| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paula Morales, Nadine Jagerovi. Antitumor Cannabinoid Chemotypes: Structural Insights. Frontiers in pharmacology. vol 10. 2020-09-29. PMID:31214034. |
cannabinoids of endogenous, phytogenic, and synthetic nature have been shown to impact the proliferation of cancer through the modulation of different proteins involved in the endocannabinoid system such as the g protein-coupled receptors cb1, cb2, and grp55, the ionotropic receptor trpv1, or the fatty acid amide hydrolase (faah). |
2020-09-29 |
2023-08-13 |
Not clear |
| Igor Grant, B Rael Cah. Cannabis and endocannabinoid modulators: Therapeutic promises and challenges. Clinical neuroscience research. vol 5. issue 2-4. 2020-09-29. PMID:18806886. |
this paper reviews current understanding of cb1, cb2, and other possible cannabinoid receptors, their arachidonic acid derived ligands (e.g. |
2020-09-29 |
2023-08-12 |
Not clear |
| Luka Dobovišek, Fran Krstanović, Simona Borštnar, Nataša Debelja. Cannabinoids and Hormone Receptor-Positive Breast Cancer Treatment. Cancers. vol 12. issue 3. 2020-09-28. PMID:32106399. |
endogenous cannabinoids together with cannabinoid receptor 1 and 2 (cb1, cb2) constitute the basis of the endocannabinoid system. |
2020-09-28 |
2023-08-13 |
Not clear |
| Abhilash Perisetti, Afrina Hossain Rimu, Salman Ali Khan, Pardeep Bansal, Hemant Goya. Role of cannabis in inflammatory bowel diseases. Annals of gastroenterology. vol 33. issue 2. 2020-09-28. PMID:32127734. |
endogenous circulating cannabinoids, or endocannabinoids, such as anandamide and 2-arachidonoyl-glycerol, their metabolizing enzymes (fatty acid amide hydrolase and monoacylglycerol lipase) and 2 g-protein coupled cannabinoid receptors, cb1 and cb2, together represent the endocannabinoid system and are present throughout the human body. |
2020-09-28 |
2023-08-13 |
human |
| Eugene L Scharf, Jon O Ebber. Endocannabinoids and Stroke Prevention: Review of Clinical Studies. Cannabis and cannabinoid research. vol 5. issue 1. 2020-09-28. PMID:32322672. |
cannabinoid receptors are reported on macrophages within atherosclerotic plaques and suggest a role for immunomodulation as a therapeutic for atherosclerosis through both peripheral immune cell cb1 antagonism and/or cb2 agonist. |
2020-09-28 |
2023-08-13 |
human |
| Pramod Theetha Kariyanna, Leanna R Smith, Karishma Patwa, Moro O Salifu, Isabel M McFarlan. Marijuana and Microcirculation: A Review. American journal of medical case reports. vol 8. issue 9. 2020-09-28. PMID:32775630. |
thc exerts effects through the cannabinoid receptors, cb1 and cb2. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ali Parlar, Seyfullah Oktay Arsla. CB2 Agonist (AM1241) Improving Effect on Ovalbumin-Induced Asthma in Rats. Iranian journal of pharmaceutical research : IJPR. vol 19. issue 1. 2020-09-28. PMID:32922464. |
in order to better understand the role of the cannabinoid (cb) 2 receptor in the ovalbumin (ova)-induced asthma model, a combination of both selective cb2 agonist (am1241) and antagonist (am630) was used to improve inflammatory hypersensitivity and edema in rats. |
2020-09-28 |
2023-08-13 |
human |
| Puspanjali Bhatta, Asmita Dhukhwa, Kelly Sheehan, Raheem F H Al Aameri, Vikrant Borse, Sumana Ghosh, Sandeep Sheth, Chaitanya Mamillapalli, Leonard Rybak, Vickram Ramkumar, Debashree Mukherje. Capsaicin Protects Against Cisplatin Ototoxicity by Changing the STAT3/STAT1 Ratio and Activating Cannabinoid (CB2) Receptors in the Cochlea. Scientific reports. vol 9. issue 1. 2020-09-24. PMID:30858408. |
capsaicin protects against cisplatin ototoxicity by changing the stat3/stat1 ratio and activating cannabinoid (cb2) receptors in the cochlea. |
2020-09-24 |
2023-08-13 |
rat |
| Manjunath Lamani, Michael S Malamas, Shrouq I Farah, Vidyanand G Shukla, Michael F Almeida, Catherine M Weerts, Joseph Anderson, JodiAnne T Wood, Karen L G Farizatto, Ben A Bahr, Alexandros Makriyanni. Piperidine and piperazine inhibitors of fatty acid amide hydrolase targeting excitotoxic pathology. Bioorganic & medicinal chemistry. vol 27. issue 23. 2020-09-24. PMID:31629610. |
the new inhibitors showed potent nanomolar inhibitory activity against human recombinant and purified rat faah, were selective (>1000-fold) against serine hydrolases mgl and abhd6 and lacked any affinity for the cannabinoid receptors cb1 and cb2. |
2020-09-24 |
2023-08-13 |
human |
| Pedro Sánchez-Aparicio, Benjamín Florán, Desiderio Rodríguez Velázquez, José Antonio Ibancovichi, Jorge Antonio Varela Guerrero, Sergio Recilla. Cannabinoids CB2 Receptors, One New Promising Drug Target for Chronic and Degenerative Pain Conditions in Equine Veterinary Patients. Journal of equine veterinary science. vol 85. 2020-09-18. PMID:31952645. |
cannabinoids cb2 receptors, one new promising drug target for chronic and degenerative pain conditions in equine veterinary patients. |
2020-09-18 |
2023-08-13 |
Not clear |
| Pedro Sánchez-Aparicio, Benjamín Florán, Desiderio Rodríguez Velázquez, José Antonio Ibancovichi, Jorge Antonio Varela Guerrero, Sergio Recilla. Cannabinoids CB2 Receptors, One New Promising Drug Target for Chronic and Degenerative Pain Conditions in Equine Veterinary Patients. Journal of equine veterinary science. vol 85. 2020-09-18. PMID:31952645. |
nowadays, the use of new alternatives for this pathology attention is demanded; in that sense, cannabinoid cb2 agonists may represent a novel alternative. |
2020-09-18 |
2023-08-13 |
Not clear |
| Pedro Sánchez-Aparicio, Benjamín Florán, Desiderio Rodríguez Velázquez, José Antonio Ibancovichi, Jorge Antonio Varela Guerrero, Sergio Recilla. Cannabinoids CB2 Receptors, One New Promising Drug Target for Chronic and Degenerative Pain Conditions in Equine Veterinary Patients. Journal of equine veterinary science. vol 85. 2020-09-18. PMID:31952645. |
the aim of this study was to contribute to understand the pharmacology of cannabinoid cb2 receptors and its potential utilization on equine veterinary patients with a chronic degenerative painful condition. |
2020-09-18 |
2023-08-13 |
Not clear |
| Ishnoor Kaur, Tapan Behl, Simona Bungau, Gokhan Zengin, Arun Kumar, Mohamed A El-Esawi, Gaurav Khullar, Thangavel Venkatachalam, Sandeep Aror. The endocannabinoid signaling pathway as an emerging target in pharmacotherapy, earmarking mitigation of destructive events in rheumatoid arthritis. Life sciences. vol 257. 2020-09-17. PMID:32698072. |
the action of endocannabinoid system in immune system regulation, via primary cb2 activation, followed by inhibition of production of pro-inflammatory cytokines, auto-antibodies and mmps, flss proliferation and t-cell mediated immune response, are elaborated as potential therapeutic regimes in rheumatoid arthritis. |
2020-09-17 |
2023-08-13 |
Not clear |
| Prabhuanand Selvaraj, Jie Wen, Mikiei Tanaka, Yumin Zhan. Therapeutic Effect of a Novel Fatty Acid Amide Hydrolase Inhibitor PF04457845 in the Repetitive Closed Head Injury Mouse Model. Journal of neurotrauma. vol 36. issue 10. 2020-09-11. PMID:30526351. |
the improved locomotor function and working memory were partially mediated by activation of both cannabinoid (cb)1 and cb2 receptors, whereas the improvement on spatial learning and memory seemed to be cb1 receptor dependent. |
2020-09-11 |
2023-08-13 |
mouse |
| Tian Hua, Xiaoting Li, Lijie Wu, Christos Iliopoulos-Tsoutsouvas, Yuxia Wang, Meng Wu, Ling Shen, Christina A Brust, Spyros P Nikas, Feng Song, Xiyong Song, Shuguang Yuan, Qianqian Sun, Yiran Wu, Shan Jiang, Travis W Grim, Othman Benchama, Edward L Stahl, Nikolai Zvonok, Suwen Zhao, Laura M Bohn, Alexandros Makriyannis, Zhi-Jie Li. Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-G Cell. vol 180. issue 4. 2020-08-24. PMID:32004463. |
activation and signaling mechanism revealed by cannabinoid receptor-g human endocannabinoid systems modulate multiple physiological processes mainly through the activation of cannabinoid receptors cb1 and cb2. |
2020-08-24 |
2023-08-13 |
human |
| Jiang Wu, Mark Hocevar, Bihua Bie, Joseph F Foss, Mohamed Nagui. Cannabinoid Type 2 Receptor System Modulates Paclitaxel-Induced Microglial Dysregulation and Central Sensitization in Rats. The journal of pain. vol 20. issue 5. 2020-08-19. PMID:30414958. |
mda7, 1-([3-benzyl-3-methyl-2,3-dihydro-1-benzofuran-6-yl]carbonyl) piperidine, is a novel highly selective cannabinoid type 2 (cb2) agonist. |
2020-08-19 |
2023-08-13 |
rat |
| Jin Cheng, Siyi Wang, Weiwei Lin, Nan Wu, Yuanqiang Wang, Maozi Chen, Xiang-Qun Xie, Zhiwei Fen. Computational Systems Pharmacology-Target Mapping for Fentanyl-Laced Cocaine Overdose. ACS chemical neuroscience. vol 10. issue 8. 2020-08-18. PMID:31257858. |
finally, we looked into the detail of jwh133, an agonist of cannabinoid 2-receptor (cb2) with potential as a therapy for cocaine and fentanyl overdose. |
2020-08-18 |
2023-08-13 |
Not clear |
| Maryna Rodrigues Gonçalves, Milena Santana da Conceição, Carlos Henrique Alves Jesus, Aléxia Thamara Gasparin, Evelize Stacoviaki Rosa, Joice Maria da Cunh. Spinal cannabinoid CB1 or CB2 receptors activation attenuates mechanical allodynia in streptozotocin-induced diabetic rats. Behavioural pharmacology. 2020-08-17. PMID:32804775. |
spinal cannabinoid cb1 or cb2 receptors activation attenuates mechanical allodynia in streptozotocin-induced diabetic rats. |
2020-08-17 |
2023-08-13 |
rat |
| Maryna Rodrigues Gonçalves, Milena Santana da Conceição, Carlos Henrique Alves Jesus, Aléxia Thamara Gasparin, Evelize Stacoviaki Rosa, Joice Maria da Cunh. Spinal cannabinoid CB1 or CB2 receptors activation attenuates mechanical allodynia in streptozotocin-induced diabetic rats. Behavioural pharmacology. 2020-08-17. PMID:32804775. |
cannabinoid receptor antagonists cb1 am251 or cb2 am630 (1 mg/kg) were given before treatment with respective agonists to confirm the involvement of cannabinoid cb1 or cb2 receptors. |
2020-08-17 |
2023-08-13 |
rat |
| Christina Miyabe Shields, Nikolai Zvonok, Alexander Zvonok, Alexandros Makriyanni. Biochemical and Proteomic Characterization of Recombinant Human α/β Hydrolase Domain 6. Scientific reports. vol 9. issue 1. 2020-08-12. PMID:30696836. |
human alpha/beta hydrolase domain 6 (habhd6) is an enzyme that hydrolyzes 2-arachidonoylglycerol (2-ag), a potent agonist at both cannabinoid cb1 and cb2 receptors. |
2020-08-12 |
2023-08-13 |
human |