| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanli Qiu, Yitian Zhao, Tao Hu, Meifang Yang, Fei Li, Cuixia Li, Weiliang Gu, Xiaodi Yang, Suwen Zhao, Houchao Ta. Development of Yin-Yang ligand for cannabinoid receptors. Bioorganic chemistry. vol 133. 2023-02-02. PMID:36731294. |
cannabinoid receptors (cbs), including cb1 and cb2, are the key components of a lipid signaling endocannabinoid system (ecs). |
2023-02-02 |
2023-08-14 |
Not clear |
| Sophie van Doorslaer de Ten Ryen, Sebastiaan Dalle, Romano Terrasi, Katrien Koppo, Giulio G Muccioli, Louise Deldicqu. Regulation of the endocannabinoid system by endurance and resistance exercise in hypoxia in human skeletal muscle. Journal of applied physiology (Bethesda, Md. : 1985). 2023-01-26. PMID:36701485. |
blood and muscle samples were taken before and after resistance and endurance exercise in normoxia and hypoxia to measure plasma endocannabinoid levels as well as muscle protein expression of cb1, cb2 and downstream signaling. |
2023-01-26 |
2023-08-14 |
human |
| Prateeksha Prateeksha, Vivek K Sharma, Shiv M Singh, Minaxi Sharma, Deepti Diwan, Abd El-Latif Hesham, Sanjay Guleria, Quang D Nguyen, Vijai K Gupta, Brahma N Sing. Tetrahydrocannabinols: potential cannabimimetic agents for cancer therapy. Cancer metastasis reviews. 2023-01-25. PMID:36696005. |
tetrahydrocannabinols (thcs) antagonize the cb1 and cb2 cannabinoid receptors, whose signaling to the endocannabinoid system is essential for controlling cell survival and proliferation as well as psychoactive effects. |
2023-01-25 |
2023-08-14 |
Not clear |
| Valentina De Nunzio, Livianna Carrieri, Maria Principia Scavo, Tamara Lippolis, Miriam Cofano, Giusy Rita Caponio, Valeria Tutino, Federica Rizzi, Nicoletta Depalo, Alberto Ruben Osella, Maria Notarnicol. Plasma-Derived Exosomes from NAFLD Patients Modulate the Cannabinoid Receptors' Expression in Cultured HepaRG Cells. International journal of molecular sciences. vol 24. issue 2. 2023-01-21. PMID:36675254. |
in the pathogenesis of nafld and liver fibrosis, the endogenous cannabinoids and their major receptors cb1 and cb2 appear to be highly involved. |
2023-01-21 |
2023-08-14 |
human |
| Laura Figuerola-Asencio, Paula Morales, Pingwei Zhao, Dow P Hurst, Sommayah S Sayed, Katsuya L Colón, María Gómez-Cañas, Javier Fernández-Ruiz, Mitchell P Croatt, Patricia H Reggio, Mary E Abood, Nadine Jagerovi. Thienopyrimidine Derivatives as GPR55 Receptor Antagonists: Insight into Structure-Activity Relationship. ACS medicinal chemistry letters. vol 14. issue 1. 2023-01-19. PMID:36655130. |
some derivatives were identified as gpr55 antagonists with functional efficacy and selectivity versus cb1 and cb2 cannabinoid receptors. |
2023-01-19 |
2023-08-14 |
human |
| Laise P A Chiari, Aldineia P da Silva, Kathia M Honório, Albérico B F da Silv. A PLS study on the psychotropic activity for a series of cannabinoid compounds. Journal of molecular modeling. vol 29. issue 2. 2023-01-19. PMID:36656418. |
the proteins that act as receptors of cannabinoid compounds were identified and characterized, being called cb1 and cb2 receptors. |
2023-01-19 |
2023-08-14 |
Not clear |
| Meenakshi Ahluwalia, Hannah Mcmichael, Manish Kumar, Mario P Espinosa, Asamoah Bosomtwi, Yujiao Lu, Hesam Khodadadi, Abbas Jarrahi, Mohammad B Khan, David C Hess, Scott Y Rahimi, John R Vender, Fernando L Vale, Molly Braun, Babak Baban, Krishnan M Dhandapani, Kumar Vaibha. Altered endocannabinoid metabolism compromises the brain-CSF barrier and exacerbates chronic deficits after traumatic brain injury in mice. Experimental neurology. 2023-01-10. PMID:36627040. |
endocannabinoids [2-arachidonoylglycerol (2-ag) and n-arachidonoylethanolamine (aea)], endogenously produced arachidonate-based lipids, are anti-inflammatory physiological ligands for two known cannabinoid receptors, cb1 and cb2, yet the molecular and cellular mechanisms underlying their effects after brain injury are poorly defined. |
2023-01-10 |
2023-08-14 |
mouse |
| Dimitris Spyridakos, Niki Mastrodimou, Kiran Vemuri, Thanh C Ho, Spyros P Nikas, Alexandros Makriyannis, Kyriaki Thermo. Blockade of CB1 or Activation of CB2 Cannabinoid Receptors Is Differentially Efficacious in the Treatment of the Early Pathological Events in Streptozotocin-Induced Diabetic Rats. International journal of molecular sciences. vol 24. issue 1. 2023-01-08. PMID:36613692. |
blockade of cb1 or activation of cb2 cannabinoid receptors is differentially efficacious in the treatment of the early pathological events in streptozotocin-induced diabetic rats. |
2023-01-08 |
2023-08-14 |
rat |
| Barbara Vuic, Tina Milos, Lucija Tudor, Marcela Konjevod, Matea Nikolac Perkovic, Maja Jazvinscak Jembrek, Gordana Nedic Erjavec, Dubravka Svob Stra. Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential. Biomedicines. vol 10. issue 12. 2022-12-23. PMID:36551756. |
cannabinoid cb2 receptors in neurodegenerative proteinopathies: new insights and therapeutic potential. |
2022-12-23 |
2023-08-14 |
Not clear |
| Barbara Vuic, Tina Milos, Lucija Tudor, Marcela Konjevod, Matea Nikolac Perkovic, Maja Jazvinscak Jembrek, Gordana Nedic Erjavec, Dubravka Svob Stra. Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential. Biomedicines. vol 10. issue 12. 2022-12-23. PMID:36551756. |
the endocannabinoid system, and in particular the cannabinoid cb2 receptors, have been extensively studied, due to their important role in neuroinflammation, especially in microglial cells. |
2022-12-23 |
2023-08-14 |
Not clear |
| Bettina Greiner, Manuela Sommerfeld, Ulrich Kintscher, Thomas Unger, Kai Kappert, Elena Kaschin. Differential Regulation of MMPs, Apoptosis and Cell Proliferation by the Cannabinoid Receptors CB1 and CB2 in Vascular Smooth Muscle Cells and Cardiac Myocytes. Biomedicines. vol 10. issue 12. 2022-12-23. PMID:36552027. |
differential regulation of mmps, apoptosis and cell proliferation by the cannabinoid receptors cb1 and cb2 in vascular smooth muscle cells and cardiac myocytes. |
2022-12-23 |
2023-08-14 |
Not clear |
| Daniela R de Oliveira, Rodolfo C Maia, Patrícia R de Carvalho França, Patrícia D Fernandes, Gisele Barbosa, Lídia M Lima, Carlos A Manssour Frag. 2-Arylpropionic Acid Pyrazolamides as Cannabinoid CB2 Receptor Inverse Agonists Endowed with Anti-Inflammatory Properties. Pharmaceuticals (Basel, Switzerland). vol 15. issue 12. 2022-12-23. PMID:36558970. |
2-arylpropionic acid pyrazolamides as cannabinoid cb2 receptor inverse agonists endowed with anti-inflammatory properties. |
2022-12-23 |
2023-08-14 |
Not clear |
| Yan-Ran Wu, Jia-Qin Tang, Wan-Nian Zhang, Chun-Lin Zhuang, Ying Sh. Rational drug design of CB2 receptor ligands: from 2012 to 2021. RSC advances. vol 12. issue 54. 2022-12-21. PMID:36540233. |
cannabinoid receptors belong to the large family of g-protein-coupled receptors, which can be divided into two receptor types, cannabinoid receptor type-1 (cb1) and cannabinoid receptor type-2 (cb2). |
2022-12-21 |
2023-08-14 |
Not clear |
| Natasha M C Oliveira, Dayane A Machado, Thauann L da Silva, Gabriel T do Val. Treatment with Cannabidiol Results in an Antioxidant and Cardioprotective Effect in Several Pathophysiologies. Current hypertension reviews. vol 18. issue 2. 2022-12-12. PMID:36508270. |
it is made up of type 1 (cb1) and type 2 (cb2) cannabinoid receptors. |
2022-12-12 |
2023-08-14 |
Not clear |
| Tamara T Lah, Bernarda Majc, Metka Novak, Ajda Sušnik, Barbara Breznik, Andrej Porčnik, Roman Bošnjak, Aleksander Sadikov, Marta Malavolta, Selma Halilčević, Jernej Mlakar, Roby Zome. The Cytotoxic Effects of Cannabidiol and Cannabigerol on Glioblastoma Stem Cells May Mostly Involve GPR55 and TRPV1 Signalling. Cancers. vol 14. issue 23. 2022-12-11. PMID:36497400. |
the large g-protein-coupled receptor family includes cannabinoid receptors cb1, cb2, gpr55, and non-specific ion receptor protein transporters trps. |
2022-12-11 |
2023-08-14 |
Not clear |
| Marcia G Honig, Nobel A Del Mar, Bob M Moore, Anton Reine. Raloxifene Mitigates Emotional Deficits after Mild Traumatic Brain Injury in Mice. Neurotrauma reports. vol 3. issue 1. 2022-12-08. PMID:36479361. |
we have previously reported that mice show increased depression, fearfulness, and anxiety, as well as visual and motor deficits, after focal cranial blast and that treatment with the cannabinoid type 2 receptor (cb2) inverse agonist, smm-189, reduces these deficits. |
2022-12-08 |
2023-08-14 |
mouse |
| Maria Sofia Basile, Emanuela Mazzo. The Role of Cannabinoid Type 2 Receptors in Parkinson's Disease. Biomedicines. vol 10. issue 11. 2022-11-26. PMID:36428554. |
cannabinoid type 2 (cb2) receptors, one of the components of the endocannabinoid system, can regulate neuroinflammation in pd. |
2022-11-26 |
2023-08-14 |
Not clear |
| Lawrence M Carey, Zhili Xu, Gabriela Rajic, Alexandros Makriyannis, Julian Romero, Cecilia Hillard, Ken Mackie, Andrea G Hohman. Peripheral sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of anti-retroviral toxic neuropathy. Pharmacological research. 2022-11-23. PMID:36417942. |
peripheral sensory neuron cb2 cannabinoid receptors are necessary for both cb2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of anti-retroviral toxic neuropathy. |
2022-11-23 |
2023-08-14 |
mouse |
| Lawrence M Carey, Zhili Xu, Gabriela Rajic, Alexandros Makriyannis, Julian Romero, Cecilia Hillard, Ken Mackie, Andrea G Hohman. Peripheral sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of anti-retroviral toxic neuropathy. Pharmacological research. 2022-11-23. PMID:36417942. |
we characterized the impact of two cb2 cannabinoid agonists (am1710 and ly2828360 - ligands differing in signaling bias and cns penetration) on neuropathic nociception induced by the antiretroviral agent zalcitabine (2'-3'-dideoxycitidine; ddc). |
2022-11-23 |
2023-08-14 |
mouse |
| Monika Vidlarova, Emil Berta, Petr Prasil, Andrea Prokopova, Sona Gurska, Marta Khoylou, Alona Rehulkova, Pavla Kourilova, Josef Chudacek, Marek Szkorupa, Jiri Klein, Jozef Skarda, Josef Srovnal, Marian Hajduc. Cannabinoid receptor 2 expression in early-stage non-small cell lung cancers identifies patients with good prognosis and longer survival. Translational lung cancer research. vol 11. issue 10. 2022-11-17. PMID:36386452. |
since the endogenous cannabinoid system is involved in both carcinogenesis and anticancer immune defense, we hypothesized that tumor tissue expression of cannabinoid 1 and 2 receptors (cb1 and cb2) may affect survival. |
2022-11-17 |
2023-08-14 |
Not clear |