| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan-Ran Wu, Jia-Qin Tang, Wan-Nian Zhang, Chun-Lin Zhuang, Ying Sh. Rational drug design of CB2 receptor ligands: from 2012 to 2021. RSC advances. vol 12. issue 54. 2022-12-21. PMID:36540233. |
cannabinoid receptors belong to the large family of g-protein-coupled receptors, which can be divided into two receptor types, cannabinoid receptor type-1 (cb1) and cannabinoid receptor type-2 (cb2). |
2022-12-21 |
2023-08-14 |
Not clear |
| Natasha M C Oliveira, Dayane A Machado, Thauann L da Silva, Gabriel T do Val. Treatment with Cannabidiol Results in an Antioxidant and Cardioprotective Effect in Several Pathophysiologies. Current hypertension reviews. vol 18. issue 2. 2022-12-12. PMID:36508270. |
it is made up of type 1 (cb1) and type 2 (cb2) cannabinoid receptors. |
2022-12-12 |
2023-08-14 |
Not clear |
| Tamara T Lah, Bernarda Majc, Metka Novak, Ajda Sušnik, Barbara Breznik, Andrej Porčnik, Roman Bošnjak, Aleksander Sadikov, Marta Malavolta, Selma Halilčević, Jernej Mlakar, Roby Zome. The Cytotoxic Effects of Cannabidiol and Cannabigerol on Glioblastoma Stem Cells May Mostly Involve GPR55 and TRPV1 Signalling. Cancers. vol 14. issue 23. 2022-12-11. PMID:36497400. |
the large g-protein-coupled receptor family includes cannabinoid receptors cb1, cb2, gpr55, and non-specific ion receptor protein transporters trps. |
2022-12-11 |
2023-08-14 |
Not clear |
| Marcia G Honig, Nobel A Del Mar, Bob M Moore, Anton Reine. Raloxifene Mitigates Emotional Deficits after Mild Traumatic Brain Injury in Mice. Neurotrauma reports. vol 3. issue 1. 2022-12-08. PMID:36479361. |
we have previously reported that mice show increased depression, fearfulness, and anxiety, as well as visual and motor deficits, after focal cranial blast and that treatment with the cannabinoid type 2 receptor (cb2) inverse agonist, smm-189, reduces these deficits. |
2022-12-08 |
2023-08-14 |
mouse |
| Maria Sofia Basile, Emanuela Mazzo. The Role of Cannabinoid Type 2 Receptors in Parkinson's Disease. Biomedicines. vol 10. issue 11. 2022-11-26. PMID:36428554. |
cannabinoid type 2 (cb2) receptors, one of the components of the endocannabinoid system, can regulate neuroinflammation in pd. |
2022-11-26 |
2023-08-14 |
Not clear |
| Lawrence M Carey, Zhili Xu, Gabriela Rajic, Alexandros Makriyannis, Julian Romero, Cecilia Hillard, Ken Mackie, Andrea G Hohman. Peripheral sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of anti-retroviral toxic neuropathy. Pharmacological research. 2022-11-23. PMID:36417942. |
peripheral sensory neuron cb2 cannabinoid receptors are necessary for both cb2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of anti-retroviral toxic neuropathy. |
2022-11-23 |
2023-08-14 |
mouse |
| Lawrence M Carey, Zhili Xu, Gabriela Rajic, Alexandros Makriyannis, Julian Romero, Cecilia Hillard, Ken Mackie, Andrea G Hohman. Peripheral sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of anti-retroviral toxic neuropathy. Pharmacological research. 2022-11-23. PMID:36417942. |
we characterized the impact of two cb2 cannabinoid agonists (am1710 and ly2828360 - ligands differing in signaling bias and cns penetration) on neuropathic nociception induced by the antiretroviral agent zalcitabine (2'-3'-dideoxycitidine; ddc). |
2022-11-23 |
2023-08-14 |
mouse |
| Monika Vidlarova, Emil Berta, Petr Prasil, Andrea Prokopova, Sona Gurska, Marta Khoylou, Alona Rehulkova, Pavla Kourilova, Josef Chudacek, Marek Szkorupa, Jiri Klein, Jozef Skarda, Josef Srovnal, Marian Hajduc. Cannabinoid receptor 2 expression in early-stage non-small cell lung cancers identifies patients with good prognosis and longer survival. Translational lung cancer research. vol 11. issue 10. 2022-11-17. PMID:36386452. |
since the endogenous cannabinoid system is involved in both carcinogenesis and anticancer immune defense, we hypothesized that tumor tissue expression of cannabinoid 1 and 2 receptors (cb1 and cb2) may affect survival. |
2022-11-17 |
2023-08-14 |
Not clear |
| Özge Boyacıoğlu, Petek Korkusu. Cannabinoids as Prospective Anti-Cancer Drugs: Mechanism of Action in Healthy and Cancer Cells. Advances in experimental medicine and biology. 2022-11-17. PMID:36396926. |
endogenous and exogenous cannabinoids modulate many physiological and pathological processes by binding classical cannabinoid receptors 1 (cb1) or 2 (cb2) or non-cannabinoid receptors. |
2022-11-17 |
2023-08-14 |
Not clear |
| Fathima Hajee Basha, Mohammad Waseem, Hemalatha Srinivasa. Promising Action of Cannabinoids on ER Stress-Mediated Neurodegeneration: An In Silico Investigation. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 41. issue 4. 2022-11-14. PMID:36374961. |
in our study, three cannabinoid receptors (cb1, cb2, and cb3) were considered to demonstrate their neuroprotective actions. |
2022-11-14 |
2023-08-14 |
Not clear |
| Shang Qiu, Xiunan Wu, Dechun Geng, Wenzhen Pan, Zheng Li, Gang Wang, Daen Li, Cheng Li, Shuo Feng, Liang Zhu, Yaozeng Xu, Fenglei Ga. H International journal of biological macromolecules. 2022-11-13. PMID:36372104. |
here, the hollow mesoporous copper sulfide (cus) was used as the carrier skeleton and the cannabinoid type 2 (cb2) receptor agonist jwh133 was efficiently loaded inside of cus through adsorption, then the outer layer was modified with hyaluronic acid (ha) to prevent the leakage of internal drugs. |
2022-11-13 |
2023-08-14 |
mouse |
| Jaqueline M Franzen, Isabel Werle, Felipe Vanz, Bruno Biscaia de Oliveira, Laura Maria Martins Nascimento, Francisco S Guimarães, Leandro J Bertogli. Cannabidiol attenuates fear memory expression in female rats via hippocampal 5-HT Neuropharmacology. 2022-11-05. PMID:36334768. |
in subsequent experiments, we investigated the estrous cycle effects and the contribution of dorsal hippocampus (dh) serotonin 1a (5-ht1a) and cannabinoid types 1 (cb1) and 2 (cb2) receptors to cbd-induced effects on memory retrieval/expression. |
2022-11-05 |
2023-08-14 |
human |
| César E Martinez Ramirez, Gonzalo Ruiz-Pérez, Todd M Stollenwerk, Christina Behlke, Ashley Doherty, Cecilia J Hillar. Endocannabinoid signaling in the central nervous system. Glia. 2022-10-29. PMID:36308424. |
cb2 cannabinoid receptors are difficult to detect in the cns but seem to "punch above their weight" as compounds targeting these receptors have significant effects on inflammatory state and behavior. |
2022-10-29 |
2023-08-14 |
Not clear |
| Esty Goldberger, Merav Tauber, Yair Ben-Chai. Voltage dependence of the cannabinoid CB1 receptor. Frontiers in pharmacology. vol 13. 2022-10-28. PMID:36304142. |
cannabinoids produce their characteristic effects mainly by binding to two types of g-protein coupled receptors (gpcrs), the cb1 and cb2 cannabinoid receptors. |
2022-10-28 |
2023-08-14 |
Not clear |
| Ana Tadijan, Ignacija Vlašić, Josipa Vlainić, Domagoj Đikić, Nada Oršolić, Maja Jazvinšćak Jembre. Intracellular Molecular Targets and Signaling Pathways Involved in Antioxidative and Neuroprotective Effects of Cannabinoids in Neurodegenerative Conditions. Antioxidants (Basel, Switzerland). vol 11. issue 10. 2022-10-27. PMID:36290771. |
cannabinoids are able to neutralize free radicals and modulate the production of reactive oxygen species and the activity of antioxidative systems acting on cb1 and cb2 cannabinoid receptors. |
2022-10-27 |
2023-08-14 |
Not clear |
| Sanela Rajlic, Luise Surmann, Pia Zimmermann, Christina Katharina Weisheit, Laura Bindila, Hendrik Treede, Markus Velten, Andreas Daiber, Georg Daniel Duer. Fatty Acid Amide Hydrolase Deficiency Is Associated with Deleterious Cardiac Effects after Myocardial Ischemia and Reperfusion in Mice. International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36293543. |
cannabinoid type-2 receptor (cb2) deficiency led to increased apoptosis and infarctions with worsened lv function in ischemic cardiomyopathy. |
2022-10-27 |
2023-08-14 |
mouse |
| Aitor Benedicto, Beatriz Arteta, Andrea Duranti, Daniel Alonso-Alconad. The Synthetic Cannabinoid URB447 Exerts Antitumor and Antimetastatic Effect in Melanoma and Colon Cancer. Pharmaceuticals (Basel, Switzerland). vol 15. issue 10. 2022-10-27. PMID:36297277. |
we used the synthetic cannabinoid urb447, a known cb2 agonist and cb1 antagonist drug, and studied prometastatic ability of mouse b16 melanoma and mca38 crc cells, by means of proliferation, apoptosis, cell cycle, migration and matrix degradation in vitro upon urb447 treatment. |
2022-10-27 |
2023-08-14 |
mouse |
| Reem Smoum, Uwe Grether, Meliha Karsak, Andrea J Vernall, Frank Park, Cecilia J Hillard, Pal Pache. Editorial: Therapeutic potential of the cannabinoid CB2 receptor. Frontiers in pharmacology. vol 13. 2022-10-24. PMID:36278235. |
editorial: therapeutic potential of the cannabinoid cb2 receptor. |
2022-10-24 |
2023-08-14 |
Not clear |
| Laura M Navarro-Saiz, Lilia J Bernal-Cepeda, Jaime E Castellano. Immune challenges upregulate the expression of cannabinoid receptors in cultured human odontoblasts and gingival fibroblasts. Acta odontologica latinoamericana : AOL. vol 35. issue 2. 2022-10-19. PMID:36260938. |
cannabinoid receptors (cb1 and cb2) are involved in analgesia by modulating the función of calcium channels that inhibit the synthesis of some neurotransmitters. |
2022-10-19 |
2023-08-14 |
human |
| Laura M Navarro-Saiz, Lilia J Bernal-Cepeda, Jaime E Castellano. Immune challenges upregulate the expression of cannabinoid receptors in cultured human odontoblasts and gingival fibroblasts. Acta odontologica latinoamericana : AOL. vol 35. issue 2. 2022-10-19. PMID:36260938. |
cb1 and cb2 transcription was analyzed by real-time pcr, proteins were detected by immunofluorescence, and functional cannabinoid receptors were evaluated by measuring intracellular calcium concentration after stimulation with cannabidiol (cbd) and pre-treatment with a cb1 antagonist, a cb2 inverse agonist and a trpv1 antagonist. |
2022-10-19 |
2023-08-14 |
human |