| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Beihong Ji, Shuhan Liu, Xibing He, Viet Hoang Man, Xiang-Qun Xie, Junmei Wan. Prediction of the Binding Affinities and Selectivity for CB1 and CB2 Ligands Using Homology Modeling, Molecular Docking, Molecular Dynamics Simulations, and MM-PBSA Binding Free Energy Calculations. ACS chemical neuroscience. vol 11. issue 8. 2021-04-14. PMID:32196303. |
there are at least two types of cannabinoid receptors, cb1 and cb2, which belong to the g protein-coupled receptor superfamily and can trigger different signaling pathways to exert their physiological functions. |
2021-04-14 |
2023-08-13 |
Not clear |
| Beihong Ji, Shuhan Liu, Xibing He, Viet Hoang Man, Xiang-Qun Xie, Junmei Wan. Prediction of the Binding Affinities and Selectivity for CB1 and CB2 Ligands Using Homology Modeling, Molecular Docking, Molecular Dynamics Simulations, and MM-PBSA Binding Free Energy Calculations. ACS chemical neuroscience. vol 11. issue 8. 2021-04-14. PMID:32196303. |
in this study, several representative agonists and antagonists of both cb1 and cb2 were systematically studied to predict their binding affinities and selectivity against both cannabinoid receptors using a set of hierarchical molecular modeling and simulation techniques, including homology modeling, molecular docking, molecular dynamics (md) simulations and end point binding free energy calculations using the molecular mechanics/poisson-boltzmann surface area-wsas (mm-pbsa-wsas) method, and molecular mechanics/generalized born surface area (mm-gbsa) free energy decomposition. |
2021-04-14 |
2023-08-13 |
Not clear |
| Piotr Wójcik, Agnieszka Gęgotek, Neven Žarković, Elżbieta Skrzydlewsk. Oxidative Stress and Lipid Mediators Modulate Immune Cell Functions in Autoimmune Diseases. International journal of molecular sciences. vol 22. issue 2. 2021-04-12. PMID:33450863. |
because the anti-inflammatory cb2 receptors are the predominant cannabinoid receptors in leukocytes, endocannabinoids are believed to act as anti-inflammatory factors that regulate compensatory mechanisms in autoimmune diseases. |
2021-04-12 |
2023-08-13 |
Not clear |
| Mohammad-Mahdi Ghanbari, Marzieh Joneidi, Bahere Kiani, Jalal Babaie, Mohammad Sayya. Cannabinoid receptors and the proconvulsant effect of toxoplasmosis in mice. Microbial pathogenesis. vol 144. 2021-04-07. PMID:32315753. |
the mice with acute and/or chronic toxoplasma infection were pretreated (through intracerebroventricular injection) with cb1 and cb2 receptor agonists (acea and hu308) and antagonists (am251 and am630), as well as jzl184 (the irreversible inhibitor of mono acyl glycerol lipase, enzyme degrading the endogenous cannabinoid 2-acyl glycerol). |
2021-04-07 |
2023-08-13 |
mouse |
| Andrea Toschi, Benedetta Tugnoli, Barbara Rossi, Andrea Piva, Ester Grill. Thymol modulates the endocannabinoid system and gut chemosensing of weaning pigs. BMC veterinary research. vol 16. issue 1. 2021-04-06. PMID:32787931. |
gene expression of cannabinoid receptors (cb1 and cb2), transient receptor potential vanilloid 1 (trpv1), the olfactory receptor or1g1, diacylglycerol lipases (dgl-α and dgl-β), fatty acid amine hydrolase (faah), and cytokines was measured, and elisas of pro-inflammatory cytokines levels were performed. |
2021-04-06 |
2023-08-13 |
Not clear |
| Feng Wang, Jing Wang, Tong Zhao, Yi Zhang, Qian L. CB2 Receptor Agonist JWH133 Activates AMPK to Inhibit Growth of C6 Glioma Cells. Open life sciences. vol 14. 2021-04-06. PMID:33817171. |
it has been reported that endocannabinoid receptor type 2 (cb2) agonist jwh133 inhibits the growth of c6 glioma cells, but the underlying mechanism has not yet been fully elucidated. |
2021-04-06 |
2023-08-13 |
Not clear |
| Graziela Vieira, Juliana Cavalli, Elaine C D Gonçalves, Saulo F P Braga, Rafaela S Ferreira, Adair R S Santos, Maíra Cola, Nádia R B Raposo, Raffaele Capasso, Rafael C Dutr. Antidepressant-Like Effect of Terpineol in an Inflammatory Model of Depression: Involvement of the Cannabinoid System and D2 Dopamine Receptor. Biomolecules. vol 10. issue 5. 2021-04-02. PMID:32443870. |
our data showed terpineol antidepressant-like modulation by cb1 and cb2 cannabinoid receptors and d2-dopaminergic receptors to further corroborate our molecular evidence. |
2021-04-02 |
2023-08-13 |
Not clear |
| Asim Kichloo, Michael Albosta, Michael Aljadah, Zain El-Amir, Ghazaleh Goldar, Muhammed Zatmar Khan, Dushyant Singh Dahiya, Srilakshmi Vallabhaneni, Farah Wani, Jagmeet Sing. Marijuana: A systems-based primer of adverse effects associated with use and an overview of its therapeutic utility. SAGE open medicine. vol 9. 2021-04-02. PMID:33786179. |
it also addresses the biochemical and behavioral changes observed with marijuana use, including the location and changes associated with cannabinoid receptors (abbreviated cb1 and cb2). |
2021-04-02 |
2023-08-13 |
Not clear |
| Luana Greco, Valentina Russo, Cinzia Rapino, Clara Di Germanio, Filomena Fezza, Nicola Bernabò, Paolo Berardinelli, Alessia Peserico, Domenico Fazio, Mauro Maccarrone, Mauro Mattioli, Barbara Barbon. Characterization of Endocannabinoid System and Interleukin Profiles in Ovine AEC: Cannabinoid Receptors Type-1 and Type-2 as Key Effectors of Pro-Inflammatory Response. Cells. vol 9. issue 4. 2021-03-29. PMID:32325674. |
then, the role of cannabinoid receptors 1 and 2 (cb1 and cb2) on interleukin expression and release was investigated in middle stage aec using selective agonists and antagonists. |
2021-03-29 |
2023-08-13 |
Not clear |
| He-Kai Shi, Hui-Cai Guo, Hou-Yue Liu, Zi-Lin Zhang, Mei-Yu Hu, Yi Zhang, Qian L. Cannabinoid type 2 receptor agonist JWH133 decreases blood pressure of spontaneously hypertensive rats through relieving inflammation in the rostral ventrolateral medulla of the brain. Journal of hypertension. vol 38. issue 5. 2021-03-24. PMID:32238784. |
the upregulation and activation of the cannabinoid type 2 (cb2) receptor may be part of the active process of limiting or downregulating the inflammatory process. |
2021-03-24 |
2023-08-13 |
rat |
| Piotr Wójcik, Neven Žarković, Agnieszka Gęgotek, Elżbieta Skrzydlewsk. Involvement of Metabolic Lipid Mediators in the Regulation of Apoptosis. Biomolecules. vol 10. issue 3. 2021-03-18. PMID:32150849. |
in contrast, in cells where cb2 receptors dominate, and cells with low cox activity, cannabinoids act in a cytoprotective manner. |
2021-03-18 |
2023-08-13 |
Not clear |
| William R Arnold, Lauren N Carnevale, Zili Xie, Javier L Baylon, Emad Tajkhorshid, Hongzhen Hu, Aditi Da. Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel. Nature communications. vol 12. issue 1. 2021-03-18. PMID:33568652. |
the endocannabinoid system is a promising target to mitigate pain as the endocannabinoids are endogenous ligands of the pain-mediating receptors-cannabinoid receptors 1 and 2 (cb1 and cb2) and trpv1. |
2021-03-18 |
2023-08-13 |
human |
| Kelly F Paton, Rahau Shirazi, Mikhail Vyssotski, Bronwyn M Kivel. N-docosahexaenoyl ethanolamine (synaptamide) has antinociceptive effects in male mice. European journal of pain (London, England). vol 24. issue 10. 2021-03-03. PMID:32852071. |
n-docosahexaenoyl ethanolamine (dhea; also known as synaptamide) binds to both the cannabinoid-1 and 2 (cb1 and cb2) cannabinoid receptors and has anti-inflammatory properties in vitro. |
2021-03-03 |
2023-08-13 |
mouse |
| Leonore Mensching, Sebastian Rading, Viacheslav Nikolaev, Meliha Karsa. Monitoring Cannabinoid CB2 -Receptor Mediated cAMP Dynamics by FRET-Based Live Cell Imaging. International journal of molecular sciences. vol 21. issue 21. 2021-03-01. PMID:33114208. |
monitoring cannabinoid cb2 -receptor mediated camp dynamics by fret-based live cell imaging. |
2021-03-01 |
2023-08-13 |
human |
| Leonore Mensching, Sebastian Rading, Viacheslav Nikolaev, Meliha Karsa. Monitoring Cannabinoid CB2 -Receptor Mediated cAMP Dynamics by FRET-Based Live Cell Imaging. International journal of molecular sciences. vol 21. issue 21. 2021-03-01. PMID:33114208. |
g-protein coupled cannabinoid cb2 receptor signaling and function is primarily mediated by its inhibitory effect on adenylate cyclase. |
2021-03-01 |
2023-08-13 |
human |
| Kenneth B Walsh, Haley K Anderse. Molecular Pharmacology of Synthetic Cannabinoids: Delineating CB1 Receptor-Mediated Cell Signaling. International journal of molecular sciences. vol 21. issue 17. 2021-02-22. PMID:32854313. |
synthetic cannabinoids (scs) are a class of new psychoactive substances (npss) that exhibit high affinity binding to the cannabinoid cb1 and cb2 receptors and display a pharmacological profile similar to the phytocannabinoid (-)- |
2021-02-22 |
2023-08-13 |
Not clear |
| Mikołaj Mizera, Dorota Latek, Judyta Cielecka-Pionte. Virtual Screening of International journal of molecular sciences. vol 21. issue 15. 2021-02-19. PMID:32722631. |
virtual screening of the selective targeting of the cannabinoid receptor 2 (cb2) is crucial for the development of peripheral system-acting cannabinoid analgesics. |
2021-02-19 |
2023-08-13 |
Not clear |
| Yingju Li, Amanda Dewar, Yeon Sun Kim, Sudhansu K Dey, Xiaofei Su. Pregnancy success in mice requires appropriate cannabinoid receptor signaling for primary decidua formation. eLife. vol 9. 2021-02-19. PMID:32990600. |
mice deficient in cannabinoid receptors, cb1 and cb2, show compromised pdz with dysregulated angiogenic factors, resulting in the retention of blood vessels and macrophages. |
2021-02-19 |
2023-08-13 |
mouse |
| Sumner Burstei. Molecular Mechanisms for the Inflammation-Resolving Actions of Lenabasum. Molecular pharmacology. vol 99. issue 2. 2021-02-18. PMID:33239333. |
a first-in-class cannabinoid analog called lenabasum that is a cb2 agonist is being developed as an inflammation-resolving drug candidate. |
2021-02-18 |
2023-08-13 |
Not clear |
| Lauren Van Hove, Kirsten R Kim, Denise M Arrick, William G Mayha. A cannabinoid type 2 (CB2) receptor agonist augments NOS-dependent responses of cerebral arterioles during type 1 diabetes. Microvascular research. vol 133. 2021-02-17. PMID:32979391. |
a cannabinoid type 2 (cb2) receptor agonist augments nos-dependent responses of cerebral arterioles during type 1 diabetes. |
2021-02-17 |
2023-08-13 |
rat |