| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vivek S Kumawat, Ginpreet Kau. CB2 receptor agonist and L- arginine combination attenuates diabetic cardiomyopathy in rats via NF-ĸβ inhibition. Canadian journal of physiology and pharmacology. 2021-12-03. PMID:34860602. |
beta-caryophyllene (bcp), a cannabinoid 2 receptor (cb2) agonist has recently been found to have cardioprotective activity as an anti-inflammatory and antioxidant molecule. |
2021-12-03 |
2023-08-13 |
rat |
| Shogo Kasuda, Takeshi Kondo, Ikuko Terazawa, Mami Morimoto, Katsuya Yuui, Risa Kud. Cardiac sudden death in a young cannabis user. Legal medicine (Tokyo, Japan). vol 53. 2021-11-25. PMID:34438239. |
both cannabinoid receptors (cb1 and cb2) were expressed in the atherosclerotic lesions. |
2021-11-25 |
2023-08-13 |
Not clear |
| Alba García-Baos, Laia Alegre-Zurano, Lídia Cantacorps, Ana Martín-Sánchez, Olga Valverd. Role of cannabinoids in alcohol-induced neuroinflammation. Progress in neuro-psychopharmacology & biological psychiatry. vol 104. 2021-11-22. PMID:32758518. |
indeed, specific modulations of the expanded endocannabinoid system have been proved to exert anti-inflammatory effects, primarily through the cb2 and pparγ signalling. |
2021-11-22 |
2023-08-13 |
Not clear |
| Mukuo Wang, Shujing Hou, Ye Liu, Dongmei Li, Jianping Li. Identification of Novel Antagonists Targeting Cannabinoid Receptor 2 Using a Multi-Step Virtual Screening Strategy. Molecules (Basel, Switzerland). vol 26. issue 21. 2021-11-18. PMID:34771087. |
the endocannabinoid system plays an essential role in the regulation of analgesia and human immunity, and cannabinoid receptor 2 (cb2) has been proved to be an ideal target for the treatment of liver diseases and some cancers. |
2021-11-18 |
2023-08-13 |
human |
| Marcia G Honig, Nobel A Del Mar, Desmond L Henderson, Dylan O'Neal, John B Doty, Rachel Cox, Chunyan Li, Aaron M Perry, Bob M Moore, Anton Reine. Raloxifene Modulates Microglia and Rescues Visual Deficits and Pathology After Impact Traumatic Brain Injury. Frontiers in neuroscience. vol 15. 2021-11-17. PMID:34776838. |
the upregulation of cannabinoid type-2 receptors (cb2) when microglia become activated allows cb2-binding drugs to selectively target microglia. |
2021-11-17 |
2023-08-13 |
mouse |
| O'Llenecia S Walker, Harmeet Gurm, Reeti Sharma, Navkiran Verma, Linda L May, Sandeep Rah. Delta-9-tetrahydrocannabinol inhibits invasion of HTR8/SVneo human extravillous trophoblast cells and negatively impacts mitochondrial function. Scientific reports. vol 11. issue 1. 2021-11-15. PMID:33597628. |
we also demonstrate that these changes in htr8/svneo biology may be variably mediated by cannabinoid receptors cb1 and cb2. |
2021-11-15 |
2023-08-13 |
human |
| Tim Ruhl, Ella F Lippold, Tim Christer, Benedikt Schaefer, Bong-Sung Kim, Justus P Beie. Genetic deletion of the cannabinoid receptors CB1 and CB2 enhances inflammation with diverging effects on skin wound healing in mice. Life sciences. vol 285. 2021-11-15. PMID:34624321. |
genetic deletion of the cannabinoid receptors cb1 and cb2 enhances inflammation with diverging effects on skin wound healing in mice. |
2021-11-15 |
2023-08-13 |
mouse |
| Tim Ruhl, Ella F Lippold, Tim Christer, Benedikt Schaefer, Bong-Sung Kim, Justus P Beie. Genetic deletion of the cannabinoid receptors CB1 and CB2 enhances inflammation with diverging effects on skin wound healing in mice. Life sciences. vol 285. 2021-11-15. PMID:34624321. |
it mediates several effects through the cannabinoid receptors cb1 and cb2. |
2021-11-15 |
2023-08-13 |
mouse |
| Yane Costa Chaves, Karina Genaro, José Alexandre Crippa, Joice Maria da Cunha, Janaína Menezes Zanovel. Cannabidiol induces antidepressant and anxiolytic-like effects in experimental type-1 diabetic animals by multiple sites of action. Metabolic brain disease. vol 36. issue 4. 2021-11-12. PMID:33464458. |
although the underlying mechanism remains unknown, the type-1a serotonin receptor (5-ht1a) and cannabinoids type-1 (cb1) and type-2 (cb2) receptors seem to play a central role in mediating the beneficial effects on emotional responses. |
2021-11-12 |
2023-08-13 |
rat |
| Nicholas Dopkins, Kathryn Miranda, Kiesha Wilson, Bryan L Holloman, Prakash Nagarkatti, Mitzi Nagarkatt. Effects of Orally Administered Cannabidiol on Neuroinflammation and Intestinal Inflammation in the Attenuation of Experimental Autoimmune Encephalomyelitis. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2021-11-10. PMID:34757526. |
cbd inhibited il-1β production independent of the classical cannabinoid receptors, cb1 and cb2. |
2021-11-10 |
2023-08-13 |
mouse |
| Chawon Yun, Meraaj S Haleem, Soyeon Jeong, Mark A Oyer, Adam J Driscoll, Kevin Y Chang, Jonghwa Yun, Jonathan Paul, Ryan J Lubbe, Stuart R Stock, Wellington K Hsu, Erin L Hs. Effect of Postoperative Analgesic Exposure to the Cannabinoid Receptor Agonist WIN55 on Osteogenic Differentiation and Spinal Fusion in Rats. The Journal of bone and joint surgery. American volume. vol 103. issue 11. 2021-11-08. PMID:33759484. |
as an alternative, the endocannabinoid system has been shown to have antinociceptive activity, while contributing to bone homeostasis via the cb1 and cb2 cannabinoid receptors. |
2021-11-08 |
2023-08-13 |
rat |
| Ayse Tarbin Jannuzzi, Mahmut Yıldız, Nilüfer Bayrak, Hatice Yıldırım, Deepak Shilkar, Venkatesan Jayaprakash, Amaç Fatih TuYu. Anticancer agents based on Plastoquinone analogs with N-phenylpiperazine: Structure-activity relationship and mechanism of action in breast cancer cells. Chemico-biological interactions. vol 349. 2021-11-08. PMID:34560069. |
based on the biological activity profile, we hypothesize that pq11 could be a modulator of the cannabinoid 2 (cb2) receptor. |
2021-11-08 |
2023-08-13 |
Not clear |
| Sergey V Popov, Leonid N Maslov, Natalia V Naryzhnaya, Alexandr V Mukhomezyanov, Andrey V Krylatov, Sergey Y Tsibulnikov, Vyacheslav V Ryabov, Michael V Cohen, James M Downe. The Role of Pyroptosis in Ischemic and Reperfusion Injury of the Heart. Journal of cardiovascular pharmacology and therapeutics. vol 26. issue 6. 2021-10-26. PMID:34264787. |
in contrast, stimulation of the cannabinoid cb2 receptor reduces i/r cardiac injury and inhibits this pathway. |
2021-10-26 |
2023-08-13 |
Not clear |
| Marialuisa de Ceglia, Juan Decara, Silvana Gaetani, Fernando Rodríguez de Fonsec. Obesity as a Condition Determined by Food Addiction: Should Brain Endocannabinoid System Alterations Be the Cause and Its Modulation the Solution? Pharmaceuticals (Basel, Switzerland). vol 14. issue 10. 2021-10-26. PMID:34681224. |
in this context, new classes of drugs acting either on cb1 and/or cb2 receptors or on synthetic and degradation enzymes of endogenous cannabinoids are being studied. |
2021-10-26 |
2023-08-13 |
Not clear |
| Magdalena Kostrzewa, Ali Mokhtar Mahmoud, Roberta Verde, Federica Scotto di Carlo, Fernando Gianfrancesco, Fabiana Piscitelli, Alessia Ligrest. Modulation of Endocannabinoid Tone in Osteoblastic Differentiation of MC3T3-E1 Cells and in Mouse Bone Tissue over Time. Cells. vol 10. issue 5. 2021-10-25. PMID:34068882. |
bone mass expresses cb1 and cb2 cannabinoid receptors and enzymatic machinery responsible for the metabolism of their endogenous ligands, endocannabinoids (aea and 2-ag). |
2021-10-25 |
2023-08-13 |
mouse |
| Waleed Hassan Almalk. A study of abnormal cannabidiols system-mediated cardiovascular protection in disrupted gut/brain axis associated depression. Journal of biochemical and molecular toxicology. 2021-10-22. PMID:34676637. |
the cardiovascular effects of tetrahydrocannabinol (thc) (the key psychotropic credential of cannabis) and endocannabinoids (thc endogenous equivalents which cause type 1 [cb1] and 2 [cb2] cannabinoids) have been extensively examined based on well-documented effects of marijuana smoke on blood pressure (bp) and heart rate (hr). |
2021-10-22 |
2023-08-13 |
Not clear |
| Chengzhi Xie, Guoxing Liu, Jiefeng Liu, Zhao Huang, Fusheng Wang, Xiaohua Lei, Xiaolong Wu, Shengfu Huang, Dewu Zhong, Xundi X. Anti-proliferative effects of anandamide in human hepatocellular carcinoma cells. Oncology letters. vol 4. issue 3. 2021-10-21. PMID:22970038. |
in our previous study, we reported that the cannabinoid receptors cb1 and cb2 are overexpressed in human hepatocellular carcinoma (hcc) tissues. |
2021-10-21 |
2023-08-12 |
human |
| Yannick Marchalant, Philip W Brownjohn, Amandine Bonnet, Torsten Kleffmann, John C Ashto. Validating Antibodies to the Cannabinoid CB2 Receptor: Antibody Sensitivity Is Not Evidence of Antibody Specificity. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 62. issue 6. 2021-10-21. PMID:24670796. |
validating antibodies to the cannabinoid cb2 receptor: antibody sensitivity is not evidence of antibody specificity. |
2021-10-21 |
2023-08-12 |
Not clear |
| Yannick Marchalant, Philip W Brownjohn, Amandine Bonnet, Torsten Kleffmann, John C Ashto. Validating Antibodies to the Cannabinoid CB2 Receptor: Antibody Sensitivity Is Not Evidence of Antibody Specificity. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 62. issue 6. 2021-10-21. PMID:24670796. |
in this report, we investigate one of the most commonly utilized commercial antibodies for the cannabinoid cb2 receptor, a gpcr, using immunoblotting in combination with mass spectrometry. |
2021-10-21 |
2023-08-12 |
Not clear |
| Mariane C G Leite-Avalca, Aleksander Zampronio, Christian Lehman. Cannabinoid Receptor 1 and 2 Signaling Pathways Involved in Sepsis. Shock (Augusta, Ga.). vol 56. issue 5. 2021-10-18. PMID:33625115. |
cannabinoid receptors include the cannabinoid type 1 receptor (cb1) and the cannabinoid type 2 receptor (cb2). |
2021-10-18 |
2023-08-13 |
Not clear |