| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Misaki Oyama, Misaki Sakamoto, Kazuki Kitabatake, Kanami Shiina, Daisuke Kitahara, Sohei Onozawa, Keisuke Nishino, Yuka Sudo, Mitsutoshi Tsukimot. Involvement of cannabinoid receptors and adenosine A2B receptor in enhanced migration of lung cancer A549 cells induced by γ-ray irradiation. Biological & pharmaceutical bulletin. 2023-11-05. PMID:37926527. |
our results indicate that a2b receptors and cannabinoid cb1, cb2 and gpr55 receptors all contribute to γ-radiation-induced acquisition of malignant phenotypes, and in particular that interactions of a2b receptor and cannabinoid cb2 and gpr55 receptors play a role in promoting cell migration and actin remodeling. |
2023-11-05 |
2023-11-08 |
human |
| Jingjing Zhang, Yali Zhu, Shuxian Chen, Zujin Xu, Bin Zhang, Anpeng Liu, Qianwen He, Jia Zha. Activation of cannabinoid receptors 2 alleviates myocardial damage in cecal ligation and puncture-induced sepsis by inhibiting pyroptosis. Immunology letters. 2023-11-02. PMID:37918639. |
it has been reported that cannabinoid receptors 2 (cb2 receptors) play an important role in the pathophysiological process of sepsis, which may also be associated with the regulation of pyroptosis, an inflammatory programmed cell death. |
2023-11-02 |
2023-11-08 |
mouse |
| Jonathan Paulo Agnes, Barbara Dos Santos, Raquel Nascimento das Neves, Vitória Maria Marques Luciano, Larissa Benvenutti, Fernanda Capitanio Goldoni, Roberta Giusti Schran, José Roberto Santin, Nara Lins Meira Quintão, Alfeu Zanotto-Filh. β-Caryophyllene Inhibits Oxaliplatin-Induced Peripheral Neuropathy in Mice: Role of Cannabinoid Type 2 Receptors, Oxidative Stress and Neuroinflammation. Antioxidants (Basel, Switzerland). vol 12. issue 10. 2023-10-30. PMID:37891972. |
in this study, we investigated the antiallodynic effect of β-caryophyllene (bcp), a cannabinoid type 2 (cb2) receptor agonist, in a mouse model of oipn. |
2023-10-30 |
2023-11-08 |
mouse |
| Sumit S Rathod, Yogeeta O Agrawal, Kartik T Nakhate, M F Nagoor Meeran, Shreesh Ojha, Sameer N Goya. Neuroinflammation in the Central Nervous System: Exploring the Evolving Influence of Endocannabinoid System. Biomedicines. vol 11. issue 10. 2023-10-30. PMID:37893016. |
both cb1 and cb2 cannabinoid receptors exhibit noteworthy physiological responses and possess diverse neuromodulatory capabilities. |
2023-10-30 |
2023-11-08 |
Not clear |
| Katarzyna Stachowic. Deciphering the mechanisms of reciprocal regulation or interdependence at the cannabinoid CB1 receptors and cyclooxygenase-2 level: Effects on mood, cognitive implications, and synaptic signaling. Neuroscience and biobehavioral reviews. 2023-10-28. PMID:37898448. |
the lipid endocannabinoid system refers to endogenous cannabinoids (ecbs), the enzymes involved in their synthesis and metabolism, and the g protein-coupled cannabinoid receptors (gpcrs), cb1, and cb2. |
2023-10-28 |
2023-11-08 |
Not clear |
| Bradley L Hoare, David N Tippett, Amandeep Kaur, Sean A Cullum, Tamara Miljuš, Eline J Koers, Clare R Harwood, Nicola Dijon, Nicholas D Holliday, David A Sykes, Dmitry Veprintse. ThermoBRET: A Ligand-Engagement Nanoscale Thermostability Assay Applied to GPCRs. Chembiochem : a European journal of chemical biology. 2023-10-24. PMID:37872746. |
here, we present a thermobret method to quantify the relative thermostability of g protein coupled receptors (gpcrs), using cannabinoid receptors (cb1 and cb2) and the b2-adrenoceptor (b2ar) as model systems. |
2023-10-24 |
2023-11-08 |
Not clear |
| Jacob N Kisiolek, Victoria A Flores, Arjun Ramani, Blake Butler, James M Haughian, Laura K Stewar. Eight Weeks of Daily Cannabidiol Supplementation Improves Sleep Quality and Immune Cell Cytotoxicity. Nutrients. vol 15. issue 19. 2023-10-14. PMID:37836465. |
the endocannabinoid system is active in nervous and immune cells and involves the expression of two cannabinoid receptor genes (cb1 and cb2), along with endogenous endocannabinoid ligands, 2-arachidonoyl glycerol (2-ag) and arachidonoyl ethanolamide (anandamide), and their synthetic enzymes. |
2023-10-14 |
2023-10-15 |
Not clear |
| Yu-Shan Lin, Wen-Hou Huang, Keng-Fu Hsu, Ming-Jer Tang, Wen-Tai Chi. Reversion of chemoresistance by endocannabinoid-induced ER stress and autophagy activation in ovarian cancer. American journal of cancer research. vol 13. issue 9. 2023-10-11. PMID:37818056. |
our results showed that ovc cells expressed both cannabinoid receptors (cbr), cb1 and cb2, suggesting the possibility of endocannabinoid system (ecs) as a target. |
2023-10-11 |
2023-10-15 |
Not clear |
| Ahmed Haider, Lu Wang, Luca Gobbi, Yinlong Li, Ahmad Chaudhary, Xin Zhou, Jiahui Chen, Chunyu Zhao, Jian Rong, Zhiwei Xiao, Lu Hou, Nehal H Elghazawy, Wolfgang Sippl, April T Davenport, James B Daunais, Hazem Ahmed, Ron Crowe, Michael Honer, Axel Rominger, Uwe Grether, Steven H Liang, Simon M Ametame. Evaluation of [ ACS chemical neuroscience. 2023-10-03. PMID:37788055. |
evaluation of [ the cannabinoid type 2 receptor (cb2) has been implicated in a variety of central and peripheral inflammatory diseases, prompting significant interest in the development of cb2-targeted diagnostic and therapeutic agents. |
2023-10-03 |
2023-10-07 |
human |
| Lin Yang, Dan Zhou, Jiaojiao Cao, Fangyuan Shi, Jiaming Zeng, Siqi Zhang, Guorui Yan, Zhihan Chen, Bo Chen, Yi Guo, Xiaowei Li. Revealing the biological mechanism of acupuncture in alleviating excessive inflammatory responses and organ damage in sepsis: a systematic review. Frontiers in immunology. vol 14. 2023-09-27. PMID:37753078. |
mechanistically, a change in the acupoint microenvironment is the initial response link for acupuncture to take effect, whereas prokr2 neurons, high-threshold thin nerve fibres, cannabinoid cb2 receptor (cb2r) activation, and ca |
2023-09-27 |
2023-10-07 |
Not clear |
| Anthony H Taylor, Panos Bachkangi, Justin C Konj. Labour and premature delivery differentially affect the expression of the endocannabinoid system in the human placenta. Histochemistry and cell biology. 2023-09-26. PMID:37750996. |
here we examined the expression of the n-acylethanolamine-modulating enzymes fatty acid amide hydrolase (faah) and n-acyl-phosphatidylethanolamine-specific phospholipase-d (nape-pld) and of the cannabinoid receptors (cb1 and cb2) in the placenta and their activation in an in vitro model of the third-trimester placenta to determine if those expressions change with labour and have functional significance. |
2023-09-26 |
2023-10-07 |
human |
| Başak Işıl Zorba, Özge Boyacioğlu, Tuğba Çağlayan, Tuba Reçber, Emirhan Nemutlu, İpek Eroğlu, Petek Korkusu. CB65 and novel CB65 liposomal system suppress MG63 and Saos-2 osteosarcoma cell growth in vitro. Journal of liposome research. 2023-09-23. PMID:37740901. |
cannabinoid ligands exert antiproliferative and apoptotic effect on osteosarcoma cells via cannabinoid 2 (cb2) or transient receptor potential vanilloid type (trpv1) receptors. |
2023-09-23 |
2023-10-07 |
Not clear |
| Ji-de Zheng, Feng-Qiang Sun, Mei-Juan Mia. [Research progress of acupuncture mediated analgesia via regulating the function of endocannabinoid system]. Zhen ci yan jiu = Acupuncture research. vol 48. issue 9. 2023-09-20. PMID:37730267. |
by reviewing literatures related to acupuncture analgesia and ecs, we summarized the effect and mechanism of acupuncture analgesia involved with regulation of ecs, pointed out cannabinoid (cb) 1 receptor and cb2 receptor exerted analgesic effect in central and peripheral neural system through mechanisms of inhibiting neural activation and anti-inflammation, respectively. |
2023-09-20 |
2023-10-07 |
Not clear |
| Michael Maes, Muanpetch Rachayon, Ketsupar Jirakran, Atapol Sughondhabirom, Abbas F Almulla, Pimpayao Sodsa. Role of T and B lymphocyte cannabinoid type 1 and 2 receptors in major depression and suicidal behaviors. Acta neuropsychiatrica. 2023-09-08. PMID:37681553. |
this study examines the number of cannabinoid type 1 (cb1) and type 2 (cb2) receptor bearing t/b lymphocytes in mdd, and the effects of in vitro cannabidiol (cbd) administration on cb1/cb2-bearing immunocytes. |
2023-09-08 |
2023-10-07 |
Not clear |
| Ziteng Wang, Eric Yu Quan Leow, Hooi Yan Moy, Eric Chun Yong Cha. Advances in urinary biomarker research of synthetic cannabinoids. Advances in clinical chemistry. vol 115. 2023-09-06. PMID:37673518. |
synthetic cannabinoids (scs) are a subclass of nps which bind to the cannabinoid receptors, cb1 and cb2, and mimic the action of cannabis. |
2023-09-06 |
2023-10-07 |
human |
| Christina A Brust, Matthew A Swanson, Laura M Boh. Structural and functional insights into the G protein-coupled receptors: CB1 and CB2. Biochemical Society transactions. vol 51. issue 4. 2023-08-30. PMID:37646476. |
the cannabinoid receptors cb1 and cb2 mediate a variety of physiological processes and continue to be explored as desirable drug targets. |
2023-08-30 |
2023-09-07 |
Not clear |
| Christina A Brust, Matthew A Swanson, Laura M Boh. Structural and functional insights into the G protein-coupled receptors: CB1 and CB2. Biochemical Society transactions. vol 51. issue 4. 2023-08-30. PMID:37646476. |
these structures will provide additional insight into the modulation and signaling mechanism of cannabinoid receptors cb1 and cb2 and aid in the development of future therapeutics. |
2023-08-30 |
2023-09-07 |
Not clear |
| Hebaallah Mamdouh Hashiesh, Azimullah Sheikh, Mohamed Fizur Nagoor Meeran, Dhanya Saraswathiamma, Niraj Kumar Jha, Bassem Sadek, Ernest Adeghate, Saeed Tariq, Saeeda Al Marzooqi, Shreesh Ojh. β-Caryophyllene, a Dietary Phytocannabinoid, Alleviates Diabetic Cardiomyopathy in Mice by Inhibiting Oxidative Stress and Inflammation Activating Cannabinoid Type-2 Receptors. ACS pharmacology & translational science. vol 6. issue 8. 2023-08-17. PMID:37588762. |
recently, it has been revealed that cannabinoid type-2 (cb2) receptors, an essential component of the endocannabinoid system, play a crucial role in the pathogenesis of obesity, hyperlipidemia, and dm. |
2023-08-17 |
2023-09-07 |
mouse |
| Pranay Wal, Ankita Wa. CBD: A Potential Lead against Hair Loss, Alopecia, and its Potential Mechanisms. Current drug discovery technologies. 2023-07-21. PMID:37475557. |
due to the presence of the endocannabinoid system (ecs) in the body, which naturally targets cb1 and cb2 receptors, the control of hair fall is possible. |
2023-07-21 |
2023-08-14 |
Not clear |
| J Maia, B M Fonseca, N Teixeira, G Correia-da-Silv. Unveiling the Angiogenic Effects of Cannabinoids: Enhancers or inhibitors? Biochemical pharmacology. 2023-07-18. PMID:37463627. |
some can activate the cannabinoid receptors type-1 and -2 (cb1 and cb2), that are part of the endocannabinoid system (ecs), alongside the endocannabinoids and their metabolic enzymes. |
2023-07-18 |
2023-08-14 |
Not clear |