| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Noa Raz, Aharon M Eyal, Dana Berneman Zeitouni, Danielle Hen-Shoval, Elyad M Davidson, Aviel Danieli, Merav Tauber, Yair Ben-Chai. SELECTED CANNABIS TERPENES SYNERGIZE WITH THC TO PRODUCE INCREASED CB1 RECEPTOR ACTIVATION. Biochemical pharmacology. 2023-04-21. PMID:37084981. |
the cannabis plant exerts its pharmaceutical activity primarily by the binding of cannabinoids to two g protein-coupled cannabinoid receptors, cb1 and cb2. |
2023-04-21 |
2023-08-14 |
Not clear |
| Nathaniel A K Glenn, David B Finlay, Emma R Carruthers, Kathleen G Mountjoy, Christopher S Walker, Natasha L Grimse. RAMP and MRAP Accessory Proteins have Selective Effects on Expression and Signalling of the CB1, CB2, GPR18 and GPR55 Cannabinoid Receptors. British journal of pharmacology. 2023-04-21. PMID:37085333. |
ramp and mrap accessory proteins have selective effects on expression and signalling of the cb1, cb2, gpr18 and gpr55 cannabinoid receptors. |
2023-04-21 |
2023-08-14 |
Not clear |
| Berhanu Geresu Kibret, Aaliyah Roberts, Adam Kneebone, Shymaa Embaby, Justin Fernandez, Qing-Rong Liu, Emmanuel S Onaiv. Cannabinoid CB2 receptors modulate alcohol induced behavior, and neuro-immune dysregulation in mice. Behavioural brain research. 2023-04-15. PMID:37061199. |
cannabinoid cb2 receptors modulate alcohol induced behavior, and neuro-immune dysregulation in mice. |
2023-04-15 |
2023-08-14 |
mouse |
| Lizbeth Magnolia Martínez-Aguilar, Alfredo Ibarra-Sánchez, Daniel José Guerrero-Morán, Marina Macías-Silva, Jesús Omar Muñoz-Bello, Alejandro Padilla, Marcela Lizano, Claudia González-Espinos. Lysophosphatidylinositol Promotes Chemotaxis and Cytokine Synthesis in Mast Cells with Differential Participation of GPR55 and CB2 Receptors. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047288. |
the lpi and o1602-dependent stimulation of bmmc also led to vegf, tnf, il-1α, and il-1β mrna accumulation, but, in contrast with chemotaxis-related processes, the effects on cytokine transcription were dependent on gpr55 and cannabinoid (cb) 2 receptors, since they were sensitive to ml193 and to the specific cb2 receptor antagonist am630. |
2023-04-13 |
2023-08-14 |
mouse |
| Daniela Navarro-Acosta, Ludis Coba-Jimenez, Alfredo Perez-Gamboa, Nestor Cubillan, Ricardo Vivas-Reye. QSAR Modelling of Biological Activity in Cannabinoids with Quantum Similarity Combinations of Charge Fitting Schemes and 3D-QSAR. Chemistry & biodiversity. 2023-04-07. PMID:37029452. |
the pubchem[https://pubchem.ncbi.nlm.nih.gov/] database provided the geometries, binding affinities(ki) to the cannabinoid receptors type 1(cb1) and 2(cb2), and the median lethal dose(ld50) to breast cancer cells. |
2023-04-07 |
2023-08-14 |
Not clear |
| b' Bruno M Fonseca, Niloy Bhowmick, Sara Cunha, Jo\\xc3\\xa3o Maia, Georgina Correia-da-Silva, Nat\\xc3\\xa9rcia Teixeira, Susana I S\\xc3\\xa. Long-Term Tamoxifen Effects in the Cyclic Interaction of the Endocannabinoid and Endocrine System in the Rat Central Nervous System. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979699.' |
within the female reproductive tract, estrogen increases the expression of the cannabinoid receptors cb1 and cb2, and modifies the levels of anandamide (aea), the major endocannabinoid, by altering the expression of both aea synthesis (nape-pld) and catabolic enzymes (faah). |
2023-03-29 |
2023-08-14 |
rat |
| Nuchjira Takheaw, Kanyaruck Jindaphun, Supansa Pata, Witida Laopajon, Watchara Kasinrer. Cannabinoid Receptor 1 Agonist ACEA and Cannabinoid Receptor 2 Agonist GW833972A Attenuates Cell-Mediated Immunity by Different Biological Mechanisms. Cells. vol 12. issue 6. 2023-03-29. PMID:36980189. |
cannabinoid receptor 1 (cb1) and cannabinoid receptor 2 (cb2) are components in the endocannabinoid system that play significant roles in regulating immune responses. |
2023-03-29 |
2023-08-14 |
Not clear |
| Mengya Wang, Man Liu, Zegang M. Cannabinoid type 2 receptor activation inhibits MPP Molecular biology reports. 2023-03-28. PMID:36977807. |
cannabinoid type 2 receptor activation inhibits mpp growing evidence indicates that cannabinoid type 2 (cb2) receptor activation inhibits neuroinflammation in the pathogenesis of parkinson's disease (pd). |
2023-03-28 |
2023-08-14 |
Not clear |
| Sara Khosropoor, Mohaddeseh Sadat Alavi, Leila Etemad, Ali Roohbakhs. Cannabidiol goes nuclear: The role of PPARγ. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 114. 2023-03-25. PMID:36965374. |
in contrast to Δ9-tetrahydrocannabinol, it has a low affinity for cannabinoid receptors cb1 and cb2, thereby it does not induce significant psychoactive effects. |
2023-03-25 |
2023-08-14 |
Not clear |
| Francesco Matrisciano, Graziano Pinn. The Strategy of Targeting Peroxisome Proliferator-Activated Receptor (PPAR) in the Treatment of Neuropsychiatric Disorders. Advances in experimental medicine and biology. vol 1411. 2023-03-23. PMID:36949324. |
interestingly, ppars are considered functionally part of the extended endocannabinoid (ecb) system that includes the classic ecb, anandamide, which act at cannabinoid receptor types 1 (cb1) and 2 (cb2) and are implicated in the pathophysiology of stress-related neuropsychiatric disorders. |
2023-03-23 |
2023-08-14 |
Not clear |
| Rodrigo Zamith Cunha, Augusta Zannoni, Giulia Salamanca, Margherita De Silva, Riccardo Rinnovati, Alessandro Gramenzi, Monica Forni, Roberto Chiocchett. Expression of cannabinoid (CB1 and CB2) and cannabinoid-related receptors (TRPV1, GPR55, and PPARα) in the synovial membrane of the horse metacarpophalangeal joint. Frontiers in veterinary science. vol 10. 2023-03-20. PMID:36937015. |
expression of cannabinoid (cb1 and cb2) and cannabinoid-related receptors (trpv1, gpr55, and pparα) in the synovial membrane of the horse metacarpophalangeal joint. |
2023-03-20 |
2023-08-14 |
human |
| Magali Merrien, Agata M Wasik, Christopher M Melén, Mohammad Hamdy Abdelrazak Morsy, Kristina Sonnevi, Henna-Riikka Junlén, Birger Christensson, Björn E Wahlin, Birgitta Sande. 2-Arachidonoylglycerol Modulates CXCL12-Mediated Chemotaxis in Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia. Cancers. vol 15. issue 5. 2023-03-11. PMID:36900374. |
the biolipid 2-arachidonoylglycerol (2-ag), an agonist for the cannabinoid receptors cb1 and cb2, is released by stromal cells in the bone marrow. |
2023-03-11 |
2023-08-14 |
Not clear |
| Lauren Van Hov. A Cannabinoid Type 2 (CB2) Receptor Agonist Augments NOS-Dependent Responses of Cerebral Arterioles During Type 1 Diabetes. South Dakota medicine : the journal of the South Dakota State Medical Association. vol 75. issue 10. 2023-03-08. PMID:36889269. |
a cannabinoid type 2 (cb2) receptor agonist augments nos-dependent responses of cerebral arterioles during type 1 diabetes. |
2023-03-08 |
2023-08-14 |
Not clear |
| Lauren Van Hov. A Cannabinoid Type 2 (CB2) Receptor Agonist Augments NOS-Dependent Responses of Cerebral Arterioles During Type 1 Diabetes. South Dakota medicine : the journal of the South Dakota State Medical Association. vol 75. issue 10. 2023-03-08. PMID:36889269. |
while activation of cannabinoid (cb2) receptors has been shown to be neuroprotective, no studies have examined whether this neuroprotection is directed at cerebral arterioles and no studies have examined whether activation of cb2 receptors can rescue cerebrovascular dysfunction during a chronic disease state such as type 1 diabetes (t1d). |
2023-03-08 |
2023-08-14 |
Not clear |
| Laila Asth, Leonardo Cardoso Cruz, Nicholas Soyombo, Pedro Rigo, Fabrício A Moreir. Effects of β -caryophyllene, A Dietary Cannabinoid, in Animal Models of Drug Addiction. Current neuropharmacology. vol 21. issue 2. 2023-03-03. PMID:36173065. |
the mechanisms of action of bcp remain uncertain, possibly including full agonism at the cannabinoid cb2 receptor (cb2r). |
2023-03-03 |
2023-10-15 |
Not clear |
| Stewart Ramsay, Nick J Spencer, Vladimir Zagorodnyu. Endocannabinoids, anandamide and 2-AG, regulate mechanosensitivity of mucosal afferents in the Guinea pig bladder. European journal of pharmacology. 2023-03-01. PMID:36858341. |
endocannabinoids, anandamide (aea) and 2-arachidonolylglycerol (2-ag), are endogenous ligands of g-protein coupled cannabinoid receptors 1 and 2 (cb1 and cb2) found in the cns and peripheral organs. |
2023-03-01 |
2023-08-14 |
Not clear |
| Stewart Ramsay, Nick J Spencer, Vladimir Zagorodnyu. Endocannabinoids, anandamide and 2-AG, regulate mechanosensitivity of mucosal afferents in the Guinea pig bladder. European journal of pharmacology. 2023-03-01. PMID:36858341. |
the inhibitory effect of maea is due to activation of both cb1 and cb2 cannabinoid receptors since it was abolished by combined application of selective cb1 (ness0327) and cb2 (sr144528) antagonists. |
2023-03-01 |
2023-08-14 |
Not clear |
| Grace A Johnson, Lucy Guerra, Asa Oxne. A Case of Panic Attacks Developing After 10 Years of Chronic Cannabis Use in a Patient With No Prior Psychiatric History. Cureus. vol 15. issue 1. 2023-02-27. PMID:36843769. |
inhibitory activity of cannabinoids (cb) at the cb1 and cb2 receptors centrally and peripherally mediate the therapeutic effects that are wielded for palliation of pain, anxiety, inflammation, and nausea in indicated conditions. |
2023-02-27 |
2023-08-14 |
Not clear |
| David A Bunsick, Jenna Matsukubo, Myron R Szewczu. Cannabinoids Transmogrify Cancer Metabolic Phenotype via Epigenetic Reprogramming and a Novel CBD Biased G Protein-Coupled Receptor Signaling Platform. Cancers. vol 15. issue 4. 2023-02-25. PMID:36831374. |
they bind to and activate two primary cannabinoid receptors, type 1 (cb1) and type 2 (cb2), and together with their metabolizing enzymes, form the endocannabinoid system. |
2023-02-25 |
2023-08-14 |
human |
| David A Bunsick, Jenna Matsukubo, Myron R Szewczu. Cannabinoids Transmogrify Cancer Metabolic Phenotype via Epigenetic Reprogramming and a Novel CBD Biased G Protein-Coupled Receptor Signaling Platform. Cancers. vol 15. issue 4. 2023-02-25. PMID:36831374. |
this review focuses on the role of cannabinoid receptors cb1 and cb2 signaling in activating numerous receptor tyrosine kinases and toll-like receptors in the induction of epigenetic landscape alterations in cancer cells, which might transmogrify cancer metabolism and epigenetic reprogramming to a metastatic phenotype. |
2023-02-25 |
2023-08-14 |
human |