| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Özge Boyacıoğlu, Petek Korkusu. Cannabinoids as Prospective Anti-Cancer Drugs: Mechanism of Action in Healthy and Cancer Cells. Advances in experimental medicine and biology. 2022-11-17. PMID:36396926. |
endogenous and exogenous cannabinoids modulate many physiological and pathological processes by binding classical cannabinoid receptors 1 (cb1) or 2 (cb2) or non-cannabinoid receptors. |
2022-11-17 |
2023-08-14 |
Not clear |
| Fathima Hajee Basha, Mohammad Waseem, Hemalatha Srinivasa. Promising Action of Cannabinoids on ER Stress-Mediated Neurodegeneration: An In Silico Investigation. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 41. issue 4. 2022-11-14. PMID:36374961. |
in our study, three cannabinoid receptors (cb1, cb2, and cb3) were considered to demonstrate their neuroprotective actions. |
2022-11-14 |
2023-08-14 |
Not clear |
| Shang Qiu, Xiunan Wu, Dechun Geng, Wenzhen Pan, Zheng Li, Gang Wang, Daen Li, Cheng Li, Shuo Feng, Liang Zhu, Yaozeng Xu, Fenglei Ga. H International journal of biological macromolecules. 2022-11-13. PMID:36372104. |
here, the hollow mesoporous copper sulfide (cus) was used as the carrier skeleton and the cannabinoid type 2 (cb2) receptor agonist jwh133 was efficiently loaded inside of cus through adsorption, then the outer layer was modified with hyaluronic acid (ha) to prevent the leakage of internal drugs. |
2022-11-13 |
2023-08-14 |
mouse |
| Jaqueline M Franzen, Isabel Werle, Felipe Vanz, Bruno Biscaia de Oliveira, Laura Maria Martins Nascimento, Francisco S Guimarães, Leandro J Bertogli. Cannabidiol attenuates fear memory expression in female rats via hippocampal 5-HT Neuropharmacology. 2022-11-05. PMID:36334768. |
in subsequent experiments, we investigated the estrous cycle effects and the contribution of dorsal hippocampus (dh) serotonin 1a (5-ht1a) and cannabinoid types 1 (cb1) and 2 (cb2) receptors to cbd-induced effects on memory retrieval/expression. |
2022-11-05 |
2023-08-14 |
human |
| César E Martinez Ramirez, Gonzalo Ruiz-Pérez, Todd M Stollenwerk, Christina Behlke, Ashley Doherty, Cecilia J Hillar. Endocannabinoid signaling in the central nervous system. Glia. 2022-10-29. PMID:36308424. |
cb2 cannabinoid receptors are difficult to detect in the cns but seem to "punch above their weight" as compounds targeting these receptors have significant effects on inflammatory state and behavior. |
2022-10-29 |
2023-08-14 |
Not clear |
| Esty Goldberger, Merav Tauber, Yair Ben-Chai. Voltage dependence of the cannabinoid CB1 receptor. Frontiers in pharmacology. vol 13. 2022-10-28. PMID:36304142. |
cannabinoids produce their characteristic effects mainly by binding to two types of g-protein coupled receptors (gpcrs), the cb1 and cb2 cannabinoid receptors. |
2022-10-28 |
2023-08-14 |
Not clear |
| Ana Tadijan, Ignacija Vlašić, Josipa Vlainić, Domagoj Đikić, Nada Oršolić, Maja Jazvinšćak Jembre. Intracellular Molecular Targets and Signaling Pathways Involved in Antioxidative and Neuroprotective Effects of Cannabinoids in Neurodegenerative Conditions. Antioxidants (Basel, Switzerland). vol 11. issue 10. 2022-10-27. PMID:36290771. |
cannabinoids are able to neutralize free radicals and modulate the production of reactive oxygen species and the activity of antioxidative systems acting on cb1 and cb2 cannabinoid receptors. |
2022-10-27 |
2023-08-14 |
Not clear |
| Sanela Rajlic, Luise Surmann, Pia Zimmermann, Christina Katharina Weisheit, Laura Bindila, Hendrik Treede, Markus Velten, Andreas Daiber, Georg Daniel Duer. Fatty Acid Amide Hydrolase Deficiency Is Associated with Deleterious Cardiac Effects after Myocardial Ischemia and Reperfusion in Mice. International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36293543. |
cannabinoid type-2 receptor (cb2) deficiency led to increased apoptosis and infarctions with worsened lv function in ischemic cardiomyopathy. |
2022-10-27 |
2023-08-14 |
mouse |
| Aitor Benedicto, Beatriz Arteta, Andrea Duranti, Daniel Alonso-Alconad. The Synthetic Cannabinoid URB447 Exerts Antitumor and Antimetastatic Effect in Melanoma and Colon Cancer. Pharmaceuticals (Basel, Switzerland). vol 15. issue 10. 2022-10-27. PMID:36297277. |
we used the synthetic cannabinoid urb447, a known cb2 agonist and cb1 antagonist drug, and studied prometastatic ability of mouse b16 melanoma and mca38 crc cells, by means of proliferation, apoptosis, cell cycle, migration and matrix degradation in vitro upon urb447 treatment. |
2022-10-27 |
2023-08-14 |
mouse |
| Reem Smoum, Uwe Grether, Meliha Karsak, Andrea J Vernall, Frank Park, Cecilia J Hillard, Pal Pache. Editorial: Therapeutic potential of the cannabinoid CB2 receptor. Frontiers in pharmacology. vol 13. 2022-10-24. PMID:36278235. |
editorial: therapeutic potential of the cannabinoid cb2 receptor. |
2022-10-24 |
2023-08-14 |
Not clear |
| Laura M Navarro-Saiz, Lilia J Bernal-Cepeda, Jaime E Castellano. Immune challenges upregulate the expression of cannabinoid receptors in cultured human odontoblasts and gingival fibroblasts. Acta odontologica latinoamericana : AOL. vol 35. issue 2. 2022-10-19. PMID:36260938. |
cannabinoid receptors (cb1 and cb2) are involved in analgesia by modulating the función of calcium channels that inhibit the synthesis of some neurotransmitters. |
2022-10-19 |
2023-08-14 |
human |
| Laura M Navarro-Saiz, Lilia J Bernal-Cepeda, Jaime E Castellano. Immune challenges upregulate the expression of cannabinoid receptors in cultured human odontoblasts and gingival fibroblasts. Acta odontologica latinoamericana : AOL. vol 35. issue 2. 2022-10-19. PMID:36260938. |
cb1 and cb2 transcription was analyzed by real-time pcr, proteins were detected by immunofluorescence, and functional cannabinoid receptors were evaluated by measuring intracellular calcium concentration after stimulation with cannabidiol (cbd) and pre-treatment with a cb1 antagonist, a cb2 inverse agonist and a trpv1 antagonist. |
2022-10-19 |
2023-08-14 |
human |
| Laura M Navarro-Saiz, Lilia J Bernal-Cepeda, Jaime E Castellano. Immune challenges upregulate the expression of cannabinoid receptors in cultured human odontoblasts and gingival fibroblasts. Acta odontologica latinoamericana : AOL. vol 35. issue 2. 2022-10-19. PMID:36260938. |
in conclusion, human odontoblasts and gingival fibroblasts express functional cb1 and cb2 cannabinoid receptors, which could be modulated to improve the treatment of pain or dental sensitivity. |
2022-10-19 |
2023-08-14 |
human |
| Laura López-Gómez, Agata Szymaszkiewicz, Marta Zielińska, Raquel Abal. The Enteric Glia and Its Modulation by the Endocannabinoid System, a New Target for Cannabinoid-Based Nutraceuticals? Molecules (Basel, Switzerland). vol 27. issue 19. 2022-10-14. PMID:36235308. |
the endogenous cannabinoid system (ecs) includes endogenous classical cannabinoids (anandamide, 2-arachidonoylglycerol), cannabinoid-like ligands (oleoylethanolamide (oea) and palmitoylethanolamide (pea)), enzymes involved in their metabolism (faah, magl, cox-2) and classical (cb1 and cb2) and non-classical (trpv1, gpr55, ppar) receptors. |
2022-10-14 |
2023-08-14 |
Not clear |
| Elina Avraamidou, Moritz Nöthel, Melina Danisch, Laura Bindila, Susanne V Schmidt, Beat Lutz, Georg Nickenig, Julian Jehl. Myeloid But Not Endothelial Expression of the CB2 Receptor Promotes Atherogenesis in the Context of Elevated Levels of the Endocannabinoid 2-Arachidonoylglycerol. Journal of cardiovascular translational research. 2022-09-30. PMID:36178662. |
myeloid but not endothelial expression of the cb2 receptor promotes atherogenesis in the context of elevated levels of the endocannabinoid 2-arachidonoylglycerol. |
2022-09-30 |
2023-08-14 |
mouse |
| Elina Avraamidou, Moritz Nöthel, Melina Danisch, Laura Bindila, Susanne V Schmidt, Beat Lutz, Georg Nickenig, Julian Jehl. Myeloid But Not Endothelial Expression of the CB2 Receptor Promotes Atherogenesis in the Context of Elevated Levels of the Endocannabinoid 2-Arachidonoylglycerol. Journal of cardiovascular translational research. 2022-09-30. PMID:36178662. |
the endocannabinoid 2-arachidonoylglycerol (2-ag) is an inflammatory mediator and ligand for the cannabinoid receptors cb1 and cb2. |
2022-09-30 |
2023-08-14 |
mouse |
| Valentina Rinaldi, Andrea Boari, Lorenzo Ressel, Laura Bongiovanni, Paolo Emidio Crisi, Emanuele Cabibbo, Riccardo Finotell. Expression of cannabinoid receptors CB1 and CB2 in canine cutaneous mast cell tumours. Research in veterinary science. vol 152. 2022-09-30. PMID:36179546. |
expression of cannabinoid receptors cb1 and cb2 in canine cutaneous mast cell tumours. |
2022-09-30 |
2023-08-14 |
Not clear |
| Valentina Rinaldi, Andrea Boari, Lorenzo Ressel, Laura Bongiovanni, Paolo Emidio Crisi, Emanuele Cabibbo, Riccardo Finotell. Expression of cannabinoid receptors CB1 and CB2 in canine cutaneous mast cell tumours. Research in veterinary science. vol 152. 2022-09-30. PMID:36179546. |
cannabinoid receptors (cb1 and cb2) belong to endocannabinoid system (ecs), which is also composed from endocannabinoids and the enzymatic systems involved in their biosynthesis and degradation. |
2022-09-30 |
2023-08-14 |
Not clear |
| María Victoria Noya-Riobó, Constanza Ágata Miguel, Delia Beatriz Soriano, Pablo Rodolfo Brumovsky, Marcelo José Villar, María Florencia Corone. Changes in the expression of endocannabinoid system components in an experimental model of chemotherapy-induced peripheral neuropathic pain: Evaluation of sex-related differences. Experimental neurology. 2022-09-30. PMID:36179876. |
the mrna levels corresponding to cannabinoid receptors (cb1, cb2), cannabinoid-related receptors (gpr55, 5ht1a, trpv1) and to the main enzymes involved in the synthesis (dagl, dagl, nape-pld) and degradation (mgl, faah) of endocannabinoids were assessed in lumbar dorsal root ganglia (drgs) and spinal cord by using real time rt-pcr. |
2022-09-30 |
2023-08-14 |
rat |
| Diego Mauricio Gómez-García, Herney Andrés García-Perdom. Medical cannabis: Critical points for clinical application Biomedica : revista del Instituto Nacional de Salud. vol 42. issue 3. 2022-09-19. PMID:36122285. |
these compounds have several physiological effects and produce their effects primarily by binding to endogenous cannabinoid receptors such as cb1 and cb2, among others.cannabis has potential therapeutic properties and its preparations have been used as traditional remedies to treat pain and emesis. |
2022-09-19 |
2023-08-14 |
Not clear |