| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuechen Liu, Yiying Wu, Dan Zhou, Yuting Xie, Yi Zhou, Yu Lu, Rui Yang, Sha Li. N‑linoleyltyrosine protects PC12 cells against oxidative damage via autophagy: Possible involvement of CB1 receptor regulation. International journal of molecular medicine. vol 46. issue 5. 2021-07-02. PMID:33000188. |
as the ligand of cannabinoid type 1 (cb1) and 2 (cb2) receptors, anandamide (aea) exerts benign antioxidant activities. |
2021-07-02 |
2023-08-13 |
Not clear |
| Angela Ramírez-López, Antoni Pastor, Rafael de la Torre, Carmen La Porta, Andrés Ozaita, David Cabañero, Rafael Maldonad. Role of the endocannabinoid system in a mouse model of Fragile X undergoing neuropathic pain. European journal of pain (London, England). vol 25. issue 6. 2021-06-25. PMID:33619843. |
the endocannabinoid system modulates pain perception and drugs targeting the cannabinoid receptor type 2 (cb2) devoid of psychoactive side effects could emerge as novel analgesics. |
2021-06-25 |
2023-08-13 |
mouse |
| Narsimha Reddy Penthala, Amal Shoeib, Soma Shekar Dachavaram, Christian V Cabanlong, Jingfang Yang, Chang-Guo Zhan, Paul L Prather, Peter A Crook. 7-Azaindolequinuclidinones (7-AIQD): A novel class of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands. Bioorganic & medicinal chemistry letters. vol 30. issue 22. 2021-06-22. PMID:32882418. |
7-azaindolequinuclidinones (7-aiqd): a novel class of cannabinoid 1 (cb1) and cannabinoid 2 (cb2) receptor ligands. |
2021-06-22 |
2023-08-13 |
Not clear |
| Narsimha Reddy Penthala, Amal Shoeib, Soma Shekar Dachavaram, Christian V Cabanlong, Jingfang Yang, Chang-Guo Zhan, Paul L Prather, Peter A Crook. 7-Azaindolequinuclidinones (7-AIQD): A novel class of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands. Bioorganic & medicinal chemistry letters. vol 30. issue 22. 2021-06-22. PMID:32882418. |
a series of n-benzyl-7-azaindolequinuclidinone (7-aiqd) analogs have been synthesized and evaluated for affinity toward cb1 and cb2 cannabinoid receptors and identified as a novel class of cannabinoid receptor ligands. |
2021-06-22 |
2023-08-13 |
Not clear |
| Erika Cottone, Valentina Pomatto, Stefania Rapelli, Rosaria Scandiffio, Ken Mackie, Patrizia Bovoli. Cannabinoid Receptor Modulation of Neurogenesis: ST14A Striatal Neural Progenitor Cells as a Simplified In Vitro Model. Molecules (Basel, Switzerland). vol 26. issue 5. 2021-06-21. PMID:33800024. |
while cb1 and cb2 receptor blockade did not affect st14a cell number, exogenous administration of the endocannabinoid 2-ag and the synthetic cb2 agonist jwh133 increased st14a cell proliferation. |
2021-06-21 |
2023-08-13 |
Not clear |
| Jing-Fang Yang, Alexander H Williams, Narsimha R Penthala, Paul L Prather, Peter A Crooks, Chang-Guo Zha. Binding Modes and Selectivity of Cannabinoid 1 (CB1) and Cannabinoid 2 (CB2) Receptor Ligands. ACS chemical neuroscience. vol 11. issue 20. 2021-06-18. PMID:32997485. |
binding modes and selectivity of cannabinoid 1 (cb1) and cannabinoid 2 (cb2) receptor ligands. |
2021-06-18 |
2023-08-13 |
Not clear |
| Slavko Komarnytsky, Thirumurugan Rathinasabapathy, Charles Wagner, Brandon Metzger, Carolina Carlisle, Chinmayee Panda, Sara Le Brun-Blashka, John P Troup, Saradhadevi Varadhara. Endocannabinoid System and Its Regulation by Polyunsaturated Fatty Acids and Full Spectrum Hemp Oils. International journal of molecular sciences. vol 22. issue 11. 2021-06-16. PMID:34067450. |
while hemp cannabinoids of thc and cbd groups show distinct but complementary actions through a variety of cannabinoid (cb1 and cb2), adenosine (a2a), and vanilloid (trpv1) receptors, they also modulate pufa metabolism within a wide variety of specialized lipid mediators that promote or resolve inflammation and oxidative stress. |
2021-06-16 |
2023-08-13 |
Not clear |
| James F Chmiel, Patrick Flume, Damian G Downey, Allen J Dozor, Carla Colombo, Henryk Mazurek, Ewa Sapiejka, Marta Rachel, Scott Constantine, Brian Conley, Nancy Dgetluck, Quinn Dinh, Barbara White, J Stuart Elbor. Safety and efficacy of lenabasum in a phase 2 randomized, placebo-controlled trial in adults with cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. vol 20. issue 1. 2021-06-15. PMID:33011099. |
lenabasum is a cannabinoid type 2 receptor (cb2) agonist that resolves inflammation in a number of in vitro and in vivo models. |
2021-06-15 |
2023-08-13 |
Not clear |
| Estefania Rojo-Bustamante, Ignacio Íñigo-Marco, Miguel Angel Abellanas, Rodrigo Vinueza-Gavilanes, Ana Baltanás, Esther Luquin, Montserrat Arrasate, Maria S Aymeric. CB2 Receptors and Neuron-Glia Interactions Modulate Neurotoxicity Generated by MAGL Inhibition. Biomolecules. vol 10. issue 8. 2021-06-14. PMID:32824740. |
blockade of cannabinoid type 2 (cb2) receptors expressed mainly by microglial cells did not affect the spontaneous neuronal death risk but decreased neuronal survival when kml29 was added. |
2021-06-14 |
2023-08-13 |
rat |
| James V Gruber, Robert Holt. Purified Cannabidiol isolate does not inhibit active caspase-1 release in NLRP inflammasome-mediated UVB or ATP-activated keratinocytes or appear to reduce key inflammatory cytokines in UVB-irradiate keratinocytes. International journal of cosmetic science. vol 43. issue 3. 2021-06-14. PMID:33559194. |
it is known that cbd will bind to cannabinoid receptors, cb1 and cb2, in the body and recent work has shown that in keratinocytes, cbd can regulate inflammation through transcriptional regulation involving the nfƙβ nuclear pathways. |
2021-06-14 |
2023-08-13 |
human |
| Samuel S Duffy, Jessica P Hayes, Nathan T Fiore, Gila Moalem-Taylo. The cannabinoid system and microglia in health and disease. Neuropharmacology. vol 190. 2021-06-09. PMID:33845074. |
homeostatic microglia synthesise the endogenous cannabinoids 2-arachidonoylglycerol and anandamide and express the cannabinoid receptors cb1 and cb2 at constitutively low levels. |
2021-06-09 |
2023-08-13 |
Not clear |
| Mansoureh Hashemi, Senada Bashi, Alireza Zal. The expression level of cannabinoid receptors type 1 and 2 in the different types of astrocytomas. Molecular biology reports. vol 47. issue 7. 2021-06-07. PMID:32623617. |
the distribution of cannabinoid receptors type 1 (cb1) and cannabinoid receptor type 2 (cb2) in blood vessels and tumor tissue of astrocytoma is still controversial. |
2021-06-07 |
2023-08-13 |
Not clear |
| Niraj Kumar Jha, Charu Sharma, Hebaallah Mamdouh Hashiesh, Seenipandi Arunachalam, Mf Nagoor Meeran, Hayate Javed, Chandragouda R Patil, Sameer N Goyal, Shreesh Ojh. β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19. Frontiers in pharmacology. vol 12. 2021-06-01. PMID:34054510. |
β-caryophyllene, a natural dietary cb2 receptor selective cannabinoid can be a candidate to target the trinity of infection, immunity, and inflammation in covid-19. |
2021-06-01 |
2023-08-13 |
Not clear |
| Niraj Kumar Jha, Charu Sharma, Hebaallah Mamdouh Hashiesh, Seenipandi Arunachalam, Mf Nagoor Meeran, Hayate Javed, Chandragouda R Patil, Sameer N Goyal, Shreesh Ojh. β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19. Frontiers in pharmacology. vol 12. 2021-06-01. PMID:34054510. |
to pharmacologically activate the cb2 receptors, a naturally occurring cannabinoid ligand, beta-caryophyllene (bcp), received attention due to its potent anti-inflammatory, antiviral, and immunomodulatory properties. |
2021-06-01 |
2023-08-13 |
Not clear |
| Dongchen An, Steve Peigneur, Jan Tytga. WIN55,212-2, a Dual Modulator of Cannabinoid Receptors and G Protein-Coupled Inward Rectifier Potassium Channels. Biomedicines. vol 9. issue 5. 2021-05-27. PMID:33924979. |
the coupling of cannabinoid receptors, cb1 and cb2, to g protein-coupled inward rectifier potassium channels, girk1 and girk2, modulates neuronal excitability in the human brain. |
2021-05-27 |
2023-08-13 |
human |
| Katarina Čern. Toxicological properties of Δ9-tetrahydrocannabinol and cannabidiol. Arhiv za higijenu rada i toksikologiju. vol 71. issue 1. 2021-05-26. PMID:32597140. |
cannabis sativa l. contains more than 100 phytocannabinoids that can interact with cannabinoid receptors cb1 and cb2. |
2021-05-26 |
2023-08-13 |
Not clear |
| Federica Geddo, Susanna Antoniotti, Giulia Querio, Iris Chiara Salaroglio, Costanzo Costamagna, Chiara Riganti, Maria Pia Gall. Plant-Derived Nutrients. vol 13. issue 3. 2021-05-24. PMID:33809114. |
among them, we focused on the natural sesquiterpene and cannabinoid type 2 (cb2) receptor agonist |
2021-05-24 |
2023-08-13 |
human |
| Thais B Alberti, Daniela S Coelho, Marcelo Maraschi. β-Caryophyllene nanoparticles design and development: Controlled drug delivery of cannabinoid CB2 agonist as a strategic tool towards neurodegeneration. Materials science & engineering. C, Materials for biological applications. vol 121. 2021-05-14. PMID:33579467. |
β-caryophyllene nanoparticles design and development: controlled drug delivery of cannabinoid cb2 agonist as a strategic tool towards neurodegeneration. |
2021-05-14 |
2023-08-13 |
Not clear |
| Thais B Alberti, Daniela S Coelho, Marcelo Maraschi. β-Caryophyllene nanoparticles design and development: Controlled drug delivery of cannabinoid CB2 agonist as a strategic tool towards neurodegeneration. Materials science & engineering. C, Materials for biological applications. vol 121. 2021-05-14. PMID:33579467. |
the sesquiterpene β-caryophyllene (bcp) is a structurally singular cannabinoid and a selective agonist of the cb2 receptor, which in addition to being expressed in the cns, is intrinsically expressed within the immune system and lacks psychoactivity. |
2021-05-14 |
2023-08-13 |
Not clear |
| Stephen Schultz, Georgianna G Gould, Nicola Antonucci, Anna Lisa Brigida, Dario Siniscalc. Endocannabinoid System Dysregulation from Acetaminophen Use May Lead to Autism Spectrum Disorder: Could Cannabinoid Treatment Be Efficacious? Molecules (Basel, Switzerland). vol 26. issue 7. 2021-05-12. PMID:33805951. |
this complex network of lipid signaling pathways comprises arachidonic acid and 2-arachidonoyl glycerol-derived compounds, their g-protein-coupled receptors (cannabinoid receptors cb1 and cb2) and the associated enzymes. |
2021-05-12 |
2023-08-13 |
human |