| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Analia Young Hwa Cho, Hery Chung, Javier Romero-Parra, Poulami Kumar, Marco Allarà, Alessia Ligresti, Carlos Gallardo-Garrido, Hernán Pessoa-Mahana, Mario Faúndez, Carlos David Pessoa-Mahan. Motifs in Natural Products as Useful Scaffolds to Obtain Novel Benzo[ International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446093. |
its two main receptors, cannabinoid type 1 (cb1) and type 2 (cb2) receptors, mediate anti-inflammatory responses; however, their differing patterns of expression make the development of cb2-selective ligands therapeutically more attractive. |
2023-07-14 |
2023-08-14 |
Not clear |
| Liana Arceri, Thanh Khoa Nguyen, Shannon Gibson, Sophia Baker, Rebecca A Winger. Cannabinoid Signaling in Kidney Disease. Cells. vol 12. issue 10. 2023-07-06. PMID:37408253. |
the two cannabinoid receptors, cb1 and cb2, are cell membrane proteins that interact with both exogenous and endogenous bioactive lipid ligands, or endocannabinoids. |
2023-07-06 |
2023-08-14 |
human |
| Dina Medina-Vera, Hongjing Zhao, Erika Bereczki, Cristina Rosell-Valle, Makoto Shimozawa, Gefei Chen, Fernando Rodríguez de Fonseca, Per Nilsson, Simone Tambar. The Expression of the Endocannabinoid Receptors CB2 and GPR55 Is Highly Increased during the Progression of Alzheimer's Disease in Biology. vol 12. issue 6. 2023-06-28. PMID:37372090. |
the expression of the endocannabinoid receptors cb2 and gpr55 is highly increased during the progression of alzheimer's disease in the endocannabinoid system (ecs) and associated lipid transmitter-based signaling systems play an important role in modulating brain neuroinflammation. |
2023-06-28 |
2023-08-14 |
Not clear |
| Dina Medina-Vera, Hongjing Zhao, Erika Bereczki, Cristina Rosell-Valle, Makoto Shimozawa, Gefei Chen, Fernando Rodríguez de Fonseca, Per Nilsson, Simone Tambar. The Expression of the Endocannabinoid Receptors CB2 and GPR55 Is Highly Increased during the Progression of Alzheimer's Disease in Biology. vol 12. issue 6. 2023-06-28. PMID:37372090. |
here we have evaluated the non-psychotropic endocannabinoid receptor type 2 (cb2) and lysophosphatidylinositol g-protein-coupled receptor 55 (gpr55) localization and expression during aβ-pathology progression. |
2023-06-28 |
2023-08-14 |
Not clear |
| Kelsey G Guenther, Zhili Xu, Julian Romero, Cecilia J Hillard, Ken Mackie, Andrea G Hohman. Conditional deletion of CB2 cannabinoid receptors from peripheral sensory neurons eliminates CB2-mediated antinociceptive efficacy in a mouse model of carrageenan-induced inflammatory pain. Neuropharmacology. 2023-06-07. PMID:37286073. |
conditional deletion of cb2 cannabinoid receptors from peripheral sensory neurons eliminates cb2-mediated antinociceptive efficacy in a mouse model of carrageenan-induced inflammatory pain. |
2023-06-07 |
2023-08-14 |
mouse |
| Karina Henrique Binda, Marucia Chacur, Daniel Oliveira Martin. Exercise Improves Orofacial Pain and Modifies Neuropeptide Expression in a Rat Model of Parkinson's Disease. Neurotoxicity research. 2023-06-02. PMID:37266893. |
in order to confirm the possible involvement of cannabinoid receptors, we also injected antagonists of cb1 and cb2 receptors. |
2023-06-02 |
2023-08-14 |
rat |
| Cristina Izquierdo-Luengo, Marc Ten-Blanco, María Ponce-Renilla, Ramiro Perezzan, Inmaculada Pereda-Pérez, Fernando Berrender. Adolescent exposure to the Spice/K2 cannabinoid JWH-018 impairs sensorimotor gating and alters cortical perineuronal nets in a sex-dependent manner. Translational psychiatry. vol 13. issue 1. 2023-05-24. PMID:37225721. |
a transitory decrease in the expression of gad67 and cb2 cannabinoid receptors in the prefrontal cortex was also found in male mice exposed to jwh-018. |
2023-05-24 |
2023-08-14 |
mouse |
| Jennifer Ana Iden, Bitya Raphael-Mizrahi, Aaron Naim, Albert Kolomansky, Tamar Liron, Drorit Neumann, Marilena Vered, Yankel Gabe. The Anti-Tumorigenic Role of Cannabinoid Receptor 2 in Non-Melanoma Skin Cancer. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175480. |
the dysregulation of the endocannabinoid system, particularly cannabinoid receptor 2 (cb2), is implicated in skin cancer development, progression, and metastasis. |
2023-05-14 |
2023-08-14 |
Not clear |
| Margaryta Tevosian, Hristo Todorov, Ermelinda Lomazzo, Laura Bindila, Natsuo Ueda, Davide Bassetti, Davide Warm, Sergei Kirischuk, Heiko J Luhmann, Susanne Gerber, Beat Lut. NAPE-PLD deletion in stress-TRAPed neurons results in an anxiogenic phenotype. Translational psychiatry. vol 13. issue 1. 2023-05-06. PMID:37149657. |
anandamide (aea) is an endogenous ligand of the cannabinoid cb1 and cb2 receptors, being a component of the endocannabinoid signaling system, which supports the maintenance or regaining of neural homeostasis upon internal and external challenges. |
2023-05-06 |
2023-08-14 |
mouse |
| Sumit S Rathod, Yogeeta O Agrawa. Phytocannabinoids as Potential Multitargeting Neuroprotectants in Alzheimer's Disease. Current drug research reviews. 2023-05-03. PMID:37132109. |
the present article also discusses the implications of cannabinoid receptors (cb1 and cb2) as well as cannabinoid enzymes (faah and magl) modulators in ad. |
2023-05-03 |
2023-08-14 |
Not clear |
| Ankush Kumar, Ojasvi Gupta, Rohit Bhatia, VikramDeep Mong. Impact of Cannabinoid Receptors in the Design of Therapeutic Agents against Human Ailments. Current topics in medicinal chemistry. 2023-05-03. PMID:37132103. |
the endocannabinoid system comprises canna-binoid receptors cb1 and cb2, which belong to g-protein coupled receptors (gpcrs). |
2023-05-03 |
2023-08-14 |
human |
| Noa Raz, Aharon M Eyal, Dana Berneman Zeitouni, Danielle Hen-Shoval, Elyad M Davidson, Aviel Danieli, Merav Tauber, Yair Ben-Chai. SELECTED CANNABIS TERPENES SYNERGIZE WITH THC TO PRODUCE INCREASED CB1 RECEPTOR ACTIVATION. Biochemical pharmacology. 2023-04-21. PMID:37084981. |
the cannabis plant exerts its pharmaceutical activity primarily by the binding of cannabinoids to two g protein-coupled cannabinoid receptors, cb1 and cb2. |
2023-04-21 |
2023-08-14 |
Not clear |
| Nathaniel A K Glenn, David B Finlay, Emma R Carruthers, Kathleen G Mountjoy, Christopher S Walker, Natasha L Grimse. RAMP and MRAP Accessory Proteins have Selective Effects on Expression and Signalling of the CB1, CB2, GPR18 and GPR55 Cannabinoid Receptors. British journal of pharmacology. 2023-04-21. PMID:37085333. |
ramp and mrap accessory proteins have selective effects on expression and signalling of the cb1, cb2, gpr18 and gpr55 cannabinoid receptors. |
2023-04-21 |
2023-08-14 |
Not clear |
| Berhanu Geresu Kibret, Aaliyah Roberts, Adam Kneebone, Shymaa Embaby, Justin Fernandez, Qing-Rong Liu, Emmanuel S Onaiv. Cannabinoid CB2 receptors modulate alcohol induced behavior, and neuro-immune dysregulation in mice. Behavioural brain research. 2023-04-15. PMID:37061199. |
cannabinoid cb2 receptors modulate alcohol induced behavior, and neuro-immune dysregulation in mice. |
2023-04-15 |
2023-08-14 |
mouse |
| Lizbeth Magnolia Martínez-Aguilar, Alfredo Ibarra-Sánchez, Daniel José Guerrero-Morán, Marina Macías-Silva, Jesús Omar Muñoz-Bello, Alejandro Padilla, Marcela Lizano, Claudia González-Espinos. Lysophosphatidylinositol Promotes Chemotaxis and Cytokine Synthesis in Mast Cells with Differential Participation of GPR55 and CB2 Receptors. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047288. |
the lpi and o1602-dependent stimulation of bmmc also led to vegf, tnf, il-1α, and il-1β mrna accumulation, but, in contrast with chemotaxis-related processes, the effects on cytokine transcription were dependent on gpr55 and cannabinoid (cb) 2 receptors, since they were sensitive to ml193 and to the specific cb2 receptor antagonist am630. |
2023-04-13 |
2023-08-14 |
mouse |
| Daniela Navarro-Acosta, Ludis Coba-Jimenez, Alfredo Perez-Gamboa, Nestor Cubillan, Ricardo Vivas-Reye. QSAR Modelling of Biological Activity in Cannabinoids with Quantum Similarity Combinations of Charge Fitting Schemes and 3D-QSAR. Chemistry & biodiversity. 2023-04-07. PMID:37029452. |
the pubchem[https://pubchem.ncbi.nlm.nih.gov/] database provided the geometries, binding affinities(ki) to the cannabinoid receptors type 1(cb1) and 2(cb2), and the median lethal dose(ld50) to breast cancer cells. |
2023-04-07 |
2023-08-14 |
Not clear |
| b' Bruno M Fonseca, Niloy Bhowmick, Sara Cunha, Jo\\xc3\\xa3o Maia, Georgina Correia-da-Silva, Nat\\xc3\\xa9rcia Teixeira, Susana I S\\xc3\\xa. Long-Term Tamoxifen Effects in the Cyclic Interaction of the Endocannabinoid and Endocrine System in the Rat Central Nervous System. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979699.' |
within the female reproductive tract, estrogen increases the expression of the cannabinoid receptors cb1 and cb2, and modifies the levels of anandamide (aea), the major endocannabinoid, by altering the expression of both aea synthesis (nape-pld) and catabolic enzymes (faah). |
2023-03-29 |
2023-08-14 |
rat |
| Nuchjira Takheaw, Kanyaruck Jindaphun, Supansa Pata, Witida Laopajon, Watchara Kasinrer. Cannabinoid Receptor 1 Agonist ACEA and Cannabinoid Receptor 2 Agonist GW833972A Attenuates Cell-Mediated Immunity by Different Biological Mechanisms. Cells. vol 12. issue 6. 2023-03-29. PMID:36980189. |
cannabinoid receptor 1 (cb1) and cannabinoid receptor 2 (cb2) are components in the endocannabinoid system that play significant roles in regulating immune responses. |
2023-03-29 |
2023-08-14 |
Not clear |
| Mengya Wang, Man Liu, Zegang M. Cannabinoid type 2 receptor activation inhibits MPP Molecular biology reports. 2023-03-28. PMID:36977807. |
cannabinoid type 2 receptor activation inhibits mpp growing evidence indicates that cannabinoid type 2 (cb2) receptor activation inhibits neuroinflammation in the pathogenesis of parkinson's disease (pd). |
2023-03-28 |
2023-08-14 |
Not clear |
| Sara Khosropoor, Mohaddeseh Sadat Alavi, Leila Etemad, Ali Roohbakhs. Cannabidiol goes nuclear: The role of PPARγ. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 114. 2023-03-25. PMID:36965374. |
in contrast to Δ9-tetrahydrocannabinol, it has a low affinity for cannabinoid receptors cb1 and cb2, thereby it does not induce significant psychoactive effects. |
2023-03-25 |
2023-08-14 |
Not clear |