| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David Ruano-Ordás, Lindsey Burggraaff, Rongfang Liu, Cas van der Horst, Laura H Heitman, Michael T M Emmerich, Jose R Mendez, Iryna Yevseyeva, Gerard J P van Weste. A multiple classifier system identifies novel cannabinoid CB2 receptor ligands. Journal of cheminformatics. vol 11. issue 1. 2021-01-15. PMID:33430920. |
we applied our technique to a dataset of cannabinoid cb2 ligands obtained from the chembl database. |
2021-01-15 |
2023-08-13 |
Not clear |
| Peggy Rentsch, Sandy Stayte, Timothy Egan, Ian Clark, Bryce Visse. Targeting the cannabinoid receptor CB2 in a mouse model of l-dopa induced dyskinesia. Neurobiology of disease. vol 134. 2021-01-13. PMID:31669673. |
here we investigate the effect of hu-308, a cannabinoid cb2 receptor agonist, on lids. |
2021-01-13 |
2023-08-13 |
mouse |
| Qi-Wen Han, Yu-He Yuan, Nai-Hong Che. The therapeutic role of cannabinoid receptors and its agonists or antagonists in Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 96. 2021-01-04. PMID:31442553. |
recent studies have found that the endocannabinoid signaling system in particular the comprised two receptors, cb1 and cb2 receptors, has a significant regulatory function in basal ganglia and is involved in the pathogenesis of pd. |
2021-01-04 |
2023-08-13 |
Not clear |
| Glauce Crivelaro do Nascimento, Daniele Pereira Ferrari, Francisco Silveira Guimaraes, Elaine Aparecida Del Bel, Mariza Bortolanza, Nilson Carlos Ferreira-Junio. Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease. Neuropharmacology. vol 163. 2021-01-04. PMID:31706993. |
further, we investigated the pathway involved in the analgesic effect of the cbd through the co-administration with a fatty acid amide hydrolase (faah) inhibitor, increasing the endogenous anandamide levels, and possible targets from anandamide, i.e., the cannabinoid receptors subtype 1 and 2 (cb1 and cb2) and the transient receptor potential vanilloid type 1 (trpv1). |
2021-01-04 |
2023-08-13 |
mouse |
| Ahmed Haider, Luca Gobbi, Julian Kretz, Christoph Ullmer, Andreas Brink, Michael Honer, Thomas J Woltering, Dieter Muri, Hans Iding, Markus Bürkler, Martin Binder, Christian Bartelmus, Irene Knuesel, Pal Pacher, Adrienne Müller Herde, Francesco Spinelli, Hazem Ahmed, Kenneth Atz, Claudia Keller, Markus Weber, Roger Schibli, Linjing Mu, Uwe Grether, Simon M Ametame. Identification and Preclinical Development of a 2,5,6-Trisubstituted Fluorinated Pyridine Derivative as a Radioligand for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors. Journal of medicinal chemistry. vol 63. issue 18. 2021-01-04. PMID:32787079. |
despite the broad implications of the cannabinoid type 2 receptor (cb2) in neuroinflammatory processes, a suitable cb2-targeted probe is currently lacking in clinical routine. |
2021-01-04 |
2023-08-13 |
Not clear |
| Aurora Musa, Nicola Simola, Gessica Piras, Francesca Caria, Emmanuel Shan Onaivi, Maria Antonietta De Luc. Neurochemical and Behavioral Characterization after Acute and Repeated Exposure to Novel Synthetic Cannabinoid Agonist 5-MDMB-PICA. Brain sciences. vol 10. issue 12. 2020-12-31. PMID:33353194. |
5f-mdmb-pica has been recently detected and classified as a highly potent agonist of cb1 and cb2 cannabinoid receptors. |
2020-12-31 |
2023-08-13 |
mouse |
| Beatrice Polini, Chiara Cervetto, Sara Carpi, Simone Pelassa, Francesca Gado, Rebecca Ferrisi, Simone Bertini, Paola Nieri, Manuela Marcoli, Clementina Maner. Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist. Life (Basel, Switzerland). vol 10. issue 12. 2020-12-29. PMID:33302569. |
positive allosteric modulation of cb1 and cb2 cannabinoid receptors enhances the neuroprotective activity of a dual cb1r/cb2r orthosteric agonist. |
2020-12-29 |
2023-08-13 |
Not clear |
| Agustín Riquelme-Sandoval, Caio O de Sá-Ferreira, Leo M Miyakoshi, Cecilia Hedin-Pereir. New Insights Into Peptide Cannabinoids: Structure, Biosynthesis and Signaling. Frontiers in pharmacology. vol 11. 2020-12-29. PMID:33362550. |
classically, the endocannabinoid system (ecs) consists of endogenous lipids, of which the best known are anandamide (aea) and 2 arachidonoylglycerol (2-ag), their enzyme machinery for synthesis and degradation and their specific receptors, cannabinoid receptor one (cb1) and cannabinoid receptor two (cb2). |
2020-12-29 |
2023-08-13 |
Not clear |
| Marisol Maya-López, Leonardo C Rubio-López, Ivana V Rodríguez-Alvarez, Julián Orduño-Piceno, Yuliza Flores-Valdivia, Aline Colonnello, Edgar Rangel-López, Isaac Túnez, Oscar Prospéro-García, Abel Santamarí. A Cannabinoid Receptor-Mediated Mechanism Participates in the Neuroprotective Effects of Oleamide Against Excitotoxic Damage in Rat Brain Synaptosomes and Cortical Slices. Neurotoxicity research. vol 37. issue 1. 2020-12-21. PMID:31286434. |
here, we investigated the protective properties of oda against the excitotoxic damage induced by quin in rat brain synaptosomes and cortical slices, and whether these effects are linked to the stimulation of the endocannabinoid system via cb1 and/or cb2 receptor activation. |
2020-12-21 |
2023-08-13 |
rat |
| Isadora L Cortez, Naielly Rodrigues da Silva, Francisco S Guimarães, Felipe V Gome. Are CB2 Receptors a New Target for Schizophrenia Treatment? Frontiers in psychiatry. vol 11. 2020-12-18. PMID:33329132. |
although initially described as present mostly in the periphery, cannabinoid type-2 (cb2) receptors are now proposed to play a role in several brain processes related to schizophrenia, such as modulation of dopaminergic neurotransmission, microglial activation, and neuroplastic changes induced by stress. |
2020-12-18 |
2023-08-13 |
Not clear |
| Alexandre C Buffon, Marcelo A Javornik, Ana C Heymanns, Daiana C Salm, VerÔnica V Horewicz, Daniel F Martins, Anna P Pioveza. Role of the endocannabinoid system on the antihyperalgesic action of gabapentin in animal model of neuropathic pain induced by partial sciatic nerve ligation. Anais da Academia Brasileira de Ciencias. vol 92. issue 4. 2020-12-18. PMID:33331440. |
the results show that endocannabinoid system contributes to the antihyperalgesic action of gabapetin in neuropathic pain by psl, suggesting participation in the medullary and peripheral levels of cb1 receptors, and the peripheral performance of cb2 receptors. |
2020-12-18 |
2023-08-13 |
mouse |
| Christian Boyer, Laura Cussonneau, Charlotte Brun, Christiane Deval, Jean-Paul Pais de Barros, Stéphanie Chanon, Nathalie Bernoud-Hubac, Patricia Daira, Alina L Evans, Jon M Arnemo, Jon E Swenson, Guillemette Gauquelin-Koch, Chantal Simon, Stéphane Blanc, Lydie Combaret, Fabrice Bertile, Etienne Lefa. Specific shifts in the endocannabinoid system in hibernating brown bears. Frontiers in zoology. vol 17. issue 1. 2020-12-12. PMID:33292302. |
in adipose and muscle tissues of hibernating bears, we found significant lower concentrations of 2-arachidonoylglycerol (2-ag), a major ligand of cannabinoid receptors 1 (cb1) and 2 (cb2). |
2020-12-12 |
2023-08-13 |
Not clear |
| J Maia, B M Fonseca, N Teixeira, G Correia-da-Silv. The fundamental role of the endocannabinoid system in endometrium and placenta: implications in pathophysiological aspects of uterine and pregnancy disorders. Human reproduction update. vol 26. issue 4. 2020-12-08. PMID:32347309. |
the endocannabinoid system (ecs) consists of the cannabinoid receptors cb1 and cb2, the main endocannabinoids anandamide (aea) and 2-arachidonoylglycerol (2-ag) and their metabolic enzymes n-acylphosphatidylethanolamine-specific phospholipase d, fatty acid amide hydrolase, diacylglycerol lipase and monoacylglycerol lipase. |
2020-12-08 |
2023-08-13 |
Not clear |
| Joseph Bouskila, Catarina Micaelo-Fernandes, Roberta M Palmour, Jean-François Bouchard, Maurice Ptit. Transient receptor potential vanilloid type 1 is expressed in the horizontal pathway of the vervet monkey retina. Scientific reports. vol 10. issue 1. 2020-12-04. PMID:32694518. |
the ubiquitous distribution of the classic endocannabinoid system (cannabinoid receptors cb1 and cb2) has been demonstrated within the monkey nervous system, including the retina. |
2020-12-04 |
2023-08-13 |
monkey |
| Mohammad Zakir Hossain, Hiroshi Ando, Shumpei Unno, Junichi Kitagaw. Targeting Peripherally Restricted Cannabinoid Receptor 1, Cannabinoid Receptor 2, and Endocannabinoid-Degrading Enzymes for the Treatment of Neuropathic Pain Including Neuropathic Orofacial Pain. International journal of molecular sciences. vol 21. issue 4. 2020-11-19. PMID:32093166. |
cannabinoids mainly act on cannabinoid 1 (cb1) and 2 (cb2) receptors, and the former is widely distributed in the brain. |
2020-11-19 |
2023-08-13 |
mouse |
| Tim Ruhl, Niklas Karthaus, Bong-Sung Kim, Justus P Beie. The endocannabinoid receptors CB1 and CB2 affect the regenerative potential of adipose tissue MSCs. Experimental cell research. vol 389. issue 1. 2020-11-13. PMID:32006556. |
the endocannabinoid receptors cb1 and cb2 affect the regenerative potential of adipose tissue mscs. |
2020-11-13 |
2023-08-13 |
human |
| Tim Ruhl, Niklas Karthaus, Bong-Sung Kim, Justus P Beie. The endocannabinoid receptors CB1 and CB2 affect the regenerative potential of adipose tissue MSCs. Experimental cell research. vol 389. issue 1. 2020-11-13. PMID:32006556. |
adipose tissue secrets various soluble factors including endocannabinoids, and atmscs express the cannabinoid receptors cb1 and cb2. |
2020-11-13 |
2023-08-13 |
human |
| Sait Bayram, Ali Parlar, Seyfullah Oktay Arsla. The curative effect of cannabinoid 2 receptor agonist on functional failure and disruptive inflammation caused by intestinal ischemia and reperfusion. Fundamental & clinical pharmacology. vol 34. issue 1. 2020-10-23. PMID:31373049. |
the aim of this study was to reveal whether therapeutic value of cannabinoid 2 (cb2) receptor activity in the intestinal i/r, via to the exogenous administration of cb2 agonist (am-1241). |
2020-10-23 |
2023-08-13 |
rat |
| Qinggang Liu, Zonglong Wu, Yaxiao Liu, Lipeng Chen, Hongda Zhao, Hongda Guo, Kejia Zhu, Wenfu Wang, Shouzhen Chen, Nan Zhou, Yan Li, Benkang Sh. Cannabinoid receptor 2 activation decreases severity of cyclophosphamide-induced cystitis via regulating autophagy. Neurourology and urodynamics. vol 39. issue 1. 2020-10-23. PMID:31729056. |
cannabinoids have been shown to exert analgesic and anti-inflammatory effects, and the effects of cannabinoids are mediated primarily by cannabinoid receptors 1 and 2 (cb1 and cb2). |
2020-10-23 |
2023-08-13 |
Not clear |
| Murat Çakır, Suat Tekin, Aslı Okan, Pınar Çakan, Züleyha Doğanyiği. The ameliorating effect of cannabinoid type 2 receptor activation on brain, lung, liver and heart damage in cecal ligation and puncture-induced sepsis model in rats. International immunopharmacology. vol 78. 2020-10-21. PMID:31767546. |
it is already known that cannabinoid type 2 (cb2) receptors, which are commonly expressed in immune cells and in many other tissues, have an effect on the regulation of immune response. |
2020-10-21 |
2023-08-13 |
rat |