| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| James F Chmiel, Patrick Flume, Damian G Downey, Allen J Dozor, Carla Colombo, Henryk Mazurek, Ewa Sapiejka, Marta Rachel, Scott Constantine, Brian Conley, Nancy Dgetluck, Quinn Dinh, Barbara White, J Stuart Elbor. Safety and efficacy of lenabasum in a phase 2 randomized, placebo-controlled trial in adults with cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. vol 20. issue 1. 2021-06-15. PMID:33011099. |
lenabasum is a cannabinoid type 2 receptor (cb2) agonist that resolves inflammation in a number of in vitro and in vivo models. |
2021-06-15 |
2023-08-13 |
Not clear |
| Estefania Rojo-Bustamante, Ignacio Íñigo-Marco, Miguel Angel Abellanas, Rodrigo Vinueza-Gavilanes, Ana Baltanás, Esther Luquin, Montserrat Arrasate, Maria S Aymeric. CB2 Receptors and Neuron-Glia Interactions Modulate Neurotoxicity Generated by MAGL Inhibition. Biomolecules. vol 10. issue 8. 2021-06-14. PMID:32824740. |
blockade of cannabinoid type 2 (cb2) receptors expressed mainly by microglial cells did not affect the spontaneous neuronal death risk but decreased neuronal survival when kml29 was added. |
2021-06-14 |
2023-08-13 |
rat |
| James V Gruber, Robert Holt. Purified Cannabidiol isolate does not inhibit active caspase-1 release in NLRP inflammasome-mediated UVB or ATP-activated keratinocytes or appear to reduce key inflammatory cytokines in UVB-irradiate keratinocytes. International journal of cosmetic science. vol 43. issue 3. 2021-06-14. PMID:33559194. |
it is known that cbd will bind to cannabinoid receptors, cb1 and cb2, in the body and recent work has shown that in keratinocytes, cbd can regulate inflammation through transcriptional regulation involving the nfƙβ nuclear pathways. |
2021-06-14 |
2023-08-13 |
human |
| Samuel S Duffy, Jessica P Hayes, Nathan T Fiore, Gila Moalem-Taylo. The cannabinoid system and microglia in health and disease. Neuropharmacology. vol 190. 2021-06-09. PMID:33845074. |
homeostatic microglia synthesise the endogenous cannabinoids 2-arachidonoylglycerol and anandamide and express the cannabinoid receptors cb1 and cb2 at constitutively low levels. |
2021-06-09 |
2023-08-13 |
Not clear |
| Mansoureh Hashemi, Senada Bashi, Alireza Zal. The expression level of cannabinoid receptors type 1 and 2 in the different types of astrocytomas. Molecular biology reports. vol 47. issue 7. 2021-06-07. PMID:32623617. |
the distribution of cannabinoid receptors type 1 (cb1) and cannabinoid receptor type 2 (cb2) in blood vessels and tumor tissue of astrocytoma is still controversial. |
2021-06-07 |
2023-08-13 |
Not clear |
| Niraj Kumar Jha, Charu Sharma, Hebaallah Mamdouh Hashiesh, Seenipandi Arunachalam, Mf Nagoor Meeran, Hayate Javed, Chandragouda R Patil, Sameer N Goyal, Shreesh Ojh. β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19. Frontiers in pharmacology. vol 12. 2021-06-01. PMID:34054510. |
β-caryophyllene, a natural dietary cb2 receptor selective cannabinoid can be a candidate to target the trinity of infection, immunity, and inflammation in covid-19. |
2021-06-01 |
2023-08-13 |
Not clear |
| Niraj Kumar Jha, Charu Sharma, Hebaallah Mamdouh Hashiesh, Seenipandi Arunachalam, Mf Nagoor Meeran, Hayate Javed, Chandragouda R Patil, Sameer N Goyal, Shreesh Ojh. β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19. Frontiers in pharmacology. vol 12. 2021-06-01. PMID:34054510. |
to pharmacologically activate the cb2 receptors, a naturally occurring cannabinoid ligand, beta-caryophyllene (bcp), received attention due to its potent anti-inflammatory, antiviral, and immunomodulatory properties. |
2021-06-01 |
2023-08-13 |
Not clear |
| Dongchen An, Steve Peigneur, Jan Tytga. WIN55,212-2, a Dual Modulator of Cannabinoid Receptors and G Protein-Coupled Inward Rectifier Potassium Channels. Biomedicines. vol 9. issue 5. 2021-05-27. PMID:33924979. |
the coupling of cannabinoid receptors, cb1 and cb2, to g protein-coupled inward rectifier potassium channels, girk1 and girk2, modulates neuronal excitability in the human brain. |
2021-05-27 |
2023-08-13 |
human |
| Katarina Čern. Toxicological properties of Δ9-tetrahydrocannabinol and cannabidiol. Arhiv za higijenu rada i toksikologiju. vol 71. issue 1. 2021-05-26. PMID:32597140. |
cannabis sativa l. contains more than 100 phytocannabinoids that can interact with cannabinoid receptors cb1 and cb2. |
2021-05-26 |
2023-08-13 |
Not clear |
| Federica Geddo, Susanna Antoniotti, Giulia Querio, Iris Chiara Salaroglio, Costanzo Costamagna, Chiara Riganti, Maria Pia Gall. Plant-Derived Nutrients. vol 13. issue 3. 2021-05-24. PMID:33809114. |
among them, we focused on the natural sesquiterpene and cannabinoid type 2 (cb2) receptor agonist |
2021-05-24 |
2023-08-13 |
human |
| Thais B Alberti, Daniela S Coelho, Marcelo Maraschi. β-Caryophyllene nanoparticles design and development: Controlled drug delivery of cannabinoid CB2 agonist as a strategic tool towards neurodegeneration. Materials science & engineering. C, Materials for biological applications. vol 121. 2021-05-14. PMID:33579467. |
β-caryophyllene nanoparticles design and development: controlled drug delivery of cannabinoid cb2 agonist as a strategic tool towards neurodegeneration. |
2021-05-14 |
2023-08-13 |
Not clear |
| Thais B Alberti, Daniela S Coelho, Marcelo Maraschi. β-Caryophyllene nanoparticles design and development: Controlled drug delivery of cannabinoid CB2 agonist as a strategic tool towards neurodegeneration. Materials science & engineering. C, Materials for biological applications. vol 121. 2021-05-14. PMID:33579467. |
the sesquiterpene β-caryophyllene (bcp) is a structurally singular cannabinoid and a selective agonist of the cb2 receptor, which in addition to being expressed in the cns, is intrinsically expressed within the immune system and lacks psychoactivity. |
2021-05-14 |
2023-08-13 |
Not clear |
| Stephen Schultz, Georgianna G Gould, Nicola Antonucci, Anna Lisa Brigida, Dario Siniscalc. Endocannabinoid System Dysregulation from Acetaminophen Use May Lead to Autism Spectrum Disorder: Could Cannabinoid Treatment Be Efficacious? Molecules (Basel, Switzerland). vol 26. issue 7. 2021-05-12. PMID:33805951. |
this complex network of lipid signaling pathways comprises arachidonic acid and 2-arachidonoyl glycerol-derived compounds, their g-protein-coupled receptors (cannabinoid receptors cb1 and cb2) and the associated enzymes. |
2021-05-12 |
2023-08-13 |
human |
| Stewart Christie, Vladimir Zagorodnyu. CB2 cannabinoid receptor agonist selectively inhibits the mechanosensitivity of mucosal afferents in the guinea pig bladder. American journal of physiology. Renal physiology. vol 320. issue 5. 2021-05-10. PMID:33749323. |
endocannabinoids are ligands of cannabinoid 1 and 2 (cb1 and cb2) receptors but can influence the activity of a variety of g protein-coupled receptors as well as ligand-gated and voltage-gated channels. |
2021-05-10 |
2023-08-13 |
Not clear |
| Elaine C D Gonçalves, Pollyana M Assis, Laura A Junqueira, Maíra Cola, Adair R S Santos, Nadia R B Raposo, Rafael C Dutr. Citral Inhibits the Inflammatory Response and Hyperalgesia in Mice: The Role of TLR4, TLR2/Dectin-1, and CB2 Cannabinoid Receptor/ATP-Sensitive K Journal of natural products. vol 83. issue 4. 2021-05-05. PMID:32150408. |
citral inhibits the inflammatory response and hyperalgesia in mice: the role of tlr4, tlr2/dectin-1, and cb2 cannabinoid receptor/atp-sensitive k citral ((2 |
2021-05-05 |
2023-08-13 |
mouse |
| Cody G Yokubaitis, Hassan N Jessani, Hongbo Li, Allison K Amodea, Sara Jane War. Effects of Cannabidiol and Beta-Caryophyllene Alone or in Combination in a Mouse Model of Permanent Ischemia. International journal of molecular sciences. vol 22. issue 6. 2021-05-03. PMID:33799861. |
we and others have previously shown that synthetic agonists of the cannabinoid cb2 receptor reduce infarct size and microglial activation in rodent models of stroke. |
2021-05-03 |
2023-08-13 |
mouse |
| Francesca Gado, Kawthar A Mohamed, Serena Meini, Rebecca Ferrisi, Simone Bertini, Maria Digiacomo, Felicia D'Andrea, Lesley A Stevenson, Robert B Laprairie, Roger G Pertwee, Clementina Maner. Variously substituted 2-oxopyridine derivatives: Extending the structure-activity relationships for allosteric modulation of the cannabinoid CB2 receptor. European journal of medicinal chemistry. vol 211. 2021-04-30. PMID:33360803. |
variously substituted 2-oxopyridine derivatives: extending the structure-activity relationships for allosteric modulation of the cannabinoid cb2 receptor. |
2021-04-30 |
2023-08-13 |
mouse |
| Ewa Poleszak, Sylwia Wośko, Karolina Sławińska, Elżbieta Wyska, Aleksandra Szopa, Jan Sobczyński, Andrzej Wróbel, Urszula Doboszewska, Piotr Wlaź, Aleksandra Wlaź, Jarosław Szponar, Piotr Skałecki, Anna Serefk. Ligands of the CB2 cannabinoid receptors augment activity of the conventional antidepressant drugs in the behavioural tests in mice. Behavioural brain research. vol 378. 2021-04-29. PMID:31626848. |
ligands of the cb2 cannabinoid receptors augment activity of the conventional antidepressant drugs in the behavioural tests in mice. |
2021-04-29 |
2023-08-13 |
mouse |
| Ewa Galaj, Guo-Hua Bi, Hong-Ju Yang, Zheng-Xiong X. Cannabidiol attenuates the rewarding effects of cocaine in rats by CB2, 5-HT Neuropharmacology. vol 167. 2021-04-23. PMID:31437433. |
strikingly, this reduction in both cocaine self-administration and bsr was blocked by am630 (a cannabinoid cb2 receptor antagonist), way100135 (a 5-ht |
2021-04-23 |
2023-08-13 |
rat |
| Teresa Chioccarelli, Marina Migliaccio, Antonio Suglia, Francesco Manfrevola, Veronica Porreca, Nadia Diano, Sonia Errico, Silvia Fasano, Gilda Cobelli. Characterization of Estrogenic Activity and Site-Specific Accumulation of Bisphenol-A in Epididymal Fat Pad: Interfering Effects on the Endocannabinoid System and Temporal Progression of Germ Cells. International journal of molecular sciences. vol 22. issue 5. 2021-04-22. PMID:33802611. |
the exposure to bpa affects the expression levels of some ecs components, namely type-1 (cb1) and type-2 cannabinoid (cb2) receptor and monoacylglycerol-lipase (magl). |
2021-04-22 |
2023-08-13 |
Not clear |