| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huaqiang Tao, Xueyan Li, Miao Chu, Qiufei Wang, Ping Li, Qibin Han, Kai Chen, Pengfei Zhu, Yuefeng Hao, Xing Yang, Dechun Geng, Ye G. CB2 regulates oxidative stress and osteoclastogenesis through NOX1-dependent signaling pathway in titanium particle-induced osteolysis. Cell death discovery. vol 9. issue 1. 2023-12-19. PMID:38104087. |
cannabinoid type ii receptor (cb2) is a seven-transmembrane receptor that is predominantly distributed in the human immune system and has been revealed to be highly expressed in bone-associated cells. |
2023-12-19 |
2023-12-21 |
human |
| Yan Costa Gonçalves, Karina Carla de Francisco Campos, Eliton da Silva Vasconcelos, Beatriz Micucci D'Almeida Eça, Francisco Tadeu Rantin, Ana Lúcia Kalinin, Diana Amaral Monteir. Activation of the cannabinoid type 2 (CB2) receptor improves cardiac contractile performance in fish, Brycon amazonicus. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-12-19. PMID:38113964. |
activation of the cannabinoid type 2 (cb2) receptor improves cardiac contractile performance in fish, brycon amazonicus. |
2023-12-19 |
2023-12-23 |
Not clear |
| Yan Costa Gonçalves, Karina Carla de Francisco Campos, Eliton da Silva Vasconcelos, Beatriz Micucci D'Almeida Eça, Francisco Tadeu Rantin, Ana Lúcia Kalinin, Diana Amaral Monteir. Activation of the cannabinoid type 2 (CB2) receptor improves cardiac contractile performance in fish, Brycon amazonicus. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-12-19. PMID:38113964. |
in addition to their well-known classical effects, cannabinoid cb1 and cb2 receptors have also been involvement in both deleterious and protective actions on the heart under various pathological conditions. |
2023-12-19 |
2023-12-23 |
Not clear |
| Yan Costa Gonçalves, Karina Carla de Francisco Campos, Eliton da Silva Vasconcelos, Beatriz Micucci D'Almeida Eça, Francisco Tadeu Rantin, Ana Lúcia Kalinin, Diana Amaral Monteir. Activation of the cannabinoid type 2 (CB2) receptor improves cardiac contractile performance in fish, Brycon amazonicus. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-12-19. PMID:38113964. |
while the potential therapeutic applications of the endocannabinoid system in the context of cardiovascular function are indeed a viable prospect, significant debate exists within the literature regarding whether cb1, cb2, or a combination of both receptors exert a favorable influence on cardiac function. |
2023-12-19 |
2023-12-23 |
Not clear |
| Oualid Abboussi, Zmarak Ahmad Khan, Hind Ibork, Simo S Zulu, William Daniels, Khalid Taghzouti, Tim G Hale. CB2 agonist mitigates cocaine-induced reinstatement of place preference and modulates the inflammatory response in mice. Behavioural pharmacology. 2023-12-12. PMID:38085651. |
in this study, we sought to investigate the therapeutic potential of the cannabinoid cb2 receptor agonist, jwh-133, in mitigating cocaine-induced inflammation and associated motivational behavioural alterations in an in vivo model. |
2023-12-12 |
2023-12-17 |
mouse |
| Oualid Abboussi, Zmarak Ahmad Khan, Hind Ibork, Simo S Zulu, William Daniels, Khalid Taghzouti, Tim G Hale. CB2 agonist mitigates cocaine-induced reinstatement of place preference and modulates the inflammatory response in mice. Behavioural pharmacology. 2023-12-12. PMID:38085651. |
moreover, they shed light on the intricate interplay between the endocannabinoid system and cocaine-induced neurobiological changes, paving the way for potential therapeutic interventions targeting cb2 receptors in the context of cocaine addiction and associated behavioural deficits. |
2023-12-12 |
2023-12-17 |
mouse |
| Mahla Masoumi, Mohammad Amin Manavi, Razieh Mohammad Jafari, Alireza Mirzaei, Keshvad Hedayatyanfard, Mohammad Taghi Beigmohammadi, Ahmad Reza Dehpou. Cannabidiol Anticonvulsant Effects Against Lithium-Pilocarpine-Induced Status Epilepticus in Male Rats Are Mediated by Neuroinflammation Modulation and Cannabinoids 1 (CB1), But Not CB2 and GABA Cannabis and cannabinoid research. 2023-11-17. PMID:37976207. |
cannabidiol anticonvulsant effects against lithium-pilocarpine-induced status epilepticus in male rats are mediated by neuroinflammation modulation and cannabinoids 1 (cb1), but not cb2 and gaba |
2023-11-17 |
2023-11-20 |
rat |
| Marizia Trevizani, Laís Lopardi Leal, João Vitor Paes Rettore, Gilson Costa Macedo, Caio César de Souza Alves, Sandra Bertelli Ribeiro de Castro, Antônio Márcio Resende do Carmo, Silvioney Augusto da Silva, Carlos Magno da Costa Maranduba, Fernando de Sá Silv. Tumor necrosis factor α, and agonist and antagonists of cannabinoid receptor type 1 and type 2 alter the immunophenotype of stem cells from human exfoliated deciduous teeth. Einstein (Sao Paulo, Brazil). vol 21. 2023-11-16. PMID:37970951. |
to verify the involvement of the endocannabinoid system in the immunomodulatory profile of stem cells from human exfoliated deciduous teeth, in the presence or absence of tnf-α, and agonist and antagonists of cb1 and cb2. |
2023-11-16 |
2023-11-20 |
human |
| Misaki Oyama, Misaki Sakamoto, Kazuki Kitabatake, Kanami Shiina, Daisuke Kitahara, Sohei Onozawa, Keisuke Nishino, Yuka Sudo, Mitsutoshi Tsukimot. Involvement of cannabinoid receptors and adenosine A2B receptor in enhanced migration of lung cancer A549 cells induced by γ-ray irradiation. Biological & pharmaceutical bulletin. 2023-11-05. PMID:37926527. |
g-protein-coupled receptors (gpcrs) such as adenosine a2b receptor and cannabinoid receptors (cb1, cb2 and gpr55) may be involved, as they are known to have roles in proliferation, invasion, migration and tumor growth. |
2023-11-05 |
2023-11-08 |
human |
| Misaki Oyama, Misaki Sakamoto, Kazuki Kitabatake, Kanami Shiina, Daisuke Kitahara, Sohei Onozawa, Keisuke Nishino, Yuka Sudo, Mitsutoshi Tsukimot. Involvement of cannabinoid receptors and adenosine A2B receptor in enhanced migration of lung cancer A549 cells induced by γ-ray irradiation. Biological & pharmaceutical bulletin. 2023-11-05. PMID:37926527. |
our results indicate that a2b receptors and cannabinoid cb1, cb2 and gpr55 receptors all contribute to γ-radiation-induced acquisition of malignant phenotypes, and in particular that interactions of a2b receptor and cannabinoid cb2 and gpr55 receptors play a role in promoting cell migration and actin remodeling. |
2023-11-05 |
2023-11-08 |
human |
| Jingjing Zhang, Yali Zhu, Shuxian Chen, Zujin Xu, Bin Zhang, Anpeng Liu, Qianwen He, Jia Zha. Activation of cannabinoid receptors 2 alleviates myocardial damage in cecal ligation and puncture-induced sepsis by inhibiting pyroptosis. Immunology letters. 2023-11-02. PMID:37918639. |
it has been reported that cannabinoid receptors 2 (cb2 receptors) play an important role in the pathophysiological process of sepsis, which may also be associated with the regulation of pyroptosis, an inflammatory programmed cell death. |
2023-11-02 |
2023-11-08 |
mouse |
| Jonathan Paulo Agnes, Barbara Dos Santos, Raquel Nascimento das Neves, Vitória Maria Marques Luciano, Larissa Benvenutti, Fernanda Capitanio Goldoni, Roberta Giusti Schran, José Roberto Santin, Nara Lins Meira Quintão, Alfeu Zanotto-Filh. β-Caryophyllene Inhibits Oxaliplatin-Induced Peripheral Neuropathy in Mice: Role of Cannabinoid Type 2 Receptors, Oxidative Stress and Neuroinflammation. Antioxidants (Basel, Switzerland). vol 12. issue 10. 2023-10-30. PMID:37891972. |
in this study, we investigated the antiallodynic effect of β-caryophyllene (bcp), a cannabinoid type 2 (cb2) receptor agonist, in a mouse model of oipn. |
2023-10-30 |
2023-11-08 |
mouse |
| Sumit S Rathod, Yogeeta O Agrawal, Kartik T Nakhate, M F Nagoor Meeran, Shreesh Ojha, Sameer N Goya. Neuroinflammation in the Central Nervous System: Exploring the Evolving Influence of Endocannabinoid System. Biomedicines. vol 11. issue 10. 2023-10-30. PMID:37893016. |
both cb1 and cb2 cannabinoid receptors exhibit noteworthy physiological responses and possess diverse neuromodulatory capabilities. |
2023-10-30 |
2023-11-08 |
Not clear |
| Katarzyna Stachowic. Deciphering the mechanisms of reciprocal regulation or interdependence at the cannabinoid CB1 receptors and cyclooxygenase-2 level: Effects on mood, cognitive implications, and synaptic signaling. Neuroscience and biobehavioral reviews. 2023-10-28. PMID:37898448. |
the lipid endocannabinoid system refers to endogenous cannabinoids (ecbs), the enzymes involved in their synthesis and metabolism, and the g protein-coupled cannabinoid receptors (gpcrs), cb1, and cb2. |
2023-10-28 |
2023-11-08 |
Not clear |
| Bradley L Hoare, David N Tippett, Amandeep Kaur, Sean A Cullum, Tamara Miljuš, Eline J Koers, Clare R Harwood, Nicola Dijon, Nicholas D Holliday, David A Sykes, Dmitry Veprintse. ThermoBRET: A Ligand-Engagement Nanoscale Thermostability Assay Applied to GPCRs. Chembiochem : a European journal of chemical biology. 2023-10-24. PMID:37872746. |
here, we present a thermobret method to quantify the relative thermostability of g protein coupled receptors (gpcrs), using cannabinoid receptors (cb1 and cb2) and the b2-adrenoceptor (b2ar) as model systems. |
2023-10-24 |
2023-11-08 |
Not clear |
| Jacob N Kisiolek, Victoria A Flores, Arjun Ramani, Blake Butler, James M Haughian, Laura K Stewar. Eight Weeks of Daily Cannabidiol Supplementation Improves Sleep Quality and Immune Cell Cytotoxicity. Nutrients. vol 15. issue 19. 2023-10-14. PMID:37836465. |
the endocannabinoid system is active in nervous and immune cells and involves the expression of two cannabinoid receptor genes (cb1 and cb2), along with endogenous endocannabinoid ligands, 2-arachidonoyl glycerol (2-ag) and arachidonoyl ethanolamide (anandamide), and their synthetic enzymes. |
2023-10-14 |
2023-10-15 |
Not clear |
| Yu-Shan Lin, Wen-Hou Huang, Keng-Fu Hsu, Ming-Jer Tang, Wen-Tai Chi. Reversion of chemoresistance by endocannabinoid-induced ER stress and autophagy activation in ovarian cancer. American journal of cancer research. vol 13. issue 9. 2023-10-11. PMID:37818056. |
our results showed that ovc cells expressed both cannabinoid receptors (cbr), cb1 and cb2, suggesting the possibility of endocannabinoid system (ecs) as a target. |
2023-10-11 |
2023-10-15 |
Not clear |
| Ahmed Haider, Lu Wang, Luca Gobbi, Yinlong Li, Ahmad Chaudhary, Xin Zhou, Jiahui Chen, Chunyu Zhao, Jian Rong, Zhiwei Xiao, Lu Hou, Nehal H Elghazawy, Wolfgang Sippl, April T Davenport, James B Daunais, Hazem Ahmed, Ron Crowe, Michael Honer, Axel Rominger, Uwe Grether, Steven H Liang, Simon M Ametame. Evaluation of [ ACS chemical neuroscience. 2023-10-03. PMID:37788055. |
evaluation of [ the cannabinoid type 2 receptor (cb2) has been implicated in a variety of central and peripheral inflammatory diseases, prompting significant interest in the development of cb2-targeted diagnostic and therapeutic agents. |
2023-10-03 |
2023-10-07 |
human |
| Lin Yang, Dan Zhou, Jiaojiao Cao, Fangyuan Shi, Jiaming Zeng, Siqi Zhang, Guorui Yan, Zhihan Chen, Bo Chen, Yi Guo, Xiaowei Li. Revealing the biological mechanism of acupuncture in alleviating excessive inflammatory responses and organ damage in sepsis: a systematic review. Frontiers in immunology. vol 14. 2023-09-27. PMID:37753078. |
mechanistically, a change in the acupoint microenvironment is the initial response link for acupuncture to take effect, whereas prokr2 neurons, high-threshold thin nerve fibres, cannabinoid cb2 receptor (cb2r) activation, and ca |
2023-09-27 |
2023-10-07 |
Not clear |
| Anthony H Taylor, Panos Bachkangi, Justin C Konj. Labour and premature delivery differentially affect the expression of the endocannabinoid system in the human placenta. Histochemistry and cell biology. 2023-09-26. PMID:37750996. |
here we examined the expression of the n-acylethanolamine-modulating enzymes fatty acid amide hydrolase (faah) and n-acyl-phosphatidylethanolamine-specific phospholipase-d (nape-pld) and of the cannabinoid receptors (cb1 and cb2) in the placenta and their activation in an in vitro model of the third-trimester placenta to determine if those expressions change with labour and have functional significance. |
2023-09-26 |
2023-10-07 |
human |