| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sara Khosropoor, Mohaddeseh Sadat Alavi, Leila Etemad, Ali Roohbakhs. Cannabidiol goes nuclear: The role of PPARγ. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 114. 2023-03-25. PMID:36965374. |
in contrast to Δ9-tetrahydrocannabinol, it has a low affinity for cannabinoid receptors cb1 and cb2, thereby it does not induce significant psychoactive effects. |
2023-03-25 |
2023-08-14 |
Not clear |
| Francesco Matrisciano, Graziano Pinn. The Strategy of Targeting Peroxisome Proliferator-Activated Receptor (PPAR) in the Treatment of Neuropsychiatric Disorders. Advances in experimental medicine and biology. vol 1411. 2023-03-23. PMID:36949324. |
interestingly, ppars are considered functionally part of the extended endocannabinoid (ecb) system that includes the classic ecb, anandamide, which act at cannabinoid receptor types 1 (cb1) and 2 (cb2) and are implicated in the pathophysiology of stress-related neuropsychiatric disorders. |
2023-03-23 |
2023-08-14 |
Not clear |
| Rodrigo Zamith Cunha, Augusta Zannoni, Giulia Salamanca, Margherita De Silva, Riccardo Rinnovati, Alessandro Gramenzi, Monica Forni, Roberto Chiocchett. Expression of cannabinoid (CB1 and CB2) and cannabinoid-related receptors (TRPV1, GPR55, and PPARα) in the synovial membrane of the horse metacarpophalangeal joint. Frontiers in veterinary science. vol 10. 2023-03-20. PMID:36937015. |
expression of cannabinoid (cb1 and cb2) and cannabinoid-related receptors (trpv1, gpr55, and pparα) in the synovial membrane of the horse metacarpophalangeal joint. |
2023-03-20 |
2023-08-14 |
human |
| Magali Merrien, Agata M Wasik, Christopher M Melén, Mohammad Hamdy Abdelrazak Morsy, Kristina Sonnevi, Henna-Riikka Junlén, Birger Christensson, Björn E Wahlin, Birgitta Sande. 2-Arachidonoylglycerol Modulates CXCL12-Mediated Chemotaxis in Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia. Cancers. vol 15. issue 5. 2023-03-11. PMID:36900374. |
the biolipid 2-arachidonoylglycerol (2-ag), an agonist for the cannabinoid receptors cb1 and cb2, is released by stromal cells in the bone marrow. |
2023-03-11 |
2023-08-14 |
Not clear |
| Lauren Van Hov. A Cannabinoid Type 2 (CB2) Receptor Agonist Augments NOS-Dependent Responses of Cerebral Arterioles During Type 1 Diabetes. South Dakota medicine : the journal of the South Dakota State Medical Association. vol 75. issue 10. 2023-03-08. PMID:36889269. |
a cannabinoid type 2 (cb2) receptor agonist augments nos-dependent responses of cerebral arterioles during type 1 diabetes. |
2023-03-08 |
2023-08-14 |
Not clear |
| Lauren Van Hov. A Cannabinoid Type 2 (CB2) Receptor Agonist Augments NOS-Dependent Responses of Cerebral Arterioles During Type 1 Diabetes. South Dakota medicine : the journal of the South Dakota State Medical Association. vol 75. issue 10. 2023-03-08. PMID:36889269. |
while activation of cannabinoid (cb2) receptors has been shown to be neuroprotective, no studies have examined whether this neuroprotection is directed at cerebral arterioles and no studies have examined whether activation of cb2 receptors can rescue cerebrovascular dysfunction during a chronic disease state such as type 1 diabetes (t1d). |
2023-03-08 |
2023-08-14 |
Not clear |
| Laila Asth, Leonardo Cardoso Cruz, Nicholas Soyombo, Pedro Rigo, Fabrício A Moreir. Effects of β -caryophyllene, A Dietary Cannabinoid, in Animal Models of Drug Addiction. Current neuropharmacology. vol 21. issue 2. 2023-03-03. PMID:36173065. |
the mechanisms of action of bcp remain uncertain, possibly including full agonism at the cannabinoid cb2 receptor (cb2r). |
2023-03-03 |
2023-10-15 |
Not clear |
| Stewart Ramsay, Nick J Spencer, Vladimir Zagorodnyu. Endocannabinoids, anandamide and 2-AG, regulate mechanosensitivity of mucosal afferents in the Guinea pig bladder. European journal of pharmacology. 2023-03-01. PMID:36858341. |
endocannabinoids, anandamide (aea) and 2-arachidonolylglycerol (2-ag), are endogenous ligands of g-protein coupled cannabinoid receptors 1 and 2 (cb1 and cb2) found in the cns and peripheral organs. |
2023-03-01 |
2023-08-14 |
Not clear |
| Stewart Ramsay, Nick J Spencer, Vladimir Zagorodnyu. Endocannabinoids, anandamide and 2-AG, regulate mechanosensitivity of mucosal afferents in the Guinea pig bladder. European journal of pharmacology. 2023-03-01. PMID:36858341. |
the inhibitory effect of maea is due to activation of both cb1 and cb2 cannabinoid receptors since it was abolished by combined application of selective cb1 (ness0327) and cb2 (sr144528) antagonists. |
2023-03-01 |
2023-08-14 |
Not clear |
| Grace A Johnson, Lucy Guerra, Asa Oxne. A Case of Panic Attacks Developing After 10 Years of Chronic Cannabis Use in a Patient With No Prior Psychiatric History. Cureus. vol 15. issue 1. 2023-02-27. PMID:36843769. |
inhibitory activity of cannabinoids (cb) at the cb1 and cb2 receptors centrally and peripherally mediate the therapeutic effects that are wielded for palliation of pain, anxiety, inflammation, and nausea in indicated conditions. |
2023-02-27 |
2023-08-14 |
Not clear |
| David A Bunsick, Jenna Matsukubo, Myron R Szewczu. Cannabinoids Transmogrify Cancer Metabolic Phenotype via Epigenetic Reprogramming and a Novel CBD Biased G Protein-Coupled Receptor Signaling Platform. Cancers. vol 15. issue 4. 2023-02-25. PMID:36831374. |
they bind to and activate two primary cannabinoid receptors, type 1 (cb1) and type 2 (cb2), and together with their metabolizing enzymes, form the endocannabinoid system. |
2023-02-25 |
2023-08-14 |
human |
| David A Bunsick, Jenna Matsukubo, Myron R Szewczu. Cannabinoids Transmogrify Cancer Metabolic Phenotype via Epigenetic Reprogramming and a Novel CBD Biased G Protein-Coupled Receptor Signaling Platform. Cancers. vol 15. issue 4. 2023-02-25. PMID:36831374. |
this review focuses on the role of cannabinoid receptors cb1 and cb2 signaling in activating numerous receptor tyrosine kinases and toll-like receptors in the induction of epigenetic landscape alterations in cancer cells, which might transmogrify cancer metabolism and epigenetic reprogramming to a metastatic phenotype. |
2023-02-25 |
2023-08-14 |
human |
| Maura Argenziano, Vincenzo Pota, Alessandra Di Paola, Chiara Tortora, Maria Maddalena Marrapodi, Giulia Giliberti, Domenico Roberti, Maria Caterina Pace, Francesca Ross. CB2 Receptor as Emerging Anti-Inflammatory Target in Duchenne Muscular Dystrophy. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834757. |
they express the cb2 receptor, one of the main elements of the endocannabinoid system, and have been proposed as an anti-inflammatory target in several inflammatory and immune diseases. |
2023-02-25 |
2023-08-14 |
Not clear |
| Jennifer Ana Iden, Bitya Raphael-Mizrahi, Zamzam Awida, Aaron Naim, Dan Zyc, Tamar Liron, Melody Kasher, Gregory Livshits, Marilena Vered, Yankel Gabe. The Anti-Tumorigenic Role of Cannabinoid Receptor 2 in Colon Cancer: A Study in Mice and Humans. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835468. |
the endocannabinoid system, particularly cannabinoid receptor 2 (cb2 in mice and cnr2 in humans), has controversial pathophysiological implications in colon cancer. |
2023-02-25 |
2023-08-14 |
mouse |
| Gamal A Mohamed, Abdelsattar M Omar, Dana F AlKharboush, Mona A Fallatah, Ikhlas A Sindi, Dina S El-Agamy, Sabrin R M Ibrahi. Structure-Based Virtual Screening and Molecular Dynamics Simulation Assessments of Depsidones as Possible Selective Cannabinoid Receptor Type 2 Agonists. Molecules (Basel, Switzerland). vol 28. issue 4. 2023-02-25. PMID:36838749. |
endocannabinoid receptors (cb1 and cb2) are g-protein-coupled receptors (gpcrs), and their activation mediates many physiological processes. |
2023-02-25 |
2023-08-14 |
Not clear |
| Rosiane Aparecida Miranda, Vanessa Silva Tavares Rodrigues, Thamara Cherem Peixoto, Alex C Manhães, Egberto Gaspar de Moura, Patricia Cristina Lisbo. Nicotine exposure during breastfeeding alters the expression of endocannabinoid system biomarkers in female but not in male offspring at adulthood. Journal of developmental origins of health and disease. 2023-02-23. PMID:36815400. |
we evaluated protein expression of n-acylphosphatidylethanolamide-phospholipase d (nape-pld), fatty acid amide hydrolase (faah), diacylglycerol lipase (dagl), monoacylglycerol lipase (magl) and cannabinoid receptors (cb1 and/or cb2) in lateral hypothalamus, paraventricular nucleus of the hypothalamus, liver, visceral adipose tissue (vat), adrenal and thyroid. |
2023-02-23 |
2023-08-14 |
rat |
| Ana Laura Torres-Román, Karla Lucero Rodríguez-Flores, Víctor Manuel Hernández-Mora, Erika Ruiz-García, Oscar Prospero-García, Alberto Guijosa, Anayansi Molina, Marcela Morales-Mulia, Michael Aschner, Abel Santamaría, Alette Ortega-Góme. Examining the Role of Histaminergic, Orexinergic, and Cannabinergic Systems in Redox Regulation in Gastric Adenocarcinoma. Mini reviews in medicinal chemistry. 2023-02-22. PMID:36809932. |
lastly, cannabinoid type 2 (cb2) receptor agonists increase ros, leading to the activation of apoptotic pathways. |
2023-02-22 |
2023-08-14 |
Not clear |
| A García-Blanco, Á Ramírez-López, F Navarrete, M S García-Gutiérrez, J Manzanares, E Martín-García, R Maldonad. Role of CB2 cannabinoid receptor in the development of food addiction in male mice. Neurobiology of disease. 2023-02-12. PMID:36775043. |
the cannabinoid cb2 receptor (cb2r) is expressed in brain areas canonically associated with addictive-like behavior and was linked to drug-addictive properties. |
2023-02-12 |
2023-08-14 |
mouse |
| Yongsoon Park, Bruce A Watkin. Dietary PUFAs and Exercise Dynamic Actions on Endocannabinoids in Brain: Consequences for Neural Plasticity and Neuroinflammation. Advances in nutrition (Bethesda, Md.). vol 13. issue 5. 2023-02-11. PMID:36774087. |
the ecbs bind to cannabinoid receptors cb1 and cb2 to exert a wide range of activities, such as stimulating appetite, influencing energy metabolism, supporting the immune system, and facilitating neuroplasticity. |
2023-02-11 |
2023-08-14 |
Not clear |
| Ghada A Omran, Eman S H Abd Allah, Sherine Ahmed Mohammed, Doaa M El Shehab. Behavioral, biochemical and histopathological toxic profiles induced by sub-chronic cannabimimetic WIN55, 212-2 administration in mice. BMC pharmacology & toxicology. vol 24. issue 1. 2023-02-08. PMID:36750905. |
win55, 212-2 mesylate is a synthetic cannabinoid (sc) agonist of cb1 and cb2 receptors with much higher affinity to cb1 receptor than tetrahydrocannabinol and many potential therapeutic effects. |
2023-02-08 |
2023-08-14 |
mouse |