| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aurélien Laguerre, Kaya Keutler, Sebastian Hauke, Carsten Schult. Regulation of Calcium Oscillations in β-Cells by Co-activated Cannabinoid Receptors. Cell chemical biology. vol 28. issue 1. 2021-08-26. PMID:33147441. |
pharmacological treatment of pancreatic β cells targeting cannabinoid receptors 1 and 2 (cb1 and cb2) has been shown to result in significant effects on insulin release, possibly by modulating intracellular calcium levels ([ca |
2021-08-26 |
2023-08-13 |
Not clear |
| Thanh C Ho, Marcus A Tius, Spyros P Nikas, Ngan K Tran, Fei Tong, Han Zhou, Nikolai Zvonok, Alexandros Makriyanni. Oxa-adamantyl cannabinoids. Bioorganic & medicinal chemistry letters. vol 38. 2021-08-25. PMID:33636308. |
the novel oxa-adamantyl cannabinoids reported here were found to be high affinity ligands for the cb1 and cb2 cannabinoid receptors. |
2021-08-25 |
2023-08-13 |
Not clear |
| Xiaoqiang Cheng, Jiayi Lin, Zhanghuan Chen, Yubo Mao, Xiexin Wu, Congxin Xu, Jiacheng Du, Zhongchen Dong, Huilin Yang, Feng Zhou, Dechun Gen. CB2-mediated attenuation of nucleus pulposus degeneration via the amelioration of inflammation and oxidative stress in vivo and in vitro. Molecular medicine (Cambridge, Mass.). vol 27. issue 1. 2021-08-25. PMID:34412587. |
cannabinoid type 2 receptor (cb2) has been shown to be involved in the pathological mechanism of a variety of diseases due to its anti-inflammatory effects and antioxidative stress capacity. |
2021-08-25 |
2023-08-13 |
Not clear |
| Priodarshi Roychoudhury, Astha Koolwal Kapoor, Declan Walsh, Henry Cortes, Hance Clark. State of the science: cannabis and cannabinoids in palliative medicine-the potential. BMJ supportive & palliative care. vol 11. issue 3. 2021-08-23. PMID:33903260. |
within palliative medicine, cannabinoid receptors (cb1 and cb2) may modulate some cancer symptoms: appetite, chemotherapy-induced nausea and vomiting, and mood, pain and sleep disorders. |
2021-08-23 |
2023-08-13 |
Not clear |
| Inês Correia-Sá, Cláudia Carvalho, Vera A Machado, Sofia Carvalho, Paula Serrão, Marisa Marques, Maria A Vieira-Coelh. Targeting cannabinoid receptor 2 (CB2) limits collagen production-An in vitro study in a primary culture of human fibroblasts. Fundamental & clinical pharmacology. 2021-08-20. PMID:34259358. |
previous studies showed that cannabinoid 2 (cb2) receptor is involved in skin inflammation, fibrogenesis and re-epithelialization in mice, indicating that this receptor may be implicated in wound healing. |
2021-08-20 |
2023-08-13 |
mouse |
| Si-Jing Hu, Chen-Xia Lian, Tao Yu, Qi Zahng, Quan-Long Zhang, Qiao-Yan Zhang, Lu-Ping Qi. [Research progress on natural cannabinoid receptor type 2( CB2R)regulators and their effects on bone metabolism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 14. 2021-08-18. PMID:34402276. |
cannabinoids in cannabis sativa can cause psychoactive effects despite various pharmacological actions they exerted by targeting cb2 r. therefore,it is of great significance to discover cb2 r regulators in non-cannabis plants for finding new lead compounds without psychoactive effects and elucidating the action mechanism of plant drugs. |
2021-08-18 |
2023-08-13 |
Not clear |
| Hebaallah Mamdouh Hashiesh, Charu Sharma, Sameer N Goyal, Niraj Kumar Jha, Shreesh Ojh. Pharmacological Properties, Therapeutic Potential and Molecular Mechanisms of JWH133, a CB2 Receptor-Selective Agonist. Frontiers in pharmacology. vol 12. 2021-08-17. PMID:34393784. |
cannabinoid (cb2)-selective agonists have been the focus of pharmacological studies because modulation of the cb2 receptor (cb2r) can be useful in the treatment of pain, inflammation, arthritis, addiction, and cancer among other possible therapeutic applications while circumventing cns-related adverse effects. |
2021-08-17 |
2023-08-13 |
Not clear |
| Hajar Miranzadeh Mahabadi, Haseeb Bhatti, Robert B Laprairie, Changiz Taghibiglo. Cannabinoid receptors distribution in mouse cortical plasma membrane compartments. Molecular brain. vol 14. issue 1. 2021-08-12. PMID:34099009. |
the type 1 and type 2 cannabinoid receptors (cb1 and cb2 receptors) are class a g protein-coupled receptors (gpcrs) that are activated by endogenous lipids called endocannabinoids to modulate neuronal excitability and synaptic transmission in neurons throughout the central nervous system (cns), and inflammatory processes throughout the body. |
2021-08-12 |
2023-08-13 |
mouse |
| Nicholas John Sadgrove, Monique S J Simmond. Topical and nutricosmetic products for healthy hair and dermal antiaging using "dual-acting" (2 for 1) plant-based peptides, hormones, and cannabinoids. FASEB bioAdvances. vol 3. issue 8. 2021-08-12. PMID:34377956. |
because of crosstalk between adenosine and cannabinoid receptors it makes sense to try combinations of specific cb2 agonists and cytokinins (or phytoestrogens). |
2021-08-12 |
2023-08-13 |
Not clear |
| Olga P Balezina, Ekaterina O Tarasova, Alexander E Gayduko. Noncanonical Activity of Endocannabinoids and Their Receptors in Central and Peripheral Synapses. Biochemistry. Biokhimiia. vol 86. issue 7. 2021-08-04. PMID:34284706. |
this review focuses on new aspects of endocannabinoid functions and mechanisms of activity in central and peripheral synapses, different from the general viewpoint that endocannabinoids are retrograde signaling molecules, which inhibit neurotransmitter release by activating specific presynaptic endocannabinoid receptors cb1 and cb2. |
2021-08-04 |
2023-08-13 |
Not clear |
| Trenton C Simmons, Sara M Freeman, Nicholas S Lackey, Brooke K Dreyer, Devanand S Manoli, Karen L Bale. Cannabinoid receptor Type 1 densities reflect social organization in Microtus. The Journal of comparative neurology. vol 529. issue 5. 2021-08-02. PMID:33460115. |
these processes are mediated through at least two distinct cannabinoid receptors (cb), cb1 and cb2. |
2021-08-02 |
2023-08-13 |
Not clear |
| Valeria Giorgi, Daniela Marotto, Alberto Batticciotto, Fabiola Atzeni, Sara Bongiovanni, Piercarlo Sarzi-Puttin. Cannabis and Autoimmunity: Possible Mechanisms of Action. ImmunoTargets and therapy. vol 10. 2021-07-30. PMID:34322454. |
renewed interest in the medicinal properties of cannabis has led to increasing research into the practical uses of cannabis derivatives, and it has been found that the endocannabinoid system (particularly cb2 receptor activation) is a possible target for the treatment of inflammatory and the autoimmune diseases related to immune cell activation. |
2021-07-30 |
2023-08-13 |
human |
| Hebaallah Mamdouh Hashiesh, Charu Sharma, Sameer N Goyal, Bassem Sadek, Niraj Kumar Jha, Juma Al Kaabi, Shreesh Ojh. A focused review on CB2 receptor-selective pharmacological properties and therapeutic potential of β-caryophyllene, a dietary cannabinoid. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 140. 2021-07-29. PMID:34091179. |
a focused review on cb2 receptor-selective pharmacological properties and therapeutic potential of β-caryophyllene, a dietary cannabinoid. |
2021-07-29 |
2023-08-13 |
human |
| Roger Gregory Biringe. The rise and fall of anandamide: processes that control synthesis, degradation, and storage. Molecular and cellular biochemistry. vol 476. issue 7. 2021-07-27. PMID:33713246. |
its effects are primarily mediated by the cannabinoid receptors cb1 and cb2, and the vanilloid trpv1 receptor. |
2021-07-27 |
2023-08-13 |
Not clear |
| Sandra Glasmacher, Jürg Gertsc. Characterization of pepcan-23 as pro-peptide of RVD-hemopressin (pepcan-12) and stability of hemopressins in mice. Advances in biological regulation. vol 80. 2021-07-21. PMID:33799079. |
rvd-hemopressin (pepcan-12) was shown to act as endogenous allosteric modulator of cannabinoid receptors, with opposite effects on cb1 and cb2, respectively. |
2021-07-21 |
2023-08-13 |
mouse |
| Anna A Karan, Yulia S Spivak, Konstantin A Gerasimov, Elena M Suleymanova, Maria N Volobueva, Alexey A Kvichansky, Lyudmila V Vinogradova, Alexey P Bolshako. CB2 receptors modulate seizure-induced expression of pro-inflammatory cytokines in the hippocampus but not neocortex. Molecular neurobiology. vol 58. issue 8. 2021-07-15. PMID:33907944. |
we compared neuroinflammatory responses induced by nonconvulsive and convulsive seizures and analyzed the role that may be played by cannabinoid cb2 receptors in the neuroinflammatory response induced by generalized tonic-clonic seizures (gtcs). |
2021-07-15 |
2023-08-13 |
Not clear |
| Xinru Tang, Zheng Liu, Xiaoqing Li, Jing Wang, Liliang L. Cannabinoid Receptors in Myocardial Injury: A Brother Born to Rival. International journal of molecular sciences. vol 22. issue 13. 2021-07-12. PMID:34206926. |
cannabinoid receptors typically include type 1 (cb1) and type 2 (cb2), and they have attracted extensive attention in the central nervous system (cns) and immune system. |
2021-07-12 |
2023-08-13 |
Not clear |
| Xinru Tang, Zheng Liu, Xiaoqing Li, Jing Wang, Liliang L. Cannabinoid Receptors in Myocardial Injury: A Brother Born to Rival. International journal of molecular sciences. vol 22. issue 13. 2021-07-12. PMID:34206926. |
herein, we introduce the general differences of cb1 and cb2 cannabinoid receptors, and summarize the functional rivalries between the two brother receptors in the setting of myocardial injuries. |
2021-07-12 |
2023-08-13 |
Not clear |
| Erik L Hodges, Jessica P Marshall, Nicole M Ashpol. Age-dependent hormesis-like effects of the synthetic cannabinoid CP55940 in C57BL/6 mice. NPJ aging and mechanisms of disease. vol 6. 2021-07-07. PMID:32655880. |
these bidirectional effects appear to be mediated via the endocannabinoid cb1 and cb2 receptors. |
2021-07-07 |
2023-08-13 |
mouse |
| Samer Narouz. Antinociception mechanisms of action of cannabinoid-based medicine: an overview for anesthesiologists and pain physicians. Regional anesthesia and pain medicine. vol 46. issue 3. 2021-07-05. PMID:33239391. |
cannabinoids (endogenous and phytocannabinoids) produce analgesia by interacting with cannabinoids receptors type 1 and 2 (cb1 and cb2), as well as putative non-cb1/cb2 receptors; g protein-coupled receptor 55, and transient receptor potential vanilloid type-1. |
2021-07-05 |
2023-08-13 |
human |