| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maura Argenziano, Vincenzo Pota, Alessandra Di Paola, Chiara Tortora, Maria Maddalena Marrapodi, Giulia Giliberti, Domenico Roberti, Maria Caterina Pace, Francesca Ross. CB2 Receptor as Emerging Anti-Inflammatory Target in Duchenne Muscular Dystrophy. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834757. |
they express the cb2 receptor, one of the main elements of the endocannabinoid system, and have been proposed as an anti-inflammatory target in several inflammatory and immune diseases. |
2023-02-25 |
2023-08-14 |
Not clear |
| Jennifer Ana Iden, Bitya Raphael-Mizrahi, Zamzam Awida, Aaron Naim, Dan Zyc, Tamar Liron, Melody Kasher, Gregory Livshits, Marilena Vered, Yankel Gabe. The Anti-Tumorigenic Role of Cannabinoid Receptor 2 in Colon Cancer: A Study in Mice and Humans. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835468. |
the endocannabinoid system, particularly cannabinoid receptor 2 (cb2 in mice and cnr2 in humans), has controversial pathophysiological implications in colon cancer. |
2023-02-25 |
2023-08-14 |
mouse |
| Gamal A Mohamed, Abdelsattar M Omar, Dana F AlKharboush, Mona A Fallatah, Ikhlas A Sindi, Dina S El-Agamy, Sabrin R M Ibrahi. Structure-Based Virtual Screening and Molecular Dynamics Simulation Assessments of Depsidones as Possible Selective Cannabinoid Receptor Type 2 Agonists. Molecules (Basel, Switzerland). vol 28. issue 4. 2023-02-25. PMID:36838749. |
endocannabinoid receptors (cb1 and cb2) are g-protein-coupled receptors (gpcrs), and their activation mediates many physiological processes. |
2023-02-25 |
2023-08-14 |
Not clear |
| Rosiane Aparecida Miranda, Vanessa Silva Tavares Rodrigues, Thamara Cherem Peixoto, Alex C Manhães, Egberto Gaspar de Moura, Patricia Cristina Lisbo. Nicotine exposure during breastfeeding alters the expression of endocannabinoid system biomarkers in female but not in male offspring at adulthood. Journal of developmental origins of health and disease. 2023-02-23. PMID:36815400. |
we evaluated protein expression of n-acylphosphatidylethanolamide-phospholipase d (nape-pld), fatty acid amide hydrolase (faah), diacylglycerol lipase (dagl), monoacylglycerol lipase (magl) and cannabinoid receptors (cb1 and/or cb2) in lateral hypothalamus, paraventricular nucleus of the hypothalamus, liver, visceral adipose tissue (vat), adrenal and thyroid. |
2023-02-23 |
2023-08-14 |
rat |
| Ana Laura Torres-Román, Karla Lucero Rodríguez-Flores, Víctor Manuel Hernández-Mora, Erika Ruiz-García, Oscar Prospero-García, Alberto Guijosa, Anayansi Molina, Marcela Morales-Mulia, Michael Aschner, Abel Santamaría, Alette Ortega-Góme. Examining the Role of Histaminergic, Orexinergic, and Cannabinergic Systems in Redox Regulation in Gastric Adenocarcinoma. Mini reviews in medicinal chemistry. 2023-02-22. PMID:36809932. |
lastly, cannabinoid type 2 (cb2) receptor agonists increase ros, leading to the activation of apoptotic pathways. |
2023-02-22 |
2023-08-14 |
Not clear |
| A García-Blanco, Á Ramírez-López, F Navarrete, M S García-Gutiérrez, J Manzanares, E Martín-García, R Maldonad. Role of CB2 cannabinoid receptor in the development of food addiction in male mice. Neurobiology of disease. 2023-02-12. PMID:36775043. |
the cannabinoid cb2 receptor (cb2r) is expressed in brain areas canonically associated with addictive-like behavior and was linked to drug-addictive properties. |
2023-02-12 |
2023-08-14 |
mouse |
| Yongsoon Park, Bruce A Watkin. Dietary PUFAs and Exercise Dynamic Actions on Endocannabinoids in Brain: Consequences for Neural Plasticity and Neuroinflammation. Advances in nutrition (Bethesda, Md.). vol 13. issue 5. 2023-02-11. PMID:36774087. |
the ecbs bind to cannabinoid receptors cb1 and cb2 to exert a wide range of activities, such as stimulating appetite, influencing energy metabolism, supporting the immune system, and facilitating neuroplasticity. |
2023-02-11 |
2023-08-14 |
Not clear |
| Ghada A Omran, Eman S H Abd Allah, Sherine Ahmed Mohammed, Doaa M El Shehab. Behavioral, biochemical and histopathological toxic profiles induced by sub-chronic cannabimimetic WIN55, 212-2 administration in mice. BMC pharmacology & toxicology. vol 24. issue 1. 2023-02-08. PMID:36750905. |
win55, 212-2 mesylate is a synthetic cannabinoid (sc) agonist of cb1 and cb2 receptors with much higher affinity to cb1 receptor than tetrahydrocannabinol and many potential therapeutic effects. |
2023-02-08 |
2023-08-14 |
mouse |
| Yanli Qiu, Yitian Zhao, Tao Hu, Meifang Yang, Fei Li, Cuixia Li, Weiliang Gu, Xiaodi Yang, Suwen Zhao, Houchao Ta. Development of Yin-Yang ligand for cannabinoid receptors. Bioorganic chemistry. vol 133. 2023-02-02. PMID:36731294. |
cannabinoid receptors (cbs), including cb1 and cb2, are the key components of a lipid signaling endocannabinoid system (ecs). |
2023-02-02 |
2023-08-14 |
Not clear |
| Sophie van Doorslaer de Ten Ryen, Sebastiaan Dalle, Romano Terrasi, Katrien Koppo, Giulio G Muccioli, Louise Deldicqu. Regulation of the endocannabinoid system by endurance and resistance exercise in hypoxia in human skeletal muscle. Journal of applied physiology (Bethesda, Md. : 1985). 2023-01-26. PMID:36701485. |
blood and muscle samples were taken before and after resistance and endurance exercise in normoxia and hypoxia to measure plasma endocannabinoid levels as well as muscle protein expression of cb1, cb2 and downstream signaling. |
2023-01-26 |
2023-08-14 |
human |
| Prateeksha Prateeksha, Vivek K Sharma, Shiv M Singh, Minaxi Sharma, Deepti Diwan, Abd El-Latif Hesham, Sanjay Guleria, Quang D Nguyen, Vijai K Gupta, Brahma N Sing. Tetrahydrocannabinols: potential cannabimimetic agents for cancer therapy. Cancer metastasis reviews. 2023-01-25. PMID:36696005. |
tetrahydrocannabinols (thcs) antagonize the cb1 and cb2 cannabinoid receptors, whose signaling to the endocannabinoid system is essential for controlling cell survival and proliferation as well as psychoactive effects. |
2023-01-25 |
2023-08-14 |
Not clear |
| Valentina De Nunzio, Livianna Carrieri, Maria Principia Scavo, Tamara Lippolis, Miriam Cofano, Giusy Rita Caponio, Valeria Tutino, Federica Rizzi, Nicoletta Depalo, Alberto Ruben Osella, Maria Notarnicol. Plasma-Derived Exosomes from NAFLD Patients Modulate the Cannabinoid Receptors' Expression in Cultured HepaRG Cells. International journal of molecular sciences. vol 24. issue 2. 2023-01-21. PMID:36675254. |
in the pathogenesis of nafld and liver fibrosis, the endogenous cannabinoids and their major receptors cb1 and cb2 appear to be highly involved. |
2023-01-21 |
2023-08-14 |
human |
| Laura Figuerola-Asencio, Paula Morales, Pingwei Zhao, Dow P Hurst, Sommayah S Sayed, Katsuya L Colón, María Gómez-Cañas, Javier Fernández-Ruiz, Mitchell P Croatt, Patricia H Reggio, Mary E Abood, Nadine Jagerovi. Thienopyrimidine Derivatives as GPR55 Receptor Antagonists: Insight into Structure-Activity Relationship. ACS medicinal chemistry letters. vol 14. issue 1. 2023-01-19. PMID:36655130. |
some derivatives were identified as gpr55 antagonists with functional efficacy and selectivity versus cb1 and cb2 cannabinoid receptors. |
2023-01-19 |
2023-08-14 |
human |
| Laise P A Chiari, Aldineia P da Silva, Kathia M Honório, Albérico B F da Silv. A PLS study on the psychotropic activity for a series of cannabinoid compounds. Journal of molecular modeling. vol 29. issue 2. 2023-01-19. PMID:36656418. |
the proteins that act as receptors of cannabinoid compounds were identified and characterized, being called cb1 and cb2 receptors. |
2023-01-19 |
2023-08-14 |
Not clear |
| Meenakshi Ahluwalia, Hannah Mcmichael, Manish Kumar, Mario P Espinosa, Asamoah Bosomtwi, Yujiao Lu, Hesam Khodadadi, Abbas Jarrahi, Mohammad B Khan, David C Hess, Scott Y Rahimi, John R Vender, Fernando L Vale, Molly Braun, Babak Baban, Krishnan M Dhandapani, Kumar Vaibha. Altered endocannabinoid metabolism compromises the brain-CSF barrier and exacerbates chronic deficits after traumatic brain injury in mice. Experimental neurology. 2023-01-10. PMID:36627040. |
endocannabinoids [2-arachidonoylglycerol (2-ag) and n-arachidonoylethanolamine (aea)], endogenously produced arachidonate-based lipids, are anti-inflammatory physiological ligands for two known cannabinoid receptors, cb1 and cb2, yet the molecular and cellular mechanisms underlying their effects after brain injury are poorly defined. |
2023-01-10 |
2023-08-14 |
mouse |
| Dimitris Spyridakos, Niki Mastrodimou, Kiran Vemuri, Thanh C Ho, Spyros P Nikas, Alexandros Makriyannis, Kyriaki Thermo. Blockade of CB1 or Activation of CB2 Cannabinoid Receptors Is Differentially Efficacious in the Treatment of the Early Pathological Events in Streptozotocin-Induced Diabetic Rats. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36613692. |
blockade of cb1 or activation of cb2 cannabinoid receptors is differentially efficacious in the treatment of the early pathological events in streptozotocin-induced diabetic rats. |
2023-01-08 |
2023-08-14 |
rat |
| Barbara Vuic, Tina Milos, Lucija Tudor, Marcela Konjevod, Matea Nikolac Perkovic, Maja Jazvinscak Jembrek, Gordana Nedic Erjavec, Dubravka Svob Stra. Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential. Biomedicines. vol 10. issue 12. 2022-12-23. PMID:36551756. |
cannabinoid cb2 receptors in neurodegenerative proteinopathies: new insights and therapeutic potential. |
2022-12-23 |
2023-08-14 |
Not clear |
| Barbara Vuic, Tina Milos, Lucija Tudor, Marcela Konjevod, Matea Nikolac Perkovic, Maja Jazvinscak Jembrek, Gordana Nedic Erjavec, Dubravka Svob Stra. Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential. Biomedicines. vol 10. issue 12. 2022-12-23. PMID:36551756. |
the endocannabinoid system, and in particular the cannabinoid cb2 receptors, have been extensively studied, due to their important role in neuroinflammation, especially in microglial cells. |
2022-12-23 |
2023-08-14 |
Not clear |
| Bettina Greiner, Manuela Sommerfeld, Ulrich Kintscher, Thomas Unger, Kai Kappert, Elena Kaschin. Differential Regulation of MMPs, Apoptosis and Cell Proliferation by the Cannabinoid Receptors CB1 and CB2 in Vascular Smooth Muscle Cells and Cardiac Myocytes. Biomedicines. vol 10. issue 12. 2022-12-23. PMID:36552027. |
differential regulation of mmps, apoptosis and cell proliferation by the cannabinoid receptors cb1 and cb2 in vascular smooth muscle cells and cardiac myocytes. |
2022-12-23 |
2023-08-14 |
Not clear |
| Daniela R de Oliveira, Rodolfo C Maia, Patrícia R de Carvalho França, Patrícia D Fernandes, Gisele Barbosa, Lídia M Lima, Carlos A Manssour Frag. 2-Arylpropionic Acid Pyrazolamides as Cannabinoid CB2 Receptor Inverse Agonists Endowed with Anti-Inflammatory Properties. Pharmaceuticals (Basel, Switzerland). vol 15. issue 12. 2022-12-23. PMID:36558970. |
2-arylpropionic acid pyrazolamides as cannabinoid cb2 receptor inverse agonists endowed with anti-inflammatory properties. |
2022-12-23 |
2023-08-14 |
Not clear |