| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adriana Díaz-Rivera, Alejandra Meza-Ríos, Victoria Chagoya de Sánchez, Gabriela Velasco-Loyden, Leonel García-Benavides, Luis F Jave-Suarez, Hugo Christian Monroy-Ramirez, Arturo Santos-García, Juan Armendáriz-Borunda, Ana Sandoval-Rodrígue. Hydrodynamics-based liver transfection achieves gene silencing of CB1 using short hairpin RNA plasmid in cirrhotic rats. PloS one. vol 15. issue 2. 2020-05-04. PMID:32053633. |
there is a correlation between the endocannabinoid system and hepatic fibrosis based on the activation of cb1 and cb2 receptors; where cb1 has profibrogenic effects. |
2020-05-04 |
2023-08-13 |
rat |
| Joshua Z Seither, Lisa J Reidy, Diane M Bolan. Identification and Quantification of 5-Fluoro ADB and the 5-Fluoro ADB Ester Hydrolysis Metabolite in Postmortem Blood Samples by LC-MS/MS. Journal of analytical toxicology. vol 44. issue 2. 2020-04-29. PMID:31274144. |
5-fluoro adb, also known as 5-fluoro mdmb-pinaca, is a potent synthetic cannabinoid that is an agonist to the human cannabinoid cb1 and cb2 receptors. |
2020-04-29 |
2023-08-13 |
human |
| Mariana M Almeida, Camilla P Dias-Rocha, Clara F Reis-Gomes, Haimei Wang, Georgia C Atella, Aline Cordeiro, Carmen C Pazos-Moura, Lisa Joss-Moore, Isis H Trevenzol. Maternal high-fat diet impairs leptin signaling and up-regulates type-1 cannabinoid receptor with sex-specific epigenetic changes in the hypothalamus of newborn rats. Psychoneuroendocrinology. vol 103. 2020-04-23. PMID:30776574. |
the ecs mainly consists of endocannabinoids derived from n-6 fatty acids and cannabinoid receptors (cb1 coded by cnr1 and cb2 coded by cnr2). |
2020-04-23 |
2023-08-13 |
rat |
| Mengjuan Lin, Lei Chen, Yong Xiao, Baoping Y. Activation of cannabinoid 2 receptor relieves colonic hypermotility in a rat model of irritable bowel syndrome. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 31. issue 6. 2020-04-17. PMID:30793435. |
we aimed to determine whether cannabinoid 2 (cb2) receptor modulates intestinal motility associated with stress-induced ibs. |
2020-04-17 |
2023-08-13 |
rat |
| Lin Cheng, Jinsi Li, Yi Zhou, Qixue Zheng, Xin Ming, Sha Li. N-Linoleyltyrosine Protects against Transient Cerebral Ischemia in Gerbil via CB2 Receptor Involvement in PI3K/Akt Signaling Pathway. Biological & pharmaceutical bulletin. vol 42. issue 11. 2020-04-16. PMID:31484847. |
anandamide (aea) played potent neuroprotective activities via cannabinoid type 1 (cb1) and 2 (cb2) receptor. |
2020-04-16 |
2023-08-13 |
mouse |
| Maura Argenziano, Chiara Tortora, Giulia Bellini, Alessandra Di Paola, Francesca Punzo, Francesca Ross. The Endocannabinoid System in Pediatric Inflammatory and Immune Diseases. International journal of molecular sciences. vol 20. issue 23. 2020-04-13. PMID:31771129. |
endocannabinoid system consists of cannabinoid type 1 (cb1) and cannabinoid type 2 (cb2) receptors, their endogenous ligands, and the enzymes responsible for their synthesis and degradation. |
2020-04-13 |
2023-08-13 |
Not clear |
| Chiara Cioni, Maristella Tassi, Giuseppe Marotta, Claudia Mugnaini, Federico Corelli, Pasquale Annunziat. A Novel Highly Selective Cannabinoid CB2 Agonist Reduces in vitro Growth and TGF-beta Release of Human Glial Cell Tumors. Central nervous system agents in medicinal chemistry. vol 19. issue 3. 2020-04-09. PMID:31549596. |
a novel highly selective cannabinoid cb2 agonist reduces in vitro growth and tgf-beta release of human glial cell tumors. |
2020-04-09 |
2023-08-13 |
human |
| Satoru Yamagishi, Yurika Iga, Masato Nakamura, Chika Takizawa, Dai Fukumoto, Takeharu Kakiuchi, Shingo Nishiyama, Hiroyuki Ohba, Hideo Tsukada, Kohji Sato, Yasuomi Ouch. Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study. Journal of neuroinflammation. vol 16. issue 1. 2020-04-02. PMID:31707986. |
type 2 endocannabinoid receptors (cb2) and translocator protein 18 kd (tspo) are considered to reflect distinct aspects of microglia-related neuroinflammatory responses in the brain. |
2020-04-02 |
2023-08-13 |
mouse |
| Wei Huang, Yaqin Xiong, Yali Chen, Yan Cheng, Rurong Wan. NOX2 is involved in CB2-mediated protection against lung ischemia-reperfusion injury in mice. International journal of clinical and experimental pathology. vol 13. issue 2. 2020-03-28. PMID:32211110. |
activation of the cannabinoid 2 (cb2) receptor limits tissue injury in some ischemia-reperfusion (i/r) models. |
2020-03-28 |
2023-08-13 |
mouse |
| Yuemin Bian, Yankang Jing, Lirong Wang, Shifan Ma, Jaden Jungho Jun, Xiang-Qun Xi. Prediction of Orthosteric and Allosteric Regulations on Cannabinoid Receptors Using Supervised Machine Learning Classifiers. Molecular pharmaceutics. vol 16. issue 6. 2020-03-16. PMID:31013097. |
in this study, supervised machine learning classifiers were built for two subtypes of cannabinoid receptors, cb1 and cb2. |
2020-03-16 |
2023-08-13 |
Not clear |
| Marta Kruk-Slomka, Izabela Banaszkiewicz, Tomasz Slomka, Grazyna Bial. Effects of Fatty Acid Amide Hydrolase Inhibitors Acute Administration on the Positive and Cognitive Symptoms of Schizophrenia in Mice. Molecular neurobiology. vol 56. issue 11. 2020-03-13. PMID:31004320. |
the ecs is composed of two types cannabinoid (cb: cb1 and cb2) receptors and their endogenous ligands, endocannabinoids. |
2020-03-13 |
2023-08-13 |
mouse |
| David Schubert, Devin Kepchia, Zhibin Liang, Richard Dargusch, Joshua Goldberg, Pamela Mahe. Efficacy of Cannabinoids in a Pre-Clinical Drug-Screening Platform for Alzheimer's Disease. Molecular neurobiology. vol 56. issue 11. 2020-03-12. PMID:31104297. |
nine of the 11 cannabinoids have the ability to protect cells in four distinct phenotypic neurodegeneration screening assays, including those using neurons that lack cb1 and cb2 receptors. |
2020-03-12 |
2023-08-13 |
Not clear |
| Ana Martín-Sánchez, Vincent Warnault, Sandra Montagud-Romero, Antoni Pastor, Neus Mondragón, Rafael De La Torre, Olga Valverd. Alcohol-induced conditioned place preference is modulated by CB2 cannabinoid receptors and modifies levels of endocannabinoids in the mesocorticolimbic system. Pharmacology, biochemistry, and behavior. vol 183. 2020-03-10. PMID:31220547. |
alcohol-induced conditioned place preference is modulated by cb2 cannabinoid receptors and modifies levels of endocannabinoids in the mesocorticolimbic system. |
2020-03-10 |
2023-08-13 |
mouse |
| Han Zhou, Xingrong Peng, Tao Hou, Nan Zhao, Minghua Qiu, Xiuli Zhang, Xinmiao Lian. Identification of novel phytocannabinoids from Ganoderma by label-free dynamic mass redistribution assay. Journal of ethnopharmacology. vol 246. 2020-02-27. PMID:31494202. |
located throughout the body, cannabinoid receptors (cb1 and cb2) are therapeutic targets for obesity/metabolic diseases, neurological/mental disorders, and immune modulation. |
2020-02-27 |
2023-08-13 |
Not clear |
| Zhigang Wang, Min Lu, Jie Ren, Xiaoxue Wu, Man Long, Longyun Chen, Zebin Che. Electroacupuncture inhibits mast cell degranulation via cannabinoid CB2 receptors in a rat model of allergic contact dermatitis. Acupuncture in medicine : journal of the British Medical Acupuncture Society. vol 37. issue 6. 2020-02-24. PMID:31429590. |
electroacupuncture inhibits mast cell degranulation via cannabinoid cb2 receptors in a rat model of allergic contact dermatitis. |
2020-02-24 |
2023-08-13 |
rat |
| Zhigang Wang, Min Lu, Jie Ren, Xiaoxue Wu, Man Long, Longyun Chen, Zebin Che. Electroacupuncture inhibits mast cell degranulation via cannabinoid CB2 receptors in a rat model of allergic contact dermatitis. Acupuncture in medicine : journal of the British Medical Acupuncture Society. vol 37. issue 6. 2020-02-24. PMID:31429590. |
cannabinoid cb2 receptors (cb2rs) are mainly present on immune cells including mast cells, which participate in 2,4-dinitrofluorobenzene (dnfb)-induced allergic contact dermatitis (acd). |
2020-02-24 |
2023-08-13 |
rat |
| Marcia G Honig, Nobel A Del Mar, Desmond L Henderson, Tyler D Ragsdale, John B Doty, Jake H Driver, Chunyan Li, Andrew P Fortugno, William M Mitchell, Aaron M Perry, Bob M Moore, Anton Reine. Amelioration of visual deficits and visual system pathology after mild TBI via the cannabinoid Type-2 receptor inverse agonism of raloxifene. Experimental neurology. vol 322. 2020-02-24. PMID:31518568. |
we have found that treatment with the cannabinoid type-2 receptor (cb2) inverse agonist smm-189 for 2 weeks after closed-head blast tbi greatly attenuates the visual deficits and retinal pathology this otherwise produces in mice, by modulating the deleterious role of microglia in the injury process after trauma. |
2020-02-24 |
2023-08-13 |
mouse |
| Mellar P Davis, Bertrand Behm, Zankhana Mehta, Carlos Fernande. The Potential Benefits of Palmitoylethanolamide in Palliation: A Qualitative Systematic Review. The American journal of hospice & palliative care. vol 36. issue 12. 2020-02-20. PMID:31113223. |
palmitoylethanolamide targets nonclassical cannabinoid receptors rather than cb1 and cb2 receptors. |
2020-02-20 |
2023-08-13 |
Not clear |
| Eva Danner, Frauke Hoffmann, Seo-Youn Lee, Fabian Cordes, Sabine Orban, Katrin Dauber, Doreen Chudziak, Gabriele Spohn, Eliza Wiercinska, Benjamin Tast, Darja Karpova, Halvard Boni. Modest and nonessential roles of the endocannabinoid system in immature hematopoiesis of mice. Experimental hematology. vol 78. 2020-02-18. PMID:31562901. |
the endocannabinoid receptor cb2 is expressed on blood cells, including stem cells, and mediates the effects of cannabinoids on the immune system. |
2020-02-18 |
2023-08-13 |
mouse |
| Natalie M Guley, Nobel A Del Mar, Tyler Ragsdale, Chunyan Li, Aaron M Perry, Bob M Moore, Marcia G Honig, Anton Reine. Amelioration of visual deficits and visual system pathology after mild TBI with the cannabinoid type-2 receptor inverse agonist SMM-189. Experimental eye research. vol 182. 2020-02-17. PMID:30922891. |
using our focal cranial blast mouse model of closed-skull mild tbi, we evaluated the ability of the cannabinoid type-2 (cb2) receptor inverse agonist smm-189, which biases microglia from the harmful m1 state to the beneficial m2 state, to mitigate visual system dysfunction and injury after tbi. |
2020-02-17 |
2023-08-13 |
mouse |