Park, Hyun-Je Park, Youngjoo Kwo. Cannabidiol, a Regulator of Intracellular Calcium and Calpain. Cannabis and cannabinoid research. 2022-02-23. PMID:35196129. |
although cbd is a kind of cannabinoid and acts on cannabinoid receptors (cb1 and cb2), molecular targets involved in diverse therapeutic properties of cbd have not been identified because cbd also interacts with other molecular targets. |
2022-02-23 |
2023-08-13 |
Not clear |
| Senthil Jayarajan, Joseph J Meissler, Martin W Adler, Toby K Eisenstei. A Cannabinoid 2-Selective Agonist Inhibits Allogeneic Skin Graft Rejection Frontiers in pharmacology. vol 12. 2022-02-21. PMID:35185546. |
a cannabinoid 2-selective agonist inhibits allogeneic skin graft rejection previous work from our laboratory showed that a cb2 selective agonist, o-1966, blocked the proliferative response of c57bl/6 mouse spleen cells exposed to spleen cells of c3heb/fej mice |
2022-02-21 |
2023-08-13 |
mouse |