| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan A Páez, Nuria E Campill. Innovative Therapeutic Potential of Cannabinoid Receptors as Targets in Alzheimer's Disease and Less Well-Known Diseases. Current medicinal chemistry. vol 26. issue 18. 2019-12-02. PMID:29484980. |
the therapeutic applications will be addressed through the study of cannabinoid agonists acting as single drugs and multi-target drugs highlighting the cb2 receptor agonist. |
2019-12-02 |
2023-08-13 |
Not clear |
| Annukka Kallinen, Rochelle Boyd, Samuel Lane, Rajiv Bhalla, Karine Mardon, Damion H R Stimson, Eryn L Werry, Roger Fulton, Mark Connor, Michael Kassio. Synthesis and in vitro evaluation of fluorine-18 benzimidazole sulfones as CB2 PET-radioligands. Organic & biomolecular chemistry. vol 17. issue 20. 2019-12-02. PMID:31070218. |
cannabinoid type 2 receptor (cb2) is up-regulated on activated microglial cells and can potentially be used as a biomarker for pet-imaging of neuroinflammation. |
2019-12-02 |
2023-08-13 |
Not clear |
| Zhenhua Shao, Jie Yin, Karen Chapman, Magdalena Grzemska, Lindsay Clark, Junmei Wang, Daniel M Rosenbau. High-resolution crystal structure of the human CB1 cannabinoid receptor. Nature. vol 540. issue 7634. 2019-11-20. PMID:27851727. |
the human cannabinoid g-protein-coupled receptors (gpcrs) cb1 and cb2 mediate the functional responses to the endocannabinoids anandamide and 2-arachidonyl glycerol (2-ag) and to the widely consumed plant phytocannabinoid Δ |
2019-11-20 |
2023-08-13 |
human |
| Omer Iqba. Endocannabinoid system and pathophysiology of adipogenesis: current management of obesity. Personalized medicine. vol 4. issue 3. 2019-11-20. PMID:29788669. |
the endocannabinoid system consists primarily of two receptors, cannabinoid (cb)1 and cb2, their endogenous ligands termed endocannabinoids and the enzymes responsible for ligand biosynthesis and degradation. |
2019-11-20 |
2023-08-13 |
human |
| Aya E Ghonim, Alessia Ligresti, Alessandro Rabbito, Ali Mokhtar Mahmoud, Vincenzo Di Marzo, Noha A Osman, Ashraf H Abad. Structure-activity relationships of thiazole and benzothiazole derivatives as selective cannabinoid CB2 agonists with in vivo anti-inflammatory properties. European journal of medicinal chemistry. vol 180. 2019-11-04. PMID:31302448. |
structure-activity relationships of thiazole and benzothiazole derivatives as selective cannabinoid cb2 agonists with in vivo anti-inflammatory properties. |
2019-11-04 |
2023-08-13 |
Not clear |
| Pauline S Santos, Thaisa C Oliveira, Luís Mário R Júnior, Ana Figueiras, Lívio C C Nune. β-caryophyllene Delivery Systems: Enhancing the Oral Pharmacokinetic and Stability. Current pharmaceutical design. vol 24. issue 29. 2019-10-24. PMID:30207226. |
the β-caryophyllene (bcp), a phytocannabinoid present in various essential oils, demonstrated selective action on the cb2 endocannabinoid receptor and attracted considerable attention because of its several pharmacological activities. |
2019-10-24 |
2023-08-13 |
Not clear |
| Emily Lorenzen, Thomas P Sakma. Receptor Structures for a Caldron of Cannabinoids. Cell. vol 176. issue 3. 2019-10-23. PMID:30682366. |
structures of the cannabinoid receptor 1 (cb1) in complex with an "ultrapotent" synthetic cannabinoid and its g protein (krishna kumar et al., 2019) and cb2 in complex with a new rationally designed inverse agonist (li et al., 2019) provide unique snapshots of the molecular pharmacology of cannabinoids. |
2019-10-23 |
2023-08-13 |
Not clear |
| Chihiro Nozaki, Elisa Nent, Andras Bilkei-Gorzo, Andreas Zimme. Involvement of leptin signaling in the development of cannabinoid CB2 receptor-dependent mirror image pain. Scientific reports. vol 8. issue 1. 2019-10-21. PMID:30018366. |
involvement of leptin signaling in the development of cannabinoid cb2 receptor-dependent mirror image pain. |
2019-10-21 |
2023-08-13 |
mouse |
| Shakiru O Alapafuja, Michael S Malamas, Vidyanand Shukla, Alexander Zvonok, Sally Miller, Laura Daily, Girija Rajarshi, Christina Yume Miyabe, Honrao Chandrashekhar, JodiAnne Wood, Sergiy Tyukhtenko, Alex Straiker, Alexandros Makriyanni. Synthesis and evaluation of potent and selective MGL inhibitors as a glaucoma treatment. Bioorganic & medicinal chemistry. vol 27. issue 1. 2019-10-17. PMID:30446439. |
the new inhibitors showed potent nanomolar inhibitory activity against recombinant human and purified rat mgl, were selective (>1000-fold) against serine hydrolases faah and abhd6 and lacked any affinity for the cannabinoid receptors cb1 and cb2. |
2019-10-17 |
2023-08-13 |
human |
| Raquel Guillamat-Prats, Martina Rami, Stephan Herzig, Sabine Steffen. Endocannabinoid Signalling in Atherosclerosis and Related Metabolic Complications. Thrombosis and haemostasis. vol 119. issue 4. 2019-09-12. PMID:30769363. |
endocannabinoids are a group of arachidonic acid-derived lipid mediators binding to cannabinoid receptors cb1 and cb2. |
2019-09-12 |
2023-08-13 |
Not clear |
| Francesco Spinelli, Linjing Mu, Simon M Ametame. Radioligands for positron emission tomography imaging of cannabinoid type 2 receptor. Journal of labelled compounds & radiopharmaceuticals. vol 61. issue 3. 2019-09-11. PMID:29110331. |
the cannabinoid type 2 (cb2) receptor is an immunomodulatory receptor mainly expressed in peripheral cells and organs of the immune system. |
2019-09-11 |
2023-08-13 |
Not clear |
| Thangesweran Ayakannu, Anthony H Taylor, Justin C Konj. Cannabinoid receptor expression in estrogen-dependent and estrogen-independent endometrial cancer. Journal of receptor and signal transduction research. vol 38. issue 5-6. 2019-09-04. PMID:30569804. |
previous studies on the expression of the classical cannabinoid receptors, cb1 and cb2, suggest these could provide good diagnostic/prognostic biomarkers for ec but those observations have been contradictory. |
2019-09-04 |
2023-08-13 |
Not clear |
| Marco Gentili, Simona Ronchetti, Erika Ricci, Rosanna Di Paola, Enrico Gugliandolo, Salvatore Cuzzocrea, Oxana Bereshchenko, Graziella Migliorati, Carlo Riccard. Selective CB2 inverse agonist JTE907 drives T cell differentiation towards a Treg cell phenotype and ameliorates inflammation in a mouse model of inflammatory bowel disease. Pharmacological research. vol 141. 2019-09-03. PMID:30552973. |
cb2 is the cannabinoid receptor that is expressed primarily on hematopoietic cells and mediates the immunoregulatory functions of cannabinoids. |
2019-09-03 |
2023-08-13 |
mouse |
| Carolina Noble, Annelies Cannaert, Kristian Linnet, Christophe P Stov. Application of an activity-based receptor bioassay to investigate the in vitro activity of selected indole- and indazole-3-carboxamide-based synthetic cannabinoids at CB1 and CB2 receptors. Drug testing and analysis. vol 11. issue 3. 2019-08-27. PMID:30280499. |
application of an activity-based receptor bioassay to investigate the in vitro activity of selected indole- and indazole-3-carboxamide-based synthetic cannabinoids at cb1 and cb2 receptors. |
2019-08-27 |
2023-08-13 |
Not clear |
| Rufaida Al-Zoubi, Paula Morales, Patricia H Reggi. Structural Insights into CB1 Receptor Biased Signaling. International journal of molecular sciences. vol 20. issue 8. 2019-08-09. PMID:31013934. |
thus far, two cannabinoid receptors, cb1 and cb2, have been discovered, which are found predominantly in the central nervous system (cb1) or the immune system (cb2), among other organs and tissues. |
2019-08-09 |
2023-08-13 |
Not clear |
| Qing-Rong Liu, Ana Canseco-Alba, Hai-Ying Zhang, Patricia Tagliaferro, Monika Chung, Eugene Dennis, Branden Sanabria, Norman Schanz, Joao Carlos Escosteguy-Neto, Hiroki Ishiguro, Zhicheng Lin, Susan Sgro, Claire M Leonard, Jair Guilherme Santos-Junior, Eliot L Gardner, Josephine M Egan, Jeung Woon Lee, Zheng-Xiong Xi, Emmanuel S Onaiv. Cannabinoid type 2 receptors in dopamine neurons inhibits psychomotor behaviors, alters anxiety, depression and alcohol preference. Scientific reports. vol 7. issue 1. 2019-08-06. PMID:29234141. |
cannabinoid cb2 receptors (cb2rs) are expressed in mouse brain dopamine (da) neurons and are involved in several da-related disorders. |
2019-08-06 |
2023-08-13 |
mouse |
| b' Agnieszka Szuster-Ciesielska, Agnieszka Zwolak, Jadwiga Daniluk, Martyna Kandefer-Szersze\\xc5\\x8. Metformin inhibits both oleic acid-induced and CB1R receptor agonist-induced lipid accumulation in Hep3B cells: The preliminary report. International journal of immunopathology and pharmacology. vol 33. 2019-07-29. PMID:30880507.' |
both endocannabinoids and metformin may modulate hepatosteatosis; therefore, it was interesting to examine whether metformin may affect lipid accumulation in hepatocytes by acting on cannabinoid receptors, cb1 and cb2, in in vitro study. |
2019-07-29 |
2023-08-13 |
Not clear |
| Nida Noreen, Faqir Muhammad, Bushra Akhtar, Farooq Azam, Muhammad Irfan Anwa. Is Cannabidiol a Promising Substance for New Drug Development? A Review of its Potential Therapeutic Applications. Critical reviews in eukaryotic gene expression. vol 28. issue 1. 2019-07-17. PMID:29773016. |
it has wide spectrum of action because it acts through endocannabinoid receptors; cb1 and cb2 and it also acts on other receptors, such as gpr18, gpr55, gpr 119, 5ht1a, and trpv2. |
2019-07-17 |
2023-08-13 |
Not clear |
| Francisco Navarrete, María Salud García-Gutiérrez, Jorge Manzanare. Pharmacological regulation of cannabinoid CB2 receptor modulates the reinforcing and motivational actions of ethanol. Biochemical pharmacology. vol 157. 2019-07-08. PMID:30063884. |
pharmacological regulation of cannabinoid cb2 receptor modulates the reinforcing and motivational actions of ethanol. |
2019-07-08 |
2023-08-13 |
Not clear |
| Maria A Sanchez-Rodriguez, Oscar Gomez, Pedro F Esteban, Daniel Garcia-Ovejero, Eduardo Molina-Holgad. The endocannabinoid 2-arachidonoylglycerol regulates oligodendrocyte progenitor cell migration. Biochemical pharmacology. vol 157. 2019-07-08. PMID:30195734. |
likewise, antagonists of the cb1 and cb2 cannabinoid receptors (am281 and am630, respectively) produced a similar inhibition of opc migration. |
2019-07-08 |
2023-08-13 |
rat |