| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gitit Kra, Jayasimha Rayalu Daddam, Uzi Moallem, Hadar Kamer, Majdoleen Ahmad, Alina Nemirovski, G Andres Contreras, Joseph Tam, Maya Zachu. Effects of Environmental Heat Load on Endocannabinoid System Components in Adipose Tissue of High Yielding Dairy Cows. Animals : an open access journal from MDPI. vol 12. issue 6. 2022-03-25. PMID:35327191. |
in addition, we examined ecbs in milk, and studied the interaction of ecbs with bovine cannabinoids receptors cb1 and cb2. |
2022-03-25 |
2023-08-13 |
cattle |
| Petr Jirasek, Alexandr Jusku, Vilim Simanek, Jana Frankova, Jan Storch, Jan Vace. Cannabidiol and periodontal inflammatory disease: A critical assessment. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. 2022-03-25. PMID:35332345. |
cannabidiol (cbd), a non-psychotropic cannabinoid produced by the genus cannabis, is a phytoceutical that activates the endocannabinoid system (ecs) through binding to cb1 and cb2 receptors. |
2022-03-25 |
2023-08-13 |
Not clear |
| Sara E Woodman, Sophia R Antonopoulos, Paul L Durha. Inhibition of Nociception in a Preclinical Episodic Migraine Model by Dietary Supplementation of Grape Seed Extract Involves Activation of Endocannabinoid Receptors. Frontiers in pain research (Lausanne, Switzerland). vol 3. 2022-03-17. PMID:35295808. |
to investigate the role of the endocannabinoid receptors in the effect of gse, some animals were injected intracisternally with the cb1 antagonist am 251 or the cb2 antagonist am 630 prior to odor inhalation. |
2022-03-17 |
2023-08-13 |
rat |
| Riccardo Vago, Francesco Fiorio, Francesco Trevisani, Andrea Salonia, Francesco Montorsi, Arianna Bettig. The Mediterranean Diet as a Source of Bioactive Molecules with Cannabinomimetic Activity in Prevention and Therapy Strategy. Nutrients. vol 14. issue 3. 2022-03-12. PMID:35276827. |
while it is known that they do not necessarily act directly on the cannabinoid receptors cb1 and cb2, their ability to regulate their expression levels has already been shown in some disease-related models, as well as their ability to modulate the activity of other components of the system. |
2022-03-12 |
2023-08-13 |
Not clear |
| Yuemin Bian, Xiang-Qun Xi. Artificial Intelligent Deep Learning Molecular Generative Modeling of Scaffold-Focused and Cannabinoid CB2 Target-Specific Small-Molecule Sublibraries. Cells. vol 11. issue 5. 2022-03-10. PMID:35269537. |
artificial intelligent deep learning molecular generative modeling of scaffold-focused and cannabinoid cb2 target-specific small-molecule sublibraries. |
2022-03-10 |
2023-08-13 |
Not clear |
| Greg Maguire, Christy Eubanks, George Ayou. Neuroprotection of retinal ganglion cells Neuronal signaling. vol 6. issue 1. 2022-03-02. PMID:35233292. |
the present study tests the putative neuroprotective effect mediated by cannabinoids at the cb1 and cb2 receptors. |
2022-03-02 |
2023-08-13 |
mouse |
| Ana Canseco-Alba, Branden Sanabria, Mariam Hammouda, Rollanda Bernadin, Marizel Mina, Qing-Rong Liu, Emmanuel S Onaiv. Cell-Type Specific Deletion of CB2 Cannabinoid Receptors in Dopamine Neurons Induced Hyperactivity Phenotype: Possible Relevance to Attention-Deficit Hyperactivity Disorder. Frontiers in psychiatry. vol 12. 2022-02-25. PMID:35211038. |
cell-type specific deletion of cb2 cannabinoid receptors in dopamine neurons induced hyperactivity phenotype: possible relevance to attention-deficit hyperactivity disorder. |
2022-02-25 |
2023-08-13 |
Not clear |
| Antonio Bruno, Ettore Dolcetti, Diego Centonz. Theoretical and Therapeutic Implications of the Spasticity-Plus Syndrome Model in Multiple Sclerosis. Frontiers in neurology. vol 12. 2022-02-24. PMID:35197915. |
muscle tone, sleep, bladder function, and the pain pathway are controlled by cannabinoid cb1 (cb1r) and cb2 receptors (cb2r) that are particularly enriched in the brainstem. |
2022-02-24 |
2023-08-13 |
Not clear |
| Ricardo Lacava Bailone, Hirla Costa Silva Fukushima, Luis Kluwe de Aguiar, Ricardo Carneiro Borr. The endocannabinoid system in zebrafish and its potential to study the effects of Cannabis in humans. Laboratory animal research. vol 38. issue 1. 2022-02-23. PMID:35193700. |
particular attention is paid to endocannabinoid system (ecb) and its main receptors (cb1 and cb2). |
2022-02-23 |
2023-08-13 |
human |
| Kyung-Hwa Jeon, Sang-Hyuck Park, Woong Jin Bae, Sae Woong Kim, Hyo Jung Park, Soomin Kim, Tae Hyung Kim, Seung Hwan Jeon, Ilbum Park, Hyun-Je Park, Youngjoo Kwo. Cannabidiol, a Regulator of Intracellular Calcium and Calpain. Cannabis and cannabinoid research. 2022-02-23. PMID:35196129. |
although cbd is a kind of cannabinoid and acts on cannabinoid receptors (cb1 and cb2), molecular targets involved in diverse therapeutic properties of cbd have not been identified because cbd also interacts with other molecular targets. |
2022-02-23 |
2023-08-13 |
Not clear |
| Senthil Jayarajan, Joseph J Meissler, Martin W Adler, Toby K Eisenstei. A Cannabinoid 2-Selective Agonist Inhibits Allogeneic Skin Graft Rejection Frontiers in pharmacology. vol 12. 2022-02-21. PMID:35185546. |
a cannabinoid 2-selective agonist inhibits allogeneic skin graft rejection previous work from our laboratory showed that a cb2 selective agonist, o-1966, blocked the proliferative response of c57bl/6 mouse spleen cells exposed to spleen cells of c3heb/fej mice |
2022-02-21 |
2023-08-13 |
mouse |
| Hina Khan, Fareeha Khalid Ghori, Uzma Ghani, Aneela Javed, Saadia Zahi. Cannabinoid and endocannabinoid system: a promising therapeutic intervention for multiple sclerosis. Molecular biology reports. 2022-02-19. PMID:35182322. |
the cannabinoid receptors 1 (cb1) and 2 (cb2) of ecs are the main ones in focus for therapeutic intervention of ms. |
2022-02-19 |
2023-08-13 |
Not clear |
| Rosaria Greco, Chiara Demartini, Anna Maria Zanaboni, Miriam Francavilla, Roberto De Icco, Lara Ahmad, Cristina Tassorell. The endocannabinoid system and related lipids as potential targets for the treatment of migraine-related pain. Headache. 2022-02-18. PMID:35179780. |
a major advance in cannabinoid research has been the discovery of the endocannabinoid system (ecs), which consists of receptors cb1 and cb2; their endogenous ligands, such as n-arachidonoylethanolamine; and the enzymes that catalyze endocannabinoid biosynthesis or degradation. |
2022-02-18 |
2023-08-13 |
Not clear |
| Si-Jing Hu, Gang Cheng, Hao Zhou, Qi Zhang, Quan-Long Zhang, Yang Wang, Yi Shen, Chen-Xia Lian, Xue-Qin Ma, Qiao-Yan Zhang, Lu-Ping Qi. Identification of Novel Cannabinoid CB2 Receptor Agonists from Botanical Compounds and Preliminary Evaluation of Their Anti-Osteoporotic Effects. Molecules (Basel, Switzerland). vol 27. issue 3. 2022-02-15. PMID:35163968. |
identification of novel cannabinoid cb2 receptor agonists from botanical compounds and preliminary evaluation of their anti-osteoporotic effects. |
2022-02-15 |
2023-08-13 |
Not clear |
| Si-Jing Hu, Gang Cheng, Hao Zhou, Qi Zhang, Quan-Long Zhang, Yang Wang, Yi Shen, Chen-Xia Lian, Xue-Qin Ma, Qiao-Yan Zhang, Lu-Ping Qi. Identification of Novel Cannabinoid CB2 Receptor Agonists from Botanical Compounds and Preliminary Evaluation of Their Anti-Osteoporotic Effects. Molecules (Basel, Switzerland). vol 27. issue 3. 2022-02-15. PMID:35163968. |
as cannabinoid cb2 receptors (cb2r) possess various pharmacological effects-including anti-epilepsy, analgesia, anti-inflammation, anti-fibrosis, and regulation of bone metabolism-without the psychoactive side effects induced by cannabinoid cb1r activation, they have become the focus of research and development of new target drugs in recent years. |
2022-02-15 |
2023-08-13 |
Not clear |
| Hae-Won Son, Declan William Al. Endocannabinoid Receptor Expression in Early Zebrafish Development. Developmental neuroscience. 2022-02-15. PMID:35168237. |
this study combines reverse-transcriptase pcr with in situ hybridizations to compile a timeline of the developmental expression of six key cannabinoid receptors; cb1, cb2, trpv1, trpa1a, trpa1b, and gpr55 in zebrafish embryos, starting from as early as 6 hours post fertilization (hpf) until 3 days post fertilization. |
2022-02-15 |
2023-08-13 |
human |
| Marcia G Honig, Nobel A Del Mar, Desmond L Henderson, Dylan O'Neal, Meghna Yammanur, Rachel Cox, Chunyan Li, Aaron M Perry, Bob M Moore, Anton Reine. Raloxifene, a cannabinoid type-2 receptor inverse agonist, mitigates visual deficits and pathology and modulates microglia after ocular blast. Experimental eye research. 2022-02-10. PMID:35143834. |
cannabinoid type-2 receptor (cb2) inverse agonists specifically target activated microglia, biasing them away from the harmful pro-inflammatory m1 state toward the helpful reparative m2 state. |
2022-02-10 |
2023-08-13 |
mouse |
| Melissa A Ribeiro, Rafael P Aguiar, Franciele F Scarante, Eduardo J Fusse, Rubia M W de Oliveira, Francisco S Guimaraes, Alline C Campo. Spontaneous Activity of CB Frontiers in pharmacology. vol 12. 2022-02-07. PMID:35126139. |
endocannabinoid system, which comprises cb2 receptors, has been associated with the chronic effects of these drugs, especially in stressed mice. |
2022-02-07 |
2023-08-13 |
mouse |
| Valerie L Joers, Hannah Staley, Maclean Bassett, Brenda D Moore, Malu Gamez Tanse. The role of cannabinoid receptor 2 in microglial clearance of human tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109165. |
cannabinoid type 2 receptors (cb2) are highly expressed in immune cells and upregulated in activated microglia under conditions of neurologic disease, such as ad. |
2022-02-03 |
2023-08-13 |
human |
| Hagar Bauminger, Hiba Zaidan, Irit Akirav, Inna Gaisler-Salomo. Anandamide Hydrolysis Inhibition Reverses the Long-Term Behavioral and Gene Expression Alterations Induced by MK-801 in Male Rats: Differential CB1 and CB2 Receptor-Mediated Effects. Schizophrenia bulletin. 2022-01-29. PMID:35092675. |
prevention of behavioral and molecular abnormalities by late-adolescence urb597 via cb1 and cb2 receptors suggests that endocannabinoid stimulation may have therapeutic potential in addressing treatment-resistant symptoms. |
2022-01-29 |
2023-08-13 |
rat |